Mapping genes that underlie ethnic differences in disease risk: Methods for detecting linkage in admixed populations, by conditioning on parental admixture

American Journal of Human Genetics

Volumn 63, Issue 1, 1998, Pages 241-251

  McKeigue, Paul M ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ETHNIC DIFFERENCE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC MARKER; GENETIC MODEL; GENETIC RISK; HIGH RISK POPULATION; HUMAN; PARENT; POPULATION GENETICS; PRIORITY JOURNAL; SIMULATION; STATISTICAL ANALYSIS;

EID: 0032231748     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301908     Document Type: Article

References (22)

1. Bowcock AM, Kidd JR, Mountain JL, Hebert JM, Carotenuto L, Kidd KK, Cavalli-Sforza LL (1991) Drift, admixture, and selection in human evolution: a study with DNA polymorphisms. Proc Natl Acad Sci USA 88:839-843
2. Cavalli-Sforza LL, Menozzi P, Piazza A (1994) The history and geography of human genes. Princeton University Press, Princeton, NJ
3. Chakraborty R, Weiss KM (1988) Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci. Proc Natl Acad Sci USA 85: 9119-9123
4. Ewens WJ, Spielman RS (1995) The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet 57:455-464
5. Gelman A, Rubin DB (1996) Markov chain Monte Carlo methods in biostatistics. Stat Methods Med Res 5:339-355
6. Jorde LB, Bamshad MJ, Watkins WS, Zenger R, Fraley AE, Krakowiak PA, Carpenter KD, et al (1995) Origins and affinities of modern humans: a comparison of mitochondrial and nuclear genetic data. Am J Hum Genet 57:523-538
7. Kaplan NL, Martin ER, Morris RW, Weir BS (1998) Marker selection for the transmission/disequilibrium test, in recently admixed populations. Am J Hum Genet 62:703-712
8. 3;5,13,14 and type 2 diabetes mellitus: an association in American Indians with genetic admixture. Am J Hum Genet 43:520-526
9. Kruglyak L, Lander ES (1995) Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454
10. Lander ES, Green P (1987) Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci USA 84: 2363-2367
11. Lin S, Thompson E, Wijsman E (1994) An algorithm for Monte Carlo estimation of genotype probabilities on complex pedigrees. Ann Hum Genet 58:343-357
12. Little RJA, Rubin DB (1987) Statistical analysis with missing data. Wiley, New York
13. MacDonald IL, Zucchini W (1997) Hidden Markov and other models for discrete-valued time series. Chapman & Hall, London
14. McKeigue PM (1997) Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations. Am J Hum Genet 60:188-196
15. National Human Genome Research Institute (1998) Methods for discovering and scoring single nucleotide polymorphisms. RFA HG-98-001, National Institutes of Health, Bethesda, MD
16. Poloni ES, Excoffier L, Mountain JL, Langaney A, Cavalli-Sforza LL (1995) Nuclear DNA polymorphism in a Mandenka population from Senegal: comparison with eight other human populations. Ann Hum Genet 59:43-61
17. Reynolds J, Weir BS, Cockerham CC (1983) Estimation of the co-ancestry coefficient: basis for a short-term genetic distance. Genetics 105:767-779
18. Risch N, Merikangas K (1996) The future of genetic studies of complex human diseases. Science 273:1516-1517
19. Sobel E, Lange K (1993) Metropolis sampling in pedigree analysis. Stat Methods Med Res 2:263-282
20. Thompson EA (1994) Monte Carlo likelihood in the genetic mapping of complex traits. Philos Trans R Soc Lond B Biol Sci 344:345-350
21. Wahlund S (1928) Zusammensetzung von Populationen und Korrelationserscheinungen vom Standpunkt der Vererbungslehre aus betrachtet. Hereditas 11:65-106
22. Wright S (1951) The genetical structure of populations. Ann Eugenics 15:322-354