Increased cyclin B1/CDC 2 kinase activity and phosphorylation of Bcl-2 associated with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells

Apoptosis

Volumn 1, Issue 2, 1996, Pages 141-146

  Huang, T S ^a  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Bax; Bcl 2; CDC 2; cyclin B1; paclitaxel

Indexed keywords

EID: 27844523837     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf01321020     Document Type: Article

References (5)

1. Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumot agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Amer Chem Soc 1971; 92: 2325-2327.
2. Forastiere AA, Neuberg D, Taylor IV SG, Deconti R, Adams G. Phase II evaluation of Taxol in advanced head and neck cancer: An Eastern Cooperative Oncology Group Trial. Monogr Natl Cancer Inst 1993; 15: 181-184.
3. Holmes FA, Walters RS, Theriault RL, et al. Phase II trial of Taxol: An active drug in the treatment of metastatic breast cancer. J Natl Cancer Inst 1991; 83: 1797-1805.
4. McGuire WP, Rowinsky EK, Rosenshein NB, et al. Taxol: A unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann Intern Med 1989; 111: 273-279.
5. Jordan MA, Toso RJ, Thrower D, Wilson L. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA 1993; 90: 9552-9556.