Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS

Mechanisms of Development

Volumn 73, Issue 1, 1998, Pages 85-93

  Pabst, Oliver ^a   Herbrand, Heike ^a   Arnold, Hans Henning ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

CNS development; Homeobox transcription factor; Nkx2 genes

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; BRAIN DEVELOPMENT; CENTRAL NERVOUS SYSTEM; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; HOMEOBOX; MOUSE; MULTIGENE FAMILY; NEUROECTODERM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; CENTRAL NERVOUS SYSTEM; ENDODERM; GENES, OVERLAPPING; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NEURAL CREST; PROTEIN BIOSYNTHESIS; SEQUENCE ALIGNMENT; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0345195959     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(98)00035-5     Document Type: Article

References (33)

1. Anukampa Barth K., Wilson S.W. Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. Development. 121:1995;1755-1768.
2. Azpiazu N., Frasch M. tinman and bagpipe: two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7:1993;1325-1340.
3. Biben C., Harvey R.P. Homeodomain factor Nkx2-5 controls left/right asymmetric expression of bHLH gene eHand during murine heart development. Genes Dev. 11:1997;1357-1369.
4. Bober E., Franz T., Arnold H.H., Gruss P., Tremblay P. Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development. 120:1994;603-612.
5. Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development. 118:1993;719-729.
6. Boettger T., Stein S., Kessel M. The chicken NKX2.8 homeobox gene: a novel member of the NK-2 gene family. Dev. Genes Evol. 207:1997;65-70.
7. Bohinski R.J., Di Lauro R., Whitsett J.A. The lung specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol. Cell. Biol. 14:1994;5671-5681.
8. Brand T., Andree B., Schneider A., Buchberger A., Arnold H.H. Chicken Nkx2-8, a novel homeobox gene expressed during early heart and foregut development. Mech. Dev. 64:1997;53-59.
9. Buchberger A., Ragge K., Arnold H.H. The myogenin gene is activated during myocyte differentiation by pre-existing, not newly synthesized transcription factor MEF-2. J. Biol. Chem. 269:1994;17289-17296.
10. Chen C.Y., Schwartz R.J. Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, Nkx2-5. J. Biol. Chem. 270:1995;15628-15633.
11. Chivitareale D., Lonigro R., Sinclair A.J., Di Lauro R. A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter. EMBO J. 8:1989;2537-2541.
12. Chivitareale D., Castelli M.P., Falasca P., Saiardi A. Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene. Mol. Endocrinol. 7:1993;1589-1595.
13. Guazzi S., Price M., De Felice M., Damante G., Mattei M.G., Di Lauro R. Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 9:1990;3631-3639.
14. Harvey R. NK-2 homeobox genes and heart development. Dev. Biol. 178:1996;203-216.
15. Jiménez F., Martin-Morris L.E., Velasco L., Chu H., Sierra J., Rosen D.R., White K. vnd, a gene required for early neurogenesis of Drosophila, encodes a homeodomain protein. EMBO J. 14:1995;3487-3495.
16. Kim Y., Nirenberg M. Drosophila NK-homeobox genes. Proc. Natl. Acad. Sci. USA. 86:1989;7716-7720.
17. Kimura S., Hara Y., Pineau T., Fernandez-Salguero P., Fox C.H., Ward J.M., Gonzalez F.J. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 10:1996;60-69.
18. Kitamura K., Miura H., Yanazawa M., Miyashita T., Kato K. Expression patterns of Brx1 (Rieg gene), sonic hedgehog, Nkx2-2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation. Mech. Dev. 67:1997;83-96.
19. Krummiauf R. Hox genes in vertebrate development. Cell. 78:1994;191-201.
20. Lee K.H., Xu Q., Breitbart R.E. A new tinman-related gene, nkx2.7, anticipates the expression of nkx2.5 and nkx2.3 in zebrafish heart and pharyngeal endoderm. Dev. Biol. 180:1996;722-731.
21. Lemaire L., Kessel M. Gastrulation and homeobox genes in chick embryos. Mech. Dev. 67:1997;3-16.
22. Lyons I., Parsons L.M., Hartley L., Li R., Andrews J.E., Robb L., Harvey R.P. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev. 9:1995;1654-1666.
23. Mann R.S. The specificity of homeotic gene function. BioEssays. 17:1995;855-863.
24. Mizuno K., Gonzalez F.J., Kimura S. Thyroid-specific enhancer-binding protein (T/EBP): cDNA cloning, functional characterization, and structural identity with thyroid transcription factor TTF-1. Mol. Cell. Biol. 11:1991;4927-4933.
25. Okkema P.G., Fire A. The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Development. 120:1994;2175-2186.
26. Pabst O., Schneider A., Brand T., Arnold H.H. The mouse Nkx2-3 homeodomain gene is expressed in gut mesenchyme during pre- and postnatal mouse development. Dev. Dyn. 209:1997;29-35.
27. Price M., Lazarro D., Pohl T., Mattei M.-G., Rüther U., Olivo J.-C., Duboule D., Di Lauro R. Regional expression of the Homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 8:1992;241-255.
28. Reecy J.M., Yamada M., Cummings K., Sosic D., Chen C.-Y., Eichele G., Olson E.N., Schwartz R.J. Chicken Nkx-2.8: a novel Homeobox gene expressed in early heart progenitor cells and pharyngeal pouch-2 and -3 endoderm. Dev. Biol. 188:1997;295-311.
29. Saha M.S., Michel R.B., Gulding K.M., Grainger R.M. A Xenopus homeobox gene defines dorsal-ventral domains in the developing brain. Development. 118:1993;193-202.
30. Shimamura K., Hartigan D.J., Martinez S., Puelles L., Rubenstein J.L.R. Longitudinal organization of the anterior neural plate and neural tube. Development. 121:1995;3923-3933.
31. Shiojima I., Komuro I., Minzuno T., Aikawa R., Akazawa H., Oka T., Yamazaki T., Yazaki Y. Molecular cloning and characterization of human cardiac homeobox gene CSX1. Circ. Res. 79:1996;920-929.
32. Smith S.T., Jaynes J.B. A conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in vivo. Development. 122:1996;3141-3150.
33. Tsao D.H.H., Gruschus J.M., Wang L.-H., Nirenberg M., Ferretti J.A. Elongation of helix III of the NK-2 homeodomain upon binding to DNA: secondary structure study by NMR. Biochemistry. 33:1994;15053-15060.