메뉴 건너뛰기




Volumn 128, Issue 11, 1998, Pages 1896-1906

Kinetic model of folate metabolism in nonpregnant women consuming [2H2]folic acid: Isotopic labeling of urinary folate and the catabolite para-acetamidobenzoylglutamate indicates slow, intake-dependent, turnover of folate pools

Author keywords

Folate; Kinetics; Modeling; Requirements stable isotopes humans

Indexed keywords

4 ACETAMIDOBENZOYLGLUTAMIC ACID; DEUTERIUM; FOLIC ACID; GLUTAMIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0031794154     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.11.1896     Document Type: Article
Times cited : (55)

References (57)
  • 1
    • 0026527718 scopus 로고
    • A pharmocokinetic comparison of intravenous versus intra-arterial folinic acid
    • Anderson, J. H., Kerr, D. J., Setanoians, A., Cooke, T. G. & McArdle, C. S. (1992) A pharmocokinetic comparison of intravenous versus intra-arterial folinic acid. Br. J. Cancer 65: 133-135.
    • (1992) Br. J. Cancer , vol.65 , pp. 133-135
    • Anderson, J.H.1    Kerr, D.J.2    Setanoians, A.3    Cooke, T.G.4    McArdle, C.S.5
  • 2
    • 0026672026 scopus 로고
    • Folic acid, 5-methyl-tetrahydrofolate, and 5-formyl-tetrahydrofolate exhibit equivalent intestinal absorption, metabolism, and in vivo kinetics in rats
    • Bhandari, S. D. & Gregory, J. F. (1992) Folic acid, 5-methyl-tetrahydrofolate, and 5-formyl-tetrahydrofolate exhibit equivalent intestinal absorption, metabolism, and in vivo kinetics in rats. J. Nutr. 122: 1847-1854.
    • (1992) J. Nutr. , vol.122 , pp. 1847-1854
    • Bhandari, S.D.1    Gregory, J.F.2
  • 5
    • 0029066299 scopus 로고
    • A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
    • Boushey, C. J., Beresford, S.A.A., Omenn, G. S., & Motulsky, A. G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. J. Am. Mad. Assoc. 274: 1049-1057.
    • (1995) J. Am. Mad. Assoc. , vol.274 , pp. 1049-1057
    • Boushey, C.J.1    Beresford, S.A.A.2    Omenn, G.S.3    Motulsky, A.G.4
  • 7
    • 0031941173 scopus 로고    scopus 로고
    • Folate catabolism in pregnant and nonpregnant women consuming controlled folate intakes
    • Caudill, M. A., Gregory, J. F., Hutson, A. C. & Bailey, L. B. (1998) Folate catabolism in pregnant and nonpregnant women consuming controlled folate intakes. J. Nutr. 128: 204-208.
    • (1998) J. Nutr. , vol.128 , pp. 204-208
    • Caudill, M.A.1    Gregory, J.F.2    Hutson, A.C.3    Bailey, L.B.4
  • 10
    • 0029684168 scopus 로고    scopus 로고
    • Modeling of folate metabolism
    • Coburn, S. P. & Townsend, D. W., eds. Academic Press, New York, NY
    • Gregory, J. F. & Scott, K. C. (1996) Modeling of folate metabolism. In: Advances in Food and Nutrition Research (Coburn, S. P. & Townsend, D. W., eds.), vol. 40, pp. 81-93. Academic Press, New York, NY.
    • (1996) Advances in Food and Nutrition Research , vol.40 , pp. 81-93
    • Gregory, J.F.1    Scott, K.C.2
  • 11
    • 0023911823 scopus 로고
    • Chemical synthesis of deuterated monoglutamate and in vivo assessment of urinary excretion of deuterated folates in man
    • Gregory, J. F. & Toth, J. P. (1988) Chemical synthesis of deuterated monoglutamate and in vivo assessment of urinary excretion of deuterated folates in man. Anal. Biochem. 170: 94-104.
