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Volumn 31, Issue 1-2, 1996, Pages 111-123

Molecular markers of senescence in fibroblast-like cultures

Author keywords

aging; cell proliferation; cellular senescence; growth control; signal transduction

Indexed keywords

ARACHIDONIC ACID; CALCIUM; COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLINE; CYTOCHROME B; CYTOKINE; DNA; EPIDERMAL GROWTH FACTOR; FIBRONECTIN; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; MESSENGER RNA; PHOSPHOLIPASE A2; PHOSPHOLIPASE C; PHOSPHOLIPID; PHOSPHOTRANSFERASE; PLASMINOGEN ACTIVATOR INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN; PROTEIN KINASE C; RAS PROTEIN; SECRETORY PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; THYMIDINE KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSCRIPTION FACTOR; UNINDEXED DRUG;

EID: 0029921312     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/0531-5565(95)02018-7     Document Type: Article
Times cited : (57)

References (123)
  • 2
    • 0028104434 scopus 로고
    • Utilization of a Fos-lacZ plasmid to investigate the activation of c-fos during cellular senescence and okadaic acid-induced apoptosis
    • AFSHARI, C.A., BIVINS, H.M., and BARRETT, J.C. Utilization of a Fos-lacZ plasmid to investigate the activation of c-fos during cellular senescence and okadaic acid-induced apoptosis. J. Gerontol. 49, B263-B269, 1994.
    • (1994) J. Gerontol. , vol.49
    • Afshari, C.A.1    Bivins, H.M.2    Barrett, J.C.3
  • 3
    • 0028364290 scopus 로고
    • Loss of serum response element-binding activity and hyperphosphorylation of serum response factor during cellular aging
    • ATADJA, P.W., STRINGER, K.F., and RIABOWOL, K.T. Loss of serum response element-binding activity and hyperphosphorylation of serum response factor during cellular aging. Mol. Cell. Biol. 14, 4991-4999, 1994.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4991-4999
    • Atadja, P.W.1    Stringer, K.F.2    Riabowol, K.T.3
  • 4
    • 0018253053 scopus 로고
    • The effect of donor age on the in vitro lifespan of cultured human arterial smooth-muscle cells
    • BIERMAN, E.L. The effect of donor age on the in vitro lifespan of cultured human arterial smooth-muscle cells. In Vitro Cell. Dev. Biol. 14, 951-955, 1978.
    • (1978) In Vitro Cell. Dev. Biol. , vol.14 , pp. 951-955
    • Bierman, E.L.1
  • 5
    • 0027431143 scopus 로고
    • Serine/threonine protein kinases and calcium-dependent protease in senescent IMR-90 fibroblasts
    • BLUMENTHAL, E.J., MILLER, A.C.K., STEIN, G.H., and MALKINSON, A.M. Serine/threonine protein kinases and calcium-dependent protease in senescent IMR-90 fibroblasts. Mech. Ageing Dev. 72, 13-24, 1993.
    • (1993) Mech. Ageing Dev. , vol.72 , pp. 13-24
    • Blumenthal, E.J.1    Miller, A.C.K.2    Stein, G.H.3    Malkinson, A.M.4
  • 6
    • 0028261160 scopus 로고
    • Escape from senescence in human diploid fibroblasts induced directly by mutant p53
    • BOND, J.A., WYLLIE, F.S., and WYNFORD-THOMAS, D. Escape from senescence in human diploid fibroblasts induced directly by mutant p53. Oncogene 9, 1885-1889, 1994.
    • (1994) Oncogene , vol.9 , pp. 1885-1889
    • Bond, J.A.1    Wyllie, F.S.2    Wynford-Thomas, D.3
  • 7
    • 0023607398 scopus 로고
    • EGF-dependent phosphorylation of the EGF receptor in plasma membranes isolated from young and senescent WI-38 cells
    • BROOKS, K.M., PHILLIPS, P.D., CARLIN, C.R., KNOWLES, B., and CRISTOFALO, V.J. EGF-dependent phosphorylation of the EGF receptor in plasma membranes isolated from young and senescent WI-38 cells. J. Cell. Physiol. 133, 523-531, 1987.
    • (1987) J. Cell. Physiol. , vol.133 , pp. 523-531
    • Brooks, K.M.1    Phillips, P.D.2    Carlin, C.R.3    Knowles, B.4    Cristofalo, V.J.5
  • 9
    • 0025182686 scopus 로고
    • Molecular biology of circulatory shock. Part II. Expression of four groups of hepatic genes is enhanced after resuscitation from cardiogenic shock
    • BUCHMAN, T.G., CABIN, D.E., VICKERS, S., DEUTSCHMAN, C.S., DELGADO, E., SUSSMAN, M.M., and BULKLEY, G.B. Molecular biology of circulatory shock. Part II. Expression of four groups of hepatic genes is enhanced after resuscitation from cardiogenic shock. Surgery 108, 559-566, 1990.
    • (1990) Surgery , vol.108 , pp. 559-566
    • Buchman, T.G.1    Cabin, D.E.2    Vickers, S.3    Deutschman, C.S.4    Delgado, E.5    Sussman, M.M.6    Bulkley, G.B.7
  • 10
    • 0021071034 scopus 로고
    • Diminished in vitro tyrosine kinase activity of the EGF receptor of senescent human fibroblasts
    • CARLIN, C.R., PHILLIPS, P.D., KNOWLES, B.B., and CRISTOFALO, V.J. Diminished in vitro tyrosine kinase activity of the EGF receptor of senescent human fibroblasts. Nature 306, 617-620, 1983.
