A chronology of fine-scale gene mapping by linkage disequilibrium

Statistical Methods in Medical Research

Volumn 10, Issue 1, 2001, Pages 57-76

  Lazzeroni, L C ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOME; CHRONOLOGY; DISEASE ASSOCIATION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC MARKER; GENETIC PREDISPOSITION; HAPLOTYPE; REVIEW; STATISTICAL ANALYSIS; STATISTICAL MODEL;

ALLELES; BIOMETRY; CHROMOSOME MAPPING; CYSTIC FIBROSIS; HAPLOTYPES; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE DISEQUILIBRIUM; MODELS, GENETIC; MODELS, STATISTICAL; MUTATION; RECOMBINATION, GENETIC;

EID: 0035063320     PISSN: 09622802     EISSN: None     Source Type: Journal    
DOI: 10.1191/096228001666442347     Document Type: Review

References (85)

1. Markov chains for Monte Carlo tests of genetic equilibrium in multidimensional contingency tables
2. Transmission/disequilibrium tests for extended marker haplotypes
3. Fine mapping of quantitative trait loci using linkage disequilibrium with closely linked marker loci
4. Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations
5. Mapping genes that underlie ethnic differences in disease risk: Methods for detecting linkage in admixed populations, by conditioning on parental admixture
6. Multipoint linkage disequilibrium mapping with particular reference to the African-American population
7. Mapping of complex traits by single-nucleotide polymorphisms
8. An efficient, robust and unified method for mapping complex traits (III): Combined linkage/linkage disequilibrium
9. QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations
10. The trimmed-haplotype test for linkage disequilibrium
11. Estimating the age of mutant disease alleles based on linkage disequilibrium
12. Detecting immigration by using multilocus genotypes
13. Allelic disequilibrium and allele frequency distribution as a function of social and demographic history
14. A coalescent approach to study linkage disequilibrium between single-nucleotide polymorphisms
15. The affected-pedigree-member method of linkage analysis
16. Linkage strategies for genetically complex traits I. Multilocus models
17. Haplotype relative risks: An easy reliable way to construct a proper control sample for risk calculations
18. A haplotype-based 'haplotype relative risk' approach to detecting allelic associations
19. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes-mellitus (IDDM)
20. The transmission disequilibrium test: History, subdivision and admixture
21. General score tests for associations of genetic markers with disease using cases and their parents
22. A conditional inference framework for extending the transmission/disequilibrium test
23. A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information
24. Detecting disease genes using family data I. Likelihood-based theory
25. Allelic association between marker loci
26. Mapping genes for complex traits in founder populations
27. Positional cloning of disease genes: Advantages of genetic isolates
28. The future of genetic studies of complex human diseases
29. Invited editorial: Linkage disequilibrium as a gene mapping tool
30. Linkage disequilibrium and gene mapping: An empirical least-squares approach
31. Haplotype fine mapping by evolutionary trees
32. Allelic association under map error and recombinational heterogeneity: A tale of two sites
33. Identification of the cystic fibrosis gene: Genetic analysis
34. Linkage disequilibrium in finite populations
35. Log-linear models for linked loci
36. The sampling distribution of linkage disequilibrium under an infinite allele model without selection
37. A comparison of linkage disequilibrium measures for fine-scale mapping
38. Linkage disequilibrium measures for fine-scale mapping: A comparison
39. Haplotype analysis to determine the position of a mutation among closely linked DNA markers
40. Complex patterns of linkage disequilibrium in the Huntington disease region
41. Mapping the Friedreich ataxia locus (FRDA) by linkage disequilibrium analysis with highly polymorphic microsatellites
42. Linkage disequilibrium between the juvenile neuronal ceroid lipofuscinosis gene and marker loci on chromosome 16p12.1
43. Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22
44. Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: Lessons learned from analysis of 35 chromosome 8p11.1-21 markers
45. Fine localization of the torsion dystonia gene (DYT1) on human chromosome 9q34: YAC map and linkage disequilibrium
46. Linkage disequilibrium and haplotype analysis among Polish families with spinal muscular atrophy
47. Linkage disequilibrium mapping in isolated founder populations: Diastrophic dysplasia in Finland
48. Mutations from bacteria from virus sensitivity to virus resistance
49. The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping
50. Localization of the EPM1 gene for progressive myoclonus epilepsy on chromosome 21: Linkage disequilibrium allows high resolution mapping
51. Measuring the strength of associations between HLA antigens and diseases
52. Fine mapping of the congenital chloride diarrhea gene by linkage disequilibrium
53. Likelihood methods for locating disease genes in nonequilibrium populations
54. Maximum-likelihood estimation of gene location by linkage disequilibrium
55. Are moment bounds on the recombination fraction between a marker and a disease locus too good to be true? Allelic association mapping revisited for simple genetic diseases in the Finnish population
56. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci
57. Disequilibrium mapping: Composite likelihood for pairwise disequilibrium
58. Likelihood analysis of disequilibrium mapping, and related problems
59. Disequilibrium likelihoods for fine-scale mapping of a rare allele
60. Linkage disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations
61. Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping
62. Bayesian fine-scale mapping of disease loci, by hidden Markov models
63. Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications
64. Mapping a disease locus by allelic association
65. Mapping disease genes using the Malecot model for allelic association and the β model for linkage
66. Fieller's theorem and linkage disequilibrium mapping
67. Mapping genes through the use of linkage disequilibrium generated by genetic drift: 'Drift mapping' in small populations with no demographic expansion
68. Mapping genes by drift-generated linkage disequilibrium
69. Rare disease genes - Lessons and challenges
70. Prospects for whole-genome linkage disequilibrium mapping of common disease genes
71. Predicting the range of linkage disequilibrium
72. Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region
73. Mapping using linkage disequilibrium estimates: A comparative study
74. Linkage disequilibrium patterns vary with chromosomal location: A case study from the von Willebrand factor region
75. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
76. Genetic epidemiology of single-nucleotide polymorphisms
77. A scan for linkage disequilibrium across the human genome
78. Linkage disequilibrium and allele-frequency distributions for 114 single-nucleotide polymorphisms in five populations
79. Linkage disequilibrium mapping of complex disease: Fantasy or reality?
80. Linkage disequilibrium mapping in isolated populations: The example of Finland revisited
81. Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods
82. Gene mapping in isolated populations: New roles for old friends?
83. Linkage disequilibrium and the search for complex disease genes
84. Linkage disequilibrium mapping of disease susceptibility genes in human populations