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Volumn 18, Issue 2, 1997, Pages 287-293

Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; DEOXYRIBONUCLEOTIDE; DEOXYURIDINE PHOSPHATE; DNA; ENDONUCLEASE; FOLIC ACID; METHIONINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PURINE; THYMIDINE TRIPHOSPHATE;

EID: 0031427093     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.2.287     Document Type: Article
Times cited : (97)

References (68)
  • 1
    • 0021053494 scopus 로고
    • Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets
    • Mikol, Y.B., Hoover, K.L., Creasia, D. and Poirier, L.A. (1983) Hepatocarcinogenesis in rats fed methyl-deficient, amino acid-defined diets. Carcinogenesis, 4, 1619-1629.
    • (1983) Carcinogenesis , vol.4 , pp. 1619-1629
    • Mikol, Y.B.1    Hoover, K.L.2    Creasia, D.3    Poirier, L.A.4
  • 2
    • 0021157513 scopus 로고
    • The induction of liver cancer by a dietary deficiency of choline and methionine without added carcinogens
    • Ghoshal, A.K. and Farber, E. (1984) The induction of liver cancer by a dietary deficiency of choline and methionine without added carcinogens. Cancer Res., 5, 1367-1370.
    • (1984) Cancer Res. , vol.5 , pp. 1367-1370
    • Ghoshal, A.K.1    Farber, E.2
  • 4
    • 0001420340 scopus 로고
    • The occurrence of neoplasms in the liver, lungs, and other tissues of the rat as a result of prolonged choline deficiency
    • Copeland, D.H. and Salmon, W.D. (1946) The occurrence of neoplasms in the liver, lungs, and other tissues of the rat as a result of prolonged choline deficiency. Am. J. Pathol. 22, 1059-1079.
    • (1946) Am. J. Pathol. , vol.22 , pp. 1059-1079
    • Copeland, D.H.1    Salmon, W.D.2
  • 5
    • 0025744010 scopus 로고
    • Nutritional model of carcinogenesis: Rats fed a choline devoid diet
    • Lombardi, B., Chandar, N. and Locker, J. (1991) Nutritional model of carcinogenesis: rats fed a choline devoid diet. Dig. Dis. Sci., 36, 979-984.
    • (1991) Dig. Dis. Sci. , vol.36 , pp. 979-984
    • Lombardi, B.1    Chandar, N.2    Locker, J.3
  • 6
    • 0026786299 scopus 로고
    • High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats
    • Nakae, D., Yoshiji, H., Mizumoto, Y., Horiguchi, K., Shiraiwa, K., Tamura, K., Denda, A. and Konishi, Y. (1992) High incidence of hepatocellular carcinomas induced by a choline deficient L-amino acid defined diet in rats. Cancer Res., 52, 5042-5045.
    • (1992) Cancer Res. , vol.52 , pp. 5042-5045
    • Nakae, D.1    Yoshiji, H.2    Mizumoto, Y.3    Horiguchi, K.4    Shiraiwa, K.5    Tamura, K.6    Denda, A.7    Konishi, Y.8
  • 7
    • 0027534980 scopus 로고
    • Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: A new perspective
    • Ghoshal, A.K. and Farber, E. (1993) Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective. Lab. Invest., 68, 255-260.
    • (1993) Lab. Invest. , vol.68 , pp. 255-260
    • Ghoshal, A.K.1    Farber, E.2
  • 8
    • 0028898669 scopus 로고
    • Methyl donors in the diet and responses to chemical carcinogens
    • Rogers, A.E. (1995) Methyl donors in the diet and responses to chemical carcinogens. Am. J. Clin. Nutr., 61(Suppl.), 659S-665S.
    • (1995) Am. J. Clin. Nutr. , vol.61 , Issue.SUPPL.
    • Rogers, A.E.1
  • 9
    • 0024522505 scopus 로고
    • Effect of dietary methyl group deficiency on folate metabolism in rats
    • Home, D.E., Cook, R.J. and Wagner, C. (1989) Effect of dietary methyl group deficiency on folate metabolism in rats. J. Nutr., 119, 618-621.
