Degradation of porous poly(anhydride-co-imide) microspheres and implications for controlled macromolecule delivery

Biomaterials

Volumn 19, Issue 1-3, 1998, Pages 163-172

  Hanes, Justin ^a   Chiba, Masatoshi ^a,b   Langer, Robert ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

Author keywords

Biocompatible; Controlled release; Degradable polymers; Microspheres; Poly(anhydride imides); Polyanhydride; Protein delivery

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; CHEMICAL BONDS; CONTROLLED DRUG DELIVERY; COPOLYMERS; DISSOLUTION; MACROMOLECULES; MONOMERS; POLYIMIDES; POROUS MATERIALS; PROTEINS; SOLUBILITY;

BOVINE SERUM ALBUMIN; POLYANHYDRIDE;

BIOMATERIALS;

BOVINE SERUM ALBUMIN; COPOLYMER; IMIDE; MICROSPHERE; POLYANHYDRIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; DEGRADATION; DISSOLUTION; EMULSION; EVAPORATION; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; SOLUBILITY; TIME;

ANIMALS; ANTIGENS; BIOCOMPATIBLE MATERIALS; CHEMISTRY, PHARMACEUTICAL; DECANOIC ACIDS; DELAYED-ACTION PREPARATIONS; EMULSIONS; HYDROGEN-ION CONCENTRATION; MACROMOLECULAR SUBSTANCES; MALE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; POLYMERS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, BOVINE; SOLUBILITY; WATER;

ANIMALIA; BOVINAE;

EID: 0031864950     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(97)00221-4     Document Type: Article

References (20)

1. [1] Peppas N, Langer R. New challenges in biomaterials. Science 1994;263:1657-1804.
2. [2] Gilding DK, Reed AM. Biodegradable polymers for use in surgery: polyglycolic/poly(lactic acid) homo- and copolymers: 1. Polymer 1979;20:1459-64.
3. [3] Langer R. New methods of drug delivery. Science 1990;249:1527-33.
4. [4] Langer R, Vacanti J. Tissue engineering. Science 1993;260:920-26.
5. [5] Rokkanen P, Bostman O, Vainionpaa S et al. Absorbable devices in the fixation of fractures. Journal of Trauma 1996;40:S123-27.
6. [6] Proceedings of the 24th International Symposium on Controlled Release Bioactive Materials, 1997, Stockholm, Sweden. Controlled Release Society, Inc.
7. [7] Lewis DH. Controlled release of bioactive agents from lactide/glycolide polymers. In: Chasin M, Langer R, editors. Biodegradable polymers as drug delivery systems. New York: Marcel Dekker, 1990:1-41.
8. [8] Göpferich A, Gref R, Minamitake Y et al. Drug delivery from bioerodible polymers: Systemic and intravenous administration. In: Cleland J, Langer R, editors. Formulation and delivery of proteins and peptides. American Chemical Society, Washington DC, 1994:242-77.
9. [9] Hanes J, Chiba M, Langer R. Synthesis and characterization of degradable anhydride-co-imide terpolymers containing trimellitylimido-L-tyrosine: novel polymers for drug delivery. Macromolecules 1996;29:5279-87.
10. [10] Kline D, Hanes J, Langer R. Adjuvant-active polymeric microparticulate vaccine-delivery systems. In: Cohen S, Bernstein H, editors. Microparticulate systems for the delivery of proteins and vaccines. New York: Marcel Dekker, 1996:349-79.
11. [11] Chiba M, Hanes J, Langer R. Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres. Biomaterials 1997;18:893-901.
12. [12] Hanes J, Cleland JL, Langer R. New advances in microsphere-based single-dose vaccines. Advances in Drug Delivery Review 1997;28:97-119.
13. [13] Mathiowitz E, Ron E, Mathiowitz G, Amato C, Langer R. Morphological characterization of bioerodible polymers. 1. Crystallinity of polyanhydride copolymers. Macromolecules 1990;23:3212-18.
14. [14] Göpferich A, Langer R. The influence of microstructure and monomer properties on the erosion mechanism of a class of polyanhydrides. Journal of Polymer Science 1993;31:2445-58.
15. [15] Anderson J. Inflammatory response to implants. Transactions of the American Society for Artifical Internal Organs. 1988;34:101-7.
16. [16] Tamada JA, Langer R. Erosion kinetics of hydrolytically degradable polymers. Proceedings of the National Academy of Sciences USA. 1993;90:552-56.
17. [17] Batycky RP, Hanes J, Langer R, Edwards DA. A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. Journal of Pharmaceutical Sciences 1997; 86:1464-77.
18. [18] Stevens VC. Vaccine delivery systems: potential methods for use in antifertility vaccines. American Journal of Reproductive Immunology 1993;29:176-88.
19. [19] Cleland JL, Powell MF, Lim A et al. Development of a single shot subunit vaccine for HIV-1. AIDS Research on Human Retrovirus 1994;10:S21-26.
20. [20] Ada G. Strategies for exploiting the immune system in the design of vaccines. Molecular Immunology 1991;28:225-30.