    • (1983) Nature , vol.306 , pp. 617-620
    • Carlin, C.R.1    Phillips, P.D.2    Knowles, B.B.3    Cristofalo, V.J.4
  • 11
    • 0028071422 scopus 로고
    • Cleavage of the EGF receptor by an endogenous leupeptin-sensitive protease active in detergent extracts of senescent but not young human diploid fibroblasts
    • CARLIN, C.R., PHILLIPS, P.D., BROOKS-FREDERICK, K.M., MILLER, S., KNOWLES, B.B., and CRISTOFALO, V.J. Cleavage of the EGF receptor by an endogenous leupeptin-sensitive protease active in detergent extracts of senescent but not young human diploid fibroblasts. J. Cell. Physiol. 160, 427-434, 1994.
    • (1994) J. Cell. Physiol. , vol.160 , pp. 427-434
    • Carlin, C.R.1    Phillips, P.D.2    Brooks-Frederick, K.M.3    Miller, S.4    Knowles, B.B.5    Cristofalo, V.J.6
  • 12
    • 0000480991 scopus 로고
    • Cultivation of adult tissues and organs outside of the body
    • CARREL, A. and BURROWS, M.T. Cultivation of adult tissues and organs outside of the body. JAMA 55, 1379-1381, 1910a.
    • (1910) JAMA , vol.55 , pp. 1379-1381
    • Carrel, A.1    Burrows, M.T.2
  • 13
    • 84943208641 scopus 로고
    • Cultivation of sarcoma outside of the body
    • CARREL, A. and BURROWS, M.T. Cultivation of sarcoma outside of the body. JAMA 55, 1554, 1910b.
    • (1910) JAMA , vol.55 , pp. 1554
    • Carrel, A.1    Burrows, M.T.2
  • 14
    • 0013662818 scopus 로고
    • On the physiochemical regulation of the growth of tissues
    • CARREL, A. and BURROWS, M.T. On the physiochemical regulation of the growth of tissues. J. Exp. Med. 13, 562-570, 1911.
    • (1911) J. Exp. Med. , vol.13 , pp. 562-570
    • Carrel, A.1    Burrows, M.T.2
  • 15
    • 84965463467 scopus 로고
    • Age and multiplication of fibroblasts
    • CARREL, A. and EBLING, A.H. Age and multiplication of fibroblasts. J. Exp. Med. 34, 599-623, 1921.
    • (1921) J. Exp. Med. , vol.34 , pp. 599-623
    • Carrel, A.1    Ebling, A.H.2
  • 16
    • 0025882841 scopus 로고
    • Senescent human fibroblasts have a posttranscriptional block in the expression of the proliferating cell nuclear antigen
    • CHANG, C., PHILLIPS, P.D., LIPSON, K.E., CRISTOFALO, V.J., and BASERGA, R. Senescent human fibroblasts have a posttranscriptional block in the expression of the proliferating cell nuclear antigen. J. Biol. Chem. 266, 8663-8666, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 8663-8666
    • Chang, C.1    Phillips, P.D.2    Lipson, K.E.3    Cristofalo, V.J.4    Baserga, R.5
  • 17
    • 0023710185 scopus 로고
    • Regulation of omithine decarboxylase and other cell cycle-regulated genes during senescence of IMR-90 human diploid fibroblasts
    • CHANG, Z.-F. and CHEN, K.Y. Regulation of omithine decarboxylase and other cell cycle-regulated genes during senescence of IMR-90 human diploid fibroblasts. J. Biol. Chem. 263, 11431-11435, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 11431-11435
    • Chang, Z.-F.1    Chen, K.Y.2
  • 18
    • 0028301074 scopus 로고
    • Decline of protein kinase C activation in response to growth stimulation during senescence of IMR-90 human diploid fibroblasts
    • CHANG, Z.F. and HUANG, D.Y. Decline of protein kinase C activation in response to growth stimulation during senescence of IMR-90 human diploid fibroblasts. Biochem. Biophys. Res. Commun. 200, 16-27, 1994.
    • (1994) Biochem. Biophys. Res. Commun. , vol.200 , pp. 16-27
    • Chang, Z.F.1    Huang, D.Y.2
  • 19
    • 0029006174 scopus 로고
    • Alterations in the molecular response to DNA damage during cellular aging of cultured fibroblasts: Reduced AP-1 activation and collagenase gene expression
    • CHOI, A.M.K., PIGNOLO, R.J., AP RHYS, C.M.J., CRISTOFALO, V.J., and HOLBROOK, N.J. Alterations in the molecular response to DNA damage during cellular aging of cultured fibroblasts: Reduced AP-1 activation and collagenase gene expression. J. Cell. Physiol. 164, 65-73, 1995.
    • (1995) J. Cell. Physiol. , vol.164 , pp. 65-73
    • Choi, A.M.K.1    Pignolo, R.J.2    Ap Rhys, C.M.J.3    Cristofalo, V.J.4    Holbrook, N.J.5
  • 20
    • 0025946177 scopus 로고
    • γ1 in IMR-90 human diploid fibroblasts at high population doubling levels
    • γ1 in IMR-90 human diploid fibroblasts at high population doubling levels. FEBS Lett. 293, 211-214, 1991.
    • (1991) FEBS Lett. , vol.293 , pp. 211-214
    • Choudhury, G.G.1    Sylvia, V.L.2    Sakaguchi, A.Y.3
  • 21
    • 0022511903 scopus 로고
    • Receptor for epidermal growth factor retains normal structure and function in aging cells
    • CHUA, C.C., GEIMAN, D.E., and LADDA, R.L. Receptor for epidermal growth factor retains normal structure and function in aging cells. Mech. Ageing Dev. 34, 35-55, 1986.
