Impact of apolipoprotein E ε4 and vascular disease on brain morphology in men from the NHLBI twin study

Stroke

Volumn 30, Issue 8, 1999, Pages 1548-1553

  DeCarli, Charles ^a   Reed, T ^b   Miller, B L ^c   Wolf, P A ^e   Swan, G E ^d   Carmelli, D ^d  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SRI INTERNATIONAL   (United States)

^e Kansas University Medical Center ^*

Author keywords

Apolipoproteins; Brain injuries; Cerebrovascular disorders; Epidemiology; Magnetic resonance imaging

Indexed keywords

APOLIPOPROTEIN E4;

ADULT; ARTICLE; BRAIN ATROPHY; BRAIN INJURY; CARDIOVASCULAR DISEASE; CEREBROVASCULAR DISEASE; GENOTYPE; HUMAN; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TWINS;

EID: 0032813761     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.30.8.1548     Document Type: Article

References (51)

1. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 1988;240:622-633.
2. Utermann G. The apolipoprotein E connection. Curr Biol. 1994;4: 362-365.
3. Siest G, Pillot T, Regis-Bailly A, Leininger-Muller B, Steinmetz J, Galteau MM, Visvikis S. Apolipoprotein E: an important gene and protein to follow in laboratory medicine. Clin Chem. 1995;41: 1068-1086.
4. Davignon J. Apolipoprotein E polymorphism and atherosclerosis. In: Born GVR, Schwartz CJ, eds. New Horizons in Coronary Heart Disease. London, England: Current Science; 1993:5.1-5.21.
5. Boerwinkle E, Visvikis S, Welsh D, Steinmetz J, Hanash SM, Sing CF. The use of measured genotype information in the analysis of quantitative phenotypes in man, II: the role of apolipoprotein E polymorphism in determining levels, variability, and covariability of cholesterol, beta-lipoprotein and triglycerides in a sample of unrelated individuals. Am J Hum Genet. 1987;27:567-582.
6. Tiret L, de Knijff P, Menzel H-J, Ehnholm C, Nicaud V, Havekas LM. ApoE polymorphism and predisposition to coronary heart disease in youths of different populations: the EARS Study. Arterioscler Thromb. 1994;14:1617-1624.
7. Ehnholm C, Lukka M, Kuusi T, Nikkila E, Utermann G. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res. 1986;27:227-235.
8. Levy RI. Declining mortality in coronary heart disease. Arteriosclerosis. 1981;1:312-325.
9. Lenzen HJ, Assmann G, Buchwaisky R, Schulte H. Association of apolipoprotein E polymorphism, low density lipoprotein cholesterol and coronary artery disease. Clin Chem. 1986;32:778-781.
10. Scheer WD, Boudreau DA, Malcom GT, Middaugh JP. Apolipoprotein E and atherosclerosis in Alaska natives. Atherosclerosis. 1995;114: 197-202.
11. Lehtinen S, Lehtimaki T, Sisto T, Salenius J-P, Nikkila M, Jokela H, Koivula T, Ebelin F, Ehnholm C. Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women. Atherosclerosis. 1995;114: 83-91.
12. Katzel JI, Fleg JI, Paidi M, Ragoobarsingh N, Goldberg AP. ApoE4 polymorphism increases the risk for exercise-induced silent myocardial ischemia in older men. Arterioscler Thromb. 1993;13:1495-1500.
13. Pedro-Botet J, Senti M, Nogues X, Rubies-Prat J, Roquer J, D'Olhaberriague L, Olive J. Lipoprotein and apolipoprotein profile in men with ischemic stroke: role of lipoprotein(a), triglyceride-rich lipoproteins and apolipoprotein E polymorphism. Stroke. 1992;23: 1556-1562.
14. Couderc R, Mahieux F, Bailleul S, Fenelon G, Mary R, Fermania J. Prevalence of apolipoprotein E phenotypes in ischemic cerebrovascular disease: a case-control study. Stroke. 1993;24:661-664.
15. Coria F, Rubio I, Nunez E, Sempere AP, Santa Engrazia N, Bayon C, Cuadrado N. Apolipoprotein E variants in ischemic stroke. Stroke. 1995; 26:2375-2376.
16. Kuusisto J, Mikkanen L, Kervinen K, Kesaniemi YA, Laakso M. Apolipoprotein E4 phenotype is not an important risk factor for coronary disease or stroke in elderly subjects. Arterioscler Thromb Vasc Biol. 1995;15:1280-1286.
17. Basun H, Corder EH, Guo Z, Lannfelt L, Corder LS, Manton KG, Winblad B, Viitanen N. Apolipoprotein E polymorphism and stroke in a population aged 75 years or more. Stroke. 1996;27:1310-1315.
18. Margaglione M, Seripa D, Gravin C, Grandone E, Vecchione G, Cappaucci G, Mrela G, Papa S, Postiglione A, Di Minno G, Fazio VM. Prevalence of apolipoprotein E alleles in healthy subjects and survivors of ischemic stroke: an Italian case-control study. Stroke. 1998;29:399-403.
19. Boon A, Lodder J, Heuts-van Raak L, Kessels F. Silent brain infarcts in 755 consecutive patients with first-ever supratentorial ischemic stroke: relationship with index-stroke subtype, vascular risk factors, and mortality. Stroke. 1994;25:2384-2390.
20. Ezekowitz MD, James KE, Nazarian SM, Davenport J, Broderick JP, Gupta SR, Thadani V, Meyer ML, Bridgers SL. Silent cerebral infarction in patients with nonrheumatic atrial fibrillation. Circulation. 1995;92: 2178-2182.
21. Jorgensen HS, Nakayama H, Raaschou HO, Gam J, Olsen TS. Silent infarction in acute stroke patients: prevalence, localization, risk factors, and clinical significance: the Copenhagen Stroke Study. Stroke. 1994;25: 97-104.
22. DeCarli C, Murphy DGM, Tran M, Grady CL, Haxby JV, Gillette JA, Salerno JA, Gonzales-Aviles A, Horwitz B, Rapoport SI, Schapiro MB. The effect of white matter hyperintensity volume on brain structure, cognitive performance and cerebral metabolism in 51 healthy adults. Neurology. 1995;45:2077-2084.
23. Yue NC, Arnold AM, Longstreth WT, Elster AD, Jungreis CA, O'Leary DH, Poirier VC, Bryan RN. Sulcal, ventricular, and white matter changes at MR imaging in the aging brain: data from the Cardiovascular Health Study. Neuroradiology. 1997;202:33-39.
24. Manolio TA, Kronmal RA, Burke GL, Poirier V, O'Leary DH, Gardin JM, Fried LP, Steinberg EP, Bryan RN. Magnetic resonance abnormalities and cardiovascular disease in older adults: the Cardiovascular Health Study. Stroke. 1994;25:318-327.
25. Liao D, Cooper L, Cai J, Toole JF, Bryan RN, Hutchinson RG, Tyroler HA. Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control: the ARIC Study. Stroke. 1996;27: 2262-2270.
26. Strassburger TL, Lee HC, Daly E, Szczepanik MR, Krasuski J, Mentis MJ, Salerno JA, DeCarli C, Schapiro MB, Alexander GE. Interactive effects of age and hypertension on volumes of brain structures. Stroke. 1997;28:1410-1417.
27. Salerno JA, Murphy DGM, Horwitz B, DeCarli C, Haxby JV, Rapoport SI, Schapiro MB. Brain atrophy in older hypertensive men: a volumetric magnetic resonance study. Hypertension. 1992;20:340-348.
28. Jablon S, Neel JV, Gershowitz H, Atkinson GF. The NAS-NRC twin panel: methods of construction of the panel, zygosity diagnosis and proposed use. Am J Hum Genet. 1967;19:133-161.
29. Feinleib M, Garrison RJ, Fabsitz RR, Christian JC, Hrubec Z, Borhani NO, Kannel WB, Rosenman RR, Schwartz JT, Wagner JO. The NHLBI Twin Study of cardiovascular risk factors: methodology and summary of results. Am J Epidemiol. 1977;106:284-295.
30. Reed T, Quiroga J, Selby JV, Carmelli D, Christian JC, Fabsitz RR, Grim CE. Concordance of ischemic heart disease in the NHLBI Twin Study after 14-18 years of follow-up. J Clin Epidemiol. 1991;44:797-805.
31. DeCarli C, Maisog J, Murphy DGM, Teichberg D, Rapoport SI, Horwitz B. Method for quantification of brain, central and subarachnoid CSF volumes from magnetic resonance images. J Comput Assist Tomogr. 1992;16:274-284.