    • (1989) J. Nutr. , vol.119 , pp. 618-621
    • Home, D.E.1    Cook, R.J.2    Wagner, C.3
  • 10
    • 85088765504 scopus 로고
    • Effect of dietary protein and amino acids in a choline-deficient diet on lipid accumulation in rat liver
    • Aovama, Y., Yasui, H. and Ashida, K. (1971) Effect of dietary protein and amino acids in a choline-deficient diet on lipid accumulation in rat liver. J. Nutr., 101, 730-746.
    • (1971) J. Nutr. , vol.101 , pp. 730-746
    • Aovama, Y.1    Yasui, H.2    Ashida, K.3
  • 11
    • 0003335338 scopus 로고
    • Nutritional requirements of the laboratory rat
    • National Academy Press, Washington, DC
    • National Research Council (1995) Nutritional requirements of the laboratory rat. In Nutrient Requirements of Laboratory Animals. National Academy Press, Washington, DC, pp. 11-79.
    • (1995) Nutrient Requirements of Laboratory Animals , pp. 11-79
  • 12
    • 0023265947 scopus 로고
    • Liver cell turnover in rats fed a choline-devoid diet
    • Chandar, N., Amenta, J., Kandala, J.C. and Lombardi, B. (1987) Liver cell turnover in rats fed a choline-devoid diet. Carcinogenesis, 8, 669-673.
    • (1987) Carcinogenesis , vol.8 , pp. 669-673
    • Chandar, N.1    Amenta, J.2    Kandala, J.C.3    Lombardi, B.4
  • 13
    • 0021025039 scopus 로고
    • The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet
    • Ghoshal, A.K., Ahluwalia, M. and Farber, E. (1983) The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet. Am. J. Pathol., 113, 309-314.
    • (1983) Am. J. Pathol. , vol.113 , pp. 309-314
    • Ghoshal, A.K.1    Ahluwalia, M.2    Farber, E.3
  • 15
  • 16
    • 0029969405 scopus 로고    scopus 로고
    • Quantification of 3′OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay
    • Basnakian, A.G. and James, S.J. (1996) Quantification of 3′OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay. DNA Cell Biol., 15, 255-262.
    • (1996) DNA Cell Biol. , vol.15 , pp. 255-262
    • Basnakian, A.G.1    James, S.J.2
  • 17
    • 0028925741 scopus 로고
    • Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl deficient rats
    • Pogribny, I.P., Basnakian, A.G., Miller, B.J., Lopatina, N.G., Poirier, L.A. and James, S.J. (1995) Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl deficient rats. Cancer Res., 55, 1894-1901.
    • (1995) Cancer Res. , vol.55 , pp. 1894-1901
    • Pogribny, I.P.1    Basnakian, A.G.2    Miller, B.J.3    Lopatina, N.G.4    Poirier, L.A.5    James, S.J.6
  • 18
  • 19
    • 0027265346 scopus 로고
    • A simplified HPLC method for quantifying ribonucleotides and deoxynucleotides in cell extracts and frozen tissues
    • Cross, D.R., Miller, B.J. and James, S.J. (1993) A simplified HPLC method for quantifying ribonucleotides and deoxynucleotides in cell extracts and frozen tissues. Cell Prolif., 26, 327-336.
    • (1993) Cell Prolif. , vol.26 , pp. 327-336
    • Cross, D.R.1    Miller, B.J.2    James, S.J.3
  • 20
    • 0024388954 scopus 로고
    • Hepatic content of S-adenosylmethionine and S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability
    • Henning, S.M., McKee, R.W. and Swendseid, M.E. (1989) Hepatic content of S-adenosylmethionine and S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability. J. Nutr., 119, 1478-1482.
    • (1989) J. Nutr. , vol.119 , pp. 1478-1482
    • Henning, S.M.1    McKee, R.W.2    Swendseid, M.E.3
  • 21
    • 0023855370 scopus 로고
    • Liver cell proliferation and incidence of hepatocellular carcinoma in rats fed consecutively a choline-devoid and choline supplemented diet
    • Chandar, N. and Lombardi, B. (1988) Liver cell proliferation and incidence of hepatocellular carcinoma in rats fed consecutively a choline-devoid and choline supplemented diet. Carcinogenesis, 9, 259-263.
    • (1988) Carcinogenesis , vol.9 , pp. 259-263
    • Chandar, N.1    Lombardi, B.2
  • 22
    • 0029294613 scopus 로고
    • In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
    • Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W. and Schulte-Hermann, R. (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology, 21, 1465-1468.
