Mouse mammary tumor virus: Immunological interplays between virus and host

Advances in Immunology

Volumn 65, Issue , 1997, Pages 139-243

  Luther, Sanjiv A ^a   Acha Orbea, Hans ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANTIBODY SPECIFICITY; ANTIGEN EXPRESSION; CLONAL ANERGY; HUMORAL IMMUNITY; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS MORPHOLOGY;

EID: 0030755062     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (589)

1. Abe, J., Forrester, J., Nakahara, T., Lafferty, J. A., Kotzin, B. L., and Leung, D. Y. (1991). Selective stimulation of human T cells with streptococcal erythrogenic toxins A and B. J. Immunol. 146, 3747-3750.
2. Abe, R., and Hodes, R. (1989). T cell recognition of minor lymphocyte stimulating (Mis) gene products. Annu. Rev. Immunol. 7, 683-708.
3. d. J. Exp. Med. 165, 1113-1129.
4. Abe, R., Ryan, J. J., and Hodes, R. J. (1987b). Mls is not a single gene, allelic system. Different stimulatory Mls determinants are the products of at least two nonallelic, unlinked genes. J. Exp. Med. 166, 1150-1155.
5. c reactive T cells. Nature 335, 827-830.
6. β12 T cell receptors for antigen. J. Immunol. 147, 739-749.
7. f system. I. A novel "polymorphism" of endogenous superantigens. J. Immunol. 149, 3429-3439.
8. Abraham, D., Muir, H., Winchester, B., and Olson, I. (1988). Lymphocytes transfer only the lysosomal form of α-D-mannosidase during cell-to-cell contact. Exp. Cell Res. 175, 158-168.
9. Abrahamson, D. R., Powers, A., and Rodewald, R. (1979). Intestinal absorption of immune complexes by neonatal rats: A route of antigen transfer from mother to young. Science 206, 567-569.
10. Abromson-Leeman, S. R., and Dorf, M. E. (1991). Extrathymic clonal deletion of self-reactive cells in athymic mice. J. Immunol. 147, 1-7.
11. Acha-Orbea, H. (1993). Bacterial and viral superantigens: Roles in autoimmunity? Ann. Rheum. Dis. 52, S6-S16.
12. Acha-Orbea, H. (1995). Superantigens and tolerance. In "T Cell Receptors" (J. I. Bell, M. J. Owen and E. Simpson, Eds.), pp. 224-265. Oxford Univ. Press, Oxford, UK.
13. Acha-Orbea, H., and MacDonald, H. R. (1995). Superantigens of mouse mammary tumor virus. Annu. Rev. Immunol. 13, 459-486.
14. Acha-Orbea, H., and Palmer, E. (1991). Mis-A retrovirus exploits the immune system. Immunol. Today 12, 356-361.
15. β14 positive T cells in mice transgenic for mammary tumor virus. Nature 350, 207-211.
16. Acha-Orbea, H., Scarpellino, L., Shakhov, A. N., Held, W., and MacDonald, H. R. (1992). Inhibition of mouse mammary tumor virus-induced T cell responses in vivo by antibodies to an open reading frame protein. J. Exp. Med. 176, 1769-1772.
17. Acha-Orbea, H., Held, W., Waanders, G. A., Shakhov, A. N., Scarpellino, L., Lees, R., and MacDonald, H. R. (1993). Exogenous and endogenous mouse mammary tumor virus superantigens. Immunol. Rev. 131, 5-25.
18. Ahmed, R., and Gray, D. (1996). Immunological memory and protective immunity: Understanding their relation. Science 272, 54-60.
19. Altmann, D. M., Takacs, K., Trowsdale, J., and Elliott, J. I. (1993). Mouse mammary tumor virus-mediated T-cell receptor negative selection in HLA-DRA transgenic mice. Hum. Immunol. 37, 149-156.
20. Altrock, B. W., Cardiff, R. D., and Blair, P. B. (1981). Murine mammary tumor virus seroepidemiology in BALB/cfC3H mice: Correlation with tumor development. J. Natl. Cancer Inst. 67, 163-168.
21. Amerongen, H. M., Weltzin, R., Famet, C. M., Michetti, P., Haseltine, W. A., and Neutra, M. R. (1991). Transepithelial transport of HIV-1 by intestinal M cells: A mechanism for transmission of AIDS. J. Acquired Immmune Defic. Syndr. 4, 760-765.
22. Anders, M. E., Scalzo, A. A., and White, D. O. (1984). Influenza viruses are T cell-independent B cell mitogens. J. Virol. 50, 960-963.
23. Andersson, M., and Acha-Orbea, H. (1994). The primary in vivo immune response to Mls-1 (Mtv-7 sag). Route of injection determines the immune response pattern. Immunology 83, 438-443.
24. Andervont, H. B. (1963). In utero transmission of the mouse mammary tumor agent. J. Natl. Cancer Inst. 31, 261-272.
25. Ando, Y., Wajjwalku, W., Niimi, N., Hiromatsu, K., Morishima, T., and Yoshikai, Y. (1995). Concomitant infection with exogenous mouse mammary tumor virus encoding I-E-dependent superantigen in I-E-negative mouse strain. J. Immunol. 154, 6219-6226.
26. a antigens from T cell subsets. Immunobiobgy 193, 378-390.
27. + T cells. J. Immunol. 151, 4445-4454.
28. Ardavin, C., Waanders, G., Ferrero, J., Anjuerre, F., Acha-Orbea, H., and MacDonald, H. R. (1996). Expression and presentation of viral superantigens by thymic and splenic dendritic cells and B cells. J. Immunol, 157, 2789-2794.
29. Arden, B., Clark, S. P., Kabelitz, D., and Mak, T. W. (1995). Mouse T-cell receptor variable gene segment families. Immunogenetics 42, 501-530.
30. Arthur, L. O., and Fine, D. L. (1978). Naturally occurring humoral immunity to murine mammary tumor virus (MuMTV) and MuMTV gp52 in mice with low mammary tumor incidence. Int. J. Cancer 22, 734-740.
31. Arthur, L. O., Bauer, R. F., Orme, L. S., and Fine, D. L. (1978a). Coexistence of the mouse mammary tumor virus (MMTV) major glycoprotein and natural antibodies to MMTV in sera of mammary tumor-bearing mice. Virology 87, 266-275.
32. Arthur, L. O., Long, C. W., Smith, G. H., and Fine, D. L. (1978b). Immunological characterization of the low-molecular-weight DNA binding protein of mouse mammary tumor virus. Int. J. Cancer 22, 433-440.
33. Astoul, E., Lafage, M., and Lafon, M. (1996). Rabies superantigen as a Vβ T-dependent adjuvant. J. Exp. Med. 183, 1623-1631.
34. Augustin, A. A., and Coutinho, A. (1980). Specific T helper cells that activate B cells polyclonally. J. Exp. Med. 151, 587-601.
35. Baccala, R., Smith, L. R., Vestberg, M., Peterson, P. A., Cole, B. C, and Theofilopoulos, A. N. (1992). Mycoplasma arthritidis mitogen. Vβ engaged in mice, rats, and humans, and requirement of HLA-DRα for presentation. Arthr. Rheum. 35, 434-442.
36. Bachmann, M. F., Kundig, T. M., Kalberer, C. P., Hengartner, H., and Zinkernagel, R. M. (1993a). Formalin inactivation of vesicular stomatitis virus impairs T-cell-but not T-helpindependent B-cell responses. J. Virol. 67, 3917-3922.
37. Bachmann, M. F., Rohrer, U. H., Kundig, T. M., Burki, K., Hengartner, H., and Zinkernagel, R. M. (1993b). The influence of antigen organization on B cell responsiveness. Science 262, 1448-1451.
38. Bachmann, M. F., Kundig, T. M., Odermatt, B., Hengartner, H., and Zinkernagel, R. M. (1994). Free recirculation of memory B cells versus antigen-dependent differentiation to antibody-forming cells. J. Immunol. 153, 3386-3397.
39. Bachmann, M. F., Hengartner, H., and Zinkernagel, R. M. (1995). Thelper cell-independent neutralizing B cell response against vesicular stomatitis virus: Role of antigen patterns in B cell induction? Eur. J. Immunol. 25, 3445-3451.
40. Ball, J. K., Arthur, L. O., and Dekaban, G. (1985). The involvement of a rype-B retrovirus in the induction of thymic lymphomas. Virology 140, 159-172.
41. 3 region of the long terminal repeat of an infectious thymotropic type B retrovirus. J. Virol. 62, 2985-2993.
42. a does not correlate with in vivo tolerance. Int. Immunol. 3, 923-931.
43. Barr, P. J. (1991). Mammalian subtilisins: The long-sought dibasic processing endoproteases. Cell 66, 1-3.
44. Behlke, M. A., Chou, H. S., Huppi, K., and Loh, D. (1986). Murine T-cell receptor mutants with deletions of β-chain variable region genes. Proc. Natl. Acad. Sci. USA 83, 767-771.
45. Benoist, C., and Mathis, D. (1989). Positive selection of the T cell repertoire: Where and when does it occur? Cell 58, 1027-1033.
46. Bentvelzen, P. (1968). Resistance to small amounts of Bittner mammary tumor virus in offspring of C57BL female mice with the virus. J. Natl. Cancer Inst. 41, 757-765.
47. Bentvelzen, P., and Brinkhof, J. (1977). Organ distribution of exogenous murine mammary rumor virus as determined by bioassay. Eur. J. Cancer 13, 241-245.
48. Bentvelzen, P., and Hilgers, J. (1980). Murine mammary tumor virus. In "Viral Oncology" (G. Klein, ed.), pp. 311-355. Raven Press, New York.
49. Bentvelzen, P., Daams, J. H., Hageman, P., Calafat, J., and Timmermans, A. (1972). Interactions between viral and genetic factors in the origin of mammary tumors in mice. J. Natl. Cancer Inst. 48, 1089-1094.
50. Bentvelzen, P., Brinkhof, J., and Westenbrink, F. (1980). Expression of endogenous mammary tumor virus in mice: Its genetic control and relevance to spontaneous carcinogenesis. In "Cold Spring Harbor Conferences on Cell Proliferation. Viruses in Naturally Occurring Cancers" (M. Essex, G. Todaro, and H. zur Hausen, Eds., pp. 1095-1104. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
51. Bentvelzen, P., Hilgers, J., and Daams, J. (1981). Humoral immunity against the mammary tumor virus. In "Mammary Tumors in the Mouse" (J. Hilgers and M. Sluyser, Eds), pp. 627-636. Elsevier/North-Holland, Biomedical Press, Amsterdam.
52. Berberian, L., Goodglick, L., Kipps, T. J., and Braun, J. (1993). Immunoglobulin VH3 gene products: Natural ligands for HIV gpl20. Science 261, 1588-1591.
53. Berg, L. J., Fazekas de St Groth, B., Pullen, A. M., and Davis, M. M. (1989a). Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection. Nature 340, 559-562.
54. Berg, L. J., Pullen, A. M., Fazekas de St Groth, B., Mathis, D., Benoist, C, and Davis, M. M. (1989b). Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell 58, 1035-1046.
55. Bernhard, W. (1958). Electron microscopy of tumor cells and tumor viruses. A review. Cancer Res. 18, 491-509.
56. a antigens: Stimulatory effect in vitro versus suppressive effect in vivo. Immunogenetics 20, 33-45.
57. Beutner, U., Frankel, W. N., Cote, M. S., Coffin, J. M., and Huber, B. T. (1992). Mls-1 is encoded by the long terminal repeat open reading frame of the mouse mammary tumor provirus Mtv-7. Proc. Natl. Acad. Sci. USA 89, 5432-5436.
58. Beutner, U., Kraus, E., Kitamura, D., Rajewsky, K., and Huber, B. T. (1994). B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. J. Exp. Med. 179, 1457-1466.
59. Beutner, U., McLellan, B., Kraus, E., and Huber, B. T. (1996). Lack of MMTV superantigen presentation in MHC class H-deficient mice. Cell. Immunol. 168, 141-147.
60. Bevilacqua, G., Marchetti, A., and Biondi, R. (1989). Ultrastructural features of the intestinal absorption of mouse mammary tumor virus in newborn BALB/cfRIII mice. Gastroenterology 96, 139-145.
61. Bill, J., and Palmer, E. (1989). Positive selection of CD4+ T cells mediated by MHC class II-bearing stromal cell in the thymic cortex. Nature 341, 649-651.
62. β11-bearing T cells. J. Exp. Med. 169, 1405-1419.
63. Bittner, J. J. (1936). Some possible effects on nursing on the mammary gland tumor incidence in mice. Science 84, 162.
64. Bittner, J. J. (1948). Some enigmas associated with the genesis of mammary cancer in mice. Cancer Res. 8, 625-639.
65. Blackman, M., Kappler, J., and Marrack, P. (1990a). The role of the T cell receptor in positive and negative selection of developing T cells. Science 248, 1335-1341.
66. Blackman, M. A., and Woodland, D. L. (1995). In vivo effects of superantigens. Life Sci. 57, 1717-1735.
67. + T cells. Science 244, 214-217.
68. a. Nature 345, 540-542.
69. Blackman, M. A., Smith, H. P., Le, P., and Woodland, D. L. (1993). Influence of the T cell receptor alpha-chain on T cell reactivity and tolerance to Mls-1 in T cell receptor beta-chain transgenic mice. J. Immunol. 151, 556-565.
70. Blair, P. B. (1968). The mammary tumor virus (MTV). Curr. Top. Microbiol. Immunol. 45, 1-69.
71. Blair, P. B., and Lane, M. A. (1974). Serum factors in mammary neoplasia: Enhancement and antagonism of spleen cell activity in vitro detected by different methods of serum factor assay. J. Immunol. 112, 439-443.
72. Blair, P. B., and Lane, M. A. (1975). Non-T cell killing of mammary tumor cells by spleen cells: Secretion of antibody and recruitment of cells. J. Immunol. 115, 184-189.
73. Blair, P. B., Lane, M. A., and Yagi, M. J. (1975). Blocking of spleen cell activity against target mammary tumor cells by viral antigens. J. Immunol. 115, 190-194.
74. Bluestone, J. A. (1995). New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2, 555-559.
75. Bolander, F. F. Jr. (1996). Requirements for mouse mammary tumor virus internalization in mouse mammary epithelial cells. J. Gen. Virol. 77, 793-796.
76. Bolander, F. F. Jr., and Blackstone, M. E. (1991). Regulation of the mouse mammary tumor virus (MMTV) binding site in cultured mammary tissue. Mol. Cell. Endocrinol. 82, 137-142.
77. Boot, L. M., and Muhlbock, O. (1956). The mammary tumor incidence in the C3H mouse strain with and without agent. Acta Unio Int. Contra Cancrum 12, 569-581.