    • (1988) Anal. Biochem. , vol.170 , pp. 94-104
    • Gregory, J.F.1    Toth, J.P.2
  • 14
    • 0023245657 scopus 로고
    • Recommended dietary intakes (RDI) of folate in humans
    • Herbert, V. (1987) Recommended dietary intakes (RDI) of folate in humans. Am. J. Clin. Nutr. 45: 661-670.
    • (1987) Am. J. Clin. Nutr. , vol.45 , pp. 661-670
    • Herbert, V.1
  • 15
    • 0018817368 scopus 로고
    • Folate levels in human liver from autopsies in Canada
    • Hoppner, K. & Lampi, B. (1980) Folate levels in human liver from autopsies in Canada. Am. J. Clin. Nutr. 33: 862-864.
    • (1980) Am. J. Clin. Nutr. , vol.33 , pp. 862-864
    • Hoppner, K.1    Lampi, B.2
  • 16
    • 0003788033 scopus 로고    scopus 로고
    • Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Institute of Medicine, National Academy of Sciences. National Academy Press, Washington, DC
    • Institute of Medicine (1998) Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Institute of Medicine, National Academy of Sciences. National Academy Press, Washington, DC.
    • (1998) Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline
  • 17
    • 0015817366 scopus 로고
    • Studies with a mathematical model of folate metabolism
    • Jackson, R. C. & Harrap, K. R. (1973) Studies with a mathematical model of folate metabolism. Arch. Biochem. Biophys. 158: 827-841.
    • (1973) Arch. Biochem. Biophys. , vol.158 , pp. 827-841
    • Jackson, R.C.1    Harrap, K.R.2
  • 18
    • 0020071242 scopus 로고
    • Integrated saturation model for tissue micronutrient concentrations applied to liver folacin
    • Keagy, P. M. (1982) Integrated saturation model for tissue micronutrient concentrations applied to liver folacin. J. Nutr. 112: 377-386.
    • (1982) J. Nutr. , vol.112 , pp. 377-386
    • Keagy, P.M.1
  • 20
  • 21
    • 0016157682 scopus 로고
    • Rapid transfer of folic acid from blood to bile in man, and its conversion into folate coenzymes and into a pteroylglutamate with little biological activity
    • Lavoie, A. & Cooper, B. A. (1974) Rapid transfer of folic acid from blood to bile in man, and its conversion into folate coenzymes and into a pteroylglutamate with little biological activity. Clin. Sci. Mol. Med. 46: 729-741.
    • (1974) Clin. Sci. Mol. Med. , vol.46 , pp. 729-741
    • Lavoie, A.1    Cooper, B.A.2
  • 23
    • 0002194171 scopus 로고
    • Folate Status: Effects on carcinogenesis
    • Bailey, L. B., ed. M. Dekker, Inc., New York, NY
    • Mason, J. (1995) Folate Status: effects on carcinogenesis. In: Folate in Health and Disease (Bailey, L. B., ed.), pp. 329-361. M. Dekker, Inc., New York, NY.
    • (1995) Folate in Health and Disease , pp. 329-361
    • Mason, J.1
  • 24
    • 0026496458 scopus 로고
    • The quantitative analysis of endogenous folate catabolites in human urine
    • McPartlin, J. M., Courtney, G., McNulty, H. Weir, D. G. & Scott, J. M. (1992) The quantitative analysis of endogenous folate catabolites in human urine. Anal. Biochem. 206: 256-261.
    • (1992) Anal. Biochem. , vol.206 , pp. 256-261
    • McPartlin, J.M.1    Courtney, G.2    McNulty, H.3    Weir, D.G.4    Scott, J.M.5
  • 26
    • 0027509137 scopus 로고
    • Bioverfügbarkeit von folsäure nach intramuskulärer und intravenöser gabe an gesunde Versuchspersonen
    • Menke, G., Müller, J., Weimann, H.-J. & Schuster, O. (1993) Bioverfügbarkeit von folsäure nach intramuskulärer und intravenöser gabe an gesunde Versuchspersonen. Arzneim.-Forsch. 43: 22-27.