    • (1995) Hepatology , vol.21 , pp. 1465-1468
    • Grasl-Kraupp, B.1    Ruttkay-Nedecky, B.2    Koudelka, H.3    Bukowska, K.4    Bursch, W.5    Schulte-Hermann, R.6
  • 23
    • 0029076761 scopus 로고
    • Demonstration of DNA damage/repair in individual cells using in situ end labelling: Association of p53 with sites of DNA damage
    • Coates, P.J., Save, V., Ansari, B. and Hall, P.A. (1995) Demonstration of DNA damage/repair in individual cells using in situ end labelling: association of p53 with sites of DNA damage. J. Pathol., 176, 19-26.
    • (1995) J. Pathol. , vol.176 , pp. 19-26
    • Coates, P.J.1    Save, V.2    Ansari, B.3    Hall, P.A.4
  • 24
    • 0028329172 scopus 로고
    • Apoptosis: Its significance in cancer and cancer therapy
    • Kerr, J.F., Winterford, C.M. and Harmon, B.V. (1994) Apoptosis: its significance in cancer and cancer therapy. Cancer, 73, 2013-2026.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.1    Winterford, C.M.2    Harmon, B.V.3
  • 26
    • 0028022902 scopus 로고
    • Apoptosis: Programmed cell death in health and disease
    • Bright, J. and Khar, A. (1994) Apoptosis: Programmed cell death in health and disease. Biosci. Rep., 14, 67-82.
    • (1994) Biosci. Rep. , vol.14 , pp. 67-82
    • Bright, J.1    Khar, A.2
  • 27
    • 0028865245 scopus 로고
    • Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
    • Lindahl, T., Satoh, M.S., Poirier, G.G. and Klungland, A. (1995) Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem. Sci., 20, 405-411.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 405-411
    • Lindahl, T.1    Satoh, M.S.2    Poirier, G.G.3    Klungland, A.4
  • 28
    • 0028077835 scopus 로고
    • The function of poly (ADP-ribosylation) in DNA breakage and rejoining
    • Shall, S. (1994) The function of poly (ADP-ribosylation) in DNA breakage and rejoining. Mol. Cell. Biochem., 138, 71-75.
    • (1994) Mol. Cell. Biochem. , vol.138 , pp. 71-75
    • Shall, S.1
  • 29
    • 0023489292 scopus 로고
    • Hydroxyurea: Effects on deoxyribonucleotide pool sizes correlated with effects on DNA repair in mammalian cells
    • Collins, A. and Oates, D.J. (1987) Hydroxyurea: effects on deoxyribonucleotide pool sizes correlated with effects on DNA repair in mammalian cells. Eur. J. Biochem., 169, 299-305.
    • (1987) Eur. J. Biochem. , vol.169 , pp. 299-305
    • Collins, A.1    Oates, D.J.2
  • 30
    • 0022256661 scopus 로고
    • Evidence for the involvement of substrate cycles in the regulation of deoxyribonucleoside triphosphate pools in 3T6 cells
    • Nicander, B. and Reichard, P. (1985) Evidence for the involvement of substrate cycles in the regulation of deoxyribonucleoside triphosphate pools in 3T6 cells. J. Biol. Chem., 260, 9216-9222.
    • (1985) J. Biol. Chem. , vol.260 , pp. 9216-9222
    • Nicander, B.1    Reichard, P.2
  • 31
    • 0027142822 scopus 로고
    • Methyl deficiency, DNA methylation, and cancer: Studies on the reversibility of the effects of a lipotrope-deficient diet
    • Christman, J.K., Chen, M.L., Sheikhnejad, G., Dizik, M., Abileah, S. and Wainfan, E. (1993) Methyl deficiency, DNA methylation, and cancer: Studies on the reversibility of the effects of a lipotrope-deficient diet. J. Nutr. Biochem., 4, 672-680.
    • (1993) J. Nutr. Biochem. , vol.4 , pp. 672-680
    • Christman, J.K.1    Chen, M.L.2    Sheikhnejad, G.3    Dizik, M.4    Abileah, S.5    Wainfan, E.6
  • 32
    • 0026579875 scopus 로고
    • Methyl groups in carcinogenesis: Effects on DNA methylation and gene expression
    • Wainfan, E. and Poirier, L.A. (1992) Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res., 52, 2071s-2077s.
    • (1992) Cancer Res. , vol.52
    • Wainfan, E.1    Poirier, L.A.2
  • 33
    • 0024313342 scopus 로고
    • Reduced DNA damage induced in human melanoma cells by dacarbazine in the presence of deoxyribonucleosides
    • Lonn, U., Lonn, S., Nylen, U. and Winblad, G. (1989) Reduced DNA damage induced in human melanoma cells by dacarbazine in the presence of deoxyribonucleosides. Cancer Res., 49, 2921-2924.
    • (1989) Cancer Res. , vol.49 , pp. 2921-2924
    • Lonn, U.1    Lonn, S.2    Nylen, U.3    Winblad, G.4
  • 34
    • 0029976175 scopus 로고    scopus 로고
    • 2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats
    • 2 inhibitor, of both cirrhosis and enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats. Carcinogenesis, 17, 467-475.
    • (1996) Carcinogenesis , vol.17 , pp. 467-475
    • Endoh, T.1    Tang, Q.2    Denda, A.3
  • 35
    • 84970073330 scopus 로고
    • Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous carcinogenesis in choline deficient rats
    • DaCosta, K.A., Cochary, E.F., Blusztajn, J.K., Garner, S.F. and Zeisel, S.H. (1994) Accumulation of 1,2-sn-diradylglycerol with increased membrane-associated protein kinase C may be the mechanism for spontaneous carcinogenesis in choline deficient rats. Arch. Toxicol., 10, 231-243.
    • (1994) Arch. Toxicol. , vol.10 , pp. 231-243
    • DaCosta, K.A.1    Cochary, E.F.2    Blusztajn, J.K.3    Garner, S.F.4    Zeisel, S.H.5
  • 36
    • 0024405585 scopus 로고
    • Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats
    • James, S.J. and Yin, L. (1989) Diet-induced DNA damage and altered nucleotide metabolism in lymphocytes from methyl-donor-deficient rats. Carcinogenesis, 10, 1209-1214.
    • (1989) Carcinogenesis , vol.10 , pp. 1209-1214
    • James, S.J.1    Yin, L.2
  • 37
    • 0027074765 scopus 로고
    • Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid
    • James, S.J., Cross, D.R. and Miller, B.J. (1992) Alterations in nucleotide pools in rats fed diets deficient in choline, methionine and/or folic acid. Carcinogenesis, 13, 2471-2474.
    • (1992) Carcinogenesis , vol.13 , pp. 2471-2474
    • James, S.J.1    Cross, D.R.2    Miller, B.J.3
  • 38
    • 0010452104 scopus 로고
    • c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet
    • Chandar, N., Lombardi, B. and Locker, J. (1989) c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet. Proc. Natl Acad. Sci. USA, 86, 2703-2707.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 2703-2707
    • Chandar, N.1    Lombardi, B.2    Locker, J.3
  • 39
    • 0023852543 scopus 로고
    • c-H-ras and c-K-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino-acid defined diets
    • Bhave, M.R., Wilson, M.J. and Poirier, L.A. (1988) c-H-ras and c-K-ras gene hypomethylation in the livers and hepatomas of rats fed methyl-deficient, amino-acid defined diets. Carcinogenesis, 9, 343-348.
    • (1988) Carcinogenesis , vol.9 , pp. 343-348
    • Bhave, M.R.1    Wilson, M.J.2    Poirier, L.A.3
  • 40
    • 0027200278 scopus 로고
    • p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male F344 rats
    • Smith, M.L., Yeleswarapu, L., Scalamogna, P., Locker, J. and Lombardi, B. (1993) p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male F344 rats. Carcinogenesis, 14, 503-510.
    • (1993) Carcinogenesis , vol.14 , pp. 503-510
    • Smith, M.L.1    Yeleswarapu, L.2    Scalamogna, P.3    Locker, J.4    Lombardi, B.5
  • 41
    • 0025870661 scopus 로고
    • Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet
    • Dizik, M., Christman, J.K. and Wainfan, E. (1991) Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet. Carcinogenesis, 12, 1307-1312.
