Evaluation of GL331 in combination with paclitaxel: GL331's interference with paclitaxel-induced cell cycle perturbation and apoptosis

Anti-Cancer Drugs

Volumn 12, Issue 3, 2001, Pages 259-266

  Huang, Tze Sing ^a   Shu, Chih Hung ^b   Chao, Yee ^b   Chen, Li Tzong ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Cyclin B1 CDC2; G2 M arrest; GL331; MAD2

Indexed keywords

4' DEMETHYL 4BETA (4'' NITROANILINO) 4 DESOXYPODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; CYCLIN B1; DNA; GL 331; HISTONE H1; PACLITAXEL; PODOPHYLLOTOXIN DERIVATIVE; PROTAMINE KINASE; TRITIUM; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA CONTENT; DNA STRAND BREAKAGE; DRUG CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; ISOTOPE LABELING; MICROTUBULE; MITOSIS; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CDC2 PROTEIN KINASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL NUCLEUS; CYCLIN B; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ANTAGONISM; DRUG EVALUATION; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; ETOPOSIDE; FLOW CYTOMETRY; FUNGAL PROTEINS; HUMANS; NASOPHARYNGEAL NEOPLASMS; NUCLEAR PROTEINS; PACLITAXEL; PRECIPITIN TESTS; PROTEIN KINASES; TETRAZOLIUM SALTS; THIAZOLES; TOXICITY TESTS; TUMOR CELLS, CULTURED;

EID: 0035061227     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200103000-00011     Document Type: Article

References (30)

1. Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide
2. New trials of GL331, a novel topoisomerase II inhibitor, in treatment of solid tumors
3. A new podophyllotoxin-derived compound GL331 has a higher ability to induce topoisomerase II-mediated DNA damage on selective sequences
4. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity
5. Bcl-2 prevents topoisomerase II inhibitor GL331-induced apoptosis is mediated by down-regulation of poly(ADP-ribose)polymerase activity
6. A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells
7. Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose)polymerase in the early stages of apoptosis
8. Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331-induced apoptosis
9. GL331-induced disruption of cyclin B1/CDC 2 complex and inhibition of CDC 2 kinase activity
10. In vitro evaluation of GL331's cancer cell killing and apoptosis-inducing activity in combination with other chemotherapeutic agents
11. Taxol dose intensification and its clinical implications
12. Phase II evaluation of Taxol in advanced head and neck cancer: An Eastern Cooperative Oncology Group Trial
13. Taxol stabilizes microtubules in mouse fibroblast cells
14. Taxol-induced polymerization of purified tubulin. Mechanism of action
15. Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and epidermal growth factor
16. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
17. 1 apoptosis
18. Activation of MAD2 checkprotein and persistence of cyclin B1/CDC2 activity associate with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells
19. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
20. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
21. CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
22. Cdc complex during mitosis
23. Combination chemotherapy
24. Choice of drugs for cancer chemotherapy
25. Increased cyclin B1/CDC2 kinase activity and phosphorylation of Bcl-2 associated with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells
26. 1 pathway
27. Topoisomerase II mediated mechanisms of drug resistance
28. Taxol in combination with doxorubicin or etoposide. Possible antagonism in vitro
29. 5-Fluorouracil interferes with paclitaxel cytotoxicity against human solid tumor cells
30. CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis