Role of the TRAF binding site and NF-κB activation in Epstein-Barr Virus latent membrane protein 1-induced cell gene expression

Journal of Virology

Volumn 72, Issue 10, 1998, Pages 7900-7908

  Devergne, Odile ^a,b   Mcfarland, Ellen Cahir ^b   Mosialos, George ^b   Izumi, Kenneth M ^b   Ware, Carl F ^c   Kieff, Elliott ^b,d  

^a INSERM   (France)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d CHANNING LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MEMBRANE PROTEIN;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; EPITHELIUM CELL; EPSTEIN BARR VIRUS; GENE EXPRESSION; GENE INDUCTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION;

EID: 0031718910     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.10.7900-7908.1998     Document Type: Article

References (60)

1. Aizawa, S., H. Nakano, T. Ishida, R. Horie, M. Nagai, K. Ito, H. Yagita, K. Okumura, J. Inoue, and T. Watanabe. 1997. Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NF-κB activation. J. Biol. Chem. 272:2042-2045.
2. Baichwal, V. R., and B. Sugden. 1988. Transformation of Balb 3T3 cells by the BNLF-1 gene of the Epstein-Barr virus. Oncogene 2:461-467.
3. Banchereau, J., F. Bazan, D. Blanchard, F. Briere, J. P. Galizzi, C. van Kooten, Y. J. Liu, F. Rousset, and S. Saeland. 1994. The CD40 antigen and its ligand. Annu. Rev. Immunol. 12:881-922.
4. Behrmann, I., H. Walczak, and P. H. Krammer. 1994. Structure of the human APO-1 gene. Eur. J. Immunol. 24:3057-3062.
5. Brodeur, S. R., G. Cheng, D. Baltimore, and D. A. Thorley-Lawson. 1997. Localisation of the major NF-κB-activating site and the sole TRAF3 binding site of LMP-1 defines two distinct signaling motifs. J. Biol. Chem. 272:19777-19784.
6. Chen, Z., J. Hagler, V. J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets I-κBα to the ubiquitin-proteasome pathway. Genes Dev. 9:1585-1597.
7. Cheng, G., A. M. Cleary, Z. S. Ye, D. I. Hong, S. Lederman, and D. Baltimore. 1995. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494-1498.
8. Cheng, J., C. Liu, W. J. Koopman, and J. D. Mountz. 1995. Characterization of the human Fas gene. Exon/intron organization and promoter region. J. Immunol. 154:1239-1245.
9. Devergne, O., M. Hummel, H. Koeppen, M. Le Beau, E. C. Nathanson, E. Kieff, and M. Birkenbach. 1996. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J. Virol. 70:1143-1153.
10. Devergne, O., E. Hatzivassiliou, K. M. Izumi, K. M. Kaye, M. F. Kleijnen, E. Kieff, and G. Mosialos. 1996. Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-κB activation. Mol. Cell. Biol. 16:7098-7108.
11. Devergne, O., M. Birkenbach, and E. Kieff. 1997. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc. Natl. Acad. Sci. USA 94:12041-12046.
12. Eliopoulos, A. G., M. Stack, C. W. Dawson, K. M. Kaye, L. Hodgkin, S. Sihota, M. Rowe, and L. S. Young. 1997. Epstein-Barr virus-encoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-κB pathway involving TNF receptor-associated factors. Oncogene 14:2899-2916.
13. Eliopoulos, A. G., and L. S. Young. 1998. Activation of the c-jun N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Oncogene 16:1731-1742.
14. Floettmann, J. E., K. Ward, A. B. Rickinson, and M. Rowe. 1996. Cytostatic effect of Epstein-Barr virus latent membrane protein-1 (LMP1) analyzed using tetracycline-regulated expression in B cell lines. Virology 223:29-40.
15. Floettmann, J. E., and M. Rowe. 1997. Epstein-Barr virus latent membrane protein 1 (LMP1) C-terminus activation region 2 (CTAR2) maps to the far C-terminus and requires oligomerisation for NF-κB activation. Oncogene 15:1851-1858.
16. Gires, O., V. Zimber-Strobl, R. Gonella, M. Ueffmg, G. Marshall, R. Zeidler, D. Pich, and W. Hammerschmidt. 1997. Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule. EMBO J. 16:6131-6140.
17. Hammerschmidt, W., B. Sugden, and V. R. Baichwal. 1989. The transforming domain alone of the latent membrane protein of Epstein-Barr virus is toxic to cells when expressed at high levels. J. Virol. 63:2469-2475.
18. Hanissian, S. H., and R. S. Geha. 1997. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 6:379-387.