    • (1993) Arzneim.-Forsch. , vol.43 , pp. 22-27
    • Menke, G.1    Müller, J.2    Weimann, H.-J.3    Schuster, O.4
  • 27
    • 0028904406 scopus 로고
    • Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells
    • Minchin, R. F. (1995) Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochem. J. 307: 1-3.
    • (1995) Biochem. J. , vol.307 , pp. 1-3
    • Minchin, R.F.1
  • 29
    • 0030908353 scopus 로고    scopus 로고
    • Folate transport protein mediates the bidirectional transport of 5-methyltetrahydrofolate in cultured human proximal tubule cells
    • Morshed, K. M., Ross, D. M. & McMartin, K. E. (1997) Folate transport protein mediates the bidirectional transport of 5-methyltetrahydrofolate in cultured human proximal tubule cells. J. Nutr. 127: 1137-1147.
    • (1997) J. Nutr. , vol.127 , pp. 1137-1147
    • Morshed, K.M.1    Ross, D.M.2    McMartin, K.E.3
  • 31
    • 0018408168 scopus 로고
    • The turnover, catabolism and excretion of folate administered at physiological concentrations in the rat
    • Murphy, M. & Scott, J. M. (1979) The turnover, catabolism and excretion of folate administered at physiological concentrations in the rat. Biochim. Biophys. Acta 583: 535-539.
    • (1979) Biochim. Biophys. Acta , vol.583 , pp. 535-539
    • Murphy, M.1    Scott, J.M.2
  • 33
    • 0030854010 scopus 로고    scopus 로고
    • Preparation of stable-isotopically labeled folates for in vivo investigation of folate absorption and metabolism
    • Pfeiffer, C. M. & Gregory, J. F. (1997) Preparation of stable-isotopically labeled folates for in vivo investigation of folate absorption and metabolism. Methods Enzymol. 281: 106-116.
    • (1997) Methods Enzymol. , vol.281 , pp. 106-116
    • Pfeiffer, C.M.1    Gregory, J.F.2
  • 34
    • 0030731777 scopus 로고    scopus 로고
    • Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined using a dual-label stable-isotope protocol
    • Pfeiffer, C. M., Rogers, L M., Bailey, L. B. & Gregory, J. F. (1997) Absorption of folate from fortified cereal-grain products and of supplemental folate consumed with or without food determined using a dual-label stable-isotope protocol. Am. J. Clin. Nutr. 66: 1388-1397.
    • (1997) Am. J. Clin. Nutr. , vol.66 , pp. 1388-1397
    • Pfeiffer, C.M.1    Rogers, L.M.2    Bailey, L.B.3    Gregory, J.F.4
  • 35
    • 0031428480 scopus 로고    scopus 로고
    • Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats
    • Pogribny, I. P., Muskhelishvilli, L., Miller, B. J. & James, S. J. (1997) Presence and consequence of uracil in preneoplastic DNA from folate/methyl-deficient rats. Carcinogenesis 18: 2071-2076.
    • (1997) Carcinogenesis , vol.18 , pp. 2071-2076
    • Pogribny, I.P.1    Muskhelishvilli, L.2    Miller, B.J.3    James, S.J.4
  • 36
    • 0026329661 scopus 로고
    • Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously
    • Priest, D. G., Schmitz, J. C., Bunni, M. A. & Stuart, R. K. (1991) Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously. J. Natl. Cancer Inst. 83: 1806-1812.