78. Brandt-Carlson, C, and Butel, J. S. (1991). Detection and characterization of a glycoprotein encoded by the mouse mammary tumor virus long terminal repeat gene. J. Virol. 65, 6051-6060.
79. Brandt-Carlson, C., Butel, J. S., and Wheeler, D. (1993). Phylogenetic and structural analyses of MMTV LTR sequences of exogenous and endogenous origins. Virology 193, 171-185.
80. Braun, M. Y., Jouvin-Marche, E., Marche, P. N., MacDonald, H. R., and Acha-Orbea, H. (1995). T cell receptor V β repertoire in mice lacking endogenous mouse mammary tumor provirus. Eur. J. Immunol. 25, 857-862.
81. Brocke, S., Gaur, A., Piercy, C., Gautam, A., Gijbels, K., Fathman, C. G., and Steinman, L. (1993). Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature 365, 642-644.
82. Bryan, W. R., Kahler, H., Shimkin, M. B., and Andervont, H. B. (1942). Extraction and ultracentrifugation of mammary tumor inciter of mice. J. Natl. Cancer Inst. 2, 441-455.
83. Buetti, E., and Diggelmann, H. (1983). Glucocorticoid regulation of mouse mammary tumor virus: Identification of a short essential DNA region. EMBO J. 2, 1423-1429.
84. Bukrinsky, M. I., Haggerty, S., Dempsey, M. P., Sharova, N., Adzhubel, A., Spitz, L., Lewis, P., Goldfarb, D., Emerman, M., and Stevenson, M. (1993). A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Nature 365, 666-669.
85. Burkly, L. C., Lo, D., Kanagawa, O., Brinster, R. L., and Flavell, R. A. (1989). T cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I-E. Nature 342, 564-566.
86. Burns, W., Billups, L. C, and Notions, A. L. (1975). Thymus dependence of viral antigens. Nature 256, 654-656.
87. Cafruny, W. A., Strancke, C. R., Kowalchyk, K., and Plagemann, P. G. (1986). Replication of lactate dehydrogenase-elevating virus in C58 mice and quantification of antiviral antibodies and of tissue virus levels as a function of development of paralytic disease. J. Gen. Virol. 67, 27-37.
88. Calafat, J., Hilgers, J., Van Bitterswijk, W. J., Verbeet, M., and Hageman, P. C. (1976). Antibody-induced modulation and shedding of mammary tumor virus antigens on the surfaces of GR ascites leukemia cells as compared with normal antigens. J. Natl. Cancer Inst. 56, 1019-1029.
89. Callahan, J. E., Herman, A., Kappler, J. W., and Marrack, P. (1990). Stimulation of B10. Br T cells with superantigenic staphylococcal toxins. J. Immunol. 144, 2473-2479.
90. + cells. J. Exp. Med. 74, 989-1000.
91. Cardiff, R. D., Puentes, M. J., Young, L. J., Smith, G. H., Teramoto, Y. A., Altrock, B. W., and Pratt, T. S. (1978). Serological and biochemical characterization of the mouse mammary tumor virus with localization of p10. Virology 85, 157-167.
92. Cazenave, P. A., Marche, P. N., Jouvin-Marche, E., Voegde, D., Bonhomme, F., Bandeira, A., and Coutinho, A. (1990). Vβ 17 gene polymorphism in wild-derived mouse strains: Two amino acid substitutions in the Vβ 17 region greatly alter T cell receptor specificity. Cell 63, 717-728.
93. Champagne, E., Scarpellino, L., Lane, P., and Acha-Orbea, H. (1996). CD28/CTLA4-B7 interaction is dispensable for T cell stimulation by mouse mammary tumor virus superantigen but not for B cell differentiation and virus dissemination. Eur. J. Immunol. 26, 1595-1602.
94. Charan, S., and Zinkernagel, R. M. (1986). Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus. J. Immunol. 136, 3057-3061.
95. Charney, J., and Moore, D. H. (1972). Immunization studies with mammary tumor virus. J. Natl. Cancer Inst. 48, 1125-1129.
96. Charney, J., Holben, J. A., Cody, C. M., and Moore, D. H. (1976). Further immunization studies with mammary tumor virus. Cancer Res. 36, 777-780.
97. Charyulu, V., Sigel, M. M., Durden, D. L., and Lopez, D. M. (1979). Mouse mammary tumor virus (MMTV) antigen (s) are present on B lymphocytes of BALB/c mice. Int. J. Cancer 24, 813-818.
98. Chervonsky, A. V., Xu, J., Barlow, A. K., Khery, M., Flavell, R. A., and Janeway, C. A. J. (1995). Direct physical interaction involving CD40 ligand on T cells and CD40 on B cells is required to propagate MMTV. Immunity 3, 139-146.
99. Cho, K., Ferrick, D. A., and Morris, D. W. (1995). Structure and biological activity of the subgenomic Mtv-6 endogenous provirus. Virology 206, 395-402.
100. Choi, Y., Kotzin, B., Herron, L., Callahan, J., Marrack, P., and Kappler, J. (1989). Interaction of Staphylococcus aureus toxin superantigens with human T cells. Proc. Natl. Acad. Sci. USA 86, 8941-8945.
101. Choi, Y., Kappler, J. W., and Marrack, P. (1991). A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumor virus. Nature 350, 203-207.
102. Choi, Y., Marrack, P., and Kappler, J. W. (1992). Structural analysis of a mouse mammary tumor virus superantigen. J. Exp. Med. 175, 847-852.
103. + T cell response to Mls-P determinants involves major histocompatibility complex class II molecules. J. Exp. Med. 173, 779-782.
104. Clark, E. A., and Ledbetter, J. A. (1994). How B and T cells talk to each other. Nature 367, 425-428.
105. d encoded products. J. Immunol. 134, 2948-2952.
106. c gene. J. Immunol. 139, 321-325.
107. Coffin, J. M. (1996). Retroviridae and their replication. In "Virology", (B. N. Fields and D. M. Knipe, Eds.), 3rd ed., Vol. 2, pp. 1767-1847. Raven Press, New York.
108. Cohen, J. C, and Varmus, H. E. (1979). Endogenous mammary tumor virus DNA varies among wild mice and segregates during inbreeding. Nature 278, 418-423.
109. Cohen, J. C, and Varmus, H. E. (1980). Proviruses of mouse mammary tumor virus in normal and neoplastic tissues from GR and C3Hf mouse strains. J. Virol. 35, 298-305.
110. β8 gene family present on the T cell receptor α/β for antigen. J. Immunol. 142, 4131-4137.
111. Cole, B. C., Kartchner, D. R., and Wells, D. J. (1990). Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis (MAM). VIII. Selective activation of T cells expressing distinct V beta T cell receptors from various strains of mice by the "superantigen" MAM. J. Immunol. 144, 425-431.
112. Cole, B. C., Knudtson, K. L., Oliphant, A., Sawitzke, A. D., Pole, A., Manohar, M., Scott Benson, L., Ahmed, E., and Atkin, C. L. (1996). The sequence of the Mycoplasma arthritides superantigen, MAM: Identification of functional domains and comparison with microbial superantigen and plant lectin mitogens. J. Exp. Med. 183, 1105-1110.
113. Coutelier, J. P., van der Logt, J. T., Heessen, F. W., Warnier, G., and Van Snick, J. (1987). IgG2a restriction of murine antibodies elicited by viral infections. J. Exp. Med. 165, 64-69.
114. Coutelier, J. P., van der Log, J. T., and Heessen, F. W. (1991). IgG subclass distribution of primary and secondary immune responses concomitant with viral infection. J. Immunol. 147, 1383-1386.
115. Coutinho, A., and Moller, G. (1975). Thymus-independent B-cell induction and paralysis. Adv. Immunol. 21, 114-236.
116. Creemers, P. (1977). The role of leukocyte subpopulations in the indirect leukocyte adherence inhibition assay in the mammary tumor virus system. Eur. J. Immunol. 7, 48-53.
117. Creemers, P., and Bentvelzen, P. (1981). Cellular immune reactivity to the mammary tumor virus. In "Mammary Tumors in the Mouse", (J. Hilgers and M. Skuyser, Eds.), pp. 637-649. Elsevier/North-Holland, Biomedical Press, Amsterdam.
118. Crisp (1854). Trans. Pathol. Soc. London 5, 348.
119. Crouse, C, and Pauley, R. J. (1989). Molecular cloning and sequencing of the Mtv-1 LTR. Virus Res. 12, 123-138.
120. a anergy in vivo. J. Immunol. 146, 2083-2087.
121. David, D., Demaison, C., Bani, L., Zouali, M., and Theze, J. (1995). Selective variations in vivo of VH3 and VH1 gene family expression in peripheral B cell IgM, IgD and IgG during HIV infection. Eur. J. Immunol. 25, 1524-1528.
122. DeKruyff, R., Ju, S. T., Laning, J., Cantor, H., and Dorf, M. E. (1986). Activation requirements of cloned inducer T cells. III. Need for two stimulator cells in the response of a cloned line to Mls determinants. J. Immunol. 137, 1109-1114.
123. DeMaeyer, E., DeMaeyer-Guignard, J., Hall, W. T., and Bailey, D. W. (1974). A locus affecting circulating interferon levels induced by mouse mammary tumor virus. J. Gen. Virol. 23, 209-211.
124. Denkers, E. Y., Caspar, P., and Sher, A. (1994). Toxoplasma gondii possesses a superantigen activity that selectively expands murine T cell receptor V beta 5-bearing CD8+ lymphocytes. J. Exp. Med. 180, 985-994.
125. b BALB/c mice. Int. Immunol. 5, 217-222.
126. Dickson, C, and Peters, G. (1981). Protein-coding potential of mouse mammary tumor virus genome RNA as examined by in vitro translation. J. Virol. 37, 36-47.
127. Dickson, C, and Peters, G. (1983). Proteins encoded by mouse mammary tumor virus. Curr. Top. Microbiol. Immunol. 106, 1-34.
128. Dickson, C, and Skehel, J. J. (1974). The polypeptide composition of mouse mammary tumor virus. Virology 58, 387-395.
129. Dickson, C., Smid, R., and Peters, G. (1981). In vitro synthesis of polypeptides encoded by the long terminal repeat region of mouse mammary tumor virus. Nature 291, 511-513.
130. Dintzis, H. M., Dintzis, R. Z., and Vogelstein, B. (1976). Molecular determinants of immunogenicity: The immunon model of immune response. Proc. Natl. Acad. Sci. USA 73, 3671-3675.
131. Dintzis, R. Z., Okajima, M., Middleton, M. H., Greene, G., and Dintzis, H. M. (1989). The immunogenicity of soluble haptenated polymers is determined by molecular mass and hapten valence. J. Immunol. 143, 1239-1244.
132. Dion, A. S., Williams, C. J., and Moore, D. H. (1977). RNase H and RNA-directed DNA polymerase: Associated enzymatic activities of murine mammary tumor virus. J. Virol. 22, 187-193.
133. Dion, A. S., Knittel, J. J., and Morneweck, S. T. (1990). Virus envelope-based peptide vaccines against virus-induced mammary tumors. Virology 179, 474-477.
134. Dmochovski, L., and Grey, C. E. (1957). Subcellular structures of possible viral origin in some mammalian tumors. Ann. N. Y. Acad. Sci. 68, 559-615.
135. Dobrescu, D., Ursea, B., Pope, M., Asch, A. S., and Posnett, D. N. (1995). Enhanced HIV-1 replication in V beta 12 T cells due to human cytomegalovirus in monocytes: Evidence for a putative herpesvirus superantigen. Cell 82, 753-763.
136. Domiati-Saad, R., Attrep, J. F., Brezinschek, H.-P., Cherrie, A. H., Karp, D. R., and Lipsky, P. E. (1996). Staphylococcal enterotoxin D functions as a human B cell superantigen by rescuing VH4-expressing B cells from apoptosis. J. Immunol. 156, 3608-3620.
137. Donehower, L. A., Huang, A. L., and Hager, G. L. (1981). Regulatory and coding potential of the mouse mammary tumor virus long terminal redundancy. J. Virol. 37, 226-238.
138. Donehower, L. A., Fleurdelys, B., and Hagler, G. L. (1983). Further evidence for the protein coding potential of the mouse mammary tumor virus long terminal repeat: Nucleotide sequence of an endogenous proviral long terminal repeat. J. Virol. 45, 941-949.
139. Doyon, L., Simard, C., Sekaly, R. P., and Jolicoeur, P. (1996). Evidence that the murine AIDS defective virus does not encode a superantigen. J. Virol. 70, 1-9.
140. Duesberg, P. H., and Cardiff, R. D. (1968). Structural relationships between the RNA of mammary tumor virus and those of other RNA tumor viruses. Virology 36, 696-700.
141. Durgam, V. R., and Tekmal, R. R. (1994). The nature and expression of int-5, a novel MMTV integration locus gene in carcinogen-induced mammary tumors. Cancer Lett. 87, 179-186.
142. Durgam, V. R., Easton, J. A., Surya, R., and Tekmal, R. R. (1995). Structure of the int-5, a novel MMTV integration genomic locus containing mouse early transposon LTR homology region. Biochim. Biophys. Acta 1263, 89-92.
143. Dustin, L. B., Bullock, E. D., Hamada, Y., Azuma, T., and Loh, D. Y. (1995). Antigen-driven differentiation of naive Ig transgenic B cells in vitro. J. Immunol. 154, 4936-4949.
144. Dux, A., and Mtihlbock, O. (1968). Propagation of the mammary tumor agent (Bittner virus) in the absence of mammary glands in mice. J. Natl. Cancer Inst. 40, 1309-1312.
145. Dux, A., Mtihlbock, O., and Bailey, D. W. (1978). Genetic analyses of differences in incidence of mammary tumors and reticulum cell neoplasms with the use of recombinant inbred lines of mice. J. Natl. Cancer Inst. 61, 1125-1129.
146. Dyson, P. J., Knight, A. M., Fairchild, S., Simpson, E., and Tomonari, K. (1991). Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumor virus genomes. Nature 349, 531-532.
147. Etkind, P. R. (1989). Expression of the int-1 and int-2 loci in endogenous mouse mammary tumor virus-induced mammary tumorigenesis in the C3Hf mouse. J. Virol. 63, 4972-4975.
148. Etkind, P. R., and Sarkar, N. H. (1983). Integration of new endogenous mouse mammary tumor virus proviral DNA at common sites in the DNA of mammary tumors of C3Hf mice and hypomethylation of the endogenous mouse mammary tumor virus proviral DNA in C3Hf mammary tumors and spleens. J. Virol. 45, 114-123.
