Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331- induced apoptosis

Cancer Research

Volumn 57, Issue 14, 1997, Pages 2974-2978

  Huang, Tze Sing ^a   Shu, Chih Hung ^b   Yang, Wen K ^a   Whang Peng, Jacqueline ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; DNA FRAGMENT; GL 331; PACLITAXEL; PHOSPHATASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; DEPHOSPHORYLATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ETIOLOGY; HUMAN; HUMAN CELL; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CDC2 PROTEIN KINASE; CDC25 PHOSPHATASE; CELL CYCLE PROTEINS; ENZYME ACTIVATION; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOPROTEIN PHOSPHATASE; PODOPHYLLOTOXIN; TUMOR CELLS, CULTURED;

EID: 0030834333     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Nurse, P. Ordering S phase and M phase in the cell cycle. Cell, 79: 547-550, 1994.
2. King, R. W., Jackson, P. K., and Kirschner, M. W. Mitosis in transition. Cell, 79: 563-571, 1994.
3. Igarashi, M., Nagata, A., Jinno, S., Suto, K., and Okayama, H. wee1-like gene in human cells. Nature (Lond.), 353: 80-83, 1991.
4. cdc2-cyclin B complex hy the human WEE1 tyrosine kinase. Science (Washington DC), 257: 1955-1957, 1992.
5. Mueller, P. R., Coleman, T. R., Kumagai, A., and Dunphy, W. G. Myt1 : a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science (Washington DC), 270: 86-90, 1995.
6. Galaktionov, K., and Beach, D. Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell, 67: 1181-1194, 1991.
7. Girard, F., Strausfeld, U., Cavadore, J., Russell, P., Fernandez, A., and Lamb, N. J. C. Cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells. J. Cell Biol. 118: 785-794, 1992.
8. Devault, A., Martinez, A-M., Fesquet, D., Labbe, J-C., Morin, N., Tassan, J-P., Nigg, E. A., Cavadore, J-C., and Doree, M. MAT1, a new RING finger protein subunit stabilizing cyclin H-cdk7 complexes in starfish and Xenopus CAK. EMBO J., 14: 5027-5036, 1995.
9. Fisher, R. P., Jin, P., Chamberlin, H. M., and Morgan, D. O. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell, 83: 47-57, 1995.
10. Tassan, J-P., Jaquenoud, M., Fry, A. M., Frutiger, S., Hughes, G. J., and Nigg, E. A. In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. EMBO J., 14: 5608-5617, 1995.
11. 2. Proc. Natl. Acad. Sci. USA, 87: 5139-5143, 1990.
12. cdc2. Cell, 67: 197-211, 1991.
13. cdc2 coincident with taxol-induced apoptosis. Cell Growth Differ., 5: 1041-1050, 1994.
14. Shu, C-H., Yang, W. K., and Huang, T-S. Increased cyclin B1/CDC 2 kinase activity and phosphorylation of Bcl-2 associated with paclitaxel-induced apoptosis in human nasopharyngeal carcinoma cells. Apoptosis, 1: 141-146, 1996.
15. Shimizu, T., O'Connor, P. M., Kohn, K. W., and Pommier, Y. Unscheduled activation of Cyclin B1/Cdc 2 kinase in human promyelocylic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage. Cancer Res., 55: 228-231, 1995.
16. Huang, T-S., Shu, C-H., Shih, Y-L., Huang, H-C., Su, Y-C., Chao, Y., Yang, W. K., and Whang-Peng J. Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide. Cancer Lett., 110: 77-85, 1996.
17. Whang-Peng, J., and Huang, T-S. New trials of GL331, a novel topoisomerase II inhibitor, in treatment of solid tumors. J. Intern. Med., 8: 6-11, 1997.
18. Huang, T-S., Yang, W. K., and Whang-Peng, J. GL331-induced disruption of cyclin B1/CDC 2 complex and inhibition of CDC 2 kinase activity. Apoptosis. 1: 213-217, 1996.
