메뉴 건너뛰기




Volumn 68, Issue 2, 1997, Pages 578-586

Ethanol promotes apoptosis in cerebellar granule cells by inhibiting the trophic effect of NMDA

Author keywords

Apoptosis; Cerebellar granule cells; Ethanol; Glycine; Intracellular Ca2+; NMDA receptor

Indexed keywords

CALCIUM ION; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 0031033269     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68020578.x     Document Type: Article
Times cited : (125)

References (52)
  • 1
    • 0020380822 scopus 로고
    • Morphological development of the rat cerebellum and a source of its mechanism
    • (Chan Palay V. and Palay S., eds), Springer-Verlag, Berlin
    • Altman J. (1982) Morphological development of the rat cerebellum and a source of its mechanism, in The Cerebellum: New Vistas (Chan Palay V. and Palay S., eds), pp. 8-49. Springer-Verlag, Berlin.
    • (1982) The Cerebellum: New Vistas , pp. 8-49
    • Altman, J.1
  • 2
    • 0023804295 scopus 로고
    • N-Methyl-D-aspartate promotes the survival of cerebellar granule cells in culture
    • Balázs R., Jørgensen O. S., and Hack N. (1988) N-Methyl-D-aspartate promotes the survival of cerebellar granule cells in culture. Neuroscience 27, 437-451.
    • (1988) Neuroscience , vol.27 , pp. 437-451
    • Balázs, R.1    Jørgensen, O.S.2    Hack, N.3
  • 3
    • 0029787119 scopus 로고    scopus 로고
    • Mechanism of ethanol inhibition of NMDA receptor function in primary cultures of cerebral cortical cells
    • Bhave S. V., Snell L. D., Tabakoff B., and Hoffman P. L. (1996) Mechanism of ethanol inhibition of NMDA receptor function in primary cultures of cerebral cortical cells. Alcohol. Clin. Exp. Res. 20, 934-941.
    • (1996) Alcohol. Clin. Exp. Res. , vol.20 , pp. 934-941
    • Bhave, S.V.1    Snell, L.D.2    Tabakoff, B.3    Hoffman, P.L.4
  • 4
    • 0025779231 scopus 로고
    • Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt
    • Bonthius D. J. and West J. R. (1991) Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt. Teratology 44, 47-163.
    • (1991) Teratology , vol.44 , pp. 47-163
    • Bonthius, D.J.1    West, J.R.2
  • 5
    • 0028799959 scopus 로고
    • Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes
    • Buller A. L., Larson H. C, Morrisett R. A., and Monaghan D. T. (1995) Glycine modulates ethanol inhibition of heteromeric N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Mol. Pharmacol. 48, 717-723.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 717-723
    • Buller, A.L.1    Larson, H.C.2    Morrisett, R.A.3    Monaghan, D.T.4
  • 7
    • 0027993025 scopus 로고
    • Cyclic AMP and ethanol interact to control apoptosis and differentiation in hypothalamic β-endorphin neurons
    • De A., Boyadjieva N. I., Pastorcic M., Reddy B. V., and Sarkar D. K. (1994) Cyclic AMP and ethanol interact to control apoptosis and differentiation in hypothalamic β-endorphin neurons. J. Biol. Chem. 269, 26697-26705.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26697-26705
    • De, A.1    Boyadjieva, N.I.2    Pastorcic, M.3    Reddy, B.V.4    Sarkar, D.K.5
  • 9
    • 0015886330 scopus 로고
    • Quantitative growth and development of human brain
    • Dobbing J. and Sands J. (1973) Quantitative growth and development of human brain. Arch. Dis. Child. 48, 757-767.
    • (1973) Arch. Dis. Child. , vol.48 , pp. 757-767
    • Dobbing, J.1    Sands, J.2
  • 10
    • 0028468558 scopus 로고
    • Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual
    • Enright H., Hebbel R. P., and Nath K. A. (1994) Internucleosomal cleavage of DNA as the sole criterion for apoptosis may be artifactual. J. Lab. Clin. Med. 124, 63-68.
