Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice

Pharmaceutical Research

Volumn 18, Issue 2, 2001, Pages 183-190

  Cisternino, Salvatore ^a   Rousselle, Christophe ^a   Dagenais, Claude ^b   Scherrmann, Jean Michel ^a,c  

^a HÔPITAL FERNAND WIDAL   (France)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c Faculte de Pharmacie   (France)

Author keywords

Blood brain barrier; In situ brain perfusion; mdr1a( ) mice; P glycoprotein; Reversal agents

Indexed keywords

COLCHICINE; DOXORUBICIN; DRUG VEHICLE; ELACRIDAR; GLYCOPROTEIN P; MORPHINE; SUCROSE; VALSPODAR; VERAPAMIL; VINBLASTINE; VINCRISTINE;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VOLUME; BRAIN PERFUSION; CALCULATION; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG SCREENING; DRUG TRANSPORT; DRUG UPTAKE; ISOTOPE LABELING; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL;

ACRIDINES; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; COLCHICINE; CYCLOSPORINS; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; ISOQUINOLINES; MALE; MICE; P-GLYCOPROTEIN; PERFUSION; TETRAHYDROISOQUINOLINES; TIME FACTORS; VERAPAMIL; VINBLASTINE;

EID: 0034960962     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011080418027     Document Type: Article

References (32)

1. The blood-brain barrier. Morphologic data
2. Multidrug resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
3. Biochemical, cellular and pharmacological aspects of the multidrug transporter
4. Identification of members of the P-glycoprotein multigene family
5. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
6. P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances ivermectin-induced neurotoxicity
7. In vitro models of the blood-brain barrier
8. Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor
9. Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein deficient mice
10. An in situ brain perfusion technique to study cerebrovascular transport in the rat
11. Role of P-glycoprotein in the blood-brain transfer of colchicine and vinblastine
12. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin and cyclosporin A
13. Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system
14. Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein
15. Altered pharmacokinetics of vinblastine in mdr1a P-glycoprotein-deficient mice
16. The role of P-glycoprotein in blood-brain barrier transport of morphine: Transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice
17. Morphine antinociception is enhanced in mdr1a gene-deficient mice
18. Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein
19. Interaction of drugs with P-glycoprotein in brain capillaries
20. Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat
21. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
22. Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo
23. Effect of PSC 833, a P-glycoprotein modulator, on the disposition of vincristine and digoxin in rats
24. Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats
25. Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates
26. Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells
27. Clinical studies with modulators of multidrug resistance
28. In vitro and in vivo reversal of multidrug resistance by GF 120918, an acridonecarboxamide derivative
29. Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats
30. New advances in the transport of doxorubicin through the blood-brain barrier by a peptide vector-mediated strategy
31. Communication between multiple drug binding sites on P-glycoprotein
32. Two transport binding sites of P-glycoprotein are unequal yet contingent: Initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence