Interferon γ derived from CD4+ T cells is sufficient to mediate T helper cell type 1 development

Journal of Experimental Medicine

Volumn 188, Issue 9, 1998, Pages 1651-1656

  Wakil, Adil E ^a   Wang, Zhi En ^a,b   Ryan, James C ^c   Fowell, Deborah J ^a   Locksley, Richard M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Interferon ; Leishmania; Listeria; Natural killer cells; T helper type 1 cells

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; HELPER CELL; IMMUNOMODULATION; LEISHMANIA MAJOR; LISTERIA MONOCYTOGENES; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; INTERFERON TYPE II; INTERLEUKIN-12; KILLER CELLS, NATURAL; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LISTERIA MONOCYTOGENES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TH1 CELLS;

EID: 0032476741     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.9.1651     Document Type: Article

References (42)

1. Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature. 383:778-793.
2. O'Garra, A. 1998. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 8: 275-283.
3. Magram, J., S.E. Connaughton, R.R. Warrer, D.M. Carvajal, C.-Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D.A. Faherty, and M.K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production. Immunity. 4:471-481.
4. Takeda, K., H. Tsutsui, T. Yoshimoto, O. Adachi, N. Yoshida, T. Kishimoto, H. Okarmura, K. Nakanishi, and S. Akira. 1998. Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 8:383-390.
5. Robinson, D., K. Shibuya, A. Mui, F. Zonin, E. Murphy, T. Sana, S.B. Hartley, S. Menon, R. Kastelein, F. Bazan, and A. O'Garra. 1997. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-γ production and activates IRAK and NFκB. Immunity. 7:571-581.
6. Graham, M.B., D.K. Dalton, D. Giltinan, V.L. Braciale, T.A. Stewart, and T.J. Braciale. 1993. Response to influenza infection in mice with a targeted disruption in the interferon γ gene. J. Exp. Med. 178:1725-1732.
7. + effector cells default to the Th2 pathway in interferon-γ-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367-1371.
8. Bouley, D.M., S. Kanangat, W. Wire, and B.T. Rouse. 1995. Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-γ knockout mice. J. Immunol. 155:3964-3971.
9. Szabo, S.J., A.S. Dighe, U. Gubler, and K.M. Murphy. 1997. Regulation of the interleukin (IL)-12R β2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185:817-824.
10. Ma, X., J.M. Chow, G. Gri, G. Carra, F. Gerosa, S.F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147-157.
11. Fowell, D.J., J. Magram, C.W. Turck, N. Killeen, and R.M. Locksley. 1997. Impaired Th2 subset development in the absence of CD4. Immunity. 6:559-569.
12. Wu, C., J. Ferrante, M.K. Gately, and J. Magram. 1997. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice. J. Immunol. 159:1658-1665.
13. + T cells upon NKR-P1 cross-linking. J. Exp. Med. 183:2391-2396.
14. Pernis, A., S. Gupta, K.J. Gollob, E. Garfein, R.L. Coffman, C. Schindler, and P. Rothman. 1995. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in Th1 cells. Science. 269:245-247.
15. + T cells during initiation of infection. J. Exp. Med. 179:447-456.
16. Hsieh, C.-S., S.E. Macatonia, C.S. Tripp, S.F. Wolf, A. O'Garra, and K.M. Murphy. 1993. Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science. 260:547-549.
17. Dalton, D.K., S. Pitts-Meek, S. Keshav, I.S. Figari, A. Bradley, and T.A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science. 259:1739-1742.
18. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V.E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
19. Openshaw, P., E.E. Murphy, N.A. Hosken, V. Maino, K. Davis, K. Murphy, and A. O'Garra. 1995. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182:1357-1367.
20. Ryan, J.C., E.C. Niemi, M.C. Nakamura, and W.E. Seaman. 1995. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J. Exp. Med. 181:1911-1915.