32. DeCarli C, Murphy DGM, Teichberg D, Campbell G, Sobering GS. Local histogram correction of MRI spatially dependent image pixel intensity nonuniformity. J Magn Reson Imaging. 1996;6:519-528.
33. Murphy DGM, DeCarli C, Schapiro MB, Rapoport SI, Horwitz B. Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Arch Neurol. 1992;49:839-845.
34. Hixon JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal. J Lipid Res. 1990;3: 545-548.
35. Schachter F, Faure-Delanef L, Guenot F, Rouger H, Froguel P, Lesueur-Ginot L, Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nat Genet. 1994;6:29-32.
36. Efron B, Tibshirani R. Bootstrap methods for standard errors, confidence intervals and other measures of statistical accuracy. Stat Sci. 1986;1: 54-77.
37. DeCarli C, Miller BL, Swan GE, Reed T, Wolf PA, Jack LM, Carmelli D. Predictors of brain morphology among the men of the NHLBI Twin Study. Stroke. 1999;30:529-536.
38. Longstreth WT, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, Enright PL, O'Leary D, Fried L. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people: the Cardiovascular Health Study. Stroke. 1996;27:1274-1282.
39. Kurumatani T, Kudo T, Ikura Y, Taked M. White matter changes in the gerbil brain under chronic cerebral hypoperfusion. Stroke. 1998;29: 1058-1062.
40. Mentis MJ, Salerno J, Horwitz B, Grady C, Schapiro MB, Murphy DG, Rapoport SI. Reduction of functional neuronal connectivity in long-term treated hypertension. Stroke. 1994;25:601-607.
41. Tajima A, Hans FJ, Livingstone D, Wei L, Finnegan W, Demarco J, Fenstermacher J. Smaller local brain volumes and cerebral atrophy in spontaneously hypertensive rats. Hypertension. 1993;21:105-111.
42. Moody DM, Bell MA, Challa VA. Features of the cerebral vascular pattern that predict vulnerability to perfusion or oxygenation deficiency: an anatomic study. AJNR Am J Neuroradiol. 1990;11:431-439.
43. Moody DM, Santamore WP, Bell MA. Does tortuosity in cerebral arterioles impair down autoregulation in hypertensives and elderly normotensives? A hypothesis and computer model. Clin Neurosurg. 1991 ;37: 372-387.
44. Chen Y, Lomnitski L, Michaelson DM, Shohami E. Motor and cognitive deficits in apolipoprotein e-deficient mice after closed head injury. Neuroscience. 1997;80:1255-1262.
45. Jack CR, Petersen RC, Xu YC, O'Brien PC, Waring SC, Tangalos EG, Smith GE, Ivnik RJ, Thibodeau SN, Kokmen E. Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol. 1998;43:303-310.
46. Soininen H, Partanen K, Pitkanen A, Hallikainen M, Hanninen T, Helisalmi S, Mannermaa A, Ryynanen M Koivisto K, Riekkinen P. Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ∈4 allele. Neurology. 1995; 45:391-392.
47. Kozachuck WE, DeCarli C, Horwitz B, Schapiro MB, Rapoport SI. White matter hyperintensities in dementia of the Alzheimer type and in healthy subjects without cerebrovascular risk factors: a magnetic resonance study. Arch Neurol. 1990;47:1306-1310.
48. Schmidt H, Schmidt R, Fazekas F, Semmler J, Kapeller P, Reinhart B, Kostner GM. Apolipoprotein E e4 allele in the normal elderly: neuropsychologic and brain MRI correlates. Clin Genet. 1996;50:293-299.
49. Schmidt R, Schmidt H, Fazekas F, Schumacher M, Niederkorn K, Kapeller P, Weinrauch V, Kostner GM. Apolipoprotein E polymorphism and silent microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study. Stroke. 1997;28:951-956.
50. Kuller LH, Shemanski L, Manolio T, Haan M, Fried L, Bryan N, Burke G, Tracy R, Bhadelia R. Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Stroke. 1998;29: 388-398.
51. Ferrucci L, Guralnik JM, Pahor M, Harris T, Corti MC, Hyman B, Wallace RB, Havlik R. Apolipoprotein E ∈2 allele and risk of stroke in the older population. Stroke. 1997;28:2410-2416.