Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)

RNA

Volumn 7, Issue 6, 2001, Pages 819-832

  Wollerton, M C ^a   Gooding, C ^a   Robinson, F ^a   Brown, E C ^a   Jackson, R J ^a   Smith, C W J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Alternative splicing; Gene regulation; nPTB; Pre mRNA splicing; PTB

Indexed keywords

ALPHA ACTININ; POLYPYRIMIDINE TRACT BINDING PROTEIN; RNA BINDING PROTEIN; TROPOMYOSIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; EXON; GENE CONTROL; GENE INSERTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; RNA PROCESSING; RNA TRANSLATION; TRANSLATION INITIATION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; EXONS; MOLECULAR SEQUENCE DATA; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTEIN BIOSYNTHESIS; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; RIBONUCLEOPROTEINS; RNA PRECURSORS; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 0034977633     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838201010214     Document Type: Article

References (62)

1. Identification of a functional mammalian spliceosome containing unspliced pre-mRNA
2. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific counterpart
3. Translation initiation on picornavirus RNA
4. Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization
5. hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing
6. An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein
7. Directing alternative splicing: Cast and scenarios
8. The polypyrimidine tract binding protein binds upstream of the neural-specific c-src exon N1 to repress splicing of the intron downstream
9. Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene
10. hnRNP H is a component of a splicing enhancer complex that activates a c-src alternative exon in neuronal cells
11. Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing
12. Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold
13. The regulation of splice-site selection, and its role in human disease
14. A Xenopus protein related to hnRNP I has a role in cytoplasmic RNA localization
15. hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer
16. The superfamily of arginine/serine-rich splicing factors
17. Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns
18. hnRNP I, the polypyrimidine tract-binding protein: Distinct nuclear localization and association with hnRNAs
19. Characterization of cDNAs encoding the polypyrimidine tract-binding protein
20. Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon
21. Role of an inhibitory pyrimidine-element and general pyrimidine-tract binding proteins in regulation of α-tropomyosin alternative splicing
22. Splicing regulation in neurons: Tinkering with cell-specific control
23. Sorting out the complexity of SR protein functions
24. The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points
25. Alternative splicing of human genes more the rule than the exception
26. Unr, a cellular cytoplasmic RNA-binding protein with five cold shock domains, is required for internal initiation of translation of human rhinovirus RNA
27. Polypyrimidine-tract binding protein (PTB) is necessary, but not sufficient, for efficient internal initiation of translation of human rhinovirus-2 RNA
28. A comparative view of initiation site selection mechanisms
29. Alternative splicing and programmed cell death
30. Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiform tumors
31. Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA
32. hnRNP complexes: Composition, structure, and function
33. Regulation of alternative 3′ splice site selection by constitutive splicing factors
34. Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation
35. Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3′-terminal exon
36. SR proteins and splicing control
37. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein
38. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event
39. Frequent alternative splicing of human genes
40. The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3′ end formation by two distinct mechanisms
41. Alpha-tropomyosin mutually exclusive exon selection: Competition between branchpoint/polypyrimidine tracts determines default exon choice
42. Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA
43. Polypyrimidine tract sequences direct selection of alternative branch sites and influence protein binding
44. Determination of functional domains in polypyrimidine-tract-binding protein
45. Characterization and molecular cloning of polypyrimidine tract-binding protein: A component of a complex necessary for pre-mRNA splicing
46. Mutation of PTB binding sites causes misregulation of alternative 3′ splice site selection in vivo
47. Multiple RRMs contribute to RNA binding specificity and affinity for polypyrimidine tract binding protein
48. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing
49. Smooth muscle alternative splicing induced in fibroblasts by heterologous expression of a regulatory gene
50. Development and characterization of a cloned rat pulmonary arterial smooth muscle cell line that maintains differentiated properties through multiple subcultures
51. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
52. Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins
53. Mutually exclusive splicing of alpha-tropomyosin exons enforced by an unusual lariat branch point location: Implications for constitutive splicing
54. Alternative pre-mRNA splicing: The logic of combinatorial control
55. Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutually exclusive exons
56. Determinants of SR protein specificity
57. Post-transcriptional regulation: The dawn of PTB
58. The protein Sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA
59. A novel isoform ratio switch of the polypyrimidine tract binding protein
60. The Sex-lethal amino terminus mediates cooperative interactions in RNA binding and is essential for splicing regulation
61. Isolation of a mammalian homologue of a fission yeast differentiation regulator
62. Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB