Muscle rad expression and human metabolism: Potential role of the novel ras-related GTPase in energy expenditure and body composition

Diabetes

Volumn 46, Issue 3, 1997, Pages 444-450

  Garvey, W Timothy ^a   Maianu, Lidia ^a   Kennedy, Adele ^a   Wallace, Penny ^a   Ganaway, Elizabeth ^a   Hamacher, Lawrence L ^b   Yarnall, David P ^b   Lenhard, James M ^b   Burns, Daniel K ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; INSULIN; RAS PROTEIN;

ADULT; ARTICLE; BASAL METABOLIC RATE; BODY COMPOSITION; BODY FAT; BODY MASS; CHROMOSOME 16; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY EXPENDITURE; FEMALE; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MUSCLE METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NORTHERN BLOTTING; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

EID: 0031040840     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.3.444     Document Type: Article

References (33)

1. Reynet C, Kahn CR: Rad: a member of the ras family overexpressed in muscle of type II diabetic humans. Science 262:1441-1444, 1993
2. Zhu J, Reynet C, Caldwell JS, Kahn CR: Characterization of rad, a new member of ras/GTPase superfamily, and its regulation by a unique GTPase-activating protein (GAP)-like activity. J Biol Chem 270:4805-4812, 1995
3. Paulik MA, Hamacher LL, Yarnall DP, Jennerman C, Maianu L, Pratley RE, Garvey WT, Burns DK, Lenhard JM: Identification of rad's effector-binding domain, intracellular localization, and analysis of expression in Pima Indians. Mol Cell Biol 7 (Suppl.):526A, 1996
4. Maguire J, Santora T, Jensen P, Siebenlist U, Yewdell J, Kelly K: Gem: an induced, immediate early protein belonging to the ras family. Science 265:241-244, 1994
5. Hall A: Ras-related proteins. Curr Opin Cell Biol 5:265-268, 1993
6. Nuoffer C, Balch WE: GTPases: multifunctional molecular switches regulating vesicular traffic. Ann Rev Biochem 63:949-990, 1994
7. Kahn CR: Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084, 1994
8. Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS: Trinucleotide repeats at the rad locus: allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q. Diabetes 44:243-247, 1995
9. Elbein SC, Chiu KC, Hoffman MD, Mayorga RA, Bragg KL, Leppert MF: Linkage analysis of 19 candidate regions for insulin resistance in familial NIDDM. Diabetes 44:1259-1265, 1995
10. Orho M, Carlsson M, Kanninen T, Groop LC: Polymorphism at the rad gene is not associated with NIDDM in Finns. Diabetes 45:429-433, 1996
11. National Diabetes Data Group: Classificiation and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
12. Garvey WT, Maianu L, Hancock JA, Golichowski AM, Baron A: Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Diabetes 41:465-475, 1992
13. Garvey WT, Olefsky JM, Griffin J, Hamman RF, Kolterman OG: The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes 34:222-234, 1985
14. Hardin DS, Azzarelli B, Edwards J, Wigglesworth J, Maianu L, Brechtel G, Johnson A, Baron A, Garvey WT: Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT4 in skeletal muscles. J Clin Endocrinol Metab 80:2437-2446, 1995
15. Ravussin E, Lillioja MB, Knowler WC, Christin L, Freymond D, Abbott WGH, Boyce V, Howard BV, Bogardus C: Reduced rate of energy expenditure as a risk factor for body-weight-gain. N Engl J Med 318:467-472, 1988
16. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685, 1970
17. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354, 1979
18. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
19. Bradford M: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle protein-dye bonding. Anal Biochem 72:248-254, 1976
20. Garvey WT, Maianu L, Brechtel G, Johnson A, Sunblad K, Hardin D: Muscle GLUT4 expression is a familiar trait and determines insulin sensitivity in humans independent of obesity (Abstract). Diabetes 43 (Suppl. 1):69A, 1994
21. Hollenbeck C, Reaven GM: Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance. J Clin Endocrinol Metab 64:1169-1173, 1987
22. Bogardus C, Lillioja S: Pima Indians as a model to study the genetics of NIDDM. J Cell Biochem 48:337-343, 1992
23. Dorin D, Cohen L, Del Villar K, Poullet P, Mohr R, Whitemay M, White O, Tamonoi F: Kir, a novel ras-related G-protein, induces invasive pseudohyphal growth in saccharomyces cerevisiae. Oncogene 11:2267-2271, 1995
24. Maassen JM, Burgering BM, Medema RH, Osterop AP, Van der Zon GC, Moller W: The role of ras proteins in insulin signal transduction. Horm Metabol Res 24:214-218, 1992
25. Baldini G, Hohl T, Lin HY, Lodish HF: Cloning of a rab3 isotype predominantly expressed in adipocytes. Proc Natl Acad Sci USA 89:5049-5052, 1992
26. Cormont M, Tanti JF, Zahraoui A, van Obberghen E, Tavitian A, LeMarchand-Brustel Y: Insulin and okadaic acid induce rab4 redistribution in adipocytes. J Biol Chem 268:19491-19497, 1993
27. Danforth E Jr: Dietary-induced thermogenesis: control of energy expenditure. Life Sci 28:1821-1827, 1981
28. Sims EAH, Danforth E Jr: Expenditure and storage of energy in man. J Clin Invest 79:1019-1025, 1987
29. Zhu J, Bilan PJ, Moyers JS, Antonetti DA, Kahn CR: Rad, a novel ras-related GTPase, interacts with skeletal muscle β-tropomyosin. J Biol Chem 271:768-773, 1996
30. Zurlo F, Larson K, Bogardus C, Ravussin E: Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest 86:1423-1427, 1990
31. Zurlo F, Ferraro T, Fontvieille AM, Rising R, Bogardus C, Ravussin E: Spontaneous physical activity and obesity: cross-sectional and longitudinal studies in Pima Indians. Am J Physiol 263:E296-E300, 1992
32. Christin L, O'Connel M, Bogardus C, Danforth E Jr, Ravussin E: Norepinephrine turnover and energy expenditure in Pima Indians and white men. Metabolism 42:723-729, 1993
33. Laville M, Auboeuf D, Khalfallah Y, Vega N, Riou JP, Vidai H: Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut4, and Upoprotein lipase mRNA levels in human muscle. J Clin Invest 98:43-49, 1996