    • (1994) J. Lab. Clin. Med. , vol.124 , pp. 63-68
    • Enright, H.1    Hebbel, R.P.2    Nath, K.A.3
  • 11
    • 0029129678 scopus 로고
    • Induction of neuronal apoptosis by excitotoxins associated with long-lasting increase of 12-O-tetradecanoylphorbol 13-acetate-responsive element-binding activity
    • Finiels F., Robert J.-J., Samolyk M.-L., Privat A., Mallet J., and Revah F. (1995) Induction of neuronal apoptosis by excitotoxins associated with long-lasting increase of 12-O-tetradecanoylphorbol 13-acetate-responsive element-binding activity. J. Neurochem. 65, 1027-1034.
    • (1995) J. Neurochem. , vol.65 , pp. 1027-1034
    • Finiels, F.1    Robert, J.-J.2    Samolyk, M.-L.3    Privat, A.4    Mallet, J.5    Revah, F.6
  • 12
    • 0023244774 scopus 로고
    • The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
    • Gallo V., Kingsbury A., Balázs R., and Jørgensen O. S. (1987) The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7, 2203-2213.
    • (1987) J. Neurosci. , vol.7 , pp. 2203-2213
    • Gallo, V.1    Kingsbury, A.2    Balázs, R.3    Jørgensen, O.S.4
  • 15
    • 0001817507 scopus 로고
    • Ethanol-like discriminative stimulus effects of non-competitive N-methyl-D-aspartate antagonists
    • Grant K. A., Knisely J. S., Tabakoff B., Barrett J. E., and Balster R. L. (1991) Ethanol-like discriminative stimulus effects of non-competitive N-methyl-D-aspartate antagonists. Behav. Pharmacol. 2, 87-95.
    • (1991) Behav. Pharmacol. , vol.2 , pp. 87-95
    • Grant, K.A.1    Knisely, J.S.2    Tabakoff, B.3    Barrett, J.E.4    Balster, R.L.5
  • 18
    • 0024348985 scopus 로고
    • N-Methyl-D-aspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production
    • Hoffman P. L., Rabe C. S., Moses F., and Tabakoff B. (1989) N-Methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J. Neurochem. 52, 1937-1940.
    • (1989) J. Neurochem. , vol.52 , pp. 1937-1940
    • Hoffman, P.L.1    Rabe, C.S.2    Moses, F.3    Tabakoff, B.4
  • 20
    • 0027076781 scopus 로고
    • Chronic exposure of cerebellar granule cells to ethanol results in increased NMDA receptor function
    • Iorio K. R., Reinlib L., Tabakoff B., and Hoffman P. L. (1992) Chronic exposure of cerebellar granule cells to ethanol results in increased NMDA receptor function. Mol. Pharmacol. 41, 1142-1148.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 1142-1148
    • Iorio, K.R.1    Reinlib, L.2    Tabakoff, B.3    Hoffman, P.L.4
  • 21
    • 0027248420 scopus 로고
    • Glutamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol
    • Iorio K. R., Tabakoff B., and Hoffman P. L. (1993) Glutamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol. Eur. J. Pharmacol. 248, 209-212.
    • (1993) Eur. J. Pharmacol. , vol.248 , pp. 209-212
    • Iorio, K.R.1    Tabakoff, B.2    Hoffman, P.L.3
  • 22
    • 0029132805 scopus 로고
    • Opposite effect of protein synthesis inhibitors on potassium deficiency-induced apoptotic cell death in immature and mature neuronal cultures
    • Kharlamov E., Cagnoli C. M., Atabay C., Ikonomović S., Grayson D. R., and Manev H. (1995) Opposite effect of protein synthesis inhibitors on potassium deficiency-induced apoptotic cell death in immature and mature neuronal cultures. J. Neurochem. 65, 1395-1398.