    • (1991) Carcinogenesis , vol.12 , pp. 1307-1312
    • Dizik, M.1    Christman, J.K.2    Wainfan, E.3
  • 42
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis: An overview of cell death
    • Majno, G. and Joris, I. (1995) Apoptosis, oncosis, and necrosis: An overview of cell death. Am. J. Pathol., 146, 3-15.
    • (1995) Am. J. Pathol. , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 44
    • 0028072164 scopus 로고
    • In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells
    • James, S.J., Basnakian, A.G. and Miller, B.J. (1994) In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Res., 54, 5075-5080.
    • (1994) Cancer Res. , vol.54 , pp. 5075-5080
    • James, S.J.1    Basnakian, A.G.2    Miller, B.J.3
  • 45
    • 0024388956 scopus 로고
    • Hepatic poly(ADP ribose) polymerase activity in methyl donor-deficient rats
    • Henning, S.M., McKee, R.W. and Swendseid, M.E. (1989) Hepatic poly(ADP ribose) polymerase activity in methyl donor-deficient rats. J. Nutr., 119, 1528-1531.
    • (1989) J. Nutr. , vol.119 , pp. 1528-1531
    • Henning, S.M.1    McKee, R.W.2    Swendseid, M.E.3
  • 47
    • 0025297930 scopus 로고
    • Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: Relationship with NAD metabolism and DNA breakage
    • Lautier, D., Poirier, D., Boudreau, A., Alaoui Jamali, M.A., Castonguay, A. and Poirier, G. (1990) Stimulation of poly(ADP-ribose) synthesis by free radicals in C3H10T1/2 cells: Relationship with NAD metabolism and DNA breakage. Biochem. Cell Biol., 68, 602-608.
    • (1990) Biochem. Cell Biol. , vol.68 , pp. 602-608
    • Lautier, D.1    Poirier, D.2    Boudreau, A.3    Alaoui Jamali, M.A.4    Castonguay, A.5    Poirier, G.6
  • 48
    • 0029592253 scopus 로고
    • Molecular mechanism of 5-fluoro-2′-deoxyuridine-induced dNTP imbalance cell death: Purification of an endonuclease involved in DNA double strand breaks during dNTP imbalance death
    • Hwang, H., Ohtani, M., Nakazawa, T. et al. (1995) Molecular mechanism of 5-fluoro-2′-deoxyuridine-induced dNTP imbalance cell death: Purification of an endonuclease involved in DNA double strand breaks during dNTP imbalance death. Nucleosid. Nucleotid., 14, 2089-2097.
    • (1995) Nucleosid. Nucleotid. , vol.14 , pp. 2089-2097
    • Hwang, H.1    Ohtani, M.2    Nakazawa, T.3
  • 49
    • 0022492499 scopus 로고
    • DNA strand breaks, NAD metabolism, and programmed cell death
    • Carson, D.A., Seto, S., Wasson, D.B. and Carrera, C.J. (1986) DNA strand breaks, NAD metabolism, and programmed cell death. Exp. Cell Res., 164, 273-281.
    • (1986) Exp. Cell Res. , vol.164 , pp. 273-281
    • Carson, D.A.1    Seto, S.2    Wasson, D.B.3    Carrera, C.J.4
  • 50
    • 0024364026 scopus 로고
    • Altered expression of retrovirus-like sequences and cellular oncogenes in mice fed methyl-deficient diets
    • Hsieh, L.L., Wainfan, E., Hoshina, S., Dizik, M. and Weinstein, I.B. (1989) Altered expression of retrovirus-like sequences and cellular oncogenes in mice fed methyl-deficient diets. Cancer Res., 49, 3795-3799.
    • (1989) Cancer Res. , vol.49 , pp. 3795-3799
    • Hsieh, L.L.1    Wainfan, E.2    Hoshina, S.3    Dizik, M.4    Weinstein, I.B.5
  • 51
    • 0024505072 scopus 로고
    • The molecular basis of mutations induced by deoxynucleotide triphosphate pool imbalances in mammalian cells
    • Meuth, M. (1989) The molecular basis of mutations induced by deoxynucleotide triphosphate pool imbalances in mammalian cells. Exp. Cell Res., 181, 305-316.
