5-Fluorouracil interferes with paclitaxel cytotoxicity against human solid tumor cells

Clinical Cancer Research

Volumn 3, Issue 10, 1997, Pages 1739-1745

  Johnson, Korey R ^a   Wang, Liming ^b   Miller III, Merrill C ^a   Willingham, Mark C ^a   Fan, Weimin ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; PACLITAXEL;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL KILLING; CELL SYNCHRONIZATION; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS SPINDLE; PRIORITY JOURNAL; SOLID TUMOR;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; G1 PHASE; HUMANS; KB CELLS; MITOSIS; PACLITAXEL; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 0030797889     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Wani, M. C., Taylor, H. L., Wall, M. E., Coffon, P., and McPhail, A. T. Plant antitumor agents. VI. The isolation and structure of paclitaxel, a novel antileukemic and antitumor agent from Taxus brevifolia. J. Am. Chem. Soc., 93: 2325-2327, 1971.
2. Rowinsky, E. K., Cazenave, L. A., and Donehower, R. C. Taxol: a novel investigational antimicrotubule agent. J. Natl. Inst. Cancer, 82: 1247-1259, 1990.
3. Wiernik, P. H., Schwartz, E. L., Strauman, J. J., Dutcher, J. P., Lipton, R. B., and Paietta, E. Phase I clinical and pharmacokinetics study of taxol. Cancer Res., 47: 2486-2493, 1987.
4. Holmes, F. A., Walter, R. S., Theriault, R. L., Forman, A. D., Newton, L. K., Raber, M. N., Buzdar, A. U., Frye, D. K. and Hortobagyi, G. N. Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer. J. Natl. Cancer Inst., 83: 1797-1805, 1991.
5. Schiff, P. B., Frant, J., and Horwitz, S. B. Promotion of microtubule assembly in vitro by paclitaxel. Nature (Lond.), 22: 665-667, 1979.
6. Manfrei, J. J., and Horwitz, S. B. Paclitaxel: an antimitotic agent with a new mechanism of action. Pharmacol. Ther., 25: 83-125, 1984.
7. Liu, Y., Bhalla, K., Hill, C., and Priest, D. G. Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in human ovarian tumor cell line. Biochem. Pharmacol., 48: 1265-1272, 1994.
8. Fan, W., Everett, E. T., Tang, C., Cooper, T., Fang, Q., Bhalla, K., and Norris, J. S. Glucocorticoid-mediated inhibition of taxol-induced apoptosis in leiomyosarcoma cells. Cell. Pharmacol., 1: 205-212, 1994.
9. Willingham, M. C., and Bhalla, K. Transient mitotic phase localization of bcl-2 oncoprotein in human carcinoma cells and its possible role in prevention of apoptosis. J. Histochem. Cytochem., 42: 441-450, 1994.
10. Cheng, L., Zheng, S., Raghunathan, K., Priest, D. G., Willingham, M. C., Norris, J. S., and Fan, W. Characterizations of taxol-induced apoptosis and altered gene expression in human breast cancer cells. Cell. Pharmacol., 2: 249-257, 1995.
11. cdc2 coincident with paclitaxel-induced apoptosis. Cell Growth Differ., 5: 1041-1050, 1994.
12. Fan, W., Cheng, L., Norris, J. S., and Willingham, M. C. Glucocorticoids selectively inhibit taxol-induced apoptosis in a human breast cancer cell line. Cell. Pharmacol., 3: 435-440, 1996.
13. Fan, W., Schandl, C. A., Cheng, L., Norris, J. S., and Willingham, M. C. Glucocorticoids modulate paclitaxel cytotoxicity in human solid tumor cells. Cell. Pharmacol., 3: 343-348, 1996.
14. Maybaum, J., Ullman, B., Mandel, H. G., Day, J. L., and Sadee, W. Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells. Cancer Res., 40: 4209-4215, 1980.
15. Klaassen, U., Harstrick, A., Wilke, H., and Seeber, S. Preclinical and clinical study results of the combination of paclitaxel and 5-fluorouracil/ folinic acid in the treatment of metastatic breast cancer. Semin. Oncol., 23 (1 Suppl. 1): 44-47, 1996.
16. Paul, D. M., Garrett, A. M., Meshad, M., DeVore, R. D., Porter, L. L., and Johnson, D. H. Paclitaxel and 5-fluorouracil in metastatic breast cancer: the US experience. Semin. Oncol., 23 (1 Suppl. 1): 48-52, 1996.
17. Klassen, U., Wilke, H., Pari, C. P., Strumberg, D., Harstrick, A., Eberhardt, W., Becher, R., Diergarten, K., and Seeber, S. Phase I/II study with paclitaxel in combination with weekly high-dose 5-fluorouracil/folinic acid in the treatment of metastatic breast cancer: an interim analysis. Semin. Oncol., 22 (6 Suppl. 14): 7-11, 1995.
18. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., and Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods, 139: 271-279, 1991.
19. Carmichael, J., Degraff, W. G., Gazdar, A. F., Minna, J. D., and Mitchell, J. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res., 47: 935-942, 1987.
20. Waring, P., Kos, F. J., and Mullbacher, A. Apoptosis or programmed cell death. Med. Res. Rev., 11: 219-236, 1991.
21. Collins, J. A., Schandl, C. A., Young, K. K., Vesely, J., and Willingham, M. C. Major DNA fragmentation is a late event in apoptosis. J. Histochem. Cytochem., in press, 1997.
22. Vokes, E. E., Stupp, R., Haraf, D., Moran, W., Malone, D., Wenig, B., Sweeney, P., and Weichselbaum, R. R. Hydroxyurea with continuous infusion paclitaxel, 5-fluorouracil, and concomitant radiotherapy for poor-prognosis head and neck cancer. Semin. Oncol., 22 (3 Suppl. 6): 47-52, 1995.
23. Ajani, J. A., Ilson, D. H., and Kelsen, D. P. The activity of paclitaxel in gastrointestinal tumors. Semin. Oncol., 22 (5 Suppl. 12): 46-53, 1995.
24. Haldar, S., Chintapalli, J., and Croce, C. M. Taxol-induced bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res., 56: 1253-1255, 1996.
25. Haldar, S., Jena, N., and Croce, C. M., Inactivation of bcl-2 by phosphorylation. Proc. Natl. Acad. Sci. USA, 92: 4507-4511, 1995.
26. Kano, Y., Akutsu, M., Tsunoda, S., Ando, J., Matsui, J., Suzuki, K., Ikeda, T., Inoue, Y., and Adachi, K. I. Schedule-dependent interaction between paclitaxel and 5-fluorouracil in human carcinoma cell lines in vitro. Br. J. Cancer, 74: 704-710, 1996.
27. Haldar, S., Basu, A., and Croce, C. M. Bcl2 is the guarding of microtubule integrity. Cancer Res., 57: 229-233, 1997.
28. Schandl, C. A., Priest, D. G., and Willingham, M. C. Phosphorylation of bcl-2 is a cell cycle-regulated event. Cell. Pharmacol., 3: 367-372, 1996.