19. Hatzivassiliou, E., W. E. Miller, N. Raab-Traub, E. Kieff, and G. Mosíalos. 1998. A fusion of the EBV latent membrane protein 1 (LMP1) transmembrane domains to the CD40 cytoplasmic domain is similar to LMP1 in constitutive activation of epidermal growth factor receptor expression, nuclear factor-κB and stress-activated protein kinase. J. Immunol. 160:1116-1121.
20. Henderson, S., M. Rowe, C. Gregory, C. D. Croom, F. Wang, R. Longnecker, E. Kieff, and A. Rickinson. 1991. Induction of Bcl-2 expression by Epstein-Barr virus latent membrane protein protects infected B cells from programmed cell death. Cell 65:1107-1115.
21. Hostager, B. S., Y. Hsing, D. E. Harms, and G. A. Bishop. 1996. Different CD40-mediated signaling events require distinct structural features. J. Immunol. 157:1047-1053.
22. Hou, J., V. Baichwal, and Z. Cao. 1994. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1. Proc. Natl. Acad. Sci. USA 91:11641-11645.
23. Hsing, Y., B. S. Hostager, and G. A. Bishop. 1997. Characterization of CD40 signaling determinants regulating nuclear factor-κB activation in B lymphocytes. J. Immunol. 159:4898-4906.
24. Hsu, H., J. Xiong, and O. V. Goeddel. 1995. The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81:495-504.
25. Hsu, H., H. B. Shu, M. P. Pan, and D. V. Goeddel. 1996. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways. Cell 84:299-308.
26. Huen, D. S., S. A. Henderson, D. Croom-Carter, and M. Rowe. 1995. The Epstein-Barr virus latent membrane protein-1 (LMP1) mediates activation of NF-κB and cell surface phenotype via two effector regions in its carboxyterminal cytoplasmic domain. Oncogene 10:549-560.
27. Ishida, T., S.-I. Mizushima, S. Azuma, N. Kabayashi, T. Tojo, K. Suzuki, S. Aizawa, T. Watanabe, G. Mosialos, E. Kieff, T. Yamamoto, and J.-I. Inoue. 1996. Identification of TRAF6, a novel tumor necrosis factor receptor-associated protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 271:28745-28748.
28. Ishida, T., T. Tojo, T. Aoki, N. Kobayashi, T. Ohishi, T. Watanabe, T. Yamamoto, and J. Inoue. 1996. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc. Natl. Acad. Sci. USA 93:9437-9442.
29. Izumi, K. M., K. M. Kaye, and E. Kieff. 1994. Epstein-Barr virus recombinant molecular genetics analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation. J. Virol. 68:4369-4376.
30. Izumi, K. M., K. M. Kaye, and E. D. Kieff. 1997. The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA 94:1447-1452.
31. Izumi, K. M., and E. D. Kieff. 1997. The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB. Proc. Natl. Acad. Sci. USA 94:12592-12597.
32. Kaye, K. M., K. M. Izumi, and E. Kieff. 1993. Epstein-Barr virus latent membrane protein 1 is essential for B lymphocyte transformation. Proc. Natl. Acad. Sci. USA 90:9150-9154.
33. Kaye, K. M., K. M. Izumi, G. Mosialos, and E. Kieff. 1995. The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B lymphocyte transformation: fibroblast cocultivation complements a critical function within the terminal 155 residues. J. Virol. 69:675-683.
34. Kaye, K. M., O. Devergne, J. N. Harada, K. M. Izumi, R. Yalamanchili, E. Kieff, and G. Mosialos. 1996. Tumor necrosis factor receptor associated factor 2 is a mediator of NF-κB activation by latent membrane protein 1, the Epstein-Barr virus transforming protein. Proc. Natl. Acad. Sci. USA 93:11085-11090.
35. Kaye, K. M., K. M. Izumi, E. Johannsen, and E. Kieff. Unpublished results.
36. Kieff, E. 1996. Epstein-Barr virus and its replication, p. 2343-2396. In B. N. Fields, D. M. Knipe, P. M. Howley, et al. (ed.), Virology 3rd ed. Raven Press. Ltd., Philadelphia, Pa.
37. Kieser, A., E. Kilger, O. Gires, M. Ueffing, W. Kolch, and W. Hammerschmidt. 1997. Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-jun N-terminal kinase cascade. EMBO J. 16:6478-6485.
38. Kilger, E., E. Kilger, O. Gries, M. Ueffling, W. Kolch, and W. Hammerschmidt. 1998. Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor. EMBO J. 17:1700-1709.
39. Kuhne, M. R., M. Robbins, J. E. Hambor, M. F. Mackey, Y. Kosaka, T. Nishimura, J. P. Gigley, R. J. Noelle, and D. M. Calderhead. 1997. Assembly and regulation of the CD40 receptor complex in human B cells. J. Exp. Med. 186:337-342.
