Detection of cell death in human skin wounds of various ages by an in situ end labeling of nuclear DNA fragments

International Journal of Legal Medicine

Volumn 110, Issue 5, 1997, Pages 240-243

  Betz, P ^a   Nerlich, A ^b   Tubel J ^b   Wiest, I ^b   Hausmann, R ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Cell death; Immunohistochemistry; Wound age

Indexed keywords

CELL NUCLEUS DNA; DNA FRAGMENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL DEATH; CELL LABELING; CLINICAL PROTOCOL; CONTROLLED STUDY; DERMIS; FORENSIC PATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; SKIN FIBROBLAST; SKIN INJURY;

ADOLESCENT; ADULT; AGED; APOPTOSIS; CELL DEATH; DNA; FIBROBLASTS; FORENSIC MEDICINE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; WOUNDS AND INJURIES;

EID: 0030811888     PISSN: 09379827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004140050078     Document Type: Article

References (11)

1. Ansari B, Coates PJ, Greenstein BD, Hall PA (1993) In situ end-labeling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 170:1-8
2. Bardales RH, Hailey LS, Xie SS, Schaefer RF, Hsu SM (1996) In situ apoptosis assay for the detection of early myocardial infarction. Am J Pathol 149:821-829
3. Baretton G, Diebold J, Christoforis G, Vogt M, Müller C, Dopfer K, Schneiderbangei K, Schmidt M, Löhrs U (1996) Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Cancer 77: 255-264
4. Betz P, Nerlich A, Wilske J, Tübel J, Penning R, Eisenmenger W (1992) Time-dependent appearance of myofibroblasts in granulation tissue of human skin wounds. Int J Legal Med 105: 99-103
5. Betz P, Nerlich A, Wilske J, Tübel J, Penning R, Eisenmenger W (1993) The time-dependent localization of Ki 67 antigen-positive cells in human skin wounds. Int J Legal Med 106:35-40
6. Desmouliere A, Redard M, Darby I, Gabbiani G (1995) Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am J Pathol 146:56-66
7. Gabbiani G, Ryan GB, Majno G (1971) Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction. Experientia 27:549-550
8. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501
9. Hockenbery D (1995) Review. Defining apoptosis. Am J Pathol 146:16-19
10. Iwasa M, Maeno Y, Inoue H, Koyama Y, Matoba R (1996) Induction of apoptotic cell death in rat thymus and spleen after a bolus injection of methamphetamine. Int J Legal Med 109:23-28
11. Majno G, Joris I (1995) Review. Apoptosis, oncosis, and necrosis. Am J Pathol 146:3-15