    • (1991) J. Natl. Cancer Inst. , vol.83 , pp. 1806-1812
    • Priest, D.G.1    Schmitz, J.C.2    Bunni, M.A.3    Stuart, R.K.4
  • 42
    • 0000152422 scopus 로고
    • Folate and neural tube defects
    • Bailey LB, ed. M. Dekker, Inc., New York, NY
    • Scott, J. M., Weir, D. G. & Kirke, P. N. (1995) Folate and neural tube defects. In: Folate in Health and Disease (Bailey LB, ed.), pp. 329-360. M. Dekker, Inc., New York, NY.
    • (1995) Folate in Health and Disease , pp. 329-360
    • Scott, J.M.1    Weir, D.G.2    Kirke, P.N.3
  • 43
    • 0024341967 scopus 로고
    • Folate-pool interconversions and interconversions of biosynthetic processes after exposure of 1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamates in antifolate action in cells
    • Seither, R. L., Trent, D. F., Mikulecky, D. C., Rape, T. J., & Goldman, I. D. (1989) Folate-pool interconversions and interconversions of biosynthetic processes after exposure of 1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamates in antifolate action in cells. J. Biol. Chem. 264: 17016-17023.
    • (1989) J. Biol. Chem. , vol.264 , pp. 17016-17023
    • Seither, R.L.1    Trent, D.F.2    Mikulecky, D.C.3    Rape, T.J.4    Goldman, I.D.5
  • 44
    • 0027382008 scopus 로고
    • Vitamin status and intake as primary determinants of homocysteinemia in an elderly population
    • Selhub, J., Jacques, P. F., Wilson, P. W., Rush, D. & Rosenberg, I. H. (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J. Am. Med. Assoc. 270: 2693-2698.
    • (1993) J. Am. Med. Assoc. , vol.270 , pp. 2693-2698
    • Selhub, J.1    Jacques, P.F.2    Wilson, P.W.3    Rush, D.4    Rosenberg, I.H.5
  • 45
    • 0030822410 scopus 로고    scopus 로고
    • Vitamin C pharmacokinetics: It's déjà vu all over again
    • Shane, B. (1997) Vitamin C pharmacokinetics: it's déjà vu all over again. Am. J. Clin. Nutr. 66: 1061-1062.
    • (1997) Am. J. Clin. Nutr. , vol.66 , pp. 1061-1062
    • Shane, B.1
  • 46
    • 0021352480 scopus 로고
    • Mechanisms of folate homeostasis
    • Steinberg, S. E. (1984) Mechanisms of folate homeostasis. Am. J. Physiol. 246: G319-G324.
    • (1984) Am. J. Physiol. , vol.246
    • Steinberg, S.E.1
  • 47
    • 0031031304 scopus 로고    scopus 로고
    • Kinetic modeling of folate metabolism using chronic administration of deuterium-labeled folic acid in adult men
    • Stites, T. E., Bailey, L. B., Scott, K. C., Toth, J. P., Fisher, W. P. & Gregory, J. F. (1997) Kinetic modeling of folate metabolism using chronic administration of deuterium-labeled folic acid in adult men. Am. J. Clin. Nutr. 65: 53-60.
    • (1997) Am. J. Clin. Nutr. , vol.65 , pp. 53-60
    • Stites, T.E.1    Bailey, L.B.2    Scott, K.C.3    Toth, J.P.4    Fisher, W.P.5    Gregory, J.F.6
  • 48
    • 0000746151 scopus 로고
    • Microbiological assay of folates
    • Picciano, M. F., Stokstad, E.L.R. & Gregory, J. F., eds. John Wiley & Sons, Inc., New York, NY
    • Tamura, T. (1990) Microbiological assay of folates. In: Folic Acid Metabolism in Health and Disease (Picciano, M. F., Stokstad, E.L.R. & Gregory, J. F., eds.), pp. 121-137. John Wiley & Sons, Inc., New York, NY.
    • (1990) Folic Acid Metabolism in Health and Disease , pp. 121-137
    • Tamura, T.1
  • 49
    • 0020580424 scopus 로고
    • Folate turnover in chronically alcoholic monkeys
    • Tamura, T. & Halsted, C. H. (1983) Folate turnover in chronically alcoholic monkeys. J. Lab. Clin. Med. 101: 623-628.
