Delayed wound healing in aged rats is associated with increased collagen gel remodeling and contraction by skin fibroblasts, not with differences in apoptotic or myofibroblast cell populations

Wound Repair and Regeneration

Volumn 9, Issue 3, 2001, Pages 223-237

  Ballas, Christopher B ^a   Davidson, Jeffrey M ^a,b,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; COLLAGEN GEL; GELATINASE A;

ADOLESCENT; AGED; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GRANULATION TISSUE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PUNCH BIOPSY; RAT; SKIN FIBROBLAST; WOUND CLOSURE; WOUND CONTRACTION; WOUND HEALING; WOUND HEALING IMPAIRMENT; ZYMOGRAPHY;

AGE FACTORS; AGING; ANIMALS; APOPTOSIS; BIOMECHANICS; BIOPSY, NEEDLE; COLLAGEN; DISEASE MODELS, ANIMAL; FIBROBLASTS; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, INBRED F344; SKIN; TENSILE STRENGTH; TIME FACTORS; WOUND HEALING;

EID: 0034910003     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1524-475X.2001.00223.x     Document Type: Article

References (91)

1. Structural and functional changes of normal aging skin
2. The ageing dermis: The main cause for the appearance of 'old' skin
3. The cellular and molecular biology of skin aging
4. Age-related changes in renal function
5. The effects of ageing on cutaneous wound healing in mammals
6. Cutaneous development, aging and repair
7. The influence of age on the healing of normal and ischemic incisional skin wounds
8. Age-related changes in wound healing
9. Impaired wound healing but unaltered colonic healing with increasing age: An experimental study in rats
10. Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans
11. Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA
12. Age-related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans
13. The effects of ageing on wound healing: Immunolocalisation of growth factors and their receptors in a murine incisional model
14. Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing
15. Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response
16. Differential effects of platelet-derived growth factor BB in accelerating wound healing in aged versus young animals: The impact of tissue hypoxia
17. Transforming growth factor-beta1 fails to stimulate wound healing and impairs its signal transduction in an aged ischemic ulcer model: Importance of oxygen and age
18. Aging, cancer, and wound healing
19. Wound healing and the inflammatory response in the aged
20. Correlations between age and rat dermis modifications. Ultrastructural- morphometric evaluations and lysyl oxidase activity
21. Advanced protein glycosylation in diabetes and aging
22. The endocrinology of aging
23. The transcriptional program in the response of human fibroblasts to serum
24. The cell biology of aging
25. Cellular aging and expression of fibronectin
26. Expression of interleukin-1 alpha and beta in early passage fibroblasts from aging individuals
27. A hypothesis that aging results from defects in genetically produced proteins
28. Mitotic misregulation and human aging
29. Cell death in granulomata: The role of apoptosis
30. Detection of cell death in human skin wounds of various ages by an in situ end labeling of nuclear DNA fragments
31. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice
32. Apoptosis during wound healing, fibrocontractive diseases and vascular wall injury
33. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar
34. Death in a dish: Controls of apoptosis within the developing retinal tissue
35. Cell death: TRAIL and its receptors
36. Apoptosis: Molecular mechanisms and implications for cancer chemotherapy
37. Caloric restriction: Conservation of cellular replicative capacity in vitro accompanies life-span extension in mice
38. Molecular markers of senescence in fibroblast-like cultures
39. In vitro study of gingival fibroblasts from normal and inflamed tissue: Age-related responsiveness
40. Growth properties and growth factor responsiveness in skin fibroblasts from centenarians
41. Cellular mechanisms for diminished scarring with aging
42. What does cell death have to do with aging?
43. Upregulation of apoptosis with dietary restriction: Implications for carcinogenesis and aging
44. Differentiation of fibroblast stem cells
45. Heterogeneity of myofibroblast phenotypic features: An example of fibroblastic cell plasticity
46. Fibroblast heterogeneity in the periodontium and other tissues
47. The biology of the myofibroblast
48. Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
49. The role of alpha1beta1 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture
50. Recombinant basic fibroblast growth factor accelerates wound healing
51. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
52. Fibroblasts from wounds of different stages of repair vary in their ability to contract a collagen gel in response to growth factors
53. Cytokines and serum cause alpha 2 beta 1 integrin-mediated contraction of collagen gels by cultured retinal pigment epithelial cells
54. Transforming growth factor-beta 1 promotes contraction of collagen gel by bovine corneal fibroblasts through differentiation of myofibroblasts
55. Epithelial mediated wound contraction in experimental wounds - The purse-string effect
56. Cultured myofibroblasts: A useful model to study wound contraction and pathological contracture
57. Cell locomotion forces versus cell contraction forces for collagen lattice contraction: An in vitro model of wound contraction
58. Dependence of collagen remodelling on alpha-smooth muscle actin expression by fibroblasts
59. Factors influencing myofibroblast differentiation during wound healing and fibrosis
60. A mechanochemical model for adult dermal wound contraction and the permanence of the contracted tissue displacement profile
61. Skin thickness changes in normal aging skin
62. Effects of short-time hydration on skin extensibility
63. Changes in the collagenous matrix of the aging human lamina cribrosa
64. The structural arteriolar changes in diabetes mellitus and essential hypertension. The relative contribution of ageing and high blood pressure
65. Histologic changes in skin associated with aging
66. Aging fibroblasts present reduced epidermal growth factor (EGF) responsiveness due to preferential loss of EGF receptors
67. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: Studies in a non-human primate model of naturally occurring disease
68. Susceptibility to TGFbeta2-induced cataract increases with aging in the rat
69. Age-related changes in the signaling and function of vascular smooth muscle cells
70. Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo
71. Mesenchymal cell activation is the rate-limiting step of granulation tissue induction
72. Macrophage colony-stimulating factor accelerates wound healing and upregulates TGF-beta1 mRNA levels through tissue macrophages
73. Current concepts in wound healing: Growth factor and macrophage interaction
74. Promotion of wound repair in old mice by local injection of macrophages
75. The myofibroblast: A quarter century after its discovery
76. On the mechanism of skin wound "contraction": A granulation tissue "knockout" with a normal phenotype
77. Wound closure: Evidence of cooperation between fibroblasts and collagen matrix
78. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
79. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing
80. Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and the relationship to cell morphology
81. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
82. Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins
83. Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta
84. Growth factor effects on the expression of collagenase and TIMP-1 in periodontal ligament cells
85. Differential effects of transforming growth factor-beta 1 on the expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in young and old human fibroblasts
86. Collagenases and tissue inhibitors of metalloproteinases: A functional balance in tissue degradation
87. The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitis
88. Cytokine-mediated regulation of 92-kilodalton type IV collagenase, tissue inhibitor or metalloproteinase-1 (TIMP-1), and TIMP-3 messenger ribonucleic acid expression in human endometrial stromal cells
89. Transforming growth factor-beta is a potent inhibitor of extracellular matrix degradation by cultured human mesangial cells