    • (1989) Exp. Cell Res. , vol.181 , pp. 305-316
    • Meuth, M.1
  • 52
    • 0021028509 scopus 로고
    • Uracil-DNA glycosylase and deoxyuridine triphosphatase: Studies of activity and subcellular location in human normal and malignant lymphocytes
    • Vilpo, J.A. and Autio-Harmainen, H. (1983) Uracil-DNA glycosylase and deoxyuridine triphosphatase: studies of activity and subcellular location in human normal and malignant lymphocytes. Scand. J. Clin. Lab. Invest., 43, 583-590.
    • (1983) Scand. J. Clin. Lab. Invest. , vol.43 , pp. 583-590
    • Vilpo, J.A.1    Autio-Harmainen, H.2
  • 53
    • 0021844644 scopus 로고
    • Orotic acid, a promoter of liver carcinogenesis induces DNA damage in rat liver
    • Rao, P.M., Rajalakshmi, S., Alam, A., Sarma, M., Pala, M. and Parodi, S. (1985) Orotic acid, a promoter of liver carcinogenesis induces DNA damage in rat liver. Carcinogenesis, 6, 765-768.
    • (1985) Carcinogenesis , vol.6 , pp. 765-768
    • Rao, P.M.1    Rajalakshmi, S.2    Alam, A.3    Sarma, M.4    Pala, M.5    Parodi, S.6
  • 54
    • 0028287342 scopus 로고
    • Sequential histopathological analysis of hepatocarcinogenesis in rats during promotion with orotic acid
    • Denda, A., Laconi, E., Rao, P.M., Rajalakshmi, S. and Sarma, D.S.R. (1994) Sequential histopathological analysis of hepatocarcinogenesis in rats during promotion with orotic acid. Cancer Lett., 82, 55-64.
    • (1994) Cancer Lett. , vol.82 , pp. 55-64
    • Denda, A.1    Laconi, E.2    Rao, P.M.3    Rajalakshmi, S.4    Sarma, D.S.R.5
  • 55
    • 0023200241 scopus 로고
    • Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes
    • Reidy, J.A. (1987) Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am. J. Med. Genet., 26, 1-5.
    • (1987) Am. J. Med. Genet. , vol.26 , pp. 1-5
    • Reidy, J.A.1
  • 56
    • 0006889222 scopus 로고
    • Accumulation of DNA strand breaks and methotrexate cytotoxicity
    • Li, J.C. and Kaminskas, E. (1984) Accumulation of DNA strand breaks and methotrexate cytotoxicity. Proc. Natl Acad. Sci., 81, 5694-5698.
    • (1984) Proc. Natl Acad. Sci. , vol.81 , pp. 5694-5698
    • Li, J.C.1    Kaminskas, E.2
  • 57
    • 0021984793 scopus 로고
    • Aspects of DNA repair and nucleotide pool imbalance
    • Holliday, R. (1985) Aspects of DNA repair and nucleotide pool imbalance. Basic Life Sci., 31, 453-460.
    • (1985) Basic Life Sci. , vol.31 , pp. 453-460
    • Holliday, R.1
  • 58
    • 0024313332 scopus 로고
    • Enhancement of methorexate-induced growth inhibition, cell killing and DNA lesions in cultured L5178 cells by the reduction of DNA repair efficiency
    • Golos, B. and Malec, J. (1989) Enhancement of methorexate-induced growth inhibition, cell killing and DNA lesions in cultured L5178 cells by the reduction of DNA repair efficiency. Biochem. Pharmacol., 38, 1743-1748.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1743-1748
    • Golos, B.1    Malec, J.2
  • 59
    • 0018912788 scopus 로고
    • Reduced rate of replication fork movement in megaloblastic anemia
    • Wickramsinghe, R.G. and Hoffbrand, A.V. (1980) Reduced rate of replication fork movement in megaloblastic anemia. J. Clin. Invest., 65, 26-30.
    • (1980) J. Clin. Invest. , vol.65 , pp. 26-30
    • Wickramsinghe, R.G.1    Hoffbrand, A.V.2
  • 60
    • 0028070613 scopus 로고
    • The effect of folic acid and/or methionine deficiency on deoxyribonucleotide pools and cell cycle distribution in mitogen-stimulated rat lymphocytes
    • James, S.J., Miller, B.J., McGarrity, L.J. and Morris, S.M. (1994) The effect of folic acid and/or methionine deficiency on deoxyribonucleotide pools and cell cycle distribution in mitogen-stimulated rat lymphocytes. Cell Prolif., 27, 395-406.
