Salient degradation features of a 50:50 PLA/PGA scaffold for tissue engineering

Tissue Engineering

Volumn 2, Issue 3, 1996, Pages 197-207

  Singhal, A R ^a   Agrawal, C M ^a   Athanasiou, K A ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; POLYGLYCOLIC ACID; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTICULAR CARTILAGE; BIOCOMPATIBILITY; BIODEGRADATION; CONTROLLED STUDY; IMPLANT; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0029967044     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.1996.2.197     Document Type: Article

References (21)

1. Athanasiou, K.A., Schmitz, J.P., Schenck, R.C., Clem, M., Aufdemorte, T., and Boyan, B.D. The use of biodegradable implants for repairing large articular cartilage defects in the rabbit. Transact. Orthop. Res. Soc. 17(1), 172, 1992.
2. Kulkarni, R.K., Pani, K.C., Neuman, C., and Leonard, F. Polylactic acid for surgical implants. Arch. Surg. 93, 839, 1966.
3. Cutright, D.E., Hunsuck, E.E., and Beasley, J.D. Fracture reduction using a biodegradable material, polylactic acid. J. Oral Surg. 29, 393, 1971.
4. Agrawal, C., Niederauer, G., Micallef, D., and Athanasiou, K. The use of PLA-PGA polymers in orthopaedics. In Encyclopedic Handbook of Biomaterials and Bioengineering. New York: Marcel Dekker, 1995, pp. 2081-2115.
5. Hollinger, J.O., and Schmitz, J.P. Restoration of bone discontinuities in dogs using a biodegradable implant. J. Oral Maxillofac. Surg. 45, 594, 1987.
6. Williams, D.F., and Mort, E. Enzyme-accelerated hydrolysis of polyglycolic acid. J. Bioeng. 1, 231, 1977.
7. Reed, A.M., and Gilding, D.K. PLA/PGA copolymers. In vivo and in vilro degradation. Transact. Soc, Biomat. 2, 15, 1978.
8. Nakamura, T., Hitomi, S., Waranabe, S., Shimizu, Y., Jamshidi, K., Hyon, S.H., and Ikada, Y. Bioabsorption of polylactides with different molecular properties. J. Biomed. Mat. Res. 23, 1115, 1989.
9. Miller, R.A., Brady, J.M., and Cutright, D.E. Degradation rates of oral resorbable implants (polylactates and polyglycolales): Rale modification with changes in PLA/PGA copolymer ratios. J. Biomed. Mat. Res. 11, 711, 1977.
10. Athanasiou, K.A., Singhal, A.R., Agrawal, C.M., and Boyan, B.D. In vitro biodegradation and release characteristics of biodegradable implants containing trypsin inhibitor. Clin. Orthop. Rel. Res. 315, 272, 1995.
11. Gilding, D.K., and Reed, A.M. Biodegradable polymers for use in surgery-polyglycolic/poly (lactic acid) homo-and copolymers: 1. Polymer 20, 1459, 1979.
12. Jamshidi, K., Hyen, S.H., Nakamura, T., Ikada, Y., Shimizu, Y., and Teramatsu, T. In Christel, P., Meunier, A., and Leein, A.J.C., eds. Biological and Biomechanical Performance of Biomaterials. Amsterdam: Elsevier Science Publishers, 1986, pp. 227-232.
13. Chu, C.C., and Browning, A. The study of thermal and gross morphologic properties of polyglycolic acid upon annealing and degradation treatments. J. Biomed. Mat. Res. 22, 699, 1988.
14. Agrawal, C.M., Niederauer, G.G., and Athanasiou, K.A. Fabrication and characterization of PLA-PGA orthopaedic implants. Tissue Eng. 1(3), 241, 1995.
15. Athanasiou, K.A., Schenck, R.C., Constantinides, G., Sylvia, V., Aufdemorte, T., and Boyan, B.D. Biodegradable carriers of TGF-b in rabbit osteochondral defects. Transact. Orthop. Res. Soc. 18(1), 288, 1993.
16. Athanasiou, K.A., Agrawal, A., and Dzida, F.J. Comparative study of intrinsic mechanical properties of human acetabular and femoral head cartilage. J. Orthop. Res. 12(3), 340, 1994.
17. Agrawal, C.M., Kennedy, M.E., and Micallef, D.M. The effects of ultrasound irradiation on a biodegradable 50-50% copolymer of polylactic and polyglycolic acids. J. Biomed. Mat. Res. 28, 851, 1994.
18. Dauner, M., Mueller, E., Wagner, B., and Plank, H. In vitro degradation of polylactides depending on different processes. In Plank, H., Dauner, M., and Renardy, M., eds. Degradation Phenomena on Polymeric Biomaterials. New York: Springer, 1992, pp. 107-121.
19. Coombes, A.G.A., and Heckman, J.D. Gel casting of resorbable polymers 1. Processing and applications. Biomaterials 13(4), 217, 1992.
20. Thompson, D.E., Agrawal, C.M., and Athanasiou, K.A. The effects of dynamic compressive loading on biodegradable implants of 50-50% polylactic acid-polyglycolic acid. Tissue Eng. 2(1), 61, 1996.
21. Li, S., Garreau, H., and Vert, M. Structure-property relationships in the case of the degradation of massive poly (x-hydroxy acids) in aqueous media, Part 3: Influence of the morphology of poly (L-lactic acid). J. Mat. Sci. Mat. Med. 1, 198, 1990.