    • (1995) J. Neurochem. , vol.65 , pp. 1395-1398
    • Kharlamov, E.1    Cagnoli, C.M.2    Atabay, C.3    Ikonomović, S.4    Grayson, D.R.5    Manev, H.6
  • 23
    • 0025166533 scopus 로고
    • Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid-and picrotoxin-induced convulsions in rats
    • Kulkarni S. K., Mehta A. K., and Ticku M. K. (1990) Comparison of anticonvulsant effect of ethanol against NMDA-, kainic acid-and picrotoxin-induced convulsions in rats. Life Sci. 46, 481-487.
    • (1990) Life Sci. , vol.46 , pp. 481-487
    • Kulkarni, S.K.1    Mehta, A.K.2    Ticku, M.K.3
  • 24
    • 0027717219 scopus 로고
    • Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes
    • Kuner T., Schoepfer R., and Korpi E. R. (1993) Ethanol inhibits glutamate-induced currents in heteromeric NMDA receptor subtypes. Neuroreport 5, 297-300.
    • (1993) Neuroreport , vol.5 , pp. 297-300
    • Kuner, T.1    Schoepfer, R.2    Korpi, E.R.3
  • 27
    • 0028081936 scopus 로고
    • Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits
    • Masood K., Wu C., Brauneis U., and Weight F. F. (1994) Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol. Pharmacol. 45, 324-329.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 324-329
    • Masood, K.1    Wu, C.2    Brauneis, U.3    Weight, F.F.4
  • 28
    • 0002335810 scopus 로고
    • Effects of prenatal exposure to ethanol on cell proliferation and neuronal migration
    • (Miller M., ed), Wiley-Liss, New York
    • Miller M. W. (1992) Effects of prenatal exposure to ethanol on cell proliferation and neuronal migration, in Development of the Central Nervous System: Effects of Alcohol and Opiates (Miller M., ed), pp. 47-69. Wiley-Liss, New York.
    • (1992) Development of the Central Nervous System: Effects of Alcohol and Opiates , pp. 47-69
    • Miller, M.W.1
  • 30
    • 0028892742 scopus 로고
    • Permanent neuronal cell loss in the cerebellum of rats exposed to continuous low blood alcohol levels during the brain growth spurt: A stereological investigation
    • Napper R. M. A. and West J. R. (1995) Permanent neuronal cell loss in the cerebellum of rats exposed to continuous low blood alcohol levels during the brain growth spurt: a stereological investigation. J. Comp. Neurol. 362, 283-292.
    • (1995) J. Comp. Neurol. , vol.362 , pp. 283-292
    • Napper, R.M.A.1    West, J.R.2
  • 31
    • 0026695401 scopus 로고
    • N-Methyl-D-aspartate responses in rat cerebellar granule cells are modified by chronic depolarisation in culture
    • Pearson H., Graham M. E., and Burgoyne R. D. (1992) N-Methyl-D-aspartate responses in rat cerebellar granule cells are modified by chronic depolarisation in culture. Neurosci. Lett. 142, 27-30.
    • (1992) Neurosci. Lett. , vol.142 , pp. 27-30
    • Pearson, H.1    Graham, M.E.2    Burgoyne, R.D.3
  • 32
    • 0026501791 scopus 로고
    • Ethanol inhibition of N-methyl-D-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine
    • Peoples R. W. and Weight F. F. (1992) Ethanol inhibition of N-methyl-D-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycine. Brain Res. 571, 342-344.
    • (1992) Brain Res. , vol.571 , pp. 342-344
    • Peoples, R.W.1    Weight, F.F.2
  • 33
    • 0024427802 scopus 로고
    • Differential neuronal loss following early postnatal alcohol exposure
    • Pierce D. R., Goodlett C. R., and West J. R. (1989) Differential neuronal loss following early postnatal alcohol exposure. Teratology 40, 113-126.
    • (1989) Teratology , vol.40 , pp. 113-126
    • Pierce, D.R.1    Goodlett, C.R.2    West, J.R.3
  • 34
    • 0025684618 scopus 로고
    • Glycine site directed agonists reverse ethanol's actions at the NMDA receptor
    • Rabe C. S. and Tabakoff B. (1990) Glycine site directed agonists reverse ethanol's actions at the NMDA receptor. Mol. Pharmacol. 38, 753-757.
