How the worm removes corpses: The nematode C. elegans as a model system to study engulfment

Cell Death and Differentiation

Volumn 8, Issue 6, 2001, Pages 564-568

  Gumienny, T L ^a,b   Hengartner, M O ^a,b  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell migration; Genetics; Phagocytosis; Rac

Indexed keywords

ANIMAL CELL; APOPTOSIS; CAENORHABDITIS ELEGANS; CELL DEATH; CONTROLLED STUDY; DROSOPHILA; DYING; EVOLUTION; GENE; GENETIC CONSERVATION; HYPOTHESIS; MODEL; NEMATODE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; VERTEBRATE;

ANIMALS; APOPTOSIS; CAENORHABDITIS ELEGANS; CELL MEMBRANE; CYTOSKELETON; MODELS, ANIMAL; PHAGOCYTOSIS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS ELEGANS; VERTEBRATA;

EID: 0034956632     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400850     Document Type: Review

References (45)

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10. A common set of genes mediate removal of both apoptotic and necrotic cell corpses in C. elegans
11. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
12. CED-2/Crkll and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
13. CED-1 is a transmembrane receptor that mediates cell-corpse engulfment in C. elegans
14. The C. elegans cell-corpse engulfment gene ced-7 encodes a protein similar to ABC transporters
15. Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans
16. The IRS-signalling system during insulin and cytokine action
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19. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
20. The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells
21. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1beta converting enzyme
22. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans
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28. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine
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30. Expression cloning of a novel scavenger receptor from human endothelial cells
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32. Interleukin-1beta secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1
33. Neuropathology of degenerative cell death in Caenorhabditis elegans
34. ABC1, the mammalian homologue of the engulfment gene ced-7, is required during phagocytosis of both necrotic and apoptotic cells
35. Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms
36. Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6
37. The human homologue of Caenorhabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cells
38. Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells
39. Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
40. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
41. Membrane recruitment of rac1 triggers phagocytosis
42. CAS/Crk coupling serves as a 'molecular switch' for induction of cell migration
43. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
44. Cell-cell adhesion via the ECM: Integrin genetics in fly and worm
45. NUC-1, a Caenorhabditis elegans DNase II homolog, functions in an intermediate step of DNA degradation during apoptosis