Quercetin glucuronides but not glucosides are present in human plasma after consumption of quercetin-3-glucoside or quercetin-4′-glucoside

Journal of Nutrition

Volumn 131, Issue 7, 2001, Pages 1938-1941

  Sesink, Aloys L A ^a   O'Leary, Karen A ^b   Hollman, Peter C H ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b INSTITUTE OF FOOD RESEARCH   (United Kingdom)

Author keywords

Bioavailability; Flavonoids; Human; Intestinal absorption; Quercetin glucuronides

Indexed keywords

ACETONITRILE; BETA GLUCURONIDASE; FLAVONOID; GLUCOSIDE; GLUCURONIDE; ISOQUERCITRIN; PHOSPHORIC ACID; QUERCETIN;

ARTICLE; BIOAVAILABILITY; BLOOD LEVEL; BLOOD SAMPLING; DIETARY INTAKE; GLUCURONIDATION; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTESTINE ABSORPTION; METABOLITE; OXIDATION;

EID: 0034937284     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.7.1938     Document Type: Article

References (26)

1. Health effects and bioavailability of dietary flavonols
2. Chemistry and biological effects of dietary phenolic compounds: Relevance to cardiovascular disease
3. Dietary intake and bioavailability of polyphenols
4. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
5. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
6. Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
7. Hydrolysis of dietary flavonoid glycosides by strains of intestinal bacteroides from humans
8. Anaerobic transformation of quercetin-3-glucoside by bacteria from the human intestinal tract
9. Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
10. Beta-Glucosidase activity in the rat small intestine toward quercetin monoglucosides
11. Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity
12. The late of naringin in humans: A key to grapefruit juice-drug interactions?
13. Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women
14. Intestinal absorption of luteolin and luteolin-7-O-beta-glucoside in rats and humans
15. Quercetin's solubility affects its accumulation in rat plasma after oral administration
16. The small intestine can both absorb and glucuronidate luminal flavonoids
17. Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway
18. The identification of flavonoids as glycosides in human plasma
19. Absorption and excretion of conjugated flavonols, including quercetin-4′-O-beta-glucoside and isorhamnetin-4′-O-beta-glucoside by human volunteers after the consumption of onions
20. Liquid chromatography/electrospray ionization mass spectrometric characterization of flavonol glycosides in tomato extracts and human plasma
21. Absorption and DNA protective effects of flavonoid glycosides from an onion meal
22. Bioavailabilities of quercetin-3-glucoside and quercetin-4′-glucoside do not differ in humans
23. Cellular uptake of dietary flavonoid quercetin 4′-beta-glucoside by sodium-dependent glucose transporter SGLT1
24. Efflux of dietary flavonoid quercetin 4′-beta-glucoside across human intestinal Caco-2 cell monolayers by apical multidrug resistance-associated protein-2
25. Conjugation position of quercetin glucuronides and effect on biological activity
26. Studies on the substrate specificity of human intestinal UDP-glucuronosyltransferases 1A8 and 1A10