In search of natural substrates and inhibitors of MDR pumps

Journal of Molecular Microbiology and Biotechnology

Volumn 3, Issue 2, 2001, Pages 247-254

  Lewis, K ^a  

^a Tufts University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BERBERINE; CARRIER PROTEIN; CATION; CHLORAMPHENICOL; CLINDAMYCIN; COUMESTROL; DALFOPRISTIN; ERGOSTEROL; ETHIDIUM BROMIDE; FOSFOMYCIN; GLYCOPROTEIN P; INF 271; ISOQUINOLINE DERIVATIVE; LINCOMYCIN; MACROLIDE; PROTEIN INHIBITOR; QUINUPRISTIN; SAPONIN DERIVATIVE; STREPTOMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; BINDING KINETICS; CELL MEMBRANE POTENTIAL; CELL SPECIFICITY; CONFERENCE PAPER; ENZYME SUBSTRATE; FUNCTIONAL ASSESSMENT; GRAM NEGATIVE BACTERIUM; HYDRATION; MEMBRANE PERMEABILITY; MOLECULAR EVOLUTION; MULTIDRUG RESISTANCE; NONHUMAN; PERMEABILITY BARRIER; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TRANSLATION REGULATION;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BACTERIA; BACTERIAL PHYSIOLOGY; BACTERIAL PROTEINS; BERBERINE; DRUG RESISTANCE, MULTIPLE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLAVONOIDS; ION PUMPS; MEMBRANE PROTEINS; PLANTS, MEDICINAL; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); BACTERIUM SUBTILIS; BERBERIS; NEGIBACTERIA;

EID: 0035088330     PISSN: 14641801     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (54)

1. A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates
2. Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro
3. Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters
4. The envelope of mycobacteria
5. Purification and ligand binding of EmrR, a regulator of a multidrug transporter
6. Isolation, characterization, and avenacin sensitivity of a diverse collection of cereal-root-colonizing fungi
7. marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli
8. Isolation and characterization of a putative multidrug resistance pump from Vibrio cholerae
9. Pharmacological activities of Chelidonium majus L. (Papaveraceae)
10. QacR is a repressor protein that regulates expression of the Staphylococcus aureus multidrug efflux pump QacA
11. Synthesis and structures of regioisomeric hydnocarpin-type flavonoglinans
12. Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance (MDR) pump. Structure-activity relationships
13. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system
14. Adaptation of Pseudomonas putida S12 to ethanol and toluene at the level of fatty acid composition of membranes
15. Is the multidrug transporter a flippase?
16. Bacteria lacking a multidrug pump: A sensitive tool for drug discovery
17. A broad-specificity multidrug efflux pump requiring a pair of homologous SMR-type proteins
18. The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae
19. Identification and molecular characterization of an efflux pump involved in Pseudomonas putida S12 solvent tolerance
20. Active efflux of organic solvents by Pseudomonas putida S12 is induced by solvents
21. Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance
22. In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleitropic drug resistance network
23. Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance
24. Multidrug resistance pumps in bacteria: Variations on a theme
25. Multidrug resistance efflux
26. Multidrug resistance: Versatile drug sensors of bacterial cells
27. Emr, an Escherichia coli locus for multidrug resistance
28. EmrR is a negative upstream regulator of the E coli multidrug resistance pump EmrA
29. Active efflux of antimicrobial agents in wild-type strains of enterococci
30. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli
31. MexXY-OprM efflux pump is required for antagonism of aminoglycosides by divalent cations in P. aeruginosa
32. The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain
33. Multiple novel inhibitors of the NorA multidrug transporter of Staphylococcus aureus
34. Overlaps and parallels in the regulation of intrinsic multiple-antibiotic resistance in Escherichi coli
35. Multidrug efflux pumps of gram-negative bacteria
36. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants
37. An isoflavonoid-inducible efflux pump in Agrobacterium tumefaciens is involved in competitive colonization of roots
38. Compromised disease resistance in saponin-deficient plants
39. Proton-dependent multidrug efflux systems
40. Unified inventory of established and putative transporters encoded within the complete genome of Saccharomyces cerevisiae
41. Mode of action of the antimycotic agent G2 isolated from alfalfa roots
42. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: Common ancestry with tetracycline- and sugar-transport proteins
43. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
44. Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor
45. 5′-Methoxyhydnocarpin and pheophorbide a: Berberis species components which potentiate berberine growth inhibition or resistant Staphylococcus aureus
46. The MarR repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli: Prototypic member of a family of bacterial regulatory proteins involved in sensing phenolic compounds
47. Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis
48. Active efflux of bile salts by Escherichia coli
49. Cis/trans isomerization of fatty acids as a defence mechanism of Pseudomonas putida strains to toxic concentrations of toluene
50. Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt
51. Bypassing the periplasm: Reconstitution of the AcrAB multidrug efflux pump of Escherichia coli
52. Preliminary structural studies on the multi-ligand-binding domain of the transcription activator, BmrR, from Bacillus subtilis
53. Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter