VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 18, 1997, Pages 9938-9943

  Takahashi, Nobuyuki ^a,b   Miner, Lucinda L ^a,b   Sora, Ichiro ^a,b   Ujike, Hiroshi ^a,b   Revay, Randal S ^a,b   Kostic, Vladimir ^c   Jackson Lewis, Vernice ^c   Przedborski, Serge ^c   Uhl, George R ^a,b,d  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Columbia University ^*  (United States)

^d Molecular Neurobiology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; AMPHETAMINE; NEUROTOXIN; OLIGONUCLEOTIDE; SINGLE STRANDED DNA;

ANIMAL CELL; ARTICLE; BLOOD PRESSURE; DNA DETERMINATION; GENOME; HEART RATE; HETEROZYGOSITY; HETEROZYGOTE; LOCOMOTION; NEUROCHEMISTRY; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; SYNAPSE VESICLE;

AMPHETAMINE; ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; DOPAMINE AGENTS; HETEROZYGOTE; LOCOMOTION; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MPTP POISONING; NEUROPEPTIDES; VESICULAR BIOGENIC AMINE TRANSPORT PROTEINS; VESICULAR MONOAMINE TRANSPORT PROTEINS;

ANIMALIA;

EID: 0030931721     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.18.9938     Document Type: Article

References (42)

1. Johnson, R. G. (1988) Physiol. Rev. 68, 232-307.
2. Henry, J.-P., Botton, D., Sagne, C., Isambert, M.-F., Desnos, C., Blanchard, V., Raisman-Vozari, R., Krejci, E., Massoulie, J. & Gasnier, B. (1994) J. Exp. Biol. 196, 251-262.
3. Liu, Y., Peter, D., Roghani, A., Schuldiner, S., Privé, G. G., Eisenberg, D., Brecha, N. & Edwards, R. H. (1992) Cell 70, 539-551.
4. Erickson, J. D., Eiden, L. E. & Hoffman, B. J. (1992) Proc. Natl. Acad. Sci. USA 89, 10993-10997.
5. National Institute of Justice (1995) Annual Report on Adult and Juvenile Arrestees (Natl. Criminal Justice Ref. Serv., Rockville, MD).
6. Kuczenski, R. & Segal, D. S. (1994) in Amphetamine and its Analogs, eds. Cho, A. K. & Segal, D. S. (Academic, San Diego), pp. 81-113.
7. Seiden, L. S., Sabol, K. E. & Ricaurte, G. A. (1993) Annu. Rev. Pharmacol. Toxicol. 32, 639-677.
8. Sulzer, D. & Rayport, S. (1990) Neuron 5, 797-808.
9. Rudnick, G. & Wall, S. C. (1992) Proc. Natl. Acad. Sci. USA 89, 1817-1821.
10. Shimada, S., Kitayama, S., Lin, C. L., Patel, A., Nanthakumar, E., Gregor, P., Kuhar, M. & Uhl, G. R. (1991) Science 254, 576-578.
11. Pacholczyk, T., Blakely, R. D. & Amara, S. G. (1991) Nature (London) 350, 350-354.
12. Blakely, R. D., Berson, H. E., Fremeau, R. T., Jr., Caron, M. G., Peek, M. M., Prince, H. K. & Bradley, C. C. (1991) Nature (London) 354, 66-70.
13. Giros, B., Jaber, M., Jones, S. R., Wightman, R. M. & Caron, M. G. (1996) Nature (London) 379, 606-616.
14. McGeer, P. L., Itagaki, S., Akiyama, H. & McGeer, E. G. (1988) Ann. Neurol. 24, 574-576.
15. Uhl, G. R., Hedreen, J. C. & Price, D. L. (1985) Neurology 35, 1215-1218.
16. Kitayama, S., Shimada, S. & Uhl, G. R. (1992) Ann. Neurol. 32, 109-111.
17. Liu, L., Xu, W., Harrington, K. A. & Emson, P. C. (1994) Mol. Brain Res. 25, 90-96.
18. Shimada, S., Kitayama, S., Walther, D. & Uhl, G. R. (1992) Mol. Brain Res. 13, 359-362.
19. Uhl, G. R., Walther, D., Mash, D., Faucheux, B. & Javoy-Agid, F. (1994) Ann. Neurol. 35, 494-498.
20. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. (1991) Cell 64, 693-702.
21. Bradley, A. ( 1987) in Tetracarcinomas and Embryonic Stem Cells, ed. Robertson, E. J. (IRL, Oxford), pp. 113-151.
22. Freed, C., Revay, R., Vaughan, R. A., Kriek, E., Grant, S., Uhl, G. R. & Kuhar, M. J. (1995) J. Comp. Neurol. 359, 340-349.
23. Boja, J. W., Carroll, F. I., Rahman, M. A., Philip, A., Lewin, A. H. & Kuhar, M. J. (1990) Eur. J. Pharmacol. 184, 329-332.
24. Marcusson, J. O., Bergstrom, M., Eriksson, K. & Ross, S. B. (1988) J. Neurochem. 50, 1783-1790.
25. Sherman, D. (1986) J. Neurochem. 47, 331-339.
26. Tejani-Butt, S. M., Brunswick, D. J. & Frazer, A. (1990) Eur. J. Pharmacol. 191, 239-243.
27. Ujike, H., Akiyama, K., Nishikawa, H., Onoue, T. & Otsuki, S. (1991) Brain Res. 540, 159-163.
28. Terai, M., Hidaka, K. & Nakamura, Y. (1989) Eur. J. Pharmacol. 173, 177-182.
29. Robinson, M. B., Anegawa, N. J., Gorry, E., Qureshi, I. A., Coyle, J. T., Lucki, I. & Batshaw, M. L. (1992) J. Neurochem. 58, 1016-1022.
30. Bylund, D. B. & Snyder, S. H. (1976) Mol. Pharmacol. 12, 568-580.
31. Przedborski, S., Jackson-Lewis, V., Yokoyama, R., Shibata, T., Dawson, V. L. & Dawson, T. M. (1996) Proc. Natl. Acad. Sci. USA 93, 4565-4571.
32. Naini, A. B., Vontzalidou, E. & Cote, L. J. (1993) Clin. Chem. 39, 247-250.
33. Jackson-Lewis, V., Jakowec, M., Burke, R. E. & Przedborski, S. (1995) Neurodegeneration 4, 257-269.
34. Ichikawa, S., Sasaoka, T. & Nagatsu, T. (1991) Biochem. Biophys. Res. Commun. 176, 1610-1616.
35. Alonso, S., Minty, A., Bourlet, Y. & Buckingham, M. (1986) J. Mol. Evol. 23, 11-22.
36. Sora, I., Takahashi, N., Funada, M., Ujike, H., Revay, R. S., Donovan, D. M., Miner, L. L. & Uhl, G. R. (1997) Proc. Natl. Acad. Sci. USA 94, 1544-1549.
37. Flint, J., Corley, R., DeFries, J. C., Fulker, D. W., Gray, J. A., Miller, S. & Collins, A. C. (1995) Science 269, 1432-1435.
38. Cooper, J. R., Bloom, F. E. & Roth, R. H. (1991) The Biochemical Basis of Neuropharmacology (Oxford Univ. Press, New York).
39. Carr, G. D., Fibiger, H. C. & Phillips, A. G. (1984) in Neuropharmacological Basis of Reward, eds. Liebman, J. M. & Copper, S. J. (Oxford Univ. Press, New York), pp. 264-319.
40. Amara, S. & Kuhar, M. J. (1993) Annu. Rev. Neurosci. 16, 73-93.
41. Miner, L. L., Drago, J., Chamberlain, P. M., Donovan, D. & Uhl, G. R. (1995) NeuroReport 6, 2314-2316.
42. Segal, D. S. & Kuczenski, R. (1994) in Amphetamine and its Analogs, eds. Cho, A. K. & Segal, D. S. (Academic, San Diego), pp. 115-150.