    • (1994) Cell Prolif. , vol.27 , pp. 395-406
    • James, S.J.1    Miller, B.J.2    McGarrity, L.J.3    Morris, S.M.4
  • 61
    • 0029112163 scopus 로고
    • Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation
    • Masutani, M., Nozaki, T., Wakabayashi, K. and Sugimura, T. (1995) Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation. Biochimie, 77, 462-465.
    • (1995) Biochimie , vol.77 , pp. 462-465
    • Masutani, M.1    Nozaki, T.2    Wakabayashi, K.3    Sugimura, T.4
  • 62
    • 0027232358 scopus 로고
    • Misincorporation of uracil into the DNA of folate and B12 deficient HL-60 cells
    • Wickramasinghe, S.N. and Fida, S. (1993) Misincorporation of uracil into the DNA of folate and B12 deficient HL-60 cells. Eur. J. Haematol., 50, 127-131.
    • (1993) Eur. J. Haematol. , vol.50 , pp. 127-131
    • Wickramasinghe, S.N.1    Fida, S.2
  • 63
    • 0028242835 scopus 로고
    • Effect of DNA cytosine methylation upon deamination- Induced mutagenesis in a natural target sequence in duplex DNA
    • Zhang, X.L. and Mathews, C.K. (1994) Effect of DNA cytosine methylation upon deamination-induced mutagenesis in a natural target sequence in duplex DNA. J. Biol. Chem., 269, 7066-7069.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7066-7069
    • Zhang, X.L.1    Mathews, C.K.2
  • 64
    • 0029154904 scopus 로고
    • DNA damage in folate deficiency
    • Blount, B.C. and Ames, B.N. (1995) DNA damage in folate deficiency. Clin. Haematol. 8, 461-478.
    • (1995) Clin. Haematol. , vol.8 , pp. 461-478
    • Blount, B.C.1    Ames, B.N.2
  • 65
    • 0012685415 scopus 로고
    • Methotrexate-induced misincorporation of uracil into DNA
    • Goulian, M., Bleile, B. and Tseng, B.Y. (1980) Methotrexate-induced misincorporation of uracil into DNA. Proc. Natl Acad. Sci. USA, 77, 1956-1960.
    • (1980) Proc. Natl Acad. Sci. USA , vol.77 , pp. 1956-1960
    • Goulian, M.1    Bleile, B.2    Tseng, B.Y.3
  • 66
    • 0021903393 scopus 로고
    • Molecular mechanisms in genetic stability and change: The role of deoxyribonucleotide pool balance
    • de Serres, F.S. (ed.). Plenum Press, New York
    • Haynes, R.H. (1985) Molecular mechanisms in genetic stability and change: the role of deoxyribonucleotide pool balance. In de Serres, F.S. (ed.), Genetic Consequences of Nucleotide Pool Imbalance. Plenum Press, New York, pp. 1-23.
    • (1985) Genetic Consequences of Nucleotide Pool Imbalance , pp. 1-23
    • Haynes, R.H.1
  • 67
    • 0002758568 scopus 로고
    • Role of folate deficiency in carcinogenesis
    • Butterworth, C.E. and Hutchenson, M.L. (eds). Academic Press, New York
    • Krumdieck, C.L. (1983) Role of folate deficiency in carcinogenesis. In Butterworth, C.E. and Hutchenson, M.L. (eds), Nutritional Factors in the Induction and Maintenance of Malignancy. Academic Press, New York, pp. 225-245.
    • (1983) Nutritional Factors in the Induction and Maintenance of Malignancy , pp. 225-245
    • Krumdieck, C.L.1
  • 68
    • 0025156152 scopus 로고
    • The specific binding of nuclear proteins to the cAMP responsive element sequence is reduced by the misincorporation of uracil and increased by the deamination of cytosine
    • Verri, A., Mazzarello, P., Biamonti, G., Spadari, S. and Focher, F. (1990) The specific binding of nuclear proteins to the cAMP responsive element sequence is reduced by the misincorporation of uracil and increased by the deamination of cytosine. Nucleic Acids Res., 18, 5775-5780.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 5775-5780
    • Verri, A.1    Mazzarello, P.2    Biamonti, G.3    Spadari, S.4    Focher, F.5


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