Enhanced transgene expression in cord blood CD34+-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified TRIP lentiviral vectors

Molecular Therapy

Volumn 3, Issue 4, 2001, Pages 438-448

  Sirven, Aude ^a   Ravet, Emmanuel ^a   Charneau, Pierre ^b   Zennou, Véronique ^b   Coulombel, Laure ^a   Guétard, Denise ^b   Pflumio, Françoise ^a   Dubart Kupperschmitt, Anne ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b INSTITUT PASTEUR   (France)

Author keywords

Central DNA flap; EF1 promoter; Gene transfer; Human hematopoietic stem cells; Lentiviral vectors; NOD SCID mouse repopulating cells; T cell differentiation; Transgene expression

Indexed keywords

CD34 ANTIGEN; ELONGATION FACTOR 1ALPHA; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; BIOTECHNOLOGY; BONE MARROW CELL; CELL DIVISION; CELL MATURATION; CELL POPULATION; CONTROLLED STUDY; DNA VECTOR; GENE DELETION; GENE EXPRESSION; GENE TRANSFER; GENETIC CONSERVATION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRINAE; LONG TERMINAL REPEAT; MOUSE; NATURAL KILLER CELL; NONHUMAN; PROMOTER REGION; REVERSE TRANSCRIPTION; SCID MOUSE; T LYMPHOCYTE; TRANSGENE; UMBILICAL CORD BLOOD;

ANIMALIA; CUCUMBER MOSAIC VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS;

EID: 0034985720     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2001.0282     Document Type: Article

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