40. Laherty, C. D., H. M. Hu, A. W. Opipari, F. Wang, and V. M. Dixit. 1992. The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor-κB. J. Biol. Chem. 267:24157-24160.
41. Lee, S. Y., A. Reichlin, A. Santana, K. A. Kokol, M. C. Nussenzweig, and Y. Choi. 1997. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity 7:703-713.
42. Liebowitz, D., J. Mannick, K. Takada, and E. Kieff. 1992. Phenotypes of Epstein-Barr virus LMP1 deletion mutants indicate transmembrane and amino-terminal cytoplasmic domains necessary for effects in B-lymphoma cells. J. Virol. 66:4612-4616.
43. Lu, J. J., J. Y. Chen, T. Y. Hsu, W. C. Yu, I. J. Su, and C. S. Yang. 1996. Induction of apoptosis in epithelial cells by Epstein-Barr virus latent membrane protein 1. J. Gen. Virol. 77:1883-1892.
44. Miller, W. E., G. Mosialos, E. Kieff, and N. Raab-Traub. 1997. Epstein-Barr virus LMPI induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-κB activation. J. Virol. 71:586-594.
45. Miller, W. E., J. L. Cheshire, and N. Raab-Traub. 1998. Interaction of tumor necrosis factor receptor-associated factor signaling proteins with the latent membrane protein 1 PXQXT motif is essential for induction of epidermal growth factor receptor expression. Mol. Cell. Biol. 18:2835-2844.
46. Mitchell, T., and B. Sugden. 1995. Stimulation of NF-κB mediated transcription by mutant derivatives of the latent membrane protein of the Epstein-Barr virus. J. Virol. 69:2968-2976.
47. Mosialos, G., M. Birkenbach, R. Yalamanchili, T. VanArsdale, C. Ware, and E. Kieff. 1995. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:389-399.
48. Nakano, H., H. Oshima, W. Chung, L. Williams-Abbott, C. F. Ware, H. Yagita, and K. Okumura. 1996. TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J. Biol. Chem 271:14661-14664.
49. Natoli, G., A. Costanzo, A. lanni, D. J. Templeton, J. R. Woodgett, C. Balsano, and M. Levrero. 1997. Activation of SAPK/JNK by TNF receptor 1 through a non cytotoxic TRAF2-dependent pathway. Science 275:200-203
50. Reinhard, C., B. Shamoon, V. Shyamala, and L. T. Williams. 1997. Tumor necrosis factor Α-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 16:1080-1092.
51. Rickinson, A. B., and E. Kieff. 1996. Epstein-Barr virus, p. 2397-2446. In B. N. Fields, D. M. Knipe, P. M. Howley, R. M. Chanock, J. L. Melnick, T. P Monath, B. Roizman, and S. Straus (ed.), Virology, 3rd ed. Raven Press, Ltd., Philadelphia, Pa.
52. Rothe, M., V. Sarma, V. M. Dixit, and D. V. Goeddel. 1995 TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 269-1424-1427.
53. Sandberg. M., W. Hammerschmidt, and B. Sugden. 1997. Characterization of LMP1's association with TRAF1, TRAF2, and TRAF3. J. Virol. 71:4649-4656.
54. Shu, H. B., M. Takeuchi, and D. V. Goeddel. 1996. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. USA 93:13973-13978.
55. Song. H. Y., C. H. Regnier, C. J. Kirschning, D. V. Goeddel, and M. Rothe. 1997. Tumor necrosis factor (TNF)-mediated kinases cascades: bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at the TNF receptor-associated factor 2. Proc. Natl. Acad. Sci. USA 94:9792-9796.
56. VanArsdale. T. L., S. L. VanArsdale, W, R. Force, B. N. Walter, G. Mosialos, E. Kieff, J. C. Reed, and C. F. Ware. 1997. Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB. Proc. Natl. Acad. Sci. USA 94:2460-2465.
57. Voraberger, G., R. Schafer, and C. Stratowa. 1991. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester. J. Immunol. 147:2777-2786.
58. Wang, D., D. Liebowitz, and E. Kieff. 1985. An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells, Cell 43:831-840.
59. Wang, D., D. Liebowitz, F. Wang, C. Gregory, A. B. Riekinson, R. Larson, T. Springer, and E. Kieff. 1988. Epstein-Barr virus latent infection membrane protein alters the human B-lymphocyte phenotype: deletion of the amino terminus abolishes activity. J. Virol. 62:4173-4184.
60. Wang, F., C. Gregory, C. Sample, M. Rowe, D. Liebowitz, R. Murray, A. Rickinson, and E. Kieff. 1990. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA2 and LMP1 cooperatively induce CD23. J. Virol. 64:2309-2318.