Unraveling human cancer in the mouse: Recent refinements to modeling and analysis

Human Molecular Genetics

Volumn 10, Issue 7, 2001, Pages 669-675

  Resor, Laura ^a   Bowen, T J ^a   Wynshaw Boris, Anthony ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER GENETICS; CANCER MODEL; CHROMOSOME REARRANGEMENT; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA MICROARRAY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE INACTIVATION; GENE OVEREXPRESSION; GENE TARGETING; GENETIC MANIPULATION; GENETIC STABILITY; HUMAN; KARYOTYPING; KNOCKOUT MOUSE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; RETROVIRUS; REVIEW; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ANIMALS; DISEASE MODELS, ANIMAL; GENETIC ENGINEERING; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NEOPLASMS; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RETROVIRIDAE; TISSUE DISTRIBUTION;

ANIMALIA; MAMMALIA; MURINAE; MUS MUSCULUS; UNIDENTIFIED RETROVIRUS;

EID: 0035060345     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.7.669     Document Type: Review

References (37)

1. Inducible gene targeting in mice using the Cre/lox system
2. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2
3. Rapid colorectal adenoma formation initiated by conditional targeting of the APC gene
4. Conditional mutation of Brcal in mammalian epithelial cells results in blunted ductal morphogenesis and tumour formation
5. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
6. Engineering a mouse balancer chromosome
7. Chromosome engineering in mice
8. Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea muta-genesis for functional analyses of the mammalian genome
9. Mouse ENU mutagenesis
10. Nested chromosomal deletions induced with retroviral vectors in mice
11. Interdigitated deletion complexes on mouse chromosome 5 induced by irradiation of embryonic stem cells
12. X-ray-induced mutations in mouse embryonic stem cells
13. Gene transfer into mammalian cells by a Rous sarcoma virus-based retroviral vector with the host range of the amphotropic murine leukemia virus
14. Expression of transduced genes in mice generated by infecting blastocyts with Avian Leukosis Virus-based retroviral vectors
15. Development of a flexible and specific gene delivery system for production of murine tumor models
16. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
17. Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of Polyoma Virus middle T antigen in vivo
18. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice
19. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
20. Transcriptional activation by tetracyclines in mammalian cells
21. Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
22. Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen
23. Essential role for oncogenic Ras in tumour maintenance
24. Role for the p53 homologue p73 in E2F-1-induced apoptosis
25. Turning on tumors to study cancer progression
26. Flipping the oncogene switch: Illumination of tumor maintenance and regression
27. Accessing genetic information with high-density DNA arrays
28. Use of a cDNA microarray to analyse gene expression patterns in human cancer
29. Expression monitoring by hybridization to high-density oligonucleotide arrays
30. cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene
31. Multicolour spectral karyotyping of human chromosomes
32. Multicolour spectral karyotyping of mouse chromosomes
33. SKY: A comprehensive diagnostic and research tool
34. Abnormal rearrangement within the alpha/delta T-cell receptor locus in lymphomas from Atm-deficient mice
35. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
36. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
37. Genome-wide analysis of DNA copy-number changes using cDNA microarrays