Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene

Nature Genetics

Volumn 13, Issue 3, 1996, Pages 275-283

  Zhao, Qi ^a   Behringer, Richard R ^a   De Crombrugghe, Benoit ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE; FOLIC ACID; MESSENGER RNA;

ANENCEPHALUS; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIAGNOSIS; EMBRYO; FETUS; FOREBRAIN; GENE EXPRESSION; GENE MUTATION; HOMEOBOX; IN SITU HYBRIDIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; MESENCHYME; MORPHOGENESIS; MOUSE; NEURAL CREST; NEURAL TUBE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKULL DEFECT;

ANENCEPHALY; ANIMALS; APOPTOSIS; DNA-BINDING PROTEINS; FEMALE; FOLIC ACID; HOMEODOMAIN PROTEINS; HUMANS; MATERNAL-FETAL EXCHANGE; MESODERM; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MUTATION; NEURAL TUBE DEFECTS; PREGNANCY; PROSENCEPHALON; SKULL;

EID: 0029946542     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0796-275     Document Type: Article

References (37)

1. Edmonds, L.D. & James, L.M. Temporal trends in the prevalence of congenital malformations at birth based on the Birth Defects Monitoring Program, United States, 1979-1987. MMWR 39, 19-23 (1990).
2. Copp, A.J., Brook, F.A., Estibeiro, J.P., Shum, A.S. & Cockroft, D.L. The embryonic development of mammalian neural tube defects. Prog. Neurobiol. 35, 363-403 (1990).
3. Hunter, A.G.W. Brain and spinal cord. in Human Malformations and Related Anomalies (eds Stevenson, R.E., Hall, J.G. & Goodman, R.M.) 109-137 (Oxford University Press, Oxford, 1993).
4. Campbell, L.R., Dayton, D.H. & Sohal, G.S. Neural tube defects: a review of human and animal studies on the etiology of neural tube defects. Teratology 34, 171-187 (1986).
5. Morriss-Kay, G.M. Growth and development of pattern in the cranial neural epithelium of rat embryos during neurulation. J. Embryol. Exp. Morph. 65 (Suppl), 225-241 (1981).
6. Geelen, J.A.G. & Langman, J. Closure of the neural tube in the cephalic region of the mouse embryo. Anat. Rec. 189, 625-640 (1977).
7. Sakai, Y. Neurulation in the mouse: manner and timing of neural tube closure. Anat. Rec. 223, 194-203 (1989).
8. Juriloff, D.M., Harris, M.J., Tom, C. & Macdonald, K.B. Normal mouse strains differ in the site of initiation of closure of the cranial neural tube. Teratology 44, 225-233 (1991).
9. Schoenwolf, G.C. & Smith, J.L. Mechanisms of neurulation: traditional viewpoint and recent advances. Development 109, 243-270 (1990).
10. Chen, Z.-F. & Behringer, R.R. twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 9, 686-699 (1995).
11. Zhao, G.-Q., Eberspaecher, H., Seldin, M.F. & deCrombrugghe, B. The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development. Mech. Dev. 48, 245-254 (1994).
12. Zhao, G.-Q., Zhou, X., Eberspaecher, H., Solursh, M. & deCrombrugghe, B. Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes. Proc. Natl. Acad. Sci. USA 90, 8633-8637 (1993).
13. Rudnick, A., Ling, T.Y., Odagiri, H., Rutter, W.J. & German, M.S. Pancreatic beta cells express a diverse set of homeobox genes. Proc. Natl. Acad. Sci. USA 91, 12203-12207 (1994).
14. Noden, D.M. Interactions and fates of avian craniofacial mesenchyme. Development 103, 121-140 (1988).
15. Le Douarin, N.M., Ziller, C. & Couly, G. Patterns of neural crest derivatives in the avian embryos: In vivo and in vitro studies. Dev. Biol. 189, 24-49 (1993).
16. Noden, D.M. The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues. Dev. Biol. 96, 144-165 (1983).
