On the role of calpain and rho proteins in regulating integrin-induced signaling

Thrombosis and Haemostasis

Volumn 82, Issue 2, 1999, Pages 385-391

  Fox, Joan E B ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALPAIN; CYTOSKELETON PROTEIN; FIBRINOGEN; INTEGRIN; PROTEIN SUBUNIT; RHO FACTOR;

ACTIN FILAMENT; ANIMAL CELL; AUTOLYSIS; CELL ADHESION; CELL MIGRATION; CELL SPREADING; CELL STRUCTURE; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSKELETON; ENDOTHELIUM CELL; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION;

EID: 0032697768     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615857     Document Type: Conference Paper

References (88)

1. Kouns WC, Fox CF, Lamoreaux WJ, Coons LB, Jennings LK. The effect of glycoprotein IIb-IIIa receptor occupancy on the cytoskeleton of resting and activated platelets. J Biol Chem. 1991;266:13891-13900.
2. Fox JEB, Shattil SJ, Kinlough-Rathbone RL, Richardson M, Packham MA, Sanan DA. The platelet cytoskeleton stabilizes the interaction between αIIbβ3 and its ligand and induces selective movements of ligand-occupied integrin. J Biol Chem. 1996;271:7004-7011.
3. Marlin ST, Morton CC, Anderson DC, Springer TA. LFA-1 Immunodeficiency disease. J Exp Med. 1986;164:855-867.
4. Meerschaert JA, Furie MB. Monocytes use either CD11/CD18 or VLA-4 to migrate across human endothelium in vitro. J Immunol. 1994;152:1915-1926.
5. Schwartz MA, Schaller MD, Ginsberg MH. Integrins: Emerging paradigms of signal transduction. Annu Rev Cell Dev Biol. 1995;11:549-599.
6. Hynes RO. Integrins: versatility, modulation, and signaling cell adhesion. Cell. 1992;69:11-25.
7. Rosales C, Juliano RL. Signal transduction by cell adhesion receptors in leukocytes. J Leukoc Biol. 1995;57:189-198.
8. Clark EA, Brugge JS. Integrins and signal transduction pathways: The road taken. Science. 1995;268:233-239.
9. Clark EA, King WG, Brugge JS, Symons M, Hynes RO. Integrin-mediated signals regulated by members of the Rho family of GTPases. J Cell Biol. 1998;142:573-586.
10. Price LS, Leng J, Schwartz MA, Bokoch GM. Activation of Rac and Cdc42 by integrin mediates cell spreading. Mol Biol Cell. 1998;9:1863-1871.
11. Nobes C, Hall A. Regulation and function of the Rho-subfamily of small GTPases. Curr Opin Genet Dev. 1994;4:77-81.
12. Nobes CD, Hall A. Rho, Rac, and Cdc42 GTPase regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell. 1995;81:53-62.
13. Machesky LM, Hall A. Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization. J Cell Biol. 1997;138:913-926.
14. Hotchin NA, Hall A. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol. 1995;131:1857-1865.
15. Remold-O'Donnell E, Rosen FS, Kenney DM. Defects in Wiskott-Aldrich Syndrome blood cells. Blood. 1996;87:2621-2631.
16. Symons M, Deny JMJ, Kariak B, Jiang S, Lemahieu V, McCormick F, Francke U, Abo A. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell. 1996;84:723-734.
17. Tolias KF, Cantley LC, Carpenter CL. Rho family GTPases bind to phosphoinositide kinases. J Biol Chem. 1995;270:17656-17659.
18. Zheng Y, Baghrodia S, Cerione RA. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. J Biol Chem. 1994;269:18727-18730.
19. 3. J Biol Chem. 1994;269:32358-32367.
20. Arcaro A, Wymann M. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J. 1993;296:297-301.
21. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, Sakaue H, Ando A, Chavanieu A, Calas B, Grigorescu F, Nishiyama M, Waterfield M, Kasuga M. Involvement of phosphoinositide 3-kinase in insulin-or IGF-1-induced membrane ruffling. EMBO J. 1994;13:2313-2321.
22. Franke TF, Kaplan DR, Cantley LC, Toker A. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science. 1997;275:665-668.
23. Datta K, Bellacosa A, Chan TO, Tsichlis PN. Akt is a direct target of the phosphatidylinositol 3-kinase. J Biol Chem. 1996;271:30835-30839.
24. Manser E, Leung T, Salihuddin H, Zhao Z-S, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994;367:40-46.
25. Manser E, Chong C, Zhao Z-S, Leung T, Michael G, Hall C, Lim L. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J Biol Chem. 1995;270:25070-25078.