    • (1990) Mol. Pharmacol. , vol.38 , pp. 753-757
    • Rabe, C.S.1    Tabakoff, B.2
  • 37
    • 0025237702 scopus 로고
    • Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex
    • Singh L., Oles R. J., and Tricklebank M. D. (1990) Modulation of seizure susceptibility in the mouse by the strychnine-insensitive glycine recognition site of the NMDA receptor/ion channel complex. Br. J. Pharmacol. 99, 285-288.
    • (1990) Br. J. Pharmacol. , vol.99 , pp. 285-288
    • Singh, L.1    Oles, R.J.2    Tricklebank, M.D.3
  • 38
    • 0028324377 scopus 로고
    • Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells
    • Snell L. D., Iorio K. R., Tabakoff B., and Hoffman P. L. (1994a) Protein kinase C activation attenuates N-methyl-D-aspartate-induced increases in intracellular calcium in cerebellar granule cells J. Neurochem. 62, 1783-1789.
    • (1994) J. Neurochem. , vol.62 , pp. 1783-1789
    • Snell, L.D.1    Iorio, K.R.2    Tabakoff, B.3    Hoffman, P.L.4
  • 39
    • 0028299735 scopus 로고
    • Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells
    • Snell L. D., Tabakoff B., and Hoffman P. L. (1994b) Involvement of protein kinase C in ethanol-induced inhibition of NMDA receptor function in cerebellar granule cells. Alcohol. Clin. Exp. Res. 37, 81-85.
    • (1994) Alcohol. Clin. Exp. Res. , vol.37 , pp. 81-85
    • Snell, L.D.1    Tabakoff, B.2    Hoffman, P.L.3
  • 40
    • 0028931374 scopus 로고
    • Quantitative changes in G proteins do not mediate ethanol-induced downregulation of adenylyl cyclase in mouse cerebral cortex
    • Tabakoff B., Whelan J. P., Ovchinnikova L., Nhamburo P., Yosnimura M., and Hoffman P. L. (1995) Quantitative changes in G proteins do not mediate ethanol-induced downregulation of adenylyl cyclase in mouse cerebral cortex. Alcohol. Clin. Exp. Res. 19, 187-194.
    • (1995) Alcohol. Clin. Exp. Res. , vol.19 , pp. 187-194
    • Tabakoff, B.1    Whelan, J.P.2    Ovchinnikova, L.3    Nhamburo, P.4    Yosnimura, M.5    Hoffman, P.L.6
  • 41
    • 0026557050 scopus 로고
    • In vivo modulation of N-methyl-D-aspartate receptor-dependent long-term potentiation by the glycine modulatory site
    • Thiels E., Weisz D. J., and Berger T. W. (1992) In vivo modulation of N-methyl-D-aspartate receptor-dependent long-term potentiation by the glycine modulatory site. Neuroscience 46, 501 -590.
    • (1992) Neuroscience , vol.46 , pp. 501-590
    • Thiels, E.1    Weisz, D.J.2    Berger, T.W.3
  • 42
    • 0022471749 scopus 로고
    • Regional distribution and extracellular level of amino acids in rat central nervous system
    • Tossman U., Jonsson G., and Ungerstedt U. (1986) Regional distribution and extracellular level of amino acids in rat central nervous system. Acta Physiol. Scand. 127, 533-545.
    • (1986) Acta Physiol. Scand. , vol.127 , pp. 533-545
    • Tossman, U.1    Jonsson, G.2    Ungerstedt, U.3
  • 43
    • 0028946358 scopus 로고
    • Calcium-mediated cell injury and cell death
    • Trump B. F. and Berezesky I. K. (1995) Calcium-mediated cell injury and cell death. FASEB J. 9, 219-228.
    • (1995) FASEB J. , vol.9 , pp. 219-228
    • Trump, B.F.1    Berezesky, I.K.2
  • 44
    • 0019797712 scopus 로고
    • Blood ethanol levels in sober alcohol users seen in an emergency room
    • Urso T., Gavaler J. S., and Van Thiel D. H. (1981) Blood ethanol levels in sober alcohol users seen in an emergency room. Life Sci. 28, 1053-1056.
