Retrovirus-mediated gene transfer into human CD34+ 38(low) primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo

Human Gene Therapy

Volumn 9, Issue 10, 1998, Pages 1497-1511

  Marandin, Aliette ^a   Dubart, Anne ^a   Pflumio, Francoise ^a   Cosset, Francois Loic ^b   Cordette, Veronique ^a   Chapel Fernandes, Sylvie ^b   Coulombel, Laure ^a   Vainchenker, William ^a   Louache, Fawzia ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN; CYTOKINE; INTERLEUKIN 3; INTERLEUKIN 6; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL CULTURE; COLONY FORMING UNIT C; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DIABETES MELLITUS; EXPRESSION VECTOR; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; RETROVIRUS; SCID MOUSE; UMBILICAL CORD BLOOD;

EID: 0032126897     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.10-1497     Document Type: Article

References (9)

1. BAUM, C.M., WEISSMAN, I.L., TSUKAMOTO, A.S., BUCKLE, A.-M, and PEAULT, B. (1992). Isolation of a candidate human hematopoietic stem-cell population. Proc. Natl. Acad. Sci. U.S.A. 89, 2804-2808.
2. BELMONT, J.W., MACGREGOR, G.R., WAGER-SMITH, K., FLETCHER, F.A., MOORE, K.A., HAWKINS, D., VILLALON, D., CHANG, S.M.-W., and CASKEY, C.T. (1988). Expression of human adenosine deaminase in murine hematopoietic cells. Mol. Cell. Biol. 8, 5116-5125.
3. BIENZLE, D., ABRAMS-OGG, A.C.G., KRUTH, S.A., ACKLAND-SNOW, J., CARTER, R.F., DICK, J.E., JACOBS, R.M., KAMEL-REID, S., and DUBÉ, I.D. (1994). Gene transfer into hematopoietic stem cells: Long-term maintenance of in vitro activated progenitors without marrow ablation. Proc. Natl. Acad. Sci. U.S.A. 91, 350-354.
4. + bone marrow cells. Blood 82, 1975-1980.
5. BRENNER, M.K., RILL, D.R., HOLLADAY, M.S., HESLOP, H.E., MOEN, R.C., BUSCHLE, M., KRANCE, R.A., SANTANA, V.N., ANDERSON, W.F., and IHLE, J.N. (1993a). Gene marking to determine whether autologous marrow infusion restores long-term haemopoiesis in cancer patients. Lancet 342, 1134-1137.
6. BRENNER, M.K., RILL, D.R., MOEN, R.C., KRANCE, R.A., MIRRO, J., JR., ANDERSON, W.F., and IHLE, J.N. (1993b). Genemarking to trace origin of relapse after autologous bone-marrow transplantation. Lancet 341, 85-86.
7. CARTER, R.F., ABRAMS-OGG, A.C.G., DICK, J.E., KRUTH, S.A., VALLI, V.E., KAMEL-REID, S., and DUBÉ, I.D. (1992). Autologous transplantation of canine long-term marrow culture cells genetically marked by retroviral vectors. Blood 79, 356-364.
8. CASSEL, A., COTTLER-FOX, M., DOREN, S., and DUNBAR, C.E. (1993). Retroviral-mediated gene transfer into CD34-enriched human peripheral blood stem cells. Exp. Hematol. 21, 585-591.
9. CHANG, J.M., and JOHNSON, G.R. (1989). Gene transfer into hemopoietic cells using retroviral vectors. Int. J. Cell Cloning 7, 264-280.