Neuropathology of degenerative cell death in Caenorhabditis elegans

Journal of Neuroscience

Volumn 17, Issue 3, 1997, Pages 1033-1045

  Hall, David H ^a   Gu, Guoqiang ^b   García Añoveros, Jaime ^b,d   Gong, Lei ^c   Chalfie, Martin ^b   Driscoll, Monica ^c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Columbia University ^*  (United States)

^c RUTGERS UNIVERSITY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Caenorhabditis elegans; deg 1 neuropathology; degenerin; mec 4; membrane cycling; necrosis; neurodegeneration

Indexed keywords

ARTICLE; CAENORHABDITIS ELEGANS; CELL SWELLING; CELL ULTRASTRUCTURE; CELL VACUOLE; GENE MUTATION; HYPOKALEMIC PERIODIC PARALYSIS; NERVE CELL DEGENERATION; NERVE CELL MEMBRANE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL;

EID: 0031027442     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-03-01033.1997     Document Type: Article

References (16)

1. Boerman RH, Ophoff RA, Links TP, van Eijk R, Sandkuijl LA, Elbaz A, Vale-Santos JE, Wintzen AR, van Deutekom JC, Isles DE, Fontaine B, Padberg GW, Frants RR (1995) Mutation in DHP receptor alpha 1 subunit (CACNL1A3) gene in a Dutch family with hypokalemic periodic paralysis. J Med Genet 32:44-47.
2. Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71-94.
3. Canessa CM, Horisberger J-D, Rossier BC (1993) Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361:467-470.
4. + channel is made of three homologous subunits. Nature 367:463-467.
5. Cannon SC, Hayward LJ, Beech J, Brown Jr RH (1995) Sodium channel inactivation is impaired in equine hyperkalemic periodic paralysis. J Neurophysiol 73:1892-1899.
6. Chalfie M, Au M (1989) Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons. Science 243:1027-1033.
7. Chalfie M, Sulston J (1981) Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev Biol 82:358-370.
8. Chalfie M, Wolinsky E (1990) The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans. Nature 345:410-416.
9. Chalfie M, Driscoll M, Huang M (1993) Degenerin similarities. Nature 361:504.
10. Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634.
11. Chung SK, Cohen RS, Pfaff DW (1990) Transneuronal degeneration in the midbrain central gray following chemical lesions in the ventromedial nucleus: a qualitative and quantitative analysis. Neuroscience 38:409-426.
12. Clarke PGH (1990) Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) 181:195-213.
13. Driscoll M, Chalfie M (1991) The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature 349:588-593.
14. Elbaz A, Vale-Santos J, Jurkatt-Rott K, Lapie P, Ophoff RA, Bady B, Links TP, Piussan C, Vila A, Monnier N, Padberg GW, Abe K, Feingold N, Guimares J, Wintzen AR, van der Hoeven JH, Saudubray JM, Grunfeld JP, Lenoir G, Nivet H, Echenne B, Frants RR, Fardeau M, Lehmann-Horn F, Fontaine B (1995) Hypokalemic periodic paralysis and the dihydropyridine receptor (CACNL1A3): genotype/phenotype correlations for two predominant mutations and evidence for the absence of a founder effect in 16 Caucasian families. Am J Hum Genet 56:374-380.
15. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 β-converting enzyme. Cell 75:641-652.
16. Zhou J, Spier SJ, Beech J, Hoffman EP (1994) Pathophysiology of sodium channelopathies: correlation of normal/mutant mRNA ratios with clinical phenotype in dominantly inherited periodic paralysis. Hum Mol Genet 3:1599-1603.