    • (1981) Life Sci. , vol.28 , pp. 1053-1056
    • Urso, T.1    Gavaler, J.S.2    Van Thiel, D.H.3
  • 45
    • 0029077393 scopus 로고
    • NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain
    • Van Lookeren Campagne M., Lucassen P. J., Vermeulen J. P., and Balázs R. (1995) NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain. Eur. J. Neurosci. 7, 1627-1640.
    • (1995) Eur. J. Neurosci. , vol.7 , pp. 1627-1640
    • Van Lookeren Campagne, M.1    Lucassen, P.J.2    Vermeulen, J.P.3    Balázs, R.4
  • 46
    • 0029005919 scopus 로고
    • Ethanol inhibits NMDA-induced toxicity and trophism in cultured cerebellar granule cells
    • Wegelius K. and Korpi E. R. (1995) Ethanol inhibits NMDA-induced toxicity and trophism in cultured cerebellar granule cells. Acta Physiol. Scand. 154, 25-34.
    • (1995) Acta Physiol. Scand. , vol.154 , pp. 25-34
    • Wegelius, K.1    Korpi, E.R.2
  • 47
    • 0025689121 scopus 로고
    • Cell population depletion associated with fetal alcohol brain damage: Mechanisms of BAC-dependent cell loss
    • West J. R., Goodlett C. R., Bonthius D. J., Hambre K. M., and Marcussen B. L. (1990) Cell population depletion associated with fetal alcohol brain damage: mechanisms of BAC-dependent cell loss. Alcohol. Clin. Exp. Res. 14, 813-818.
    • (1990) Alcohol. Clin. Exp. Res. , vol.14 , pp. 813-818
    • West, J.R.1    Goodlett, C.R.2    Bonthius, D.J.3    Hambre, K.M.4    Marcussen, B.L.5
  • 48
    • 0029077601 scopus 로고
    • The co-agonist concept: Is the NMDA-associated glycine receptor saturated in vivo?
    • Wood P. L. (1995) The co-agonist concept: is the NMDA-associated glycine receptor saturated in vivo? Life Sci. 57, 301-310.
    • (1995) Life Sci. , vol.57 , pp. 301-310
    • Wood, P.L.1
  • 49
    • 0028047489 scopus 로고
    • A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices
    • Woodward J. J. (1994) A comparison of the effects of ethanol and the competitive glycine antagonist 7-chlorokynurenic acid on N-methyl-D-aspartic acid-induced neurotransmitter release from rat hippocampal slices. J. Neurochem. 62, 987-991.
    • (1994) J. Neurochem. , vol.62 , pp. 987-991
    • Woodward, J.J.1
  • 50
    • 0025019986 scopus 로고
    • Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from striatal slices: Reversal by glycine
    • Woodward J. J. and Gonzales R. A. (1990) Ethanol inhibition of N-methyl-D-aspartate-stimulated endogenous dopamine release from striatal slices: reversal by glycine. J. Neurochem. 54, 712-715.
    • (1990) J. Neurochem. , vol.54 , pp. 712-715
    • Woodward, J.J.1    Gonzales, R.A.2
  • 51
    • 0028133050 scopus 로고
    • Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons
    • Yan G., Ni B., Weller M., Wood K. A., and Paul S. M. (1994) Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res. 656, 43-51.
    • (1994) Brain Res. , vol.656 , pp. 43-51
    • Yan, G.1    Ni, B.2    Weller, M.3    Wood, K.A.4    Paul, S.M.5
  • 52
    • 0028946296 scopus 로고
    • Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons
    • Yan G.-M., Lin S.-Z., Irwin R. P., and Paul S. M. (1995) Activation of muscarinic cholinergic receptors blocks apoptosis of cultured cerebellar granule neurons. Mol. Pharmacol. 47, 248-257.
    • (1995) Mol. Pharmacol. , vol.47 , pp. 248-257
    • Yan, G.-M.1    Lin, S.-Z.2    Irwin, R.P.3    Paul, S.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.