Expression of a retrovirally transduced gene under control of an internal housekeeping gene promoter does not persist due to methylation and is restored partially by 5-azacytidine treatment

Gene Therapy

Volumn 5, Issue 10, 1998, Pages 1299-1305

  Kuriyama, S ^a   Sakamoto, T ^a   Kikukawa, M ^a   Nakatani, T ^a   Toyokawa, Y ^a   Tsujinoue, H ^a   Ikenaka, K ^b   Fukui, H ^a   Tsujii, T ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

5 azacytidine; Gene therapy; Internal promoter; Methylation; Retrovirus; Thymidine kinase

Indexed keywords

ALBUMIN; AZACITIDINE; GANCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DRUG RESISTANCE; EXPRESSION VECTOR; FEMALE; GENE EXPRESSION; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HOUSEKEEPING GENE; LIVER CELL CARCINOMA; LONG TERMINAL REPEAT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECOMBINANT GENE; RETROVIRUS; SOUTHERN BLOTTING; TRANSGENE; VIRUS GENE;

EID: 0031787122     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300738     Document Type: Article

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