Genetic evidence for a protein kinase A/Cubitus interruptus complex that facilitates processing of Cubitus interruptus in Drosophila

Genetics

Volumn 158, Issue 3, 2001, Pages 1157-1166

  Kiger Jr , John A ^a   O'Shea, Cristin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MEMBRANE PROTEIN; PROTEIN CI; PROTEIN CI 155; PROTEIN CI 75; PROTEIN COS2; PROTEIN FU; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; DROSOPHILA; EMBRYO SEGMENTATION; ENZYME PHOSPHORYLATION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REPRESSOR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ALLELES; ANIMALS; CATALYSIS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; INSECT PROTEINS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; TRANSCRIPTION FACTORS; TRANSGENES;

ARACHNIDA; CUBITUS; CUBITUS INTERRUPTUS; ERINACEIDAE; HEXAPODA;

EID: 0034917610     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Ci, a complex transducer of the Hedgehog signal
2. Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
3. Dimerization/docking domain of the type Iα regulatory subunit of cAMP-dependent protein kinase
4. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein
5. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
6. Regulation-defective mutants of type I cAMP-dependent protein kinase
7. GFP-tagged balancer chromosomes for Drosophila melanogaster
8. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
9. Dual roles for Patched in sequestering and transducing Hedgehog
10. Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus
11. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
12. Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions
13. The function of engrailed and the specification of Drosophila wing pattern
14. Molecular characterization of a novel A Kinase Anchor Protein from Drosophila melanogaster
15. Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: Effect of MgATP on protein-protein interactions
16. Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: Influence of amino terminus on cAMP binding and holoenzyme formation
17. Functional inactivation of genes by dominant negative mutations
18. Transducing Hedgehog: The story so far
19. Protein kinase A and Hedgehog signalling in Drosophila limb development
20. Regulation of the Hedgehog and Wingless signaling pathways by the F-box/WD40-repeat protein Slimb
21. Transducing the Hedgehog signal
22. Isolation and characterization of Drosophila cAMP-dependent protein kinase genes
23. Transgenic inhibitors identify two roles for Protein Kinase A in Drosophila development
24. Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning
25. Function of protein kinase A in Hedgehog signal transduction and Drosophila imaginal disc development
26. Generation of a novel A Kinase Anchor Protein and a myristoylated alanine-rich C Kinase substrate-like analog from a single gene
27. More surprises in the hedgehog signaling pathway
28. Hedgehog controls limb development by regulating the activities of distinct transcriptional and repressor forms of Cubitus interruptus
29. Suppressor of Fused opposes Hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus
30. Suppressor of fused links Fused and Cubitus interruptus on the Hedgehog signaling pathway
31. Sonic hedgehog signaling by the Patched-Smoothened receptor complex
32. Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos
33. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
34. Protein kinase A and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginal discs
35. Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
36. Identification of critical determinants for autoinhibition in the pseudosubstrate region of type Iα cAMP-dependent protein kinase
37. Proteolysis of Cubitus interruptus in Drosophila requires phosphorylation by Protein Kinase A
38. Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A
39. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2
40. A cAMP-phosphodiesterase controls PKA-dependent differentiation
41. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
42. Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCP
43. A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing
44. Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A
45. Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs
46. cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes
47. Protein kinase A antagonizes Hedgehog signaling by regulating both the activator and repressor forms of Cubitus interruptus
48. The subcellular localization and activity of Drosophila Cubitus interruptus are regulated at multiple levels
49. Identification of a signal for rapid export of proteins from the nucleus
50. 2--dependent interaction of the inhibitor protein of the cAMP-dependent protein kinase with the catalytic subunit
51. Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase
52. Activation of protein kinase A-independent pathways by Gsα in Drosophila
53. The transcriptional activity of NF-kB is regulated by the IkB-associated PKAc subunit through ia cyclic-AMP-independent mechanism