Functional plasticity of the LACK-reactive Vβ4-Vα8 CD4+ T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB/c mice

European Journal of Immunology

Volumn 31, Issue 4, 2001, Pages 1288-1296

  Maillard, Ivan ^a   Launois, Pascal ^a   Himmelrich, Hayo ^a   Acha Orbea, Hans ^a   Diggelmann, Heidi ^a   Locksley, Richard M ^b   Louis, Jacques A ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

BALB; C mice; LACK reactive CD4+ T cells; Leishmania major

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 4; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CELL MATURATION; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; IMMUNOREACTIVITY; INFECTION SENSITIVITY; INOCULATION; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; MOUSE STRAIN; NEWBORN; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH2 CELL; VIRUS INFECTION;

ANIMALS; ANTIBODIES; ANTIGENS, PROTOZOAN; CELL DIFFERENTIATION; COMPLEMENTARITY DETERMINING REGIONS; FEMALE; INTERFERON TYPE II; INTERLEUKIN-4; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MAMMARY TUMOR VIRUS, MOUSE; MICE; MICE, INBRED BALB C; PROTOZOAN PROTEINS; RNA, MESSENGER; SUPERANTIGENS; TH2 CELLS; TIME FACTORS; TRANSDUCTION, GENETIC; UP-REGULATION;

EID: 0035057963     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200104)31:4<1288::AID-IMMU1288>3.0.CO;2-8     Document Type: Article

References (39)

1. The regulation of immunity to Leishmania major
2. + T cells through IL-12 produced by Listeria-induced macrophages
3. + T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int
4. + T cells
5. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an αβ T cell-receptor transgenic system
6. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
7. IL-4-deficient Balb/c mice resist infection with Leishmania major
8. -
9. + T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice
10. Expression cloning of a protective Leishmania antigen
11. Resistance to Leishmania major induced by tolerance to a single antigen
12. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease
13. Helper T cell differentiation is controlled by the cell cycle
14. Mouse mammary tumor virus: Immunological interplays between virus and host
15. A Vβ4-specific superantigen encoded by a new exogenous mouse mammary tumor virus
16. Constructing polycompetitor cDNAs for quantitative PCR
17. An exogenous mouse mammary tumor virus with properties of Mls-1a
18. + T cells by staphylococcal enterotoxin B
19. The effects of chronic infection with a superantigen-producing virus
20. Preferential binding of mouse mammary tumor virus to B lymphocytes
21. Superantigens augment antigen-specific Th1 responses by inducing IL-12 production in macrophages
22. T cell activation determined by T cell receptor number and tunable thresholds
23. The interplay between the duration of TCR and cytokine signaling determines T cell polarization
24. Impaired Th2 subset development in the absence of CD4
25. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
26. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness
27. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
28. + T cells resulting in a state of unresponsiveness to IL-12
29. + T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
30. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells
31. + T cells is sufficient to mediate T helper cell type 1 development
32. + T cell subsets. Lymphokine secretion of memory cells and of effector cells that develop from precursors in vitro
33. + T cells to rapidly secrete IL-4 in BALB/c mice infected with Leishmania major
34. B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulated the initial production of IL-4
35. Stability of Th1 and Th2 populations
36. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
37. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
38. + T cell population isolated from an effector site contains cells with flexible cytokine profiles
39. + T cell-intrinsic mechanism