    • (1986) Mech. Ageing Dev. , vol.34 , pp. 35-55
    • Chua, C.C.1    Geiman, D.E.2    Ladda, R.L.3
  • 22
    • 0010710816 scopus 로고
    • Cellular senescence: Factors modulating cell proliferation in vitro
    • Bourliere, F., Courtois, Y., Macieira-Coelho, A., and Robert, L. (Editors), INSERM, Paris
    • CRISTOFALO, V.J. Cellular senescence: Factors modulating cell proliferation in vitro. In: INSERM, Bourliere, F., Courtois, Y., Macieira-Coelho, A., and Robert, L. (Editors), pp. 65-92, INSERM, Paris, 1973.
    • (1973) INSERM , pp. 65-92
    • Cristofalo, V.J.1
  • 23
    • 0023811135 scopus 로고
    • Cellular biomarkers of aging
    • CRISTOFALO, V.J. Cellular biomarkers of aging. Exp. Gerontol. 23, 297-305, 1988.
    • (1988) Exp. Gerontol. , vol.23 , pp. 297-305
    • Cristofalo, V.J.1
  • 25
    • 0027163464 scopus 로고
    • Replicative senescence of human fibroblast-like cells in culture
    • CRISTOFALO, V.J. and PIGNOLO, R.J. Replicative senescence of human fibroblast-like cells in culture. Physiol. Rev. 73, 617-638, 1993.
    • (1993) Physiol. Rev. , vol.73 , pp. 617-638
    • Cristofalo, V.J.1    Pignolo, R.J.2
  • 27
    • 0024423686 scopus 로고
    • Alterations in the responsiveness of senescent cells to growth factors
    • Cancer and Aging, Richardson, A. (Editor)
    • CRISTOFALO, V.J., PHILLIPS, P.D., SORGER, T., and GERHARD, G. Alterations in the responsiveness of senescent cells to growth factors. In: Cancer and Aging, Richardson, A. (Editor). J. Gerontol. 44, 55-62, 1989b.
    • (1989) J. Gerontol. , vol.44 , pp. 55-62
    • Cristofalo, V.J.1    Phillips, P.D.2    Sorger, T.3    Gerhard, G.4
  • 28
    • 85030190682 scopus 로고    scopus 로고
    • Effects of cellular aging on the induction of c-fos by antioxidant treatments
    • in press
    • CRISTOFALO, V.J., KEOGH, B.P., TRESINI, M., and ALLEN, R.G. Effects of cellular aging on the induction of c-fos by antioxidant treatments. Exp. Gerontol. (in press).
    • Exp. Gerontol.
    • Cristofalo, V.J.1    Keogh, B.P.2    Tresini, M.3    Allen, R.G.4
  • 29
    • 0027208232 scopus 로고
    • Effects of the tumor promoting agent phorbol 12-myristate 13-acetate (PMA) on the proliferation of young and senescent WI-38 human diploid fibroblasts
    • DE TATA, V., PTASZNIK, A., and CRISTOFALO, V.J. Effects of the tumor promoting agent phorbol 12-myristate 13-acetate (PMA) on the proliferation of young and senescent WI-38 human diploid fibroblasts. Exp. Cell Res. 205, 261-269, 1993.
    • (1993) Exp. Cell Res. , vol.205 , pp. 261-269
    • De Tata, V.1    Ptasznik, A.2    Cristofalo, V.J.3
  • 30
    • 0028290512 scopus 로고
    • Altered prolife of transcription factor-binding activities in senescent human fibroblasts
    • DIMRI, G.P. and CAMPISI Altered prolife of transcription factor-binding activities in senescent human fibroblasts. Exp. Cell Res. 212, 132-140, 1994.
    • (1994) Exp. Cell Res. , vol.212 , pp. 132-140
    • Dimri, G.P.1    Campisi2
  • 31
    • 0028361374 scopus 로고
    • Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
    • DIMRI, G.P., HARA, E., and CAMPISI, J. Regulation of two E2F-related genes in presenescent and senescent human fibroblasts. J. Biol. Chem. 269, 16180-16186, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16180-16186
    • Dimri, G.P.1    Hara, E.2    Campisi, J.3
  • 33
    • 0028220204 scopus 로고
    • p53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
    • DULIC, V., KAUFMANN, W.K., WILSON, S.J., TISTY, T.D., LEES, E., HARPER, J.W., ELLEDGE, S.J., and REED, S.I. p53-Dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76, 1013-1023, 1994.
    • (1994) Cell , vol.76 , pp. 1013-1023
    • Dulic, V.1    Kaufmann, W.K.2    Wilson, S.J.3    Tisty, T.D.4    Lees, E.5    Harper, J.W.6    Elledge, S.J.7    Reed, S.I.8
  • 34
    • 0343855600 scopus 로고
    • The permanent life of connective tissue outside of the organism
    • EBELING, A.H. The permanent life of connective tissue outside of the organism. J. Exp. Med. 17, 273-285, 1913.
    • (1913) J. Exp. Med. , vol.17 , pp. 273-285
    • Ebeling, A.H.1
  • 35
    • 0342549974 scopus 로고
    • Measurement of the growth of tissues in vitro
    • EBELING, A.H. Measurement of the growth of tissues in vitro. J. Exp. Med. 34, 231-243, 1921.