26. Martin GA, Bollag G, McCormick F, Abo A. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 1995;14:1970-1978.
27. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 1995;82:643-653.
28. Tsukita S, Yonemura S, Tsukita S. ERM proteins: head-to-tail regulation of actin-plasma membrane interaction. Trends Biochem Sci. 1997;22:53-58.
29. Gilmore AP, Burridge K. Regulation of vinculin binding to talin and actin by phospatidylinositol-4-5-bisphosphate. Nature. 1996;381:531-535.
30. Chrzanowska-Wodnicka M, Burridge K. Rho-stimulated contractility drives the formation of stress fibers and focal adhesions. J Cell Biol. 1996;133:1403-1415.
31. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996;273:245-248.
32. Amano M, Ito M, Kimura K, Fukata Y, Chihara K, Nakano T, Matsuura Y, Kaibuchi K. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem. 1996;271:20246-20249.
33. Burridge K, Chrzanowska-Wodnicka. Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol. 1996;12:463-519.
34. Kimura K, Fukata Y, Matsuoka Y, Bennett V, Matsuura Y, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. J Biol Chem. 1998;273:5542-5548.
35. Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, Tsukita S, Tsukita S. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol. 1998;140:647-657.
36. Shaw RJ, Henry M, Solomon F, Jacks T. RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts. Mol Biol Cell. 1998;9:403-419.
37. Boguski MS, McCormick F. Proteins regulating Ras and its relatives. Nature. 1993;366:643-654.
38. Bokoch GM, Der CJ. Emerging concepts in the Ras superfamily of GTP-binding proteins. FASEB J. 1993;7:750-759.
39. Bollag G, McCormick F. Regulators and effectors of ras proteins. Annu Rev Cell Biol. 1991;7:601-632.
40. 2-terminal kinase activation. J Cell Biol. 1997;137:387-398.
41. Ma AD, Metjian A, Bagrodia S, Taylor S, Abrams CS. Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase γ, a Rac guanosine exchange factor, and Rac. Mol Cell Biol. 1998;18:4744-4751.
42. Guan J-L, Trevithick JE, Hynes RO. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Reg. 1991;2:951-964.
43. 1 integrins. Proc Natl Acad Sci USA. 1991;88:8392-8396.
44. Clark EA, Brugge JS. Tyrosine phosphorylation in platelets. Potential roles in intracellular signal transduction. TMC. 1993;3:218-.
45. 3. J Biol Chem. 1994;269:28859-28864.
46. FAK in platelets. J Cell Biol. 1992;119:905-912.
47. Kornberg L, Earp HS, Parsons JT, Schaller M, Juliano RL. Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J Biol Chem. 1992;267:23439-23442.
48. Croall DE, Demartino GN. Calcium-activated neutral protease (Calpain) system: Structure, function, and regulation. Physiol Rev. 1991;71:813-847.
49. Saido TC, Sorimachi H, Suzuki K. Calpain: New perspectives in molecular diversity and physiological-pathological involvement. FASEB J. 1994;8:814-822.
50. Mellgren RL. Calcium-dependent proteases: An enzyme system active at cellular membranes? FASEB J. 1987;1:110-115.
51. Suzuki K, Imajoh S, Emori Y, Kawasaki H, Minami Y, Ohno S: Regulation of activity of calcium activated neutral protease; In: Weber G, ed. Advances in Enzyme Regulation. Oxford: Pergamon Press, 1988;153-169.
52. Sorimachi H, Ishiura S, Suzuki K. Structure and physiological function of calpains. Biochem J. 1997;328:721-32.
53. Fox JEB, Taylor RG, Taffarel M, Boyles JK, Goll DE. Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIa. J Cell Biol. 1993;120:1501-1507.
54. 2+. J Biol Chem. 1977;252:5602-5605.
55. Fox JEB, Reynolds CC, Phillips DR. Calcium-dependent proteolysis occurs during platelet aggregation. J Biol Chem. 1983;258:9973-9981.
56. 3) in von Willebrand factor-induced signal transduction. J Biol Chem. 1997;272:21847-21854.
57. 2+-dependent protease during platelet aggregation. J Biol Chem. 1985;260:1060-1066.
58. 2+-dependent protease during platelet activation. Blood. 1987;69:537-545.
59. Earnest JP, Santos GF, Zuerbig S, Fox JEB. Dystrophin-related protein in the platelet membrane skeleton. Integrin-induced change in detergent-insolubility and cleavage by aggregating platelets. J Biol Chem. 1995;270:27259-27265.