    • (1983) J. Lab. Clin. Med. , vol.101 , pp. 623-628
    • Tamura, T.1    Halsted, C.H.2
  • 50
    • 84944001028 scopus 로고
    • High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum
    • Vester, B. & Rasmussen, K. (1991) High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur. J. Clin. Chem. Clin. Biochem. 29: 549-554.
    • (1991) Eur. J. Clin. Chem. Clin. Biochem. , vol.29 , pp. 549-554
    • Vester, B.1    Rasmussen, K.2
  • 51
    • 0026736227 scopus 로고
    • In vivo folate kinetics during chronic supplementation of human subjects with deuterium-labeled folic acid
    • Von der Porten, A., Gregory, J. F., Toth, J. P., Cerda, J. J., Curry, S. H. & Bailey, L. B. (1992) In vivo folate kinetics during chronic supplementation of human subjects with deuterium-labeled folic acid. J. Nutr. 122: 1293-1299.
    • (1992) J. Nutr. , vol.122 , pp. 1293-1299
    • Von Der Porten, A.1    Gregory, J.F.2    Toth, J.P.3    Cerda, J.J.4    Curry, S.H.5    Bailey, L.B.6
  • 52
    • 0002942853 scopus 로고
    • Biochemical role of folate in cellular metabolism
    • Bailey, L. B., ed. M. Dekker, Inc., New York, NY
    • Wagner, C. (1995) Biochemical role of folate in cellular metabolism. In: Folate in Health and Disease (Bailey, L. B., ed.), pp. 23-42. M. Dekker, Inc., New York, NY.
    • (1995) Folate in Health and Disease , pp. 23-42
    • Wagner, C.1
  • 53
    • 0028357751 scopus 로고
    • Relationship between urinary excretion of p-aminobenzoylglutamate and folate status of growing rats
    • Wang, C., Song, S., Bailey, L. B. & Gregory, J. F. (1994) Relationship between urinary excretion of p-aminobenzoylglutamate and folate status of growing rats. Nutr. Res. 14: 875-884.
    • (1994) Nutr. Res. , vol.14 , pp. 875-884
    • Wang, C.1    Song, S.2    Bailey, L.B.3    Gregory, J.F.4
  • 54
    • 0018580281 scopus 로고
    • Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics
    • White, J. C. (1979) Reversal of methotrexate binding to dihydrofolate reductase by dihydrofolate. Studies with pure enzyme and computer modeling using network thermodynamics. J. Biol. Chem. 254: 10889-10895.
    • (1979) J. Biol. Chem. , vol.254 , pp. 10889-10895
    • White, J.C.1
  • 55
    • 0015916666 scopus 로고
    • Polyglutamyl metabolites of folic acid in human liver
    • Whitehead, V. M. (1973) Polyglutamyl metabolites of folic acid in human liver. Lancet 1: 743-745.
    • (1973) Lancet , vol.1 , pp. 743-745
    • Whitehead, V.M.1
  • 56
    • 0029907888 scopus 로고    scopus 로고
    • Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: A comment and analysis
    • Young, V. R. (1996) Evidence for a recommended dietary allowance for vitamin C from pharmacokinetics: a comment and analysis. Proc. Nat. Acad. Sci. U.S.A. 93: 14344-14348.
    • (1996) Proc. Nat. Acad. Sci. U.S.A. , vol.93 , pp. 14344-14348
    • Young, V.R.1
  • 57
    • 0017671363 scopus 로고
    • Effect of folacin deficiency on folacin-binding proteins in the rat
    • Zamierowski, M. M. & Wagner, C. (1977) Effect of folacin deficiency on folacin-binding proteins in the rat. J. Nutr. 107: 1937-1945.
    • (1977) J. Nutr. , vol.107 , pp. 1937-1945
    • Zamierowski, M.M.1    Wagner, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.