    • (1921) J. Exp. Med. , vol.34 , pp. 231-243
    • Ebeling, A.H.1
  • 37
    • 0026781080 scopus 로고
    • Stimulation of DNA synthesis in senescent human cells following incubation with plasma membranes
    • FREDERICH, K.M., PHILLIPS, P.D., and CRISTOFALO, V.J. Stimulation of DNA synthesis in senescent human cells following incubation with plasma membranes. Exp. Cell Res. 202, 386-390, 1992.
    • (1992) Exp. Cell Res. , vol.202 , pp. 386-390
    • Frederich, K.M.1    Phillips, P.D.2    Cristofalo, V.J.3
  • 38
    • 0026082163 scopus 로고
    • EGF- and PDGF-stimulated phosphorylation in young and senescent WI-38 cells
    • GERHARD, G.S., PHILLIPS, P.D., and CRISTOFALO, V.J. EGF- and PDGF-stimulated phosphorylation in young and senescent WI-38 cells. Exp. Cell Res. 193, 87-92, 1991.
    • (1991) Exp. Cell Res. , vol.193 , pp. 87-92
    • Gerhard, G.S.1    Phillips, P.D.2    Cristofalo, V.J.3
  • 39
    • 0025145238 scopus 로고
    • Replicative senescence: The human fibroblast comes of age
    • GOLDSTEIN, S. Replicative senescence: The human fibroblast comes of age. Science 249, 1129-1133, 1990.
    • (1990) Science , vol.249 , pp. 1129-1133
    • Goldstein, S.1
  • 40
    • 0025946601 scopus 로고
    • Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts
    • GOLDSTEIN, S., MOERMAN, E.J., JONES, R.A., and BAXTER, R.C. Insulin-like growth factor binding protein 3 accumulates to high levels in culture medium of senescent and quiescent human fibroblasts. Proc. Natl. Acad. Sci. USA 88, 9680-9684, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 9680-9684
    • Goldstein, S.1    Moerman, E.J.2    Jones, R.A.3    Baxter, R.C.4
  • 41
    • 0028088709 scopus 로고
    • Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner Syndrome
    • GOLDSTEIN, S., MOERMAN, E.J., FUJII, S., and SOBEL, B.E. Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner Syndrome. J. Cell. Physiol. 161, 571-579, 1994.
    • (1994) J. Cell. Physiol. , vol.161 , pp. 571-579
    • Goldstein, S.1    Moerman, E.J.2    Fujii, S.3    Sobel, B.E.4
  • 42
    • 0028108405 scopus 로고
    • Basal and induced amounts of interleukin-6 mRNA decline progressively with age in human fibroblasts
    • GOODMAN, L. and STEIN, G.H. Basal and induced amounts of interleukin-6 mRNA decline progressively with age in human fibroblasts. J. Biol. Chem. 269, 19250-19255, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19250-19255
    • Goodman, L.1    Stein, G.H.2
  • 43
    • 0022257331 scopus 로고
    • Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent cells by Simian Virus 40 infection
    • GORMAN, S.D. and CRISTOFALO, V.J. Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent cells by Simian Virus 40 infection. J. Cell. Physiol. 125, 122-126, 1985.
    • (1985) J. Cell. Physiol. , vol.125 , pp. 122-126
    • Gorman, S.D.1    Cristofalo, V.J.2
  • 44
    • 0022979431 scopus 로고
    • Analysis of the G1 arrest position of senescent WI-38 cells by quinacrine dihydrochloride nuclear fluorescence-evidence for a late G-1 arrest
    • GORMAN, S.D. and CRISTOFALO, V.J. Analysis of the G1 arrest position of senescent WI-38 cells by quinacrine dihydrochloride nuclear fluorescence-evidence for a late G-1 arrest. Exp. Cell Res. 167, 87-94, 1986.
    • (1986) Exp. Cell Res. , vol.167 , pp. 87-94
    • Gorman, S.D.1    Cristofalo, V.J.2
  • 45
    • 0026055983 scopus 로고
    • Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1
    • HARA, E., TSURUI, H., SHINOZAKI, A., NAKADA, S., and ODA, K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of lifespan in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 179, 528-534, 1991.
    • (1991) Biochem. Biophys. Res. Commun. , vol.179 , pp. 528-534
    • Hara, E.1    Tsurui, H.2    Shinozaki, A.3    Nakada, S.4    Oda, K.5
  • 46
    • 0027976669 scopus 로고
    • Id-related genes encoding helix-loop-helix proteins are required for G, progression and are repressed in senescent human fibroblasts
    • HARA, E., YAMAGUCHI, T., NOJIMA, H., IDE, T., CAMPISI, J., OKAYAMA, H., and ODA, K. Id-related genes encoding helix-loop-helix proteins are required for G, progression and are repressed in senescent human fibroblasts. J. Biol. Chem. 269, 2139-2145, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2139-2145
    • Hara, E.1    Yamaguchi, T.2    Nojima, H.3    Ide, T.4    Campisi, J.5    Okayama, H.6    Oda, K.7
  • 47
    • 0026908206 scopus 로고
    • The endoplasmic reticulum-Golgi intermediate compartment
    • HAURI, H.-P. and SCHWEIZER, A. The endoplasmic reticulum-Golgi intermediate compartment. Curr. Opin. Cell Biol. 4, 600-608, 1992.
    • (1992) Curr. Opin. Cell Biol. , vol.4 , pp. 600-608
    • Hauri, H.-P.1    Schweizer, A.2
  • 48
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • HAYFLICK, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636, 1965.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 49
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • HAYFLICK, L. and MOORHEAD, P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621, 1961.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 50
    • 0022508325 scopus 로고
    • The effect of dexamethasone on epidermal growth factor binding and stimulation of proliferation in young and senescent WI-38 cells
    • HOSOKAWA, M., PHILLIPS, P.D., and CRISTOFALO, V.J. The effect of dexamethasone on epidermal growth factor binding and stimulation of proliferation in young and senescent WI-38 cells. Exp. Cell Res. 164, 408-414, 1986.