17. Graham, A., Heyman, I. & Lumsden, A. Even-numbered rhombomeres control the apoptotic elimination of neural crest cells from odd-numbered rhombomeres in the chick hindbrain. Development 119, 233-245 (1993).
18. Smithells, R.W. et al. Prevention of neural tube defect recurrences in Yorkshire: final report. Lancet 2, 498-499 (1989).
19. Le Douarin, N.M. The Neural Crest. (Cambridge University Press, London, 1982).
20. Couly, G.F., Coltey, P.M. & Le Douarin, N.M. The triple origin of skull in higher vertebrates: a study in quail-chick chimeras. Development 117, 409-429 (1993).
21. Cheyette, B.N., Green, P.J., Martin, K., Garren, H., Hartenstein, V. & Zipursky, S.L. The Drosophila sine oculis locus encodes a homeodomain-containing protein required for the development of the entire visual system. Neuron 12, 977-996 (1994).
22. Xiong, W.C. & Montell, C. Defective glia induce neuronal apoptosis in the repo visual system of Drosophila. Neuron 14, 581-590 (1995).
23. Wolf, C., Thisse, C., Stoetzel, C., Thisse, B., Gerlinger, P & Perrin-Schmitt, F. The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and Drosophila twist genes. Dev. Biol. 143, 363-373 (1991).
24. Mitchell, P.J., Timmons, P.M., Hebert, J.M., Rigby, P.W.J. & Tjian, R. Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 5, 105-119 (1991).
25. Morriss, G.M. & Solursh, M. The role of primary mesenchyme in normal and abnormal morphogenesis of mammalian neural folds. Zoon 6, 33-38 (1978).
26. Morriss, G.M. & Solursh, M. Regional differences in mesenchymal cell morphology and glycosaminoglycans in early neural fold stage rat embryos. J. Embryol. Exp. Morphol. 46, 37-52 (1978).
27. Gordon, R. A review of the theories of vertebrate neurulation and their relationship to the mechanics of neural tube birth defects. J. Embryol. Exp. Morphol. 89, 229-255 (1985).
28. Morris-Wiman, J. & Brinkley, L.L. Changes in mesenchymal cell and hyaluronate distribution correlate with in vivo elongation of the mouse mesencephalic neural folds. Anat. Rec. 226, 383-395 (1990).
29. Soriano, P., Montgomery, C., Geske, R. & Bradley, A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693-702 (1991).
30. Mansour, S.L., Thomas, K.R. & Capecchi, M.R. Disruption of the protooncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348-352 (1988).
31. McMahon, A.P. & Bradley, A. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62, 1073-1085 (1990).
32. Bradley, A. Production and analysis of chimeric mice. in Teratocarcinomas and Embryonic Stem Cells: A Practical Approach (ed. Robertson, E.J.), 113-151 (IRL Press, Oxford, 1987).
33. Kochhar, D.M. Limb development in mouse embryos. I. Analysis of teratogenic effects of retinoic acid. Teratology 7, 289-298 (1973).
34. Ojeda, J.L., Barbosa, E. & Bosque, P.G. Selective skeletal staining in whole chicken embryos: a rapid alcian blue technique. Stain Technol. 45, 137-138 (1970).
35. Kaufman, M.H. Morphological stages of postimplantation embryonic development. in Postimplantation Mammalian Embryos, A Practical Approach (eds Copp, A.J. & Cockroft, D.L.) 81-91 (IRL Press, Oxford, 1990).
36. Wilkinson, D.G., Bailes, J.A., Champion, J.E. & McMahon, A.P. A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development 99, 493-500 (1987).
37. Sassoon, D.A., Garner, I. & Buckingham, M. Transcripts of a-cardiac and a-skeletal actins are early markers for myogenesis in the mouse embryo. Development 104, 155-164 (1988).