149. Eynon, E. E., and Parker, D. C. (1992). Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175, 131-138.
150. + T cells with Mtv-3. Immunogenetics 34, 227-230.
151. + T-cell deletion and a new mouse mammary tumor provirus, Mtv-44. Immunogenetics 36, 189-194.
152. Fasel, N., Pearson, K., Buetti, E., and Diggelmann, H. (1982). The region of mouse mammary tumor virus DNA containing the long terminal repeat includes a long coding sequence and signals for hormonally regulated transcription. EMBO J. 1, 3-7.
153. Fehr, T., Bachmann, M. F., Bluethmann, H., Kikutani, H., Hengartner, H., and Zinkernagel, R. M. (1996). T-independent activation of Bcells by vesicular stomatitis virus: Noevidence for the need of a second signal. Cell. Immunol. 168, 184-192.
154. Feldman, M., and Basten, A. (1971). The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response. J. Exp. Med. 134, 103-117.
155. Feldman, M., and Nossal, G. J. V. (1972). Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages. Transplant. Rev. 13, 3-34.
156. Ferrick, D. A., Cho, K.; Gemmell, H. L., and Morris, D. W. (1992). Genetic analysis of the effects of Mtv-2 on the T cell repertoire in the WXG-2 mouse strain. Int. Immunol. 4, 805-810.
157. Festenstein, H. (1966). Antigenic strength investigated by mixed cultures of allogeneic mouse spleen cells. Ann. N. Y. Acad. Sci. 129, 567-572.
158. Festenstein, H. (1973). Immunogenic and biological aspects of in vitro allotransformation (MLR) in the mouse. Transplant Rev. 15, 62-88.
159. Festenstein, H. (1974). Pertinent features of M locus determinants including revised nomenclature and strain distribution. Transplantation 18, 555-557.
160. Fine, D. L., Arthur, L. O., and Gardner, M. B. (1978). Prevalence of murine mammary tumor virus antibody and antigens in normal and tumor-bearing feral mice. J. Natl. Cancer Inst. 61, 485-491.
161. Finkelman, F. D., Lees, A., and Morris, S. C. (1992). Antigen presentation by B lymphocytes to CD4+ T lymphocytes in vivo: Importance for B lymphocyte and T lymphocyte activation. Sem. Immunol. 4, 247-255.
162. Fleischer, B., and Schrezenmeier, H. (1988). T cell stimulation by staphylococcal enterotox-ins. Clonally variable response and requirements for major histocompatibility complex class II molecules on accessory or target cells. J. Exp. Med. 167, 1697-1707.
163. Fleischer, B., Gerlach, D., Fuhrmann, A., and Schmidt, K. H. (1995). Superantigens and pseudosuperantigens of gram-positive cocci. Med. Microbiol. Immunol. 184, 1-8.
164. Foo-Phillips, M., Kozak, C. A., Principato, M. A., and Abe, R. (1992). Characterization of the Mlsf system. II. Identification of mouse mammary tumor virus proviruses involved in the clonal deletion of self-Mls-reactive T cells. J. Immunol. 149, 3440-3447.
165. Forsthuber, T., Yip, H. C., and Lehmann, P. V. (1996). Induction of TH1 and TH2 immunity in neonatal mice. Science 271, 1728-1730.
166. Fowlkes, B. J., and Pardoll, D. M. (1989). Molecular and cellular events of T cell development. Adv. Immunol. 44, 207-264.
167. + precursor stage. Nature 334, 620-623.
168. Foy, T. M., Page, D. M., Waldschmidt, T. J., Schoneveld, A., Laman, J. D., Masters, S. R., Tygrett, L., Ledbetter, J. A., Aruffo, A., Claassen, E., Xu, J. C., Flavell, R. A., Oehen, S., Hedrick, S. M., and Noelle, R. J. (1995). An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 182, 1377-1388.
169. Frankel, W. N., Rudy, C., Coffin, J. M., and Huber, B. T. (1991). Linkage of Mis genes to endogenous mammary tumor viruses of inbred mice. Nature 349, 526-528.
170. Fraser, J. D. (1989). High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature 339, 221-223.
171. Fraser, J. D., and Hudson, K. R. (1995). A structural model of bacterial superantigen binding to MHC class II and T cell receptors. In "T Cell Receptors" (J. I. Bell, M. J. Owen, and E. Simpson, Eds.), pp. 425-446. Oxford Univ. Press, Oxford, UK.
172. Freer, G., Burkhart, C., Rulicke, T., Ghelardi, E., Rohrer, U. H., Pircher, H., Zinkernagel, R. M., and Hengartner, H. (1995). Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor beta chain transgenic mouse. Eur. J. Immunol. 25, 1410-1416.
173. Friedman, S. M., Crow, M. K., Tumang, J. R., Tumang, M., Xu, Y. Q., Hodtsev, A. S., Cole, B. C, and Posnett, D. N. (1991). Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): Generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cells. J. Exp. Med. 174, 891-900.
174. Fry, A. M., and Matis, L. A. (1988). Self-tolerance alters T-cell receptor expression in an antigen-specific MHC-restricted immune response. Nature 335, 830-832.
175. Fry, A. M., Jones, L. A., Kruisbeek, A. M., and Matis, L. A. (1989). Thymic requirement for clonal deletion during T cell development. Science 246, 1044-1046.
176. Fuchs, E. J., and Matzinger, P. (1992). B cells turn off virgin but not memory T cells. Science 258, 1156-1159.
177. Galelli, A., and Truffa-Bachi, P. (1993). Urtica dioica agglutinin. A superantigenic lectin from stinging nettle rhizome. J. Immunol. 151, 1821-1831.
178. Galelli, A., Delcourt, M., Wagner, M. C., Peumans, W., and Truffa-Bachi, P. (1995). Selective expansion followed by profound deletion of mature V beta 8.3+ T cells in vivo after exposure to the superantigenic lectin Urtica dioica agglutinin. J. Immunol. 154, 2600-2611.
179. Gallahan, D., and Callahan, R. (1987). Mammary tumorigenesis in feral mice: Identification of a new int locus in mouse mammary tumor virus (Czech II) -induced mammary tumors. J. Virol. 61, 66-74.
180. Gallahan, D., Kozak, C, and Callahan, R. (1987). A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17. J. Virol. 61, 218-220.
181. Gao, E.-K., Kanagawa, O., and Sprent, J. (1989). Capacity of unprimed CD4+ and CD8+ T cells expressing Vβ11 receptors to respond to I-E alloantigens in vivo. J. Exp. Med. 170, 1947-1957.
182. Gaugler, B., Langlet, C., Martin, J. M., Schmitt-Verhulst, A. M., and Guimezanes, A. (1991). Evidence for quantitative and qualitative differences in functional activation of Mis-reactive T cell clones and hybridomas by antigen or TcR/CD3 antibodies. Eur. J. Immunol. 21, 2581-2589.
183. Gay, F. W., Clarke, J. K., and Dermott, E. (1970). Direct cell to cell transfer of Bittner virus. J. Gen. Virol. 7, 75-79.
184. Gerlach, D., Reichardt, W., Fleischer, B., and Schmidt, K. H. (1994). Separation of mitogenic and pyrogenic activities from so-called erythrogenic toxin type B (Streptococcal proteinase). Int. J. Med. Microbiol. Virol. Parasitol. Infect. Dis. 280, 507-514.
185. Gershon, J. M., Tagliabue, A., and Herberman, R. B. (1981). Systemic and in situ natural killer activity in transplanted and spontaneous mammary tumors in C3H/HeN mice. J. Reticuloendoth. Soc. 29, 15-21.
186. Gill, R., Wang, H., Bluethmann, H., Iglesias, A., and Wei, W. Z. (1994a). Activation of natural killer cells by mouse mammary tumor virus C4 in BALB/c and T-cell receptor Vβ2-transgenic mice. Cancer Res. 54, 1529-1535.
187. Gill, R. F., Abastado, J. P., and Wei, W. Z. (1994b). Systematic identification of H-2 Kd binding peptides and induction of peptide specific CTL. J. Immunol. Methods 176, 245-253.
188. Gillette, R. W., and Lowery, L. T. (1977). Naturally occurring lymphocyte reactivity to purified mammary tumor virus antigens. J. Reticuloendoth. Soc. 21, 1-6.
189. Gillette, R. W., Robertson, S., Brown, R., and Blackman, K. E. (1974). Expression of mammary tumor virus antigen on the membranes of lymphoid cells. J. Natl. Cancer Inst. 53, 499-505.
190. Glimcher, L. H., and Kara, C. J. (1992). Sequences and factors: a guide to MHC class-II transcription. Annu. Rev. Immunol. 10, 13-49.
191. Gold, D. P., Surh, C. D., Sellins, K. S., Schroder, K., Sprent, J., and Wilson, D. B. (1994). Rat T cell responses to superantigens. II. Allelic differences in Vβ8.2 and Vβ8.5 β chains determine responsiveness to staphylococcal enterotoxin B and mouse mammary tumor virus-encoded products. J. Exp. Med. 179, 63-69.
192. Gollob, K. J., and Palmer, E. (1991). Physiologic expression of two superantigens in the BDF1 mouse. J. Immunol. 147, 2447-2454.
193. 5+ T lymphocytes. Proc. Natl. Acad. Sci. USA 89, 5138-5142.
194. Gollob, K. J., and Palmer, E. (1993). Aberrant induction of T cell tolerance in B cell suppressed mice. J. Immunol. 150, 3705-3711.
195. Golovkina, T. V., Chervonsky, A., Dudley, J. P., and Ross, S. R. (1992). Transgenic mouse mammary tumor virus superantigen expression prevents viral infection. Cell 69, 637-645.
196. Golovkina, T. V., Prescott, J. A., and Ross, S. R. (1993). Mouse mammary tumor virus-induced tumorigenesis in sag transgenic mice: A laboratory model for natural selection. J. Virol. 67, 7690-7694.
197. Golovkina, T. V., Chervonsky, A., Prescott, J. A., Janeway, C. A. Jr., and Ross, S. R. (1994a). The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells. J. Exp. Med. 179, 439-446.
198. Golovkina, T. V., Jaffe, A. B., and Ross, S. R. (1994b). Coexpression of exogenous and endogenous mouse mammary tumor virus RNA in vivo results in viral recombination and broadens the virus host range. J. Virol. 68, 5019-5026.
199. Golovkina, T. V., Dudley, J. P., Jaffe, A. B., and Ross, S. R. (1995). Mouse mammary tumor viruses with functional superantigen genes are selected during in vivo infection. Proc. Natl. Acad. Sci. USA 92, 4828-4832.
200. Gonnella, P. A., and Neutra, M. R. (1984). Membrane-bound and fluid-phase macromolecules enter separate prelysosomal compartments in absorptive cells of suckling rat ileum. J. Cell. Biol. 99, 909-917.
201. Gooding, L. R. (1992). Virus proteins that counteract host immune defenses. Cell 71, 5-7.
202. Gorczynski, R. M., Kilburn, D. G., Knight, R. A., Narbusy, C., Parker, D. C., and Smith, J. B. (1975). Nonspecific and specific immunosuppression in tumor-bearing mice by soluble immune complexes. Nature 254, 141-143.
203. Gray, D. (1993). Immunological memory. Annu. Rev. Immunol. 11, 49-77.
204. Grewal, I. S., and Flavell, R. A. (1996). A central role of CD40 ligand in the regulation of CD4+ T cell responses. Immunol. Today 17, 410-414.
205. Grewal, I. S., Xu, J., and Flavell, R. A. (1995). Impairment of antigen-specific T cell priming in mice lacking CD40 ligand. Nature 378, 617-620.
206. Groner, B., and Hynes, N. E. (1980). Number and location of mouse mammary tumor virus proviral DNA in mouse DNA of normal tissue and of mammary tumors. J. Virol. 33, 1013-1025.
207. Gunzburg, W. H., and Salmons, B. (1992). Factors controlling the expression of mouse mammary tumor virus. Biochem. J. 283, 625-632.
208. Gunzburg, W. H., Hynes, N. E., and Groner, B. (1984). The metliylation pattern of endogenous mouse mammary tumor virus proviral genes is tissue specific and stably inherited. Virology 138, 212-224.
209. Gunzburg, W. H., Heinemann, F., Wintersperger, S., Miedike, T., Wagner, H., Erfle, V., and Salmons, B. (1993). Endogenous superantigen expression controlled by a novel promoter in the MMTV long terminal repeat. Nature 364, 154-158.
210. Haga, S., Shigesada, K., Namba, Y., Tanaka, H., Imai, S., Morimoto, J., Hiroishi, S., Yamamoto, H., Sarkar, N. H., and Hilgers, J. (1992). Polyclonal and monoclonal antibodies monospecific to MMTV LTR ORF protein produced in E. coli. Cancer Lett. 65, 201-207.
211. Hageman, P. C., Calafat, J., and Hilgers, J. (1981). The biology of the mouse mammary tumor virus. In "Mammary Tumors of the Mouse" (J. Hilgers and M. Sluyser, Eds.), pp. 391-463. Elsevier/North-Holland, Amsterdam.
212. Hainaut, P., Francois, C., Carlberg-Bacq, C.-M., Vaira, D., and Osterrieth, P. M. (1983). Peroral infection of suckling mice with milk-borne mouse mammary tumor virus: Uptake of the main viral antigens by the gut. J. Gen. Virol. 64, 2535-2548.
213. Hainaut, P., Castellazzi, M, Gonzales, D., Clausse, N., Hilgers, J., and Crepin, M. (1990). A congenic line of the BALB/c mouse strain with the endogenous mouse mammary tumor virus proviral gene Mtv-3: Tissue-specific expression and correlation with resistance to mouse mammary tumor virus infection and tumorigenesis. Cancer Res. 50, 3754-3760.
214. Hamilos, D. L., Mascali, J. J., Chesnut, R. W., Young, R. M., Ishioka, G., and Grey, H. M. (1989). The role of dendritic cells as stimulators of minor lyymphocyte stimulating locus-specific T cell responses in the mouse. J. Immunol. 142, 1069-1078.
215. a gene products. Proc. Natl. Acad. Sci. USA 86, 6293-6296.
216. r inbred mouse strain with a massive deletion of T cell receptor Vβ genes. J. Exp. Med. 169, 1903-1901.
217. Harding, C. V., Roof, R. W., Allen, P. M.; and Unanue, E. R. (1991). Effects of pH and polysaccharides on peptide binding to class II major histocompatibility complex molecules. Proc. Natl. Acad. Sci. USA 88, 2740-2744.
218. a antigens. Long-term progeny of dividing cells include cells with a naive phenotype. J. Immunol. 156, 48-55.
219. Heise, M., Chow, K., and Kanagawa, O. (1993). Interaction between T cells and murine acquired immunodeficiency virus superantigen: Effect of second signal on T cell reactivity to the MAIDS virus superantigen. Int. Immunol. 5, 583-590.
220. Held, W., Shakhov, A. N., Waanders, G., Scarpellino, L., Luethy, R., Kraehenbuhl, J. P., MacDonald, H. R., and Acha-Orbea, H. (1992). An exogenous mouse mammary tumor virus with properties of Mls-l" (Mtv-7). J. Exp. Med. 175, 1623-1633.
221. + T cells are required to stimulate B cells after infection with mouse mammary tumor virus. J. Exp. Med. 177, 359-366.
222. Held, W., Waanders, G. A., Shakhov, A. N., Scarpellino, L., Acha-Orbea, H., and MacDonald, H. R. (1993b). Superantigen-induced immune stimulation amplifies mouse mammary tumor virus infection and allows virus transmission. Cell 74, 529-540.
223. Held, W., Waanders, G. A., Acha-Orbea, H., and MacDonald, H. R. (1994a). Reverse transcriptase-dependent and -independent phases of infection with mouse mammary tumor virus: Implications for superantigen function. J. Exp. Med. 180, 2347-2351.
224. Held, W., Waanders, G. A., MacDonald, H. R., and Acha-Orbea, H. (1994b). MHC class II hierarchy of superantigen presentation predicts efficiency of infection with mouse mammary tumor virus. Int. Immunol. 6, 1403-1407.
225. Hendrick, J. C., Francois, C., Calberg-Bacq, C.-M., Colin, C., Franchimont, P., Gosselin, L., Kozma, S., and Osterrieth, P. M. (1978). Radioimmunoassay for protein p28 of murine mammary tumor virus in organs and serum of mice and search for related antigens in human sera and breast cancer extracts. Cancer Res. 38, 1826-1831.
226. Hengartner, H., Odermatt, B., Schneider, R., Schreyer, M., Walle, G., MacDonald, H. R., and Zinkernagel, R. M. (1988). Deletion of self-reactive T cells prior to entering the thymus medulla. Nature 336, 388-390.
227. Herrmann, T., and MacDonald, H. R. (1993). The CD8 T cell response to staphylococcal enterotoxins. Sem. Immunol. 5, 33-39.
228. Herrmann, T., Accolla, R. S., and MacDonald, H. R. (1989). Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class II isotypes. Eur. J. Immunol. 19, 2171-2174.
229. + cells to bacterial superantigens. Eur. J. Immunol. 22, 1935-1938.
230. + cells but fails to trigger cytotoxicity. Eur. J. Immunol. 22, 2789-2793.
231. Herrmann, T., Hochgrebe, T., Torres-Nagel, N. E., Huber, B. T., and Hunig, T. (1994). Control of rat T cell response to retroviral and bacterial superantigens by class II MHC products and TCRB V8.2 alleles. J. Immunol. 152, 4300-4309.
232. Heston, W. E., and Deringer, M. K. (1952). Test for a maternal influence in the development of mammary gland tumors in agent-free strain C3Hb mice. J. Natl. Cancer Inst. 13, 167-175.
233. Heston, W. E., and Parks, W. P. (1977). Mammary tumors and mammary tumor virus expression in hybrid mice of strains C57BL and GR. J. Exp. Med. 146, 1206-1220.
234. Hilkens, J., van der Zeijst, B., Buijs, F., Kroezen, V., Bleumink, N., and Hilgers, J. (1983). Identification of a cellular receptor for mouse mammary tumor virus and mapping of its gene to chromosome 16. J. Virol. 45, 140-147.
235. Hill, C. M., and Littman, D. R. (1996). Natural resistance to HIV? Nature 382, 668-669.
236. Ho, F., Lortan, J. E., MacLennan, I. C. M., and Khan, M. (1986). Distinct short-lived and long-lived antibody-producing cell populations. Eur. J. Immunol. 16, 1297-1301.
237. β negative selection in an athymic environment. Science 246, 1041-1044.
238. Hodes, R. J., Novick, M. B., Palmer, L. D., and Knepper, J. E. (1993). Association of a Vβ2-specific superantigen with a tumorigenic milk-borne mouse mammary tumor virus. J. Immunol. 150, 1422-1428.
239. β specificity. J. Exp. Med. 177, 175-184.
240. Hudson, K. R., Tiedemann, R. E., Urban, R. G., Lowe, S. C., Strominger, J. L., and Fraser, J. D. (1995). Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class 11. J. Exp. Med. 182, 711-720.
241. Hugin, A. W., Vacchio, M. S., and Morse, H., III. (1991). A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice. Science 252, 424-427.
242. Hynes, N., van Ooyen, A. J., Kennedy, N., Herrlich, P., Ponta, H., and Groner, B. (1983). Proc. Natl. Acad. Sci. USA 80, 3637-3641.
243. Ignatowicz, L., Kappler, J., and Marrack, P. (1992). The effects of chronic infection with a superantigen-producing virus. J. Exp. Med. 175, 917-923.
244. Ignatowicz, L., Kappler, J. W., Marrack, P., and Scherer, M. T. (1994). Identification of two Vβ 7-specific viral superantigens. J. Immunol. 152, 65-71.
245. Ihle, J. N., Arthur, L. O., and Fine, D. L. (1976). Autogenous immunity to mouse mammary tumor virus in mouse strains of high and low mammary tumor incidence. Cancer Res. 36, 2840-2844.
246. Imai, S., Morimoto, J., Tsubura, Y., Iwai, Y., Okumoto, M., Takamori, Y., Tsubura, A., and Hilgers, J. (1983a). Tissue and organ distribution of mammary tumor virus antigens in low and high mammary cancer strain mice. Eur. J. Cancer Clin. Oncol. 19, 1011-1019.
247. Imai, S., Tsubura, Y., Hilgers, J., and Michalides, R. (1983b). A new locus (Mtv-4) for endogenous mammary tumor virus expression and early mammary tumor development in the SHN mouse strain. J. Natl. Cancer Inst. 71, 517-521.
248. Imanishi, K., Igarashi, H., and Uchiyama, T. (1990). Activation of murine T cells by streptococcal pyrogenic exotoxin type A. J. Immunol. 145, 3170-3176.
249. Inaba, M., Inaba, K., Hosono, M., Kumamoto, T., Ishidia, T., Muramatsu, S., Masuda, T., and Ikehara, S. (1991). Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J. Exp. Med. 173, 549-559.
250. Jacks, T., Townsley, K., Varmus, H. E., and Majors, J. (1987). Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins. Proc. Natl. Acad. Sci. USA 84, 4298-4302.
251. Janeway, C. A. Jr. (1991). Selective elements for the Vβ region of the T cell receptor. Mls and the bacterial toxic mitogens. Adv. Immunol. 50, 1-53.
252. Janeway, C. A. Jr., Yagi, J., Conrad, P. J., Katz, M. E., Jones, B., Vroegop, S., and Buxser, S. (1989). T-cell responses to Mls and to bacterial proteins that mimic its behavior. Immunol. Rev. 107, 61-88.
253. Jardetzky, T. S., Brown, J. H., Gorga, J. C., Stern, L. J., Urban, R. G., Chi, Y. I., Stauffacher, C., Strominger, J. L., and Wiley, D. C. (1994). Three-dimensional structure of a human class II histocompatibility complexed with superantigen. Nature 368, 711-718.
254. Jarvis, C. D., Germain, R. N., Hager, G. L., Damschroder, M., and Matis, L. A. (1994). Tissue-specific expression of messenger RNAs encoding endogenous viral superantigens. J. Immunol. 152, 1032-1038.
255. Jones, B., and Janeway, C. A. Jr. (1982). MHC recognition by clones of Mis specific T-lymphocytes. Immunogenetics 16, 243-255.
256. Jones, L. A., Chin, L. T., Longo, D. L., and Kruisbeek, A. M. (1990). Peripheral clonal elimination of functional T cells. Science 250, 1726-1729.
257. Jouvin-Marche, E., Cazenave, P.-A., Voegtle, D., and Marche, P. (1992). Vpl7 T-cell deletion by endogenous mammary tumor virus in wild-type-derived mouse strains. Proc. Natl. Acad. Sci. USA 89, 3232-3235.
258. Jouvin-Marche, E., Marche, P. N., Six, A., Liebe-Gris, C., Voegtle, D., and Cazenave, P. A. (1993). Identification of an endogenous mammary tumor vims involved in the clonal deletion of Vβ2 T cells. Eur. J. Immunol. 23, 2758-2764.
259. Kanagawa, O., and Maki, R. (1989). Inhibition of MHC class II-restricted T cell response by Lyt-2 antigen. J. Exp. Med. 170, 901-912.
260. β6 domain imparts reactivity to the Mls-P antigen. Cell. Immunol. 119, 412-426.
261. Kanagawa, O., Nussrallah, B. A., Wiebenga, M. E., Murphy, K. M., Morse, H. III, and Carbone, F. R. (1992). Murine AIDS superantigen reactivity of the T cells bearing V beta 5 T cell antigen receptor. J. Immunol. 149, 9-16.
262. Kanagawa, O., Wiebenga, M. E., and Vaupel, B. A. (1993). Defective T cell receptor-mediated signaling and differential induction of T cell functions by murine AIDS virus superantigen. J. Immunol. 150, 1865-1872.
263. Kanagawa, O., Gayama, S., and Vaupel, B. (1994). Functional and phenotypic change of T cells in murine acquired immune deficiency. J. Immunol. 152, 4671-4679.
264. Kang, J. J., Schwegel, T., and Knepper, J. E. (1993). Sequence similarity between the long terminal repeat coding regions of mammary-tumorigenic BALB/cV and renal-tumorigenic C3H-K strains of mouse mammary tumor virus. Virology 196, 303-308.
265. Kappler, J. W., Roehm, N., and Marrack, P. (1987a). T cell tolerance by clonal elimination in the thymus. Cell 49, 273-280.
266. Kappler, J. W., Wade, T., White, J., Kushnir, W., Blackman, M., Bill, J., Roehm, N., and Marrack, P. (1987b). A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product. Cell 49, 263-271.
267. Kappler, J. W., Staerz, U. D., White, J., and Marrack, P. C. (1988). Self-tolerance eliminates T cells specific for Mis-modified products of the major histocompatibility complex. Nature 332, 35-40.
268. β-specific stimulation of human T cells by staphylococcal toxins. Science 244, 811-813.
269. a haplotype. J. Exp. Med. 169, 1533-1541.
270. Kappler, J. W., Herman, A., Clements, J., and Marrack, P. (1992). Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J. Exp. Med. 175, 387-396.
271. Karapetian, O., Shakliov, A. N., Kraehenbuhl, J. P., and Acha-Orbea, H. (1994). Retroviral infection of neonatal Peyer's patch lymphocytes: The mouse mammary tumor virus model. J. Exp. Med. 180, 1511-1516.
272. + T cell clonotype. J. Exp. Med. 168, 1553-1562.
273. +T cells in staphylococcus enterotoxin B-primed mice. J. Exp. Med. 172, 1065-1070.
274. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature 349, 245-248.
275. Kearney, E. R., Pape, K. A., Loh, D. Y., and Jenkins, M. K. (1994). Visualization of peptidespecific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339.
276. Kelsall, B. L., and Strober, W. (1996). Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J. Exp. Med. 183, 237-247.
277. Kennedy, N., Knedlitschek, G., Groner, B., Hynes, N. E., Herrlich, P., Michalides, R., and van Ooyen, A. J. J. (1982). Long terminal repeats of endogenous mouse mammary tumor virus contain a long open reading frame which extends into adjacent sequences. Nature 295, 622-624.
278. Keren, D. F. (1992). Antigen processing in the mucosal immune system. Sem. Immunol. 4, 217-226.
279. Kindred, B. (1979). Nude mice in immunology. Prog. Allergy 26, 137-238.
280. King, L. B., and Corley, R. B. (1990). Lipopolysaccharide and dexamethasone induce mouse mammary tumor proviral gene expression and differentiation in B lymphocytes through distinct regulatory pathways. Mol. Cell. Biol. 10, 4211-4220.
281. King, L. B., Lund, F. E., White, D. A., Sharma, S., and Corley, R. B. (1990). Molecular events in B lymphocyte differentiation. Inducible expression of the endogenous mouse mammary tumor proviral gene, Mtv-9. J. Immunol. 144, 3218-3227.
282. Kisielow, P., and von Boehmer, H. (1995). Development and selection of T cells: Facts and puzzles. Adv. Immunol. 58, 87-209.
283. Knight, A. M., Harrison, G. M., Pease, R. J., Robinson, P. J., and Dyson, P. J. (1992). Biochemical analysis of the mouse mammary tumor virus long terminal repeat product: Evidence for the molecular structure of an endogenous superantigen. Eur. J. Immunol. 22, 879-882.
284. Koizumi, A., Tsukada, M., and Kamiyama, S. (1992). A skin-specific MMTV provirus is stably transmitted by horizontal transmission. Tohoku J. Exp. Med. 167, 171-180.
285. Koizumi, A., Tsukada, M., Sugawara, K., and Kusano, T. (1994). Transcription of multiple exogenous mouse mammary tumor viruses in a single mammary tumor of an SHN mouse. Lab. Animal Sci. 44, 584-589.
286. Koretweg, R. (1934). Ned. Tijdschr. Geneesk. 78, 240-245.
287. Korman, A. J., Bourgarel, P., Meo, T., and Rieckhof, G. E. (1992). The mouse mammary tumour virus long terminal repeat encodes a type II transmembrane glycoprotein. EMBO J. 11, 1901-1905.
288. Kotzin, B. L., Babcock, S. K., and Herron, L. R. (1988). Deletion of potentially self-reactive T cell receptor specificities in L3T4"Lyt2" T cells of Ipr mice. J. Exp. Med. 168, 2221-2229.
289. Kotzin, B. L., Leung, D. Y., Kappler, J., and Marrack, P. (1993). Superantigens and their potential role in human disease. Adv. Immunol. 54, 99-166.
290. Kozak, C., Peters, G., Pauley, R., Morris, V., Michaelides, R., Dudley, J., Green, M., Davisson, M., Prakash, O., Vaidya, A., Hilgers, J., Verstraeten, A., Hynes, N., Diggelmann, H., Peterson, D., Cohen, J. C., Dickson, C., Sarkar, N., Nusse, R., Varmus, H., and Callahan, R. (1987). A standardized nomenclature for endogenous mouse mammary tumor viruses. J. Virol. 61, 1651-1654.
291. Kozma, S., Osterrieth, P. M., François, C, and Calberg-Bacq, C. M. (1980). Distribution of mouse mammary tumor virus antigens in RIII mice as detected by immunofluorescence on tissue sections and by immunoassays in sera and organ extracts. J. Gen. Virol. 51, 327-339.