21. + T cell subsets and induces early resistant to Leishmania major in mice. J. Exp. Med. 178:567-577.
22. Laskay, T., M. Rollinghoff, and W. Solbach. 1993. Natural killer cells participate in the early defense against Leishmania major infection in mice. Eur. J. Immunol. 23:2237-2241.
23. Holaday, B.J., M.D. Sadick, Z.-E. Wang, S.L. Reiner, F.P. Heinzel, T.G. Parslow, and R.M. Locksley. 1991. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1-and Th2-like cell lines. J. Immunol. 147:1653-1658.
24. Reiner, S.L., and R.M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
25. Macatonia, S.E., C.-S. Hsieh, K.M. Murphy, and A. O'Garra. 1993. Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int. Immunol. 5: 1119-1128.
26. Wenner, C.A., M.L. Guler, S.E. Macatonia, A. O'Garra, and K.M. Murphy. 1996. Roles of IFN-γ and IFN-α in IL-12-induced T helper cell-1 development. J. Immunol. 156:1442-1447.
27. Bradley, L.M., D.K. Dalton, and M. Croft. 1996. A direct role for IFN-γ in regulation of Th1 cell development. J. Immunol. 157:1350-1358.
28. Nakamura, T., R.K. Lee, S.Y. Nam, E.R. Podack, K. Bottomly, and R.A. Flavell. 1997. Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J. Immunol. 158:2648-2653.
29. Szabo, S.J., N.G. Jacobson, A.S. Dighe, U. Gubler, and K.M. Murphy. 1995. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity. 2:665-675.
30. Thierfelder, W.E., J.M. van Deursen, K. Yamamoto, R.A. Tripp, S.R. Sarawar, R.T. Carson, M.Y. Sangster, D.A.A. Vignah, P.C. Doherty, G.C. Grosveld, and J.N. Ihle. 1996. Requirement for stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 382:171-174.
31. Kaplan, M.H., Y.-L. Sun, T. Hoey, and M.J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in stat4-deficient mice. Nature. 382:174-177.
32. Flesch, I.E.A., J.H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethniann, and S.H.E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181:1615-1621.
33. Guler, M.L., J.D. Gorham, C.-S. Hsieh, A.J. Mackey, R.G. Steen, W.F. Dietrich, and K.M. Murphy. 1996. Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development. Science. 271:964-967.
34. Guler, M.L., N.G. Jacobson, U. Gubler, and K.M. Murphy. 1997. T cell genetic background determines maintenance of IL-12 signaling. Effects on BALB/c and B10.D2 T helper cell type 1 phenotype development. J. Immunol. 159:1767-1774.
35. Hsieh, C.-S., S.E. Macatonia, A. O'Garra, and K.M. Murphy. 1995. T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181: 713-721.
36. Scharton-Kersten, T., L.C.C. Afonso, M. Wysocka, G. Trinchieri, and P. Scott. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 development in experimental leishmaniasis. J. Immunol. 154:5320-5330.
37. Orange, J.S., B. Wang, C. Terhorst, and C.A. Biron. 1995. Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration. J. Exp. Med. 182:1045-1056.
38. Diefenbach, A., H. Schindler, N. Donhauser, E. Lorenz, T. Laskay, J. MacMicking, M. Rollinghoff, I. Gresser, and C. Bogdan. 1998. Type 1 interferon (IFN α/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity. 8:77-87.
39. Stenger, S., H. Thuring, M. Rollinghoff, and C. Bogdan. 1994. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J. Exp. Med. 180:783-793.
40. Schmitz, J., A. Thiel, R. Kuhn, K. Rajewsky, and W. Muller. 1994. Induction of interleukin-4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-T cells. J. Exp. Med. 179:1349-1353.
41. Launois, P., I. Maillard, S. Pingel, K.G. Swihart, I. Xenarios, H. Acha-Orbea, H. Diggelmann, R.M. Locksley, H.R. MacDonald, and J.A. Louis. 1997. IL-4 rapidly produced by Vβ4Vα8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity. 6: 541-549.
42. Lange, C., T. Schuler, and T. Blankenstein. 1998. Interleukin 4 gene-defective mice reconstituted with wild-type bone marrow fail to produce normal immunoglobulin E levels. J. Exp. Med. 187:1487-1493.