Mta, a global MerR-type regulator of the Bacillus subtilis multidrug-efflux transporters

Molecular Microbiology

Volumn 31, Issue 5, 1999, Pages 1549-1559

  Baranova, Natalya N ^a   Danchin, Antoine ^b   Neyfakh, Alexander A ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; REGULATOR PROTEIN; THIOSTREPTON; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BACILLUS SUBTILIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE INDUCTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; STREPTOMYCES LIVIDANS; TRANSCRIPTION REGULATION;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); POSIBACTERIA; PTEROGYNE NITENS; STREPTOMYCES LIVIDANS;

EID: 0033023361     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1999.01301.x     Document Type: Article

References (33)

1. Ahmed, M., Borsch, C.M., Taylor, S.S., Vazquez-Laslop, N., and Neyfakh, A.A. (1994) A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. J Biol Chem 269: 28506-28513.
2. Ahmed, M., Lyass, L., Markham, P.N., Taylor, S.S., Vazquez-Laslop, N., and Neyfakh, A.A. (1995) Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J Bacteriol 177: 3904-3910.
3. Bolhuis, H., Poelarends, G., van Veen, H.W., Poolman, B., Driessen, A.J.M., and Konings, W.N. (1996) The lactococcal ImrP gene encodes a proton motive force-dependent drug transporter. J Biol Chem 270: 26092-26098.
4. Bolhuis, H., van Veen, H.W., Poolman, B., Driessen, A.J., and Konings, W.N. (1997) Mechanisms of multidrug transporters. FEMS Microbiol Rev 21: 55-84.
5. Bron, S. (1990) Plasmids. In Molecular Biological Methods for Bacillus. Harwood, C.R., and Cutting, S.M. (eds). Chichester: John Wiley & Sons, pp. 75-174.
6. Chiu, M.L., Folcher, M., Griffin, P., Holt, T., Klatt, T., and Thompson, C.J. (1996) Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividans. Biochemistry 35: 2332-2341.
7. Cutting, S.M., and Vander Horn, P.B. (1990) Genetic analysis. In Molecular Biological Methods for Bacillus. Harwood, C.R., and Cutting, S.M. (eds). Chichester: John Wiley & Sons, pp. 27-74.
8. Edgar, R., and Bibi, E. (1997) MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition. J Bacteriol 179: 2274-2280.
9. Gottesman, M.M., and Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem 62: 385-427.
10. Guilfoile, P.G., and Hutchinson, C.R. (1991) A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin. Proc Natl Acad Sci USA 88: 8553-8557.
11. Holmes, D.J., Caso, J.L., and Thompson, C.J. (1993) Autogenous transcriptional activation of a thiostrepton-induced gene in Streptomyces lividans. EMBO J 12: 3183-3191.
12. Kohler, T., Michea-Hamzehpour, M., Henze, U., Gotoh, N., Curty, L.K., and Pechere, J.C. (1997) Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa. Mol Microbiol 23: 345-354.
13. Kunst, F., Ogasawara, N., Moszer, I., et al. (1997) The complete genome sequence of the Gram-positive bacterium Bacillus subtilis. Nature 390: 249-256.
14. Markham, P.N., Ahmed, M., and Neyfakh, A.A. (1996) The drug-binding activity of the multidrug-responding transcriptional regulator BmrR resides in its C-terminal domain. J Bacteriol 178: 1473-1475.
15. Markham, P.N., LoGuidice, J., and Neyfakh, A.A. (1997) Broad ligand specificity of the transcriptional regulator of the Bacillus subtilis multidrug transporter Bmr. Biochem Biophys Res Commun 239: 269-272.
16. Murakami, T., Holt, T.G., and Thompson, C.J. (1989) Thiostrepton-induced gene expression in Streptomyces lividans. J Bacteriol 171: 1459-1466.
17. Neyfakh, A.A. (1997) Natural functions of bacterial multidrug transporters. Trends Microbiol 5: 309-313.
18. Neyfakh, A.A., Bidnenko, V.E., and Chen, L.B. (1991) Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system. Proc Natl Acad Sci USA 88: 4781-4785.
19. Nikaido, H. (1996) Multidrug efflux pumps of Gram-negative bacteria. J Bacteriol 178: 5853-5859.
20. Ohki, R., and Murata, M. (1997) bmr3, a third multidrug transporter gene of Bacillus subtilis. J Bacteriol 179: 1423-1427.
21. Paulsen, I.T., Brown, M.H., and Skurray, R.A. (1996) Proton-dependent multidrug efflux systems. Microbiol Rev 60: 575-608.
22. Plater, R., and Robinson, J.A. (1992) Cloning and sequence of a gene encoding macrotetrolide antibiotic resistance from Streptomyces griseus. Gene 112: 117-122.
23. Poole, K., Krebes, K., McNally, C., and Neshat, S. (1993) Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J Bacteriol 175: 7363-7372.
24. Poole, K., Gotoh, N., Tsujimoto, H., Zhao, Q., Wada, A., Yamasaki, T., et al. (1996) Overexpression of the mexC-mexD-oprJ operon in nfxB-type multidrug resistant strains of Pseudomonas aeruginosa. Mol Microbiol 21: 713-724.
25. Qi, Y., and Hulett, F.M. (1998) PhoP-P and RNA polymerase sigmaA holoenzyme are sufficient for transcription of Pho regulon promoters in Bacillus subtilis: PhoP-P activator sites within the coding region stimulate transcription in vitro. Mol Microbiol 28: 1187-1197.
26. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
27. Steinmetz, M., and Richter, R. (1994) Easy cloning of mini-Tn10 insertions from the Bacillus subtilis chromosome. J Bacteriol 176: 1761-1763.
28. Summers, A.O. (1992) Untwist and shout: a heavy metal-responsive transcriptional regulator, J Bacteriol 174: 3097-3101.
29. Thanassi, D.G., Cheng, L.W., and Nikaido, H. (1997) Active efflux of bile salts by Escherichia coli. J Bacteriol 179: 2512-2518.
30. Vandeyar, M.A., and Zahler, S.A. (1986) Chromosomal insertions of Tn917 in Bacillus subtilis. J Bacteriol 167: 530-534.
31. Van Veen, H.W., Venema, K., Bolhuis, H., Oussenko, I., Kok, J., Poolman, B., et al. (1996) Multidrug resistance mediated by a bacterial homolog of the human multidrug transporter MDR1. Proc Natl Acad Sci USA 93: 10668-10672.
32. Woolridge, D.P., Vazquez-Laslop, N., Markham, P.N., Chevalier, M.S., Gerner, E.W., and Neyfakh, A.A. (1997) Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt. J Bio Chem 272: 8864-8866.
33. Wray, Jr, L.V., and Fisher, S.H. (1994) Analysis of Bacillus subtilis hut operon expression indicates that histidine-dependent induction is mediated primarily by transcriptional antitermination and that amino acid repression is mediated by two mechanisms: regulation of transcription initiation and inhibition of histidine transport. J Bacteriol 176: 5466-5473.