292. Krummenacher, C, and Diggelmann, H. (1993). The mouse mammary tumor virus long terminal repeat encodes a 47kDa glycoprotein with a short half-life in mammalian cells. Mol. Immunol. 30, 1151-1157.
293. Krummenacher, C., Diggelmann, H., and Acha-Orbea, H. (1996). In vivo effects of a recombinant vaccinia virus expressing a mouse mammary tumor virus superantigen. J. Virol. 70, 3026-3031.
294. Kuo, W.-L., Vilander, L. R., Huang, M., and Peterson, D. O. (1988). A transcriptionally defective long terminal repeat within an endogenous copy of mouse mammary tumor virus proviral DNA. J. Virol. 62, 2394-2402.
295. Labrecque, N., Thibodeau, J., and Sekaly, R.-P. (1993a). Interactions between staphylococcal superantigens and MHC class II molecules. Sem. Immunol. 5, 23-32.
296. β restriction and conserved evolutionary features. J. Exp. Med. 177, 1735-1743.
297. Lafon, M., and Galelli, A. (1996). Superantigens related to rabies. Springer Sem. Immunopa-thol. 17, 307-318.
298. Lafon, M., Lafage, M., Martinez-Arends, A., Ramirez, R., Vuillier, F., Charron, D., Lotteau, V., and Scott-Algara, D. (1992). Evidence for a viral superantigen in humans. Nature 358, 507-510.
299. Lafon, M., Scott-Algara, D., Marche, P. N., Cazenave, P. A., and Jouvin-Marche, E. (1994). Neonatal deletion and selective expansion of mouse T cells by exposure to rabies virus nucleocapsid superantigen. J. Exp. Med. 180, 1207-1215.
300. Lalor, P. A., Nossal, G. J. V., Sanderson, R. D., and McHeyzer-Williams, M. G. (1992). Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl) acetyl (NP)-specific, IgGl+ B cells from antibody secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur. J. Immunol. 22, 3001-3011.
301. Lamb, J. R., Skidmore, B. J., Green, N., Chiller, J. M., and Feldman, M. (1983). Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med. 157, 1434-1447.
302. Lambert, J. F., Acha-Orbea, H., Kolb, E., and Diggelmann, H. (1993). The 3' half of the mouse mammary tumor virus orf gene is not sufficient for its superantigen function in transgenic mice. Mol. Immunol. 30, 1399-1404.
303. Lane, M. A., Roubinian, J., Slomich, M., Trefts, P., and Blair, P. B. (1975). Characterization of cytotoxic effector cells in the mouse mammary tumor system. J. Immunol. 114, 24-29.
304. + T cells. J. Exp. Med. 179, 819-830.
305. β gene usage in primary mixed lymphocyte reactions: Evidence for directive usage by different antigen-presenting cells and Mis-like determinants on T cell blasts. Eur. J. Immunol. 20, 1223-1229.
306. Lathrop, A. E. C, and Loeb, L. (1918). Further investigations on the origin of tumors in mice. V. The tumor role in hybrid strains. J. Exp. Med. 28, 475-500.
307. Lavrin, D. H., Blair, P. B., and Weiss, D. W. (1966). Immunology of spontaneous mammary carcinomas in mice IV. Association of the mammary tumor virus widi the immunogenicity of C3H nodules and tumors. Cancer Res. 26, 929-934.
308. Le Bon, A., Desaymard, C, and Papiernik, M. (1995). Neonatal impaired response to viral superantigen encoded by MMTV (SW) and Mtv-7. Int. Immunol. 7, 1897-1903.
309. Le Bon, A., Lucas, B., Vasseur, F., Penit, C, and Papiernik, M. (1996). In vivo T cell response to viral superantigen. Selective migration rather than proliferation. J. Immunol. 156, 4602-4608.
310. Lee, W. T., and Vitetta, E. S. (1992). Memory T cells are anergic to the superantigen Staphylococcal enterotoxin B. J. Exp. Med. 176, 575-579.
311. Liao, L., Fraser, J. D., Popowicz, A., and Posnett, D. N. (1996). TCR binding differences for a bacterial superantigen (SEE) and a viral superantigen (Mtv-9). 184, 1471-1482.
312. Liao, N. S., and Raulet, D. H. (1992). Expression of the Mls-la superantigen results in an increased frequency of Vβ 14+ T cells. J. Immunol. 149, 1151-1155.
313. Lilliehook, B., Jacobsson, H., and Blomgren, H. (1975). Specifically decreased MLC response of lymphocytes from DBA mice injected with cells from H-2 compatible, M antigen incompatible strain C3H. No such effect after injection of H-2 disparate C3H-hybrid cells. Scand. J. Immmunol. 4, 209-216.
314. Linsley, P. S., and Ledbetter, J. A. (1993). The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11, 191-212.
315. Liu, Y. J., Zhang, J., Lane, P. J., Chan, E. Y. T., and MacLennan, I. C. M. (1991). Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21, 2951-2962.
316. Lopez, D. M., Charyulu, V., and Paul, R. D. (1985). B cell subsets in spleens of BALB/c mice: Identification and isolation of MMTV-expressing and MMTV-responding subpopulations. J. Immunol. 134, 603-607.
317. Lopez-Cepero, M., Wang, Y., Keydar, I., Brandt-Carlson, C., Butel, J. S., and Lopez, D. M. (1995). Detection of retroviral superantigen and products of the envelope gene from endogenous mouse mammary tumor virus in B cells from BALB/c mice. Cell. Immunol. 163, 191-197.
318. Lorenz, R. G., and Allen, P. M. (1989). Thymic cortical epithelial cells lack full capacity for antigen presentation. Nature 340, 557-559.
319. Louie, M. C., Nelson, C. A., and Loh, D. Y. (1989). Identification and characterization of new murine T cell receptor β-chain variable region (Vβ) genes. J. Exp. Med. 170, 1987-1998.
320. Lukacher, A. E., Ma, Y., Carroll, J. P., Abromson Leeman, S. R., Laning, J. C., Dorf, M. E., and Benjamin, T. L. (1995). Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen. J. Exp. Med. 181, 1683-1692.
321. Lund, F. E., and Corley, R. B. (1991). Regulated expression of mouse mammary tumor proviral genes in cells of the B cell lineage. J. Exp. Med. 174, 1439-1450.
322. Lund, F. E., Randall, T. D., Woodland, D. L., and Corley, R. B. (1993). MHC class II limits the functional expression of endogenous superantigens in B cells. J. Immunol. 150, 78-86.
323. Luther, S. A., and Acha-Orbea, H. (1996). Immune response to mouse mammary tumor virus. Curr. Opin. Immunol. 8, 498-502.
324. Luther, S., Shakhov, A. N., Xenarios, I., Haga, S., Imai, S., and Acha-Orbea, H. (1994). New infectious mammary tumor virus superantigen with Vβ-specificity identical to staphylococcal enterotoxin B (SEB). Eur. J. Immunol. 24, 1757-1764.
325. + thymocytes controlled by MHC class II gene products. Nature 336, 471-473.
326. a-encoded antigens. Nature 332, 40-45.
327. MacDonald, H. R., Hengartner, H., and Pedrazzini, T. (1988c). Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment. Nature 335, 174-176.
328. a-encoded antigens. Immunol. Rev. 107, 89-108.
329. MacDonald, H. R., Lees, R. K., and Louis, J. A. (1989b). Clonal deletion of autoreactive T lymphocytes: Insights from neonatal ontogeny. In "Progress in Immunology" (F. E. A. Melchers, Ed.), pp. 561-565. Springer-Verlag, Berlin/New York.
330. a-encoded determinants. J. Exp. Med. 171, 1381-1386.
331. + peripheral T cells responding to staphylococcal enterotoxin B in vivo. Eur. J. Immunol. 21, 1963-1966.
332. MacDonald, H. R., Casanova, J.-L., Maryanski, J., and Cerottini, J.-C. (1993). Oligoclonal expansion of MHC class I restricted cytolytic T lymphocytes during a primary immune response in vivo: Direct monitoring by flow cytometry and polymerase chain reaction. J. Exp. Med. 177, 1487-1492.
333. MacLennan, I. C. M. (1994). Germinal centers. Annu. Rev. Immunol. 12, 117-139.
334. MacPhail, S., and Stutman, O. (1986). H-2-linked genes determine the level of the primary in vitro anti-Mis response. Immunogenetics 24, 139-145.
335. Maillard, I., Erny, K., Acha-Orbea, H., and Diggelmann, H. (1996). A Vβ4-specific superantigen encoded by a new exogenous mouse mammary tumor virus. Eur. J. Immunol. 26, 1000-1006.
336. Majors, J., and Varmus, H. E. (1983a). A small region of the mouse mammary tumor virus long terminal repeat confers glucocorticoid hormone regulation on a linked heterologous gene. Proc. Natl. Acad. Sci. USA 80, 5866-5870.
337. Majors, J. E., and Varmus, H. E. (1983b). Nucleotide sequencing of an apparent proviral copy of env mRNA defines determinants of expression of the mouse mammary tumor virus env gene. J. Virol. 47, 495-504.
338. Marchetti, A., Buttitta, F., Miyazaki, S., Gallahan, D., Smith, G. H., and Callahan, R. (1995). Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. J. Virol. 69, 1932-1938.
339. Marcus, S. L., Sarlcar, N. H., and Modak, M. J. (1976). Purification and properties of murine mammary tumor virus DNA polymerase. Virology 71, 242-254.
340. Marrack, P., and Kappler, J. (1990). The staphylococcal enterotoxins and their relatives. Science 248, 705-711.
341. Marrack, P., Lo, D., Brinster, R., Palmiter, R., Burkly, L., Flavell, R. H., and Kappler, J. (1988). The effect of thymus environment on T cell development and tolerance. Cell 53, 627-634.
342. Marrack, P., Kushnir, E., and Kappler, J. (1991). A maternally inherited superantigen encoded by a mammary tumor virus. Nature 349, 524-526.
343. Massey, R. J., and Schochetman, G. (1981). Topographical analysis of viral epitopes using monoclonal antibodies: Mechanism of virus neutralization. Virology 115, 20-32.
344. Massey, R., Arthur, L. O., Long, C. W., and Schochetman, G. (1980a). C3H/HeN mammary tumor-bearing mice develop type-specific neutralizing antibodies and group-specific precipitating antibodies for the mouse mammary tumor virus. J. Virol. 33, 123-128.
345. Massey, R. J., Arthur, L. O., Nowinski, R. C., and Schochetman, G. (1980b). Monoclonal antibodies identify individual determinants on mouse mammary tumor virus glycoprotein gp52 with group, class, or type specificity. J. Virol. 34, 635-643.
346. Matsuzawa, A., Sayama, K., Tsubura, A., and Murakami, A. (1990). A congenic line of the DDD mouse strain, DDD/l-Mtv-2/Mtv-2: Establishment and mammary tumorigenesis. Jpn. J. Cancer Res. 81, 639-644.
347. Matsuzawa, A., Nakano, H., Yoshimoto, T., and Sayama, K. (1995). Biology of mouse mammary tumor virus (MMTV). Cancer Lett. 90, 3-11.
348. Mazda, O., Watanabe, Y., Gyotoku, J.-I., and Katsura, Y. (1991). Requirement of dendritic cells and B cells in the clonal deletion of Mis-reactive T cells in the thymus. J. Exp. Med. 173, 539-547.
349. McCormack, J. E., Kappler, J., and Marrack, P. (1994). Stimulation with specific antigen can block superantigen-mediated deletion of T cells in vivo. Proc. Natl. Acad. Sci. USA 91, 2086-2090.
350. McDuffie, M., Schweiger, D., Reitz, B., Ostrowska, A., Knight, A. M., and Dyson, P. J. (1992). I-E-independent deletion of Vβ17a+ T cells by Mtv-3 from the nonobese diabetic mouse. J. Immunol. 148, 2097-2102.
351. Menendez Arias, L., Risco, C., Pinto da Silva, P., and Oroszlan, S. (1992). Purification of immature cores of mouse mammary tumor virus and immunolocalization of protein domains. J. Virol. 66, 5615-5620.
352. Michalides, R., van Nie, R., Nusse, R., Hynes, N. E., and Groner, B. (1981). Mammary tumor induction loci in GR and DBAf mice contain one provirus of the mouse mammary tumor virus. Cell 23, 165-173.
353. Michalides, R., Verstraeten, R., Shen, F. W., and Hilgers, J. (1985). Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A. Virology 142, 278-290.
354. Milich, D. R., and McLachlan, A. (1986). The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science 234, 1398-1401.
355. Miller, C. L., Garner, R., and Paetkau, V. (1992). An activation-dependent, T-lymphocytespecific transcriptional activator in the mouse mammary tumor virus env gene. Mol. Cell. Biol. 12, 3262-3272.
356. Mix, D., and Winslow, G. M. (1996). Proteolytic processing activates a viral superantigen. J. Exp. Med., 184, 1549-1554.
357. Modlin, C. S., Todd, G. T., Cohen, T. D., and Fairchild, R. L. (1995). Transfer of endogenous retroviral superantigen from donor to recipient B cells following priming to induce peripheral T cell tolerance. Cell. Immunol. 164, 217-226.
358. Modlin, C. S., Muruve, N. A., Stanko, D., Caulfield, M. J., and Fairchild, R. L. (1996). Recipient polyclonal B cell activation and immunoglobulin production induced by priming with a retroviral superantigen. Cell. Immunol. 169, 252-263.
359. Mohan, N., Mottershead, D., Subramanyam, M., Beutner, U., and Huber, B. T. (1993). Production and characterization of an Mls-1-specific monoclonal antibody. J. Exp. Med. 177, 351-358.
360. a determinants. J. Immunol. 143, 39-44.
361. Mollick, J. A., Cook, R. G., and Rich, R. R. (1989). Class 11 MHC molecules are specific receptors for staphylococcal enterotoxins. Science 244, 817-820.
362. Mollick, J. A., Miller, G. G., Musser, J. M., Cook, R. G., Grossman, D., and Rich, R. R. (1993). A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C. J. Clin. Invest. 92, 710-719.
363. Mond, J. J., Stein, K. E., Subbarao, B., and Paul, W. E. (1979). Analysis of B cell activation requirements with TNP-conjugated polyacrylamide beads. J. Immunol. 123, 239-245.
364. Mond, J. J., Lees, A., and Snapper, C. M. (1995). T cell-independent antigens type 2. Annu. Rev. Immunol. 13, 655-692.
365. Moore, D. H., and Holben, J. A. (1978). Observations on the question of horizontal transmission of mouse mammary tumor virus. Cancer Res. 38, 2455-2457.
366. Moore, D. H., Charney, J., Lasfargues, E. Y., Sarkar, N. H., Rubin, R. C, and Ames, R. P. (1969). Mammary tumor virus (MTV) virions in a transplantable ependymoblastoma. Proc. Soc. Exp. Biol. Med. 132, 125-127.
367. Moore, D. H., Charney, J., and Holben, J. A. (1974). Titrations of various mouse mammary tumor viruses in different mouse strains. J. Nad. Cancer Inst. 52, 1757-1761.
368. Moore, R., Dixon, M., Smith, R., Peters, G., and Dickson, C. (1987). Complete nucleotide sequence of a milk-transmitted mouse mammary tumor virus: Two frameshift suppression events are required for translation of gag and pol. J. Virol. 61, 480-490.
369. Morimoto, J., Imai, S., Tsubura, Y., and Hilgers, J. (1985). Horizontal transmission of the mouse mammary tumor virus in cage mates of the same and opposite sex of low and high mammary cancer strain mice. Jikken Dobutsu. Exp. Anim. 34, 141-146.
370. Morishima, C., Norby-Slycord, C., McConnell, K. R., Finch, R. J., Nelson, A. J., Farr, A. G., and Pullen, A. M. (1994). Expression of two structurally identical viral superantigens results in thymic elimination at distinct developmental stages. J. Immunol. 153, 5091-5103.
371. Moriyama, T., Guilhot, S., Klopchin, K., Moss, B., Pinkert, C. A., Palmiter, R. D., Brinster, R. L., Kanagawa, O., and Chisari, F. V. (1990). Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science 248, 361-364.
372. Morris, V. L., Rao, T. R., Kozak, C. A., Gray, D. A., Lee, C. E., Cornell, T. J., Taylor, C. B., Jones, R. F., and McGrath, C. M. (1991). Characterization of Int-5, alocus associated with early events in mammary carcinogenesis. Oncogene Res. 6, 53-63.
373. Morton, D. L., Miller, G. F., and Wood, D. A. (1969). Demonstration of tumor-specific immunity against antigens unrelated to the mammary tumor virus in spontaneous mammary adenocarcinomas. J. Natl. Cancer Inst. 42, 289-301.
374. Mottershead, D. G., Hsu, P. N., Urban, R. G., Strominger, J. L., and Huber, B. T. (1995). Direct binding of the Mtv7 superantigen (Mls-1) to soluble MHC class II molecules. Immunity 2, 149-154.
375. Muhlbock, O., and Dux, A. (1971). Histocompatibility genes and susceptibility to mammary tumor virus (MTV) in mice. Transplant. Proc. 3, 1247-1250.
376. Muhlbock, O., and Dux, A. (1974). Histocompatibility genes (the H-2 complex) and susceptibility to mammary tumor virus in mice. J. Natl. Cancer Inst. 53, 993-996.
377. Mukhopadhyay, R., Medina, D., and Butel, J. S. (1995). Expression of the mouse mammary tumor virus long terminal repeat open reading frame promotes tumorigenic potential of hyperplastic mouse mammary epithelial cells. Virology 211, 84-93.
378. Muller, M., and Zotter, S. (1973). Mammary tumor virus (MTV) infection of CBA/Bln mice involving production of antibodies to MTV. J. Natl. Cancer Inst. 50, 713-717.
379. Murosaki, S., Yoshikai, Y., Ishida, A., Nakamura, T., Matsuzaki, G., Takimoto, H., Yuuki, H., and Nomoto, K. (1991). Failure of T cell receptor Vβ negative selection in murine intestinal intra-epithelial lymphocytes. Int. Immunol. 3, 1005-1013.
380. Nakamura, N., Wajjwalku, W., Nishimura, H., Okubo, H., Niimi, N., Ando, Y., and Yoshikai, Y. (1996). Nucleotide sequences of env and 3'LTR orf genes of endogenous mouse mammary tumor viruses encoding superantigen specific for TcrVβ2. Immunogenetics 44, 319-320.
381. Nandi, S. (1974). Mechanism of resistance to mammary tumor development in C57BL and I strains of mice. II. Inherent differences between the two strains. J. Natl. Cancer Inst. 52, 1797-1804.
382. Nandi, S., and DeOme, K. B. (1965). An interference phenomenon associated with resistance to infection with mouse mammary tumor virus. J. Natl. Cancer Inst. 35, 299-308.
383. Nandi, S., and McGrath, C. M. (1973). Mammary neoplasia in mice. Adv. Cancer Res. 17, 353-414.
384. Nandi, S., Haslam, S., and Helmich, C. (1971). Inheritance of susceptibility to erydirocyte-borne Bittner virus in mice. Transplant. Proc. 3, 1251-1257.
385. Nandi, S., Haslam, S., and Helmich, C. (1972). Cell-associated mammary tumor virus in blood of BALB/cfC3H mice. J. Natl. Cancer Inst. 48, 1085-1088.
386. Neutra, M. R., Pringault, E., and Kraehenbuhl, J.-P. (1996). Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu. Rev. Immunol. 14, 275-300.
387. Niimi, N., Wajjwalku, W., Ando, Y., Tomida, S., Takeuchi, M., Ueda, M., Kaneda, T., and Yoshikai, Y. (1994). Delay in expression of a mammary tumor provirus is responsible for defective clonal deletion during postnatal period. Eur. J. Immunol. 24, 488-491.
388. Niimi, N., Wajjwalku, W., Ando, Y., Nakamura, N., Ueda, M., and Yoshikai, Y. (1995). A novel Vβ 2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus. J. Virol. 69, 7269-7273.
389. Nishio, M., Xu, L., Sasaki, M., Haga, S., Okumoto, M., Mori, N., Sarkar, N. H., Acha-Orbea, H., Enami, J., and Imai, S. (1994). Complete nucleotide sequence of mouse mammary tumor virus from JYG Chinese wild mouse: Absence of bacterial insertion sequences in the cloned viral gag gene. Breast Cancer 1, 89-94.
390. Noon, M. C., Wolford, R. G., and Parks, W. P. (1975). Expression of mouse mammary tumor viral polypeptides in milks and tissues. J. Immunol. 115, 653-658.
391. Nusse, R., van der Ploeg, L., van Duijn, L., Michalides, R., and Hilgers, J. (1979). Impaired maturation of mouse mammary tumor virus precursor polypeptides in lymphoid leukemia cells, producing intracytoplasmic A particles and no extracellular B-type virions. J. Virol. 32, 251-258.
392. Nusse, R., de Moes, J., Hilkens, J., and van Nie, R. (1980). Localization of a gene for expression of mouse mammary tumor virus antigens in the GR/Mtv-2 mouse strain. J. Exp. Med. 152, 712-719.
393. Nusse, R., and Varmus, H. E. (1982). Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell 31, 99-109.
394. Nusse, R., and Varmus, H. E. (1992). Wnt genes. Cell 69, 1073-1087.
395. Ochi, A., and Kawabe, Y. (1992). Death by superantigen. Nature 355, 211-212.
396. Ohmen, J. D., Barnes, P. F., Grisso, C. L., Bloom, B. R., and Modlin, R. L. (1994). Evidence for a superantigen in human tuberculosis. Immunity 1, 35-43.
397. β7 gene segment. J. Immunol. 144, 3473-3477.
398. Oldstone, M. B. (1989). Viral persistence. Cell 56, 517-520.
399. Olsen, I., Dean, M. F., Harris, G., and Muir, H. (1981). Direct transfer of a lysosomal enzyme from lymphoid cells to deficient fibroblasts. Nature 291, 244-247.
400. O'Rourke, A. M., Mescher, M. F., and Webb, S. R. (1990). Activation of phosphoinositide hydrolysis in T cells by H-2 alloantigen but not Mis determinants. Science 249, 171-174.
401. Palmer, L. D., Saha, B., Hodes, R. J., and Abe, R. (1996). The role of CD28 costimulation in immune-mediated responses against mouse mammary tumor viruses. J. Immunol. 156, 2112-2118.
402. Pantaleo, G., Demarest, J. F., Soudeyns, H., Graziosi, C., Denis, F., Adelsberger, J. W., Borrow, P., Saag, M. S., Shaw, G. M., Sekaly, R. P., Fauci, A. S. (1994). Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV. Nature 370, 463-467.
403. b mice. J. Exp. Med. 175, 453-460.
404. Papiernik, M., Pontoux, C., and Golstein, P. (1995). Non-exclusive Fas control and age dependence of viral superantigen-induced clonal deletion in lupus-prone mice. Eur. J. Immunol. 25, 1517-1523.
405. Park, C. G., Jung, M. Y., Choi, Y., and Winslow, G. M. (1995). Proteolytic processing is required for viral superantigen activity. J. Exp. Med. 181, 1899-1904.
406. Parks, W. P., Howk, R. S., Scolnick, E. M., Oroszlan, S., and Gilden, R. V. (1974). Immunochemical characterization of two major polypeptides from murine mammary tumor virus. J. Virol. 13, 1200-1210.
407. Pascual, V., and Capra, J. D. (1991). B-cell superantigens. Curr. Biol. 1, 315-317.
408. Passey, R. D., Dmochowski, L., Reed, R., and Astbury, W. T. (1950). Biophysical studies of extracts of tissues of high- and low-breast-cancer strain mice. Biochim. Biophys. Acta 4, 391-409.
409. + T cells. Eur. J. Immunol. 24, 1102-1108.
410. Penninger, J. M., Schilham, M. W., Timms, E., Wallace, V. A., and Mak, T. W. (1995). T cell repertoire and clonal deletion of Mtv superantigen-reactive T cells in mice lacking CD4 and CD8 molecules. Eur. J. Immunol. 25, 2115-2118.
411. Peters, G., and Glover, C. (1980). tRNA's and priming of RNA-directed DNA synthesis in mouse mammary tumor virus. J. Virol. 35, 31-40.
412. Peters, G., Brookes, S., Smith, R., and Dickson, C. (1983). Tumorigenesis by mouse mammary tumor virus: Evidence for a common region for provirus integration in mammary tumors. Cell 33, 369-377.
413. Peters, G., Lee, A. E., and Dickson, C. (1986). Concerted activation of potential protoonco-genes in carcinomas induced by mouse mammary tumor virus. Nature 320, 628-631.
414. Peters, G., Brookes, S., Smith, R., Placzek, M., and Dickson, C. (1989). The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors. Proc. Natl. Acad. Sci. USA 86, 5678-5682.
415. Peters, G., Placzek, M., Brookes, S., Kozak, C., Smith, R., and Dickson, C. (1992). Characterization, chromosome assignment, and segregation analysis of endogenous proviral units of mouse mammary tumor virus. J. Virol. 59, 535-544.
416. Phillips, J. H., Gumperz, J. E., Parham, P., and Lanier, L. L. (1995). Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268, 403-405.
417. Pinto, M., Torten, M., and Birnbaum, S. C. (1978). Suppression of the in vivo humoral and cellular immune response by staphylococcal enterotoxin B. Transplantation 25, 320-323.
418. Pircher, H. P., Biirki, K., Lang, R., Hengartner, H., and Zinkernagel, R. M. (1989). Tolerance induction in double specific T cell receptor transgenic mice varies with antigen. Nature 342, 559-561.
419. Poussier, P., Edouard, P., Lee, C., Binnie, M., and Julius, M. (1992). Thymus-independent development and negative selection of T cells expressing T cell receptor α β in the intestinal epithelium: Evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes. J. Exp. Med. 176, 187-199.
420. Pucillo, C., Cepeda, R., and Hodes, R. J. (1993). Expression of a MHC class II transgene determines both superantigenicity and susceptibility to mammary tumor virus infection. J. Exp. Med. 178, 1441-1445.
421. Pullen, A. M., Marrack, P., and Kappler, J. W. (1988). The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335, 796-801.
422. + T cells are controlled by multiple genes. J. Immunol. 142, 3033-3037.
423. Pullen, A. M., Potts, W., Wakeland, E. K., Kappler, J., and Marrack, P. (1990a). Surprisingly uneven distribution of the T cell receptor Vβ repertoire in wild mice. J. Exp. Med. 171, 49-62.
424. a. Cell 61, 1365-1374.
425. β. J. Exp. Med. 173, 1183-1192.
426. Pullen, A. M., and Bogatzki, L. Y. (1996). Receptors on T cells escaping superantigenmediated deletion lack special β-chain junctional region structural characteristics. J. Immunol. 156, 1865-1872.
427. β3-specific superantigens. J. Exp. Med. 175, 41-47.
428. Racevskis, J. (1986). Expression of the protein product of the mouse mammary tumor virus long terminal repeat gene in phorbole ester-treated T-cell leukemia cells. J. Virol. 58, 441-449.
429. Racevskis, J., and Sarkar, N. H. (1982). ML antigen of DBA/2 mouse leukemias: Expression of an endogenous murine mammary tumor virus. J. Virol. 42, 804-813.
430. a expressing cells. Nature 339, 541-544.
431. Ramsdell, F., and Fowlkes, B. J. (1990). Clonal deletion versus clonal anergy: The role of the thymus in inducing self tolerance. Science 248, 1342-1348.
432. Ramsdell, F., and Fowlkes, B. J. (1992). Maintenance of in vivo tolerance by persistence of antigen. Science 257, 1130-1134.
433. Ramsdell, F., Lantz, T., and Fowlkes, B. J. (1989). A nondeletional mechanism of thymic self-tolerance. Science 246, 1038-1041.
434. Raulet, D. H. (1994). MHC class I-deficient mice. Adv. Immunol. 55, 386-421.
435. Redmond, S., Peters, G., and Dickson, C. (1984). Mouse mammary tumor virus can mediate cell fusion at reduced pH. Virology 133, 393-402.
436. Reinitz, D. M., and Mansfield, J. M. (1990). T-cell-independent and T-cell-dependent B-cell responses to exposed variant surface glycoprotein epitopes in Trypanosome-infected mice. Infect. Immun. 58, 2337-2342.
437. Renno, T., Hahne, M., and MacDonald, H. R. (1995). Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo. J. Exp. Med. 181, 2283-2287.
438. Renno, T., Hahne, M., Tschopp, J., and MacDonald, H. R. (1996). Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand. J. Exp. Med. 183, 431-437.
439. Ridge, J. P., Fuchs, E. J., and Matzinger, P. (1996). Neonatal tolerance revisited: Turning on newborn T cells witli dendritic cells. Science 271, 1723-1726.
440. Ringold, G. M., Dobson, D. E., Grove, J. R., Hall, C. V., Lee, F., and Vannice, J. L. (1983). Glucocorticoid regulation of gene expression: Mouse mammary tumor virus as a model system. Recent Prog. Hormone Res. 39, 387-424.