60. Fox JEB, Saido TC: Calpain in signal transduction; In: Wang KKW, Yuen P-W, eds. The Pharmacology and Toxicology of Calpain. Washington, D.C.: Taylor and Francis. In Press.
61. Du X, Saido TC, Tsubuki S, Indig FE, Williams MJ, Ginsberg MH. Calpain cleavage of the cytoplasmic domain of the integrin β3 subunit. J Biol Chem.. 1995;270:26146-26151.
62. 2+-activated, phospholipid-dependent protein kinase. Eur J Biochem. 1985;151:419-423.
63. 8rc is an endogenous substrate for calpain in human blood platelets. J Biol Chem. 1993;268:12603-12608.
64. FAK) cleavage and regulation by calpain. Biochem J. 1996;318:41-47.
65. Frangioni JV, Oda A, Smith M, Salzman EW, Neel BG. Calpain catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. EMBO J. 1993;12:4843-4856.
66. Gu M, Majerus P. The properties of the protein tyrosine phosphatase PTPMEG. J Biol Chem. 1996;271:27751-27759.
67. Banfic H, Tang X, Batty I, Downes C, Chen C, Rittenhouse S. A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets. J Biol Chem. 1998;273:13-16.
68. Norris FA, Atkins RC, Majerus PW. Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human platelets. J Biol Chem. 1997;272:10987-10989.
69. Huang C, Tandon NN, Greco NJ, Ni Y, Wang T, Zhan X. Proteolysis of platelet cortactin by calpain. J Biol Chem. 1997;272:19248-19252.
70. ras activating protein with the membrane skeleton. J Biol Chem. 1993;268:25973-25984.
71. c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol. 1993;13:1863-1871.
72. 3-mediated translocation of CDC42Hs to the cytoskeleton in stimulated human platelets. J Biol Chem. 1995;270:17321-17326.
73. Falet H, Ramos-Morales F, Bachelot C, Fischer S, Rendu F. Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human platelets. FEBS Lett. 1996;383:165-169.
74. Fischer TH, Gatling MN, McCormick F, Duffy CM, White GC, II. Incorporation of Rap 1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium. J Biol Chem. 1994;269:17257-17261.
75. c-src, phospholipase C, inositol-lipid, and diacylglycerol kinases with the cytoskeletons of thrombin-stimulated platelets. J Biol Chem. 1991;266:15705-15709.
76. Guinebault C, Payrastre B, Racaud-Sultan C, Mazarguil H, Breton M, Mauco G, Plantavid M, Chap H. Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85α with actin filaments and focal adhesion kinase. J Cell Biol. 1995;129:831-842.
77. c-src to the cytoskeleton during platelet aggregation. EMBO J. 1992;11:855-861.
78. Li RY, Gaits F, Ragab A, Ragab-Thomas JMF, Chap H. Translocation of an SH2-containing protein tyrosine phosphate (SH-PTP1) to the cytoskeleton of thrombin-activated platelets. FEBS Lett. 1994;343:89-93.
79. Zhang J, Fry MJ, Waterfield MD, Jaken S, Liao L, Fox JEB, Rittenhouse SE. Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets. J Biol Chem. 1992;267:4686-4692.
80. Fox JEB. The Platelet Cytoskeleton Thromb. Haemost 1993;70:884-893.
81. Shattil SJ, Brugge JS. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr Opin Cell Biol. 1991;3:869-879.
82. Fujimoto T, Fujimura K, Kuramoto A. Electrophysiological evidence that glycoprotein IIb-IIIa complex is involved in calcium channel activation on human platelet plasma membrane. J Biol Chem. 1991;266:16370-16375.
83. Rybak ME, Renzulli LA, Bruns MJ, Cahaly DP. Platelet glycoproteins IIb and IIIa act as a calcium channel in liposomes. Blood. 1988;72:714-720.
84. 2+ transport: A comparison of results obtained with platelets and human erythroleukemia cells. Blood. 1991;78:2887-2893.
85. Beckerle MC, Burridge K, DeMartino GN, Croall DE. Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion. Cell. 1987;51:569-577.
86. Potter DA, Tirnauer JS, Janssen R, Croall DE, Hughes CN, Fiacco KA, Mier JW, Maki M, Herman IM. Calpain regulates actin remodeling during cell spreading. J Cell Biol. 1998;141:1-16.
87. Huttenlocher A, Palecek SP, Lu Q, Zhang W, Mellgren RL, Lauffenburger DA, Ginsberg MH, Horwitz AF. Regulation of cell migration by the calcium-dependent protease calpain. J Biol Chem. 1997;272:32719-32722.
88. Kulkarni S, Goll DE, Saido TC, Suzuki K, Fox JEB. Regulation of focal contact formation by calpain. Mol Biol Cell. 1997;8:282a.