    • (1986) Exp. Cell Res. , vol.164 , pp. 408-414
    • Hosokawa, M.1    Phillips, P.D.2    Cristofalo, V.J.3
  • 51
    • 0027768579 scopus 로고
    • Braking the cycle
    • HUNTER, T. Braking the cycle. Cell 75, 839-841, 1993.
    • (1993) Cell , vol.75 , pp. 839-841
    • Hunter, T.1
  • 53
    • 0026522609 scopus 로고
    • Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts
    • KUMAR, S., MILLIS, A.J., and BAGLIONI, C. Expression of interleukin 1-inducible genes and production of interleukin 1 by aging human fibroblasts. Proc. Natl. Acad. Sci. USA 89, 4683-4687, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 4683-4687
    • Kumar, S.1    Millis, A.J.2    Baglioni, C.3
  • 54
    • 0025827242 scopus 로고
    • Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area
    • KUMAZAKI, T., ROBETORYE, R.S., ROBERTORYE, S.C., and SMITH, J.R. Fibronectin expression increases during in vitro cellular senescence: Correlation with increased cell area. Exp. Cell Res. 195, 13-19, 1991.
    • (1991) Exp. Cell Res. , vol.195 , pp. 13-19
    • Kumazaki, T.1    Robetorye, R.S.2    Robertorye, S.C.3    Smith, J.R.4
  • 55
    • 0027215534 scopus 로고
    • Suppression of the growth factor-mediated induction of c-fos and down-modulation of AP-1-binding activity are not required for cellular senescence
    • LUCIBELLO, F.C., BRUSSELBACH, S., SEWING, A., and MULLER, R. Suppression of the growth factor-mediated induction of c-fos and down-modulation of AP-1-binding activity are not required for cellular senescence. Oncogene 8, 1667-1672, 1993a.
    • (1993) Oncogene , vol.8 , pp. 1667-1672
    • Lucibello, F.C.1    Brusselbach, S.2    Sewing, A.3    Muller, R.4
  • 56
    • 0027269711 scopus 로고
    • Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts
    • LUCIBELLO, F.C., SEWING, A., BRUSSELBACH, S., BURGER, C., and MULLER, R. Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts. J. Cell Sci. 105, 123-133, 1993b.
    • (1993) J. Cell Sci. , vol.105 , pp. 123-133
    • Lucibello, F.C.1    Sewing, A.2    Brusselbach, S.3    Burger, C.4    Muller, R.5
  • 57
    • 0013918813 scopus 로고
    • The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro
    • MACIEIRA-COELHO, A., PONTEN, J., and PHILLIPSON, L. The division cycle and RNA synthesis in diploid human cells at different passage levels in vitro. Exp. Cell Res. 42, 673-684, 1966.
    • (1966) Exp. Cell Res. , vol.42 , pp. 673-684
    • Macieira-Coelho, A.1    Ponten, J.2    Phillipson, L.3
  • 58
    • 0023869405 scopus 로고
    • Binding of soluble fibronectin and its subsequent incorporation into the extracellular matrix by early and late passage human skin fibroblasts
    • MANN, D.M., MCKEOWN-LONGO, P.J., and MILLIS, A.J. Binding of soluble fibronectin and its subsequent incorporation into the extracellular matrix by early and late passage human skin fibroblasts. J. Biol. Chem. 263, 2756-2760, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 2756-2760
    • Mann, D.M.1    McKeown-Longo, P.J.2    Millis, A.J.3
  • 59
    • 0027728976 scopus 로고
    • How p53 suppresses cell growth
    • MARX, J. How p53 suppresses cell growth. Science 262, 1644-1645, 1993.
    • (1993) Science , vol.262 , pp. 1644-1645
    • Marx, J.1
  • 60
    • 0018358261 scopus 로고
    • Senescent human diploid cells in culture: Survival, DNA synthesis and morphology
    • MATSUMURA, T., ZERRUDO, Z., and HAYFLICK, L. Senescent human diploid cells in culture: Survival, DNA synthesis and morphology. J. Gerontol. 34, 328-334, 1979.
    • (1979) J. Gerontol. , vol.34 , pp. 328-334
    • Matsumura, T.1    Zerrudo, Z.2    Hayflick, L.3
  • 61
    • 0024398094 scopus 로고
    • Collagenase production by early and late passage cultures of human fibroblasts
    • MILLIS, A.J., SOTTILE, J., HOYLE, M., MANN, D.M., and DIEMER, V. Collagenase production by early and late passage cultures of human fibroblasts. Exp. Gerontol. 24, 559-575, 1989.
    • (1989) Exp. Gerontol. , vol.24 , pp. 559-575
    • Millis, A.J.1    Sottile, J.2    Hoyle, M.3    Mann, D.M.4    Diemer, V.5
  • 62
    • 0026793281 scopus 로고
    • Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts
    • MILLIS, A.J., HOYLE, M., MCCUE, H.M., and MARTINI, H. Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp. Cell Res. 201, 373-379, 1992.
    • (1992) Exp. Cell Res. , vol.201 , pp. 373-379
    • Millis, A.J.1    Hoyle, M.2    McCue, H.M.3    Martini, H.4
  • 63
    • 0018862459 scopus 로고
    • Cellular senescence in a cloned strain of bovine fetal aortic endothelial cells
    • MUELLER, S.N., ROSEN, E.M., and LEVINE, E.M. Cellular senescence in a cloned strain of bovine fetal aortic endothelial cells. Science 207, 889-891, 1980.