441. Ritzi, E., Martin, D. S., Stolfi, R. L., and Spiegelman, S. (1976). Plasma levels of a viral protein as a diagnostic signal for the presence of tumor: The murine mammary tumor model. Proc. Natl. Acad. Sci. USA 73, 4190-4194.
442. Robbins, J., Blondel, B. J., Gallahan, D., and Callahan, R. (1992). Mouse mammary tumor gene int-3: A member of the notch gene family transforms mammary epithelial cells. J. Virol. 66, 2594-2599.
443. Rocha, B., Vassalli, P., and Guy-Grand, D. (1991). The Vj3 repertoire of mouse gut homodimeric a CD8+ T cell receptor a β+ lymphocytes reveals a major extrathymic pathway of T cell differentiation. J. Exp. Med. 173, 483-486.
444. Roe, T., Reynolds, T. C., Yu, G., and Brown, P. O. (1993). Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12, 2099-2108.
445. Ronchese, F., Hausmann, B., Hubele, S., and Lane, P. (1994). Mice transgenic for a soluble form of murine CTLA-4 show enhanced expansion of antigen-specific CD4+ T cells and defective antibody production in vivo. J. Exp. Med. 179, 809-817.
446. Rongey, R. W., Abtin, A. H., Estes, J. D., and Gardner, M. B. (1975). Mammary tumor virus particles in the submaxillary gland, seminal vesicle, and nonmammary tumors of wild mice. J. Natl. Cancer Inst. 54, 1149-1156.
447. Rosenwasser, O. A., Fairchild, S., and Tomonari, K. (1993). New superantigen specificity created by two amino acid replacements. Immunogenetics 38, 367-369.
448. Rott, O., and Fleischer, B. (1994). A superantigen as virulence factor in an acute bacterial infection. J. Infect. Dis. 169, 1142-1146.
449. Roubinan, J. R., Lane, M. A., Slomich, M., and Blair, P. B. (1976). Stimulation of immune mechanisms against mammary tumors by incomplete T cell depletion. J. Immunol. 117, 1767-1773.
450. Rudy, C. K., Kraus, E., Palmer, E., and Huber, B. T. (1992). Mls-1-like superantigen in the MA/MyJ mouse is encoded by a new mammary tumor provirus that is distinct from MH-1. J. Exp. Med. 175, 1613-1621.
451. c determinants. J. Immunol. 138, 4085-4092.
452. Ryan, J. J., Lejeune, H. B., Mond, J. J., and Finkelman, F. D. (1991). Allostimulatory analysis of a newly-defined and widely-distributed Mls superantigen. Immunogenetics 34, 88-100.
453. Salmons, B., Erfle, V., Brem, G., and Gunzburg, W. H. (1990). naf, a trans-regulating negative-acting factor encoded within the mouse mammary tumor virus open reading frame region. J. Virol. 64, 6355-6359.
454. Sarkar, N. H. (1986). The effects of 2-deoxyglucose and tunicamycin on the biosynthesis of the murine mammary tumor virus proteins, and on the assembly and release of the virus. Virology 150, 419-438.
455. Sarkar, N. H., and Dion, A. S. (1975). Polypeptides of the mouse mammary tumor virus. I. Characterization of two group-specific antigens. Virology 64, 471-491.
456. Sarkar, N. H., and Moore, D. H. (1974). Surface structure of mouse mammary tumor virus. Virology 61, 38-55.
457. Sarkar, N. H., and Moore, D. H. (1978). Immunization of mice against murine mammary tumor virus infection and mammary tumor development. Cancer Res. 38, 1468-1472.
458. Sarkar, N. H., and Whittington, E. S. (1977). Identification of the structural proteins of the murine mammary tumor virus that are serologically related to the antigens of intracytoplasmic type-A particles. Virology 81, 91-106.
459. Sarkar, N. H., Taraschi, N. E., Pomenti, A. A., and Dion, A. S. (1976). Polypeptides of the mouse mammary tumor virus. II. Identification of two major glycoproteins with the viral structure. Virology 69, 677-690.
460. Sarkar, N. H., Haga, S., Lehner, A. F., Zhao, W., Imai, S., and Moriwaki, K. (1994). Insertional mutation of int protooncogenes in the mammary tumors of a new strain of mice derived from the wild in China: Normal- and tumor-tissue-specific expression of int-3 transcripts. Virology 203, 52-62.
461. Sarzotti, M., Robbins, D. S., and Hoffman, P. M. (1996). Induction of protective CTL responses in newborn mice by a murine retrovirus. Science 271, 1726-1728.
462. Sasso, E. H., Silverman, J. G., and Mannik, M. (1989). Human IgM molecules that bind staphylococcal protein A contain VHIII H chains. J. Immunol. 142, 2778-2783.
463. Scher, I. (1982). The CBA/N mouse strain: An experimental model illustrating the influence of the x-chromosomes on immunity. Adv. Immunol. 33, 1-71.
464. Scherer, M. T., Ignatowicz, L., Winslow, G. M., Kappler, J. W., and Marrack, P. (1993). Superantigens: Bacterial and viral proteins that manipulate the immune system. Annu. Rev. Cell Biol. 9, 101-128.
465. Scherer, M. T., Ignatowicz, L., Pullen, A., Kappler, J., and Marrack, P. (1995). The use of mammary tumor virus (Mtv) -negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J. Exp. Med. 182, 1493-1504.
466. Schiffenbauer, J., Johnson, H. M., Butfiloski, E. J., Wegrzyn, L., and Soos, J. M. (1993). Staphylococcal enterotoxins can reactivate experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. USA 90, 8543-8546.
467. Schlom, J., Colcher, D., Spiegelman, S., and Gillespie, D. (1973). Quantitation of RNA tumor viruses and viruslike particles in human milk by hybridization to polyadenylic acid sequences. Science 179, 696-698.
468. a mice. Implications for T cell development and autoimmunity. J. Exp. Med. 169, 2149-2158.
469. Schochetman, G., Arthur, L. O., Long, C. W., and Massey, R. J. (1979a). Mice with spontaneous mammary tumors develop type-specific neutralizing and cytotoxic antibodies against the mouse mammary tumor virus envelope protein gp52. J. Virol. 32, 131-139.
470. Schochetman, G., Long, C, and Massey, R. (1979b). Generation of a mouse mammary tumor virus (MMTV) pseudotype of Kirsten sarcoma virus and restriction of MMTV gag expression in heterologous infected cells. Virology 97, 342-353.
471. Schochetman, G., Altrock, B., Arthur, L., Lovinger, G., and Massey, R. (1980). Mouse mammary tumor virus: Role of class-specific antigenic determinants on the envelope glycoprotein in the development of autogeneous immunity and binding of virus to cell receptors. In "Viruses in Naturally Occurring Cancers" (Essex, M., Todaro, G., zurMausen, M., Eds.), pp. 1133-1148.
472. Schwartz, R. H. (1996). Models of T cell anergy: Is there a common mechanism?J. Exp. Med. 184, 1-8.
473. Shahinian, A., Pfeffer, K., Lee, K. P., Kundig, T. M., Kishihara, K., Wakeham, A., Kawai, K., Ohashi, P. S., Thompson, C. B., and Mak, T. W. (1993). Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609-612.
474. Shakhov, A. N., Wang, H., Acha-Orbea, H., Pauley, R. J., and Wei, W. Z. (1993). A new infectious mammary tumor virus in the milk of mice implanted with C4 hyperplastic alveolar nodules. Eur. J. Immunol. 23, 2765-2769.
475. Sharpe, A. H. (1995). Analysis of costimulation in vivo using transgenic and "knockout" mice. Curr. Opin. Immunol. 7, 389-395.
476. Sharrow, S. O., Mathieson, B. J., and Singer, A. (1981). Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras. J. Immunol. 126, 1327-1335.
477. Sicinski, P., Rowinski, J., Warchol, J. B., Jarzabek, Z., Gut, W., Szczygiel, B., Bielecki, K., and Koch, G. (1990). Poliovirus type 1 enters the human host through intestinal M cells. Gastroenterology 98, 56-58.
478. Simister, N. E., and Mostov, K. E. (1989). An Fc receptor structurally related to MHC class I antigens. Nature 337, 184-187.
479. Simpson, E., Dyson, P. J., Knight, A. M., Robinson, P. J., Elliott, J. I., and Altman, D. M. (1993). T-cell receptor selection by mouse mammary tumor viruses and MHC molecules. Immunol. Rev. 131, 93-115.
480. + and abnormal Ipr and gld cell populations. J. Exp. Med. 170, 1869-1877.
481. Smith, G. H., and Lee, B. K. (1975). Mouse mammary tumor virus polypeptide precursors in intracytoplasmic A particles. J. Natl. Cancer Inst. 55, 493-496.
482. Smith, G. L. (1994). Virus strategies for evasion of the host response to infection. Trends Microbiol. 2, 81-88.
483. Smith, H., Chen, I.-M., Kubo, R., and Tung, K. S. K. (1989). Neonatal thymectomy results in a repertoire enriched in T cells deleted in adult thymus. Science 245, 749-752.
484. β8.1 transgenic mice. J. Immunol. 149, 887-896.
485. Smith, K. G., Hewitson, T. D., Nossal, G. J. V., and Tarlinton, D. M. (1996). The phenotype and fate of the antibody-forming cells of the splenic foci. Eur. J. Immunol. 26, 444-448.
486. Smith, L. R., Plaza, A., Singer, P. A., and Theofilopoulos, A. N. (1990). Coding sequence polymorphisms among Vβ T cell receptor genes. J. Immunol. 144, 3234-3237.
487. a. J. Exp. Med. 170, 595-600.
488. Sprent, J., and Webb, S. R. (1987). Function and specificity of T cell subsets in the mouse. Adv. Immunol. 41, 39-133.
489. Sprent, J., Gao, E.-K., and Webb, S. R. (1990). T cell reactivity to MHC molecules: Immunity versus tolerance. Science 248, 1357-1363.
490. Spriggs, M. K. (1996). One step ahead of the game: Viral immunomodulatory molecules. Annu. Rev. Immunol. 14, 101-130.
491. Squartini, F., Olivi, M., and Bolis, G. B. (1970). Mouse strain and breeding stimulation as factors influencing the effect of thymectomy on mammary tumorigenesis. Cancer Res. 30, 2069-2072.
492. Staff of the Roscoe B. Jackson Memorial Laboratory (1933). The existence of nonchromosomal influence in the incidence of mammary tumors in mice. Science 78, 465-466.
493. Steiner, D. F., Smeekens, S. P., Ohagi, S., and Chan, S. J. (1992). The new enzymology of precursor proteases. J. Biol. Chem. 267, 23435-23438.
494. Stolfl, R. L., Fugmann, R. A., Stolfi, L. M., and Martin, D. S. (1975). Development and inhibition of cytotoxic antibody against spontaneous murine breast cancer. J. Immunol. 114, 1824-1830.
495. Stuart, P. M., and Woodward, J. G. (1992). Yersinia enterolytica produces superantigen activity. J. Immunol 148, 225-233.
496. Stuck, B., Boyse, E. A., Old, L. J., and Carswell, E. A. (1964). ML: A new antigen found in leukemias and mammary tumors of the mouse. Nature 203, 1033-1034.
497. Stutman, O. (1976). Correlation of in vitro and in vivo studies of antigens relevant to the control of murine breast cancer. Cancer Res. 36, 739-747.
498. Stutman, O., and Shen, F.-W. (1978). H-2 restriction and non-restriction of T-cell-mediated cytotoxicity against mouse mammary tumor targets. Nature 276, 181-182.
499. Subramanyam, M., McLellan, B., Labrecque, N., Sekaly, R. P., and Huber, B. T. (1993). Presentation of the Mls-1 superantigen by human HLA class II molecules to murine T cells. J. Immunol. 151, 2538-2545.
500. Sutkowski, N., Palkama, T., Ciurli, C., Sekaly, R.-P., Thorley-Lawson, D. A., and Huber, B. T. (1996). An Epstein-Barr virus-associated superantigen. J. Exp. Med. 184, 1-10.
501. Szomolanyi-Tsuda, E., and Welsh, R. M. (1996). T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice. J. Exp. Med. 183, 403-411.
502. Tanaka, H. (1977). Precursor-product relationship between nonglycosylated polypeptides of A and B particles of mouse mammary tumor virus. Virology 76, 835-850.
503. Tanaka, H., Tamura, A., and Tsujimura, D. (1972). Properties of the intracytoplasmic A particles purified from mouse tumors. Virology 49, 61-78.
504. Tanaka, S., and Matsuzawa, A. (1990). The NXSM recombinant inbred strains of mice: Genetic profile for 58 loci including the Mtv proviral loci. Genetics 125, 431-446.
505. Taniguchi, Y. (1987). Electron-microscopic studies on the production and localization of murine mammary tumor virus (MMTV) particles in vivo. J. Nara Med. Assoc. 38, 480-500.
506. Tekmal, R. R., and Durgam, V. R. (1995). The overexpression of int-5/Aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation. Cancer Lett. 88, 147-155.
507. Teramoto, Y. A., Puentes, M. J., Young, L. J., and Cardiff, R. D. (1974). Structure of the mouse mammary tumor virus: Polypeptides and glycoproteins. J. Virol. 13, 411-418.
508. Tew, J. G., DiLosa, R. M., Burton, G. F., Kosco, M. H., Kupp, L. I., Masuda, A., and Szakal, A. K. (1992). Germinal centers and antibody production in bone marrow. Immunol. Rev. 126, 99-112.
509. Thibodeau, J., Labrecque, N., Denis, F., Huber, B. T., and Sekaly, R. P. (1994). Binding sites for bacterial and endogenous retroviral superantigens can be dissociated on major histocompatibility complex class II molecules. J. Exp. Med. 179, 1029-1034.
510. Thompson, C. B. (1995). Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell 81, 979-982.
511. a. Cell. Immunol. 154, 380-392.
512. Tomai, M., Kotb, M., Majumdar, G., and Beachey, E. H. (1990). Superantigenicity of streptococcal M protein. J. Exp. Med. 172, 359-362.
513. Tomai, M. A., Beachey, E. H., Majumdar, G., and Kotb, M. (1992). Metabolically active antigen presenting cells are required for human T cell proliferation in response to the superantigen streptococcal M protein. FEMS Microbiol. Immunol. 4, 155-164.
514. Tomonari, K. (1994). Tcrb-V12-specific superantigens encoded by mouse mammary tumor proviruses. Immunogenetics 39, 65-67.
515. Tomonari, K., Fairchild, S., Rosenwasser, O. A., Robinson, P. J., Knight, A. M., and Dyson, P. J. (1992). Endogenous ligands selecting T cells expressing particular V beta elements. Int. Rev. Immunol. 8, 289-309.
