The effect of substrate binding on the conformation and structural stability of Herpes simplex virus type 1 thymidine kinase

Protein Science

Volumn 10, Issue 1, 2001, Pages 63-73

  Wurth, Christine ^a   Kessler, Ulrich ^a   Vogt, Joachim ^b   Schulz, Georg E ^b   Folkers, Gerd ^a   Scapozza, Leonardo ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Circular dichroism; Conformation; Crystal structure; Herpes simplex virus type 1 thymidine kinase; Structural stability; Thermal denaturation

Indexed keywords

LIGAND; NUCLEOSIDE MONOPHOSPHATE KINASE; THYMIDINE KINASE;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DENATURATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; HERPES SIMPLEX VIRUS 1; PRIORITY JOURNAL; THERMOSTABILITY;

ANTIGENS, SURFACE; BINDING SITES; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; HERPESVIRUS 1, HUMAN; LIGANDS; PROTEIN CONFORMATION; PROTEIN DENATURATION; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; THYMIDINE KINASE; TUMOR MARKERS, BIOLOGICAL;

HERPES; HUMAN HERPESVIRUS 1;

EID: 0035104129     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.27401     Document Type: Article

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