    • (1980) Science , vol.207 , pp. 889-891
    • Mueller, S.N.1    Rosen, E.M.2    Levine, E.M.3
  • 64
    • 0025866760 scopus 로고
    • Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence
    • MURANO, S., THWEATT, R., SHMOOKLER-REIS, R.J., JONES, R.A., MOERMAN, E.J., and GOLDSTEIN, S. Diverse gene sequences are overexpressed in Werner syndrome fibroblasts undergoing premature replicative senescence. Mol. Cell. Biol. 11, 3905-3914, 1991.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3905-3914
    • Murano, S.1    Thweatt, R.2    Shmookler-Reis, R.J.3    Jones, R.A.4    Moerman, E.J.5    Goldstein, S.6
  • 66
    • 0027759806 scopus 로고
    • Dams and sluices
    • NASMYTH, K. and HUNT, T. Dams and sluices. Nature 366, 634-635, 1993.
    • (1993) Nature , vol.366 , pp. 634-635
    • Nasmyth, K.1    Hunt, T.2
  • 67
    • 0028342664 scopus 로고
    • Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen
    • NODA, A., NING, Y., VENABLE, S.F., PEREIRA-SMITH, O.M., and SMITH, J.R. Cloning of senescent cell derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res. 211, 90-98, 1994.
    • (1994) Exp. Cell Res. , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Pereira-Smith, O.M.4    Smith, J.R.5
  • 68
    • 0018388828 scopus 로고
    • Complementation in heterokaryons derived from a thymidine kinase deficient cell line and senescent human diploid cells
    • NORWOOD, T.H., RABINOVITCH, P.S., and ZEIGLER, C.J. Complementation in heterokaryons derived from a thymidine kinase deficient cell line and senescent human diploid cells. Fed. Proc. 38, 1868-1872, 1979.
    • (1979) Fed. Proc. , vol.38 , pp. 1868-1872
    • Norwood, T.H.1    Rabinovitch, P.S.2    Zeigler, C.J.3
  • 70
    • 0021050054 scopus 로고
    • Thymidine triphosphate synthesis in senescent WI38 cells. Relationship to loss of replicative capacity
    • OLASHAW, N.E., KRESS, E.D., and CRISTOFALO, V.J. Thymidine triphosphate synthesis in senescent WI38 cells. Relationship to loss of replicative capacity. Exp. Cell Res. 149, 547-554, 1983.
    • (1983) Exp. Cell Res. , vol.149 , pp. 547-554
    • Olashaw, N.E.1    Kress, E.D.2    Cristofalo, V.J.3
  • 71
    • 0028898823 scopus 로고
    • Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors
    • OSHIMA, J., CAMPISI, J., TANNOCK, T.C.A., and MARTIN, G.M. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J. Cell. Physiol. 162, 277-283, 1994.
    • (1994) J. Cell. Physiol. , vol.162 , pp. 277-283
    • Oshima, J.1    Campisi, J.2    Tannock, T.C.A.3    Martin, G.M.4
  • 72
    • 0028146852 scopus 로고
    • Global change of gene expression at late G0/S boundary may occur in human IMR-90 diploid fibroblasts during senescence
    • PANG, J.H. and CHEN, K.Y. Global change of gene expression at late G0/S boundary may occur in human IMR-90 diploid fibroblasts during senescence. J. Cell. Physiol. 160, 531-538, 1994.
    • (1994) J. Cell. Physiol. , vol.160 , pp. 531-538
    • Pang, J.H.1    Chen, K.Y.2
  • 74
    • 0026027972 scopus 로고
    • The relationship between the rate of entry into S phase, concentration of DNA polymerase alpha, and cell volume in human diploid fibroblast-like monokaryon cells
    • PENDERGRASS, W.R., ANGELLO, J.C., KIRSCHNER, M.D., and NORWOOD, T.H. The relationship between the rate of entry into S phase, concentration of DNA polymerase alpha, and cell volume in human diploid fibroblast-like monokaryon cells. Exp. Cell Res. 192, 418-425, 1991.
    • (1991) Exp. Cell Res. , vol.192 , pp. 418-425
    • Pendergrass, W.R.1    Angello, J.C.2    Kirschner, M.D.3    Norwood, T.H.4
  • 75
    • 0022205326 scopus 로고
    • Senescent and quiescent cell inhibitors of DNA synthesis. Membrane-associated proteins
    • PEREIRA-SMITH, O.M., FISHER, S.F., and SMITH, J.R. Senescent and quiescent cell inhibitors of DNA synthesis. Membrane-associated proteins. Exp. Cell Res. 160, 297-306, 1985.
    • (1985) Exp. Cell Res. , vol.160 , pp. 297-306
    • Pereira-Smith, O.M.1    Fisher, S.F.2    Smith, J.R.3
  • 76
    • 0343050763 scopus 로고
    • Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors
    • PETERSON, C. and GOLDMAN, J.E. Alterations in calcium content and biochemical processes in cultured skin fibroblasts from aged and Alzheimer donors. Proc. Natl. Acad. Sci. USA 83, 2758-2762, 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 2758-2762
    • Peterson, C.1    Goldman, J.E.2
  • 77
    • 0023037796 scopus 로고
    • Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors
    • PETERSON, C., RATAN, R.R., SHELANSKI, M.L., and GOLDMAN, J.E. Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors. Proc. Natl. Acad. Sci. USA 83, 7999-8001, 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 7999-8001
    • Peterson, C.1    Ratan, R.R.2    Shelanski, M.L.3    Goldman, J.E.4
  • 78
    • 0020647035 scopus 로고
    • 125I]EGF binding ability is stable throughout the replicative life span of WI-38 cells
    • 125I]EGF binding ability is stable throughout the replicative life span of WI-38 cells. J. Cell. Physiol. 114, 311-316, 1983.