516. β-specific positive and negative selection. Immunol. Rev. 131, 131-168.
517. Torres, B. A., Griggs, N. D., and Johnson, H. M. (1993). Bacterial and retroviral superantigens share a common binding region on class II MHC antigens. Nature 364, 152-154.
518. Trono, D. (1995). HIV accessory proteins: Leading roles for the supporting casts. Cell 82, 189-192.
519. + T cells. J. Immunol. 150, 5519-5528.
520. Tsiagbe, V. K., Yashimoto, T., Asakawa, J., Cho, S. Y., Meruelo, D., and Thorbecke, G. J. (1993b). Linkage of superantigen-like stimulation of syngeneic T cells in a mouse model of follicular center B cell lymphoma to transcription of endogenous mammary tumor virus. EMBO J. 12, 2313-2320.
521. Tsubura, A., Inaba, M., Imai, S., Murakami, A., Oyaizu, N., Yasumizu, R., Ohnishi, Y., Tanaka, H., Morii, S., and Ikehara, S. (1988). Intervention of T-cells in transportation of mouse mammary tumor virus (milk factor) to mammary gland cells in vivo. Cancer Res. 48, 6555-6559.
522. Tsubura, Y., Imai, S., Morimoto, J., and Hilgers, J. (1981). Strain difference in the expression of mammary tumor virus antigen in the male genital organs of mice during aging. Gann 72, 424-429.
523. Tucek, C. L., Desaymard, C., and Papiemik, M. (1993). A kinetic study on the deletion of thymic, peripheral, and gut-associated V beta 6+ T cells in an Mls-lb BALB/c colony infected with an exogenous mouse mammary tumor virus. J. Immunol. 151, 759-766.
524. Tumang, J. R., Posnett, D. N., Cole, B. C., Crow, M. K., and Friedman, S. M. (1990). Helper T cell-dependent human B cell differentiation mediated by a mycoplasmal superantigen bridge. J. Exp. Med. 171, 2153-2158.
525. β12-expressing T cells: Effects of a new Mis-determinant. J. Exp. Med. 172, 807-813.
526. a superantigen-specific T cell responses. J. Exp. Med. 175, 1405-1408.
527. Vaidya, A. B., Long, C. A., Sheffield, J. B., Tamura, A., and Tanaka, H. (1980). Murine mammary tumor virus deficient in the major glycoprotein: Biochemical and biological studies on virions produced by a lymphoma cell line. Virology 104, 279-293.
528. Van Blitterswijk, W. J., Emmelot, P., Hilgers, J., Kamlag, D., Nusse, R., and Feltkamp, C. A. (1975). Quantitation of virus-induced (MLr) and normal (Thy.1.2) cell surface antigens in isolated plasma membranes and the extracellular ascites fluid of mouse leukemia cells. Cancer Res. 35, 2743-2751.
529. van Blitterswijk, W. J., Emmelot, P., Hilkmann, H. A. M., Hilgers, J., and Feltkamp, C. A. (1979). Rigid plasma-membrane-derived vesicles, enriched in tumour-associated surface antigens (MLr), occurring in the ascites fluid of a murine leukaemia (GRSL). Int. J. Cancer 23, 62-70.
530. van Essen, D., Kikutani, H., and Gray, D. (1995). CD40 ligand-transduced costimulation of T cells in the development of helper function. Nature 378, 620-623.
531. van Klaveren, P., and Bentvelzen, P. (1988). Transactivating potential of the 3' open reading frame of murine mammary tumor virus. J. Virol. 62, 4410-4413.
532. van Nie, R., and Verstraeten, A. A. (1975). Studies of genetic transmission of mammary tumor virus by C3Hf mice. Int. J. Cancer 16, 922-931.
533. Varmus, H. E., and Swanstrom, R. (1984). RNA tumor viruses. In "RNA Tumor Viruses" (R. Weiss, N. Teich, H. E. Varmus, and J. Coffin, Eds.), pp. 369-512. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
534. Varmus, H. E., Bishop, J. M., Nowinski, R. C, and Sarkar, N. H. (1972). Mammary tumor virus specific nucleotide sequences in DNA of high and low incidence mouse strains. Nature 238, 189-190.
535. Vasquez-Kristiansen, S., Pascual, V., and Lipsky, P. E. (1996). Staphylococcal protein A induces biased production of Ig by VH3 expressing B lymphocytes. J. Immunol. 153, 2974-2982.
536. Velin, D., Acha-Orbea, H., and Kraehenbuhl, J. P. (1996). The neonatal Fc receptor is not required for mucosal infection of mouse mammary tumor virus. J. Virol. 70, 7250-7254.
537. Vella, A. T., McCormack, J. E., Linsley, P. S., Kappler, J. W., and Marrack, P. (1995). Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2, 261-270.
538. Verstraeten, A. A., Van Nie, R., Kwa, H. G., and Hageman, P. C. (1975). Quantitative estimation of mouse mammary tumor virus (MTV) antigens by radioimmunoassay. Int. J. Cancer 15, 270-281.
539. Viville, S., Neefjes, J., Lotteau, V., Dierich, A., Lemeur, M., Ploegh, H., Benoist, C, and Mathis, D. (1993). Mice lacking the MHC class II-associated invariant chain. Cell 72, 635-648.
540. von Boehmer, H., and Sprent, J. (1974). Expression of M locus differences by B cells but not T cells. Nature 249, 363-365.
541. β domains. Eur. J. Immunol. 22, 291-293.
542. β repertoire among superantigen reactive murine T cells. Int. Immunol. 5, 55-61.
543. Waanders, G. A., Shakhov, A. N., Held, W., Karapetian, O., Acha-Orbea, H., and MacDonald, H. R. (1993b). Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus. J. Exp. Med. 177, 1359-1366.
544. Waanders, G. A., Lees, R. K., Held, W., and MacDonald, H. R. (1995). Quantitation of endogenous mouse mammary tumor virus superantigen expression by lymphocyte subsets. Eur. J. Immunol. 25, 2632-2637.
545. Wajjwalku, W., Takahashi, M., Miyaishi, O., Lu, J., Sakata, K., Yokoi, T., Saga, S., Imai, M., Matsuyama, M., and Hoshino, M. (1991). Tissue distribution of mouse mammary tumor virus (MMTV) antigens and new endogenous MMTV loci in Japanese laboratory mouse strains. Jpn. J. Cancer Res. 82, 1413-1420.
546. Wajjwalku, W., Tomida, S., Takahashi, M., Matsuyama, M., and Yoshikai, Y. (1993). A gene encoding the ligand for deletion of T cells bearing TcrVβ 6 and Vβ 8.1 cosegregates with a new endogenous mouse mammary tumor virus. Immunogeneties 37, 397-400.
547. Wajjwalku, W., Ando, Y., Niimi, N., and Yoshikai, Y. (1995). A novel exogenous mammary tumor vims encoding MHC class II H2E-independent superantigen specific for Tcr-V β 14. Immunogeneties 41, 156-158.
548. Wall, K. A., Lorber, M. I., Loken, M. R., McClatchey, S., and Fitch, F. W. (1983). Inhibition of proliferation of Mls- and 1α-reactive cloned T cells by a monoclonal antibody against a determinant shared between I-A and I-E. J. Immunol. 131, 1056-1064.
549. Wang, H., Gill, R. F., Lichlyter, D., Iglesias, A., Bluethmann, H., and Wei, W. Z. (1994). Deletion of CD4+ T cells and thymocytes by apoptosis in mouse mammary tumor virus (C4) -infected V beta 2 transgenic mice. Eur. J. Immunol. 24, 2950-2956.
550. Waterhouse, P., Penninger, J. M., Timms, E., Wakehan, A., Shahinian, A., Lee, K. P., Thompson, C. B., Griesser, H., and Mak, T. W. (1995). Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270, 985-988.
551. Webb, S., Morris, C., and Sprent, J. (1990). Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity. Cell 63, 1249-1256.
552. a determinants. Immunol. Rev. 107, 141-158.
553. + T cells. Science 248, 1643-1646.
554. a determinants. J. Exp. Med. 171, 953-958.
555. a antigens in vivo. Immunol. Rev. 131, 169-188.
556. a determinants. J. Exp. Med. 169, 1-12.
557. Webb, S. R., Hutchinson, J., Hayden, K., and Sprent, J. (1994). Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo. J. Immunol. 152, 586-597.
558. Weber, G. F., Abromson-Leeman, S., and Cantor, H. (1995). A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death. Immunity 2, 363-372.
559. Wei, W.-Z., and Heppner, G. (1987). Natural killer activity of lymphocyte infiltrates in mouse mammary lesions. Br. J. Cancer 55, 589-594.
560. Wei, W. Z., Malone, K., Mahoney, K., and Heppner, G. (1986). Characterizations of lymphocytic infiltrates in normal, preneoplastic, and neoplastic mouse mammary tissues. Cancer Res. 46, 2680-2685.
561. d -restricted immunogenic peptide. Int. J. Cancer 66, 659-663.
562. Weiss, R., Teich, N., Varmus, H., and Coffin, J. (1985). "RNA Tumor Viruses", 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
563. Weiss, R. A., and Tailor, C. S. (1995). Retrovirus receptors. Cell 82, 531-533.
564. Wellinger, R. J., Garcia, M., Vessaz, A., and Diggelmann, H. (1986). Exogenous mouse mammary tumor virus proviral DNA isolated from a kidney adenocarcinoma cell line contains alterations in the U3 region of the long terminal repeat. J. Virol. 60, 1-11.
565. White, J., Herman, A., Pullen, A. M., Kubo, R., Kappler, J. W., and Marrack, P. (1989). The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice. Cell 56, 27-35.
566. Widera, G., Burkly, L. C., Pinkert, C. A., Bottger, E. C., Cowing, C., Palmiter, R. D., Brinster, R. L., and Flavell, R. A. (1989). Transgenic mice selectively lacking MHC class II (I-E) expression on B cells: An in vivo approach to investigate la gene function. Cell 51, 175-187.
567. Williams, A. F., Strominger, J. L., Bell, J., Mak, T. W., Kappler, J., Marrack, P., Arden, B., Lefranc, M. P., Hood, L., Tonegawa, S., and Davis, M. (1993). Nomenclature of T-cell receptor (TCR) gene segments of the immune system. WHO Bull. 71, 113-115.
568. Winslow, G. M., Scherer, M. T., Kappler, J. W., and Marrack, P. (1992). Detection and biochemical characterization of the mouse mammary tumor virus 7 superantigen (Mls-D. Cell 71, 719-730.
569. Winslow, G. M., Marrack, P., and Kappler, J. W. (1994). Processing and major histocompatibility complex binding of the Mtv-7 superantigen. Immunity 1, 23-33.
570. Wolf, J. L., Rubin, D. H., Finberg, R. S., Kauffman, R. S., Sharpe, A. H., Trier, J. S., and Fields, B. N. (1981). Intestinal M cells: A pathway for entry of reovirus into the host. Science 212, 471-472.
571. Woodland, D., Happ, M. P., Bill, J., and Palmer, E. (1990). Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells. Science 247, 964-967.
572. Woodland, D. L., Happ, M. P., Gollob, K. I., and Palmer, E. (1991a). An endogenous retrovirus mediating deletion of αβ T cells? Nature 349, 529-530.
573. Woodland, D. L., Lund, F. E., Happ, M. P., Blackman, M. A., Palmer, E., and Corley, R. B. (1991b). Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci. J. Exp. Med. 174, 1255-1258.
574. Woodland, D. L., Wen, R., and Blackman, M. A. (1997). Why do superantigens care about peptides? Immunol. Today, 18, 18-22.
575. Yagi, M. J., Stutzman, R. E., Robertson, B. H., and Compans, R. W. (1978). Structural components of mouse mammary tumor virus. II. Isolation and purification of virion polypeptides. J. Virol. 26, 448-456.
576. Yazdanbakhsh, K., Park, C. G., Winslow, G. M., and Choi, Y. (1993). Direct evidence for the role of COOH terminus of mouse mammary tumor virus superantigen in determining T cell receptor Vβ specificity. J. Exp. Med. 178, 737-741.
577. Yoshimoto, T., Nagase, H., Nakano, H., Matsuzawa, A., and Nariuchi, H. (1994). A Vβ8.2-specific superantigen from exogenous mouse mammary tumor virus carried by FM mice. Eur. J. Immunol. 24, 1612-1619.
578. Yoshino, K., Abe, J., Murata, H., Takao, T., Kohsaka, T., Shimonishi, Y., and Takeda, T. (1994). Purification and characterization of a novel superantigen produced by a clinical isolate of Yersinia pseudotuberculosis. FEBS Lett. 356, 141-144.
579. Yuuki, H., Yoshikai, Y., Kishihara, K., Iwasaki, A., Matsuzaki, G., Ogimoto, M., and Nomoto, K. (1990). Deletion of self-reactive T cells in nude mice grafted with neonatal allogeneic thymus. J. Immunol. 144, 474-479.
580. Zak-Nejmark, T., Steuden, J., and Radzikowski, C. (1978). Mammary leukemia (ML) antigen isolated from L 1210 leukemia cells. Int. J. Cancer 21, 490-495.
581. Zavada, J., Dickson, C., and Weiss, R. (1977). Pseudotypes of vesicular stomatitis virus with envelope antigens provided by murine mammary tumor virus. Virology 82, 221-231.
582. Zhang, D. J., Tsiagbe, V. K., and Thorbecke, G. J. (1996). Control of endogenous MMTV superantigen expression in SJL lymphomas by a promoter within the env region. J. Immunol. 157, 3510-3517.
583. + single transgenic mice. J. Immunol. 146, 854-859.
584. + T cells in transgenic mice. Immunogenetics 35, 219-223.
585. Zinkernagel, R. M. (1993). Immunity to viruses. In "Fundamental Immunology" (B. Paul, Ed.), 3rd ed., pp. 1211-1250. Raven Press, New York.
586. Zinkernagel, R. M. (1996). Immunology taught by viruses. Science 271, 173-178.
587. Zinkernagel, R. M., Cooper, S., Chambers, J., Lazzarini, R. A., Hengartner, H., and Arnheirer, H. (1990). Virus-induced autoantibody response to a transgenic viral antigen. Nature 345, 68-71.
588. Zinkernagel, R. M., Pircher, H. P., Ohashi, P., Oehen, S., Odermatt, B., Mak, T., Arnheiter, H., Burki, K., and Hengartner, H. (1991). T and B cell tolerance and responses to viral antigens in transgenic mice: Implications for the pathogenesis of autoimmune versus immunopathological disease. Immunol. Rev. 122, 133-171.
589. Zouali, M. (1995). B-cell superantigens: Implications for selection of the human antibody repertoire. Immunol. Today 16, 399-405.