19. Lock, R. B., and Ross, W. E. DNA topoisomerases in cancer therapy. Anticancer Drug Des., 2: 151-164, 1987.
20. Liu, L. F. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem., 58: 351-375, 1989.
21. Sullivan, D. M., Chow, K-C., and Ross, W. E. Topoisomerase II-mediated mechanisms of drug resistance. In: D. Kessel (ed.). Resistance to Antineoplastic Drugs, pp. 281-292. Boca Raton, FL: CRC Press, 1989.
22. 1 pathway. Proc. Natl. Acad. Sci. USA., 92: 4793-4797, 1995.
23. Yuan, C-C., Huang, H-C., Tsai, L-C., Ng, H-T., and Huang, T-S. Cytokeratin-19 associated with apoptosis and chemosensitivity in human cervical cancer cells. Apoptosis, 2: 101-105, 1997.
24. Galaktionov, K., Jessus, C., and Beach, D. Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle transduction. Genes Dev., 9: 1046-1058, 1995.
25. Conklin, D. S., Galaktionov, K., and Beach, D. 14-3-3 proteins associate with cdc25 phosphatases. Proc. Natl. Acad. Sci. USA, 92: 7892-7896, 1995.
26. Wang, Z-Q., Kuo, Y-H., Schnur, D., Bowen, P., Liu, S-Y., Han, F-S., Chang, J-Y., Cheng, Y-C., and Lee, K-H. Antitumor agents. 113. New 4β-arylamino derivatives of 4′-O-demethylepipodophyllotoxic and related compounds as potent inhibitors of human DNA topoisomerase II. J. Med. Chem., 33: 2660-2665, 1990.
27. Chang, J-Y., Han, F-S., Liu, S-Y., Wang, Z-Q., Lee, K-H., and Cheng, Y-C. Effect of 4β-arylamino derivatives of 4′-O-demethylepipodophyllotoxin on human DNA topoisomerase II, tubulin polymerization, KB cells, and their resistant variants. Cancer Res., 51: 1755-1759, 1991.
28. Cho, S. J., Kashiwada, Y., Bastow, K. F., Cheng, Y-C., and Lee, K-H. Antitumor agents. 164. Podophenazine, 2″,3″-dichloropodophenazine, benzopodophenazine, and their 4β-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors. J Med. Chem., 39: 1396-1402, 1996.
29. cdc2 activation required for apoptosis. Science (Washington DC), 263: 1143-1145, 1994.
30. Fotedar, R., Flatt, J., Gupta, S., Margolis, R. L., Fitzgerald, P., Messier, H., and Fotedar, A. Activation-induced T-cell death is cell cycle dependent and regulated by cyclin B. Mol. Cell. Biol., 15: 932-942, 1995.
31. Dunphy, W. G., and Newport, J. W. Unraveling of mitotic control mechanisms. Cell, 55: 925-928, 1988.
32. Martin, S. J., Green, D. R., and Cotter, T. G. Dicing with death: dissecting the components of the apoptosis machinery. Trends Biochem. Sci., 19: 26-30, 1994.
33. Galaktionov, K., Chen, X., and Beach, D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature (Lond.), 382: 511-517, 1996.
34. Chen, Y-R., Wang, X., Templeton, D., Davis, R. J., and Tan, T-H. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and γ radiation. J. Biol. Chem., 271: 31929-31936, 1996.
35. Ueda, Y., Hirai, S-i., Osada, S-i., Suzuki, A., Mizuno, K., and Ohno, S. Protein kinase C δ activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem., 271: 23512-23519, 1996.
36. van Aelst, L., Barr, M., Marcus, S., Polverino, A., and Wigler, M. Complex formation between Ras and Raf and other protein kinases. Proc. Natl. Acad. Sci. USA, 90: 6213-6217, 1993.
37. Kyriakis, J. M., App, H., Zhang, X., Banerjee, P., Brautigan, D. L., Rapp, U. R., and Avruch, J. Raf-1 activates MAP kinase-kinase. Nature (Lond.), 358: 417-421, 1992.
38. Perkins, N. D., Felzien, L. K., Betts, J. C., Leung, K., Beach, D., and Nabel, G. J. Regulation of NF-kB by cyclin-dependent kinases associated with the p300 coactivator. Science (Washington DC), 275: 523-527, 1997.