    • (1983) J. Cell. Physiol. , vol.114 , pp. 311-316
    • Phillips, P.D.1    Kuhnle, E.2    Cristofalo, V.J.3
  • 79
    • 0021350634 scopus 로고
    • Progressive loss of the response of senescing WI-38 cells to platelet-derived growth factor, epidermal growth factor, insulin, transferrin, and dexamethasone
    • PHILLIPS, P.D., KAJI, K., and CRISTOFALO, V.J. Progressive loss of the response of senescing WI-38 cells to platelet-derived growth factor, epidermal growth factor, insulin, transferrin, and dexamethasone. J. Gerontol. 39, 11-17, 1984.
    • (1984) J. Gerontol. , vol.39 , pp. 11-17
    • Phillips, P.D.1    Kaji, K.2    Cristofalo, V.J.3
  • 80
    • 0023632276 scopus 로고
    • Insulin-like growth factor-I: Specific binding to high and low affinity sites and mitogenic action throughout the life span of WI-38 cells
    • PHILLIPS, P.D., PIGNOLO, R.J., and CRISTOFALO, V.J. Insulin-like growth factor-I: Specific binding to high and low affinity sites and mitogenic action throughout the life span of WI-38 cells. J. Cell. Physiol. 133, 135-143, 1987.
    • (1987) J. Cell. Physiol. , vol.133 , pp. 135-143
    • Phillips, P.D.1    Pignolo, R.J.2    Cristofalo, V.J.3
  • 81
    • 0026544969 scopus 로고
    • Renewed DNA synthesis in senescent WI-38 cells by expression of an inducible chimeric c-fos construct
    • PHILLIPS, P.D., PIGNOLO, R.J., NISHIKURA, K., and CRISTOFALO, V.J. Renewed DNA synthesis in senescent WI-38 cells by expression of an inducible chimeric c-fos construct. J. Cell. Physiol. 151, 206-212, 1992.
    • (1992) J. Cell. Physiol. , vol.151 , pp. 206-212
    • Phillips, P.D.1    Pignolo, R.J.2    Nishikura, K.3    Cristofalo, V.J.4
  • 82
    • 85030195625 scopus 로고
    • Differential expression of a novel cell cycle-regulated transcript in late population doubling level WI-38 cells
    • San Francisco, CA
    • PIGNOLO, R.J., ROTENBERG, M.O., and CRISTOFALO, V.J. Differential expression of a novel cell cycle-regulated transcript in late population doubling level WI-38 cells (Abstract). 44th Ann. Meet. Gerontol Soc. Am., San Francisco, CA, 1991, p. 74.
    • (1991) 44th Ann. Meet. Gerontol Soc. Am. , pp. 74
    • Pignolo, R.J.1    Rotenberg, M.O.2    Cristofalo, V.J.3
  • 84
    • 0027502881 scopus 로고
    • Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the GO state
    • PIGNOLO, R.J., ROTENBERG, M.O., and CRISTOFALO, V.J. Senescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the GO state. J. Biol. Chem. 268, 8949-8957, 1993b.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8949-8957
    • Pignolo, R.J.1    Rotenberg, M.O.2    Cristofalo, V.J.3
  • 85
    • 0028335752 scopus 로고
    • Alterations in contact and density-dependent arrest state in senescent WI-38 cells
    • PIGNOLO, R.J., ROTENBERG, M.O., and CRISTOFALO, V.J. Alterations in contact and density-dependent arrest state in senescent WI-38 cells. In Vitro Cell. Dev. Biol, 30, 471-476, 1994.
    • (1994) In Vitro Cell. Dev. Biol , vol.30 , pp. 471-476
    • Pignolo, R.J.1    Rotenberg, M.O.2    Cristofalo, V.J.3
  • 86
    • 0028924851 scopus 로고
    • Analysis of EPC-1 growth state-dependent expression, specificity, and conservation of related sequences
    • PIGNOLO, R.J., ROTENBERG, M.O., and CRISTOFALO, V.J. Analysis of EPC-1 growth state-dependent expression, specificity, and conservation of related sequences. J. Cell. Physiol. 162, 110-118, 1995.
    • (1995) J. Cell. Physiol. , vol.162 , pp. 110-118
    • Pignolo, R.J.1    Rotenberg, M.O.2    Cristofalo, V.J.3
  • 87
    • 0013683264 scopus 로고
    • Aging properties of glia
    • Bourliere, F., Courtois, Y., Macieira-Coelho, A., and Robert, L. (Editors), INSERM, Paris
    • PONTEN, J. Aging properties of glia. In: INSERM, Bourliere, F., Courtois, Y., Macieira-Coelho, A., and Robert, L. (Editors), pp. 53-64, INSERM, Paris, 1973.
    • (1973) In: INSERM , pp. 53-64
    • Ponten, J.1
  • 88
    • 0025015197 scopus 로고
    • Novel monoclonal antibodies identify antigenic determinants unique to cellular senescence
    • PORTER, M.B., PEREIRA-SMITH, O.M., and SMITH, J.R. Novel monoclonal antibodies identify antigenic determinants unique to cellular senescence. J. Cell. Physiol. 142, 425-433, 1990.
