In vitro release of trypanocidal drugs from biodegradable implants based on poly(ε-caprolactone) and poly(D,L-lactide)

Journal of Controlled Release

Volumn 55, Issue 1, 1998, Pages 79-85

  Lemmouchi, Yahia ^a   Schacht, Etienne ^a   Lootens, Catherine ^a  

^a Inst Biomed Technol IBITECH U   (Belgium)

Author keywords

Biodegradable polyesters; Ethidium bromide; In vitro release; Isometamidium chloride; Trypanosomiasis

Indexed keywords

ANTITRYPANOSOMAL AGENT; ETHIDIUM; ISOMETAMIDIUM CHLORIDE; POLYCAPROLACTONE; POLYLACTIDE; POLYMER;

ARTICLE; DRUG MANUFACTURE; DRUG MIXTURE; DRUG RELEASE; IN VITRO STUDY; MOLECULAR WEIGHT; OSMOTIC PRESSURE; PRIORITY JOURNAL;

BIOCOMPATIBLE MATERIALS; DIFFERENTIAL THERMAL ANALYSIS; DRUG IMPLANTS; ETHIDIUM; MOLECULAR WEIGHT; PHENANTHRIDINES; POLYESTERS; SOLUBILITY; TRYPANOCIDAL AGENTS;

EID: 0031783897     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(98)00021-2     Document Type: Article

References (13)

1. Dolan R.B., Okech G., Alushula H., Muguti M., Stevenson P.D., Njogu A.R. Homidium bromide as a chemoprophylactic for cattle trypanosomiasis in Kenya. Acta Trop. 47:1990;137-144.
2. Dolan R.B., Stevenson P.G.W., Alushula H., Okech G. Failure of chemoprophylaxis against bovine trypanosomiasis on Galana Ranch in Kenya. Acta Trop. 51:1992;113-121.
3. Kinabo L.D.B. Pharmcology of existing drugs for animal trypanomiasis. Acta Trop. 54:1993;169-183.
4. Kuzoe F.A.S. Current situation of African trypanosomiasis. Acta Trop. 54:1993;153-162.
5. Peregrine A.S., Moloo S.K., Whitelaw D.D. Difference in sensitivity of Kenya trypanosoma vivax populations to the prophylactic and therapeutic actions of isometamidium chloride in Boran cattle. Trop. Animal Healh Prod. 23:1991;29-38.
6. Holland S.J., Tighe B.J., Gould P.L. Polymers for biomedical devices: 1. The potential of polyesters as controlled macromolecular release systems. J. Control. Release. 4:1986;155-180.
7. D.H. Lewis, Controlled release of bioactive agents from lactide/glycolide polymers, in: M. Chasin, R. Langer (Eds.), Biodegradable Polymers as Drug Delivery Systems, Marcel Dekker, NY, Basel, Hong Kong, 1990, pp. 1-43.
8. C. Pitt, Poly-ε-caprolactone and its copolymers, in: M. Chasin and R. Langer (Eds.), Biodegradable Polymers as Drug Delivery Systems, Marcel Dekker, NY, Basel, Hong Kong, 1990, pp. 71-120.
9. Lemmouchi Y., Schacht E. Preparation and in vitro evaluation of biodegradable poly(ε-caprolactone-co-D,L-lactide)(X-Y) devices containing trypanocidal drugs. J. Control. Release. 45:1997;227-233.
10. Persche H., Vollner L. Determination of the trypanocidal drugs homidium, isometamidium and quinapyramine in bovine serum or plasma using HPLC. Acta Trop. 42:1985;209-216.
11. Omelczulk M.O., MacGinity J.W. The influence of polymer glass transition temperature and molecular weight on drug release from tablets containing poly(D,L-lactid acid). Pharm. Res. 9:1992;26-32.
12. Zhang X., Wyss U.P., Pichora D., Goosen M.F.A. A mechanistic of antibiotics release from biodegradable poly(D,L-lactide) cylinders. J. Control. Release. 31:1994;129-144.
13. Pitt C., Jeffcoat R., Zweidinger R., Schinlder A. Sustained drug delivery systems: I. The permeability of poly(-caprolactone), poly(D,L-lactic acid) and their copolymers. J. Biomed. Mater. Res. 13:1979;497-507.