An efficient, robust and unified method for mapping complex traits (III): Combined linkage/linkage-disequilibrium analysis

American Journal of Medical Genetics

Volumn 84, Issue 5, 1999, Pages 433-453

  Zhao, Lue Ping ^a,b   Quiaoit, Fil ^a   Aragaki, Corinne ^a   Hsu, Li ^a  

^a USA   (United States)

^b Division of Public Health Sciences   (United States)

Author keywords

Affected pedigree members; Candidate genes; Complex traits; Environmental factors; Gene environmental interaction; Gene gene interaction; IDDM; Linkage; Linkage disequilibrium; Major gene; Natural selection; Pedigrees; Population admixture; Sibpairs

Indexed keywords

ARTICLE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; PEDIGREE; PENETRANCE; PRIORITY JOURNAL; QUANTITATIVE GENETICS;

ALLELES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; DIABETES MELLITUS, TYPE 1; FEMALE; GENE FREQUENCY; GENETIC MARKERS; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MALE; MATHEMATICS; MODELS, GENETIC; PEDIGREE; QUANTITATIVE TRAIT, HERITABLE;

GENETTA;

EID: 0038829956     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19990611)84:5<433::AID-AJMG8>3.0.CO;2-N     Document Type: Article

References (36)

1. Bodmer WF. 1992. Early British discoveries in human genetics: contributions of R.A. Fisher and J.B.S. Haldane to the development of blood groups. Am J Hum Genet 50:671-676.
2. Collins A, Morton NE. 1998. Mapping a disease locus by allelic association. Proc Nat Acad Sci USA 95:1741-1745.
3. Davies JL, Cucca F, Goy JV, Atta ZAA, Merriman ME, Wilson A, Barnett AH, Bain SC, Todd JA. 1996. Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes. Hum Mol Genet 5:1071-1074.
4. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SCL, Jenkins SC, Palmer SM, Balfour KM, Rowe BR, Farrall M, Barnett AH, Bain SC, Todd JA. 1994. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 371:130-136.
5. Devlin B, Risch N. 1995. A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics 29:311-322.
6. Everitt BS. 1986. The analysis of contingency tables. London: Chapman and Hall.
7. Ewens WJ, Spielman RS. 1995. The transmission/disequilibrium test: history, subdivision, and admixture. Am J Hum Genet 57:455-464.
8. Felsenstein J. 1992. Theoretical evolutionary genetics. Seattle: University of Washington/ASUW Publishing.
9. Fisher RA. 1947. The rhesus factor: a study in scientific method. Am Sci 35:95-103.
10. Guo SW. 1997. Linkage disequilibrium measures for fine-scale mapping: a comparison. Hum Hered 47:301-314.
11. Jennings HS. 1917. The numerical results of diverse systems of breeding, with respect to two pairs of characters, linked or independent, with special relation to the effects of linkage. Genetics 2:97-155.
12. Johnson NL, Kotz S. 1972. Distributions in statistics: continuous multivariate distributions. New York: John Wiley & Sons, Inc.
13. Jorde LB. 1995. Linkage disequilibrium as a gene-mapping tool. Am J Hum Genet 56:11-4.
14. Kaplan NL, Hill WG, Weir BS. 1995. Likelihood methods for locating disease genes in nonequilibrium populations. Am J Hum Genet 56:18-32.
15. Kaplan NL, Martin ER, Morris RW, Weir BS. 1998. Marker selection for the transmission/disequilibrium test, in recently admixed populations. Am J Hum Genet 62:703-712.
16. Lander ES, Botstein D. 1989. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121:185-199.
17. Lander ES, Kruglyak L. 1996. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet 11: 241-247.
18. Lazzeroni LC, Lange K. 1998. A conditional inference framework for extending the transmission/disequilibrium test. Hum Hered 48:67-81.
19. Liang KY, Zeger SL. 1986. Longitudinal data analysis using generalized linear models. Biometrika 73:13-22.
20. McCullagh P, Neider JA. 1989. Generalized linear models, 2nd ed. New York: Chapman and Hall.
21. Prentice RL. 1988. Correlated binary regression with covariates specific to each binary observation. Biometrics 44:1033-1048
22. Prentice RL, Zhao LP. 1991. Estimating equations for parameters in means and covariances of multivariate discrete continuous responses. Biometrics 47:825-839.
23. Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-1517.
24. Robbins RB. 1918. Some applications of mathematics to breeding problems. III. Genetics*UL1* *UL0*3:375-389.
25. Self SG, Longton G, Kopecky KJ, Liang KY. 1991. On estimating HLA/ disease association with application to a study of aplastic anemia. Biometrics 47:53-61.
26. Spielman RS, McGinnis RE, Ewens WJ. 1993. The transmission/disequilibrium test detects cosegregation and linkage. Am J Hum Genet 54: 559-560.
27. Terwilliger JD. 1995. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56:777-787.
28. Weiss KM. 1995. genetic variation and human disease: principles and evolutionary approaches. Cambridge, U.K.: Cambridge University Press.
29. Xiong MM, Guo SW. 1997. Fine-scale genetic mapping based on linkage disequilibrium-theory and applications. Am J Hum Genet 60:1513-1531.
30. Zeger SL, Liang KY. 1986. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 42:121-130.
31. Zhao LP, Hsu L, Davidov O, Potter J, Elston R, Prentice RL. 1997. Population-based family study designs: an interdisciplinary research framework for genetic epidemiolgy. Genet Epidemiol 14:365-388.
32. Zhao LP Prentice RL. 1990. Correlated binary regression using a quadratic exponential model. Biometrika 77:642-648.
33. Zhao LP, Prentice RL, Sef SG. 1992. Multivariate mean parameter estimation by using a partly exponential model. J R Statist Soc B 54:805-811.
34. Zhao LP, Quiaoit F, Hsu L, Aragaki C. 1998a. An efficient, robust and unified framework for mapping complex traits. I. Two-point linkage analysis. Am J Med Genet 77:366-383.
35. Zhao LP, Quiaoit F, Aragaki C, Hsu L. 1998b. An efficient, robust and unified framework for mapping complex traits. II. Multipoint linkage analysis. Am J Med Genet 79:48-61.
36. Zhao LP, Aragaki C, Hsu L, Quiaoit F. 1998c. Mapping complex traits with single nucleotide polymorphism. Am J Hum Genet 63:225-240.