Insulin and glucocorticoids differentially regulate leptin transcription and secretion in brown adipocytes

FASEB Journal

Volumn 15, Issue 8, 2001, Pages 1357-1366

  Buyse, Marion ^a   Viengchareun, Say ^a   Bado, André ^a   Lombès, Marc ^a  

^a INSERM   (France)

Author keywords

Cell line; Ob gene; Obesity; Signaling pathway; Uncoupling protein

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR; CYCLOHEXIMIDE; DACTINOMYCIN; GLUCOCORTICOID; INSULIN; LEPTIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; UNCOUPLING PROTEIN 1;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BODY WEIGHT; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HOMEOSTASIS; HORMONAL REGULATION; METABOLIC REGULATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RNA STABILITY; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

ANIMALIA;

EID: 0034995116     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0669com     Document Type: Article

References (63)

1. Positional cloning of the mouse obese gene and its human homologue
2. Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans
3. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
4. The stomach is a source of leptin
5. Leptin and leptin receptor expression in rat and mouse pituitary cells
6. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
7. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
8. Weight-reducing effects of the plasma protein encoded by the obese gene
9. Effects of the obese gene product on body weight regulation in ob/ob mice
10. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice
11. Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects
12. Nutritional regulation of leptin in humans
13. Dexamethasone stimulates leptin release from human adipocytes: Unexpected inhibition by insulin
14. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP
15. Expression of ob gene in adipose cells. Regulation by insulin
16. Regulation of ob gene mRNA levels in cultured adipocytes
17. Transient increase in obese gene expression after food intake or insulin administration
18. Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes
19. Insulin and insulin-like growth factor 1 antagonize the stimulation of ob gene expression by dexamethasone in cultured rat adipose tissue
20. The uncoupling protein homologues: UCP1, UCP2, UCP3. StUCP and AtUCP
21. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue
22. Human immortalized brown adipocytes express functional beta3-adrenoceptor coupled to lipolysis
23. Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture
24. Protein kinase C mediates tumor necrosis factor-alpha-induced inhibition of obese gene expression and leptin secretion in brown adipocytes
25. Leptin gene is expressed in rat brown adipose tissue at birth
26. Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action
27. The mineralocorticoid receptor mediates aldosterone-induced differentiation of T37i cells into brown adipocytes
28. Mineralocorticoid and glucocorticoid receptors inhibit UCP expression and function in brown adipocytes
29. Direct solution hybridization of guanidine thiocyanate-solubilized cells for quantitation of mRNAs in hepatocytes
30. Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes
31. Characterization of NPY receptors controlling lipolysis and leptin secretion in human adipocytes
32. Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes
33. Regulation of leptin production in cultured mature white adipocytes
34. The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes
35. Insulin stimulates both leptin secretion and production by rat white adipose tissue
36. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
37. Isoproterenol and somatostatin decrease plasma leptin in humans: A novel mechanism regulating leptin secretion
38. Isoproterenol decreases leptin expression in adipose tissue of obese humans
39. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
40. Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma
41. Reduced expression of the leptin gene (ob) by catecholamine through a G(S) protein-coupled pathway in 3T3-L1 adipocytes
42. Short-term dexamethasone treatment increases plasma leptin independently of changes in insulin sensitivity in healthy women
43. Glucocorticoids induce the expression of the leptin gene through a non-classical mechanism of transcriptional activation
44. Regulation of obese mRNA expression by hormonal factors in primary cultures of rat adipocytes
45. The regulation of leptin gene expression in the C6 glioblastoma cell line
46. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression
47. The mouse obese gene. Genomic organization, promoter activity, and activation by CCAAT/enhancer-binding protein alpha
48. Transcriptional regulation of leptin gene promoter in rat
49. Genomic structure and promoter analysis of the human obese gene
50. Regulation of leptin promoter function by Sp1, C/EBP, and a novel factor
51. TRANSFAC: An integrated system for gene expression regulation
52. The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression
53. Identification of the promoter of the mouse obese gene
54. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein alpha
55. Tumour necrosis factor-alpha regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs) alpha and beta and determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes
56. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein alpha and delta genes in 3T3-L1 adipocytes and white adipose tissue
57. Signaling pathways through which insulin regulates CCAAT/enhancer binding protein alpha (C/EBPalpha) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expression
58. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
59. Mechanisms of glucocorticoid-receptor-mediated repression of gene expression
60. Role of brown adipose tissue thermogenesis in control of thermoregulatory feeding in rats: A new hypothesis that links thermostatic and glycostatic hypotheses for control of food intake
61. Leptin increases uncoupling protein expression and energy expenditure
62. Leptin induction of UCP1 gene expression is dependent on sympathetic innervation
63. Direct effects of leptin on brown and white adipose tissue