    • (1990) J. Cell. Physiol. , vol.142 , pp. 425-433
    • Porter, M.B.1    Pereira-Smith, O.M.2    Smith, J.R.3
  • 89
    • 0022475554 scopus 로고
    • The growth of WI-38 cells in a serum-free, growth factor-free, medium with elevated calcium concentrations
    • PRAEGER, F.C. and CRISTOFALO, V.J. The growth of WI-38 cells in a serum-free, growth factor-free, medium with elevated calcium concentrations. In Vitro Cell. Dev. Biol. 22, 355-359, 1986a.
    • (1986) In Vitro Cell. Dev. Biol. , vol.22 , pp. 355-359
    • Praeger, F.C.1    Cristofalo, V.J.2
  • 91
    • 0022551787 scopus 로고
    • Influence of increased extracellular calcium concentration and donor age on density-dependent growth inhibition of human fibroblasts
    • PRAEGER, F.C. and GILCHREST, B.A. Influence of increased extracellular calcium concentration and donor age on density-dependent growth inhibition of human fibroblasts. Proc. Soc. Exp. Biol. Med. 182, 315-321, 1986.
    • (1986) Proc. Soc. Exp. Biol. Med. , vol.182 , pp. 315-321
    • Praeger, F.C.1    Gilchrest, B.A.2
  • 92
    • 0016729431 scopus 로고
    • Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells
    • RHEINWALD, J.G. and GREEN, H. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 6, 331-334, 1975.
    • (1975) Cell , vol.6 , pp. 331-334
    • Rheinwald, J.G.1    Green, H.2
  • 93
    • 0026599596 scopus 로고
    • Transcription factor AP-I activity is required for initiation of DNA synthesis and is lost during cellular aging
    • RIABOWOL, K., SCHIFF, J., and OILMAN, M.Z. Transcription factor AP-I activity is required for initiation of DNA synthesis and is lost during cellular aging. Proc. Natl. Acad. Sci. USA 89, 157-161, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 157-161
    • Riabowol, K.1    Schiff, J.2    Oilman, M.Z.3
  • 94
    • 0001111837 scopus 로고
    • Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts
    • RITTLING, S.R., BROOKS, K.M., CRISTOFALO, V.J., and BASERGA, R. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts. Proc. Natl. Acad. Sci. USA 83, 3316-3320, 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 3316-3320
    • Rittling, S.R.1    Brooks, K.M.2    Cristofalo, V.J.3    Baserga, R.4
  • 95
    • 0027052384 scopus 로고
    • Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis
    • ROSE, D.W., MCCABE, G., FERAMISCO, J.R., and ADLER, M. Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis. J. Cell Biol. 119, 1405-1411, 1992.
    • (1992) J. Cell Biol. , vol.119 , pp. 1405-1411
    • Rose, D.W.1    McCabe, G.2    Feramisco, J.R.3    Adler, M.4
  • 97
    • 0025052004 scopus 로고
    • Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
    • SESHADRI, T. and CAMPISI, J. Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 247, 205-209, 1990.
    • (1990) Science , vol.247 , pp. 205-209
    • Seshadri, T.1    Campisi, J.2
  • 98
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • SHAY, J.W., PEREIRA-SMITH, O.M., and WRIGHT, W.E. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196, 33-39, 1991.
    • (1991) Exp. Cell Res. , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 99
    • 0025365870 scopus 로고
    • Early kinase C dependent events in aging human diploid fibroblasts
    • SHIGEOKA, H. and YANG, H.C. Early kinase C dependent events in aging human diploid fibroblasts. Mech. Ageing Dev. 55, 49-59, 1990.
    • (1990) Mech. Ageing Dev. , vol.55 , pp. 49-59
    • Shigeoka, H.1    Yang, H.C.2
  • 100
    • 0026717013 scopus 로고
    • Inhibitors of DNA synthesis derived from senescent human diploid fibroblasts
    • SMITH, J.R. Inhibitors of DNA synthesis derived from senescent human diploid fibroblasts. Exp. Gerontol. 27, 409-412, 1992.
    • (1992) Exp. Gerontol. , vol.27 , pp. 409-412
    • Smith, J.R.1
  • 101
    • 0024049918 scopus 로고
    • Differential response of early and late passage fibroblasts to collagenase stimulatory factor in conditioned media
    • SOTTILE, J., HOYLE, M., and MILLIS, A.J. Differential response of early and late passage fibroblasts to collagenase stimulatory factor in conditioned media. Collagen Related Res. 8, 361-374, 1988.
    • (1988) Collagen Related Res. , vol.8 , pp. 361-374
    • Sottile, J.1    Hoyle, M.2    Millis, A.J.3
  • 102
    • 0024541932 scopus 로고
    • Regulation of collagenase and collagenase mRNA production in early and late-passage human diploid fibroblasts
    • SOTTILE, J., MANN, D.M., DIEMER, V., and MILLIS, A.J. Regulation of collagenase and collagenase mRNA production in early and late-passage human diploid fibroblasts. J. Cell. Physiol. 138, 281-290, 1989.
    • (1989) J. Cell. Physiol. , vol.138 , pp. 281-290
    • Sottile, J.1    Mann, D.M.2    Diemer, V.3    Millis, A.J.4
  • 103
    • 0022912672 scopus 로고
    • Membrane-associated inhibitor of DNA synthesis in senescent human diploid fibroblasts: Characterization and comparison to quiescent cell inhibitor
    • STEIN, G.H. and ATKINS, L. Membrane-associated inhibitor of DNA synthesis in senescent human diploid fibroblasts: Characterization and comparison to quiescent cell inhibitor. Proc. Natl. Acad. Sci. USA 83, 9030-9034, 1986.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 