Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts

Oncogene

Volumn 19, Issue 12, 2000, Pages 1529-1537

  Plyte, Simon ^a,c   Majolini, M Bernardetta ^a   Pacini, Sonia ^a   Scarpini, Francesca ^a   Bianchini, Cinzia ^a   Lanfrancone, Luisa ^b   Pelicci, Piergiuseppe ^b   Baldari, Cosima T ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c PFIZER INC   (United States)

Author keywords

Lipid raft; Membrane localization; Ras; Shc adaptor; TCR

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; LIPID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; RAS PROTEIN;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CHIMERA; CYTOSOL; ENZYME ACTIVATION; GENE TARGETING; MEMBRANE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 0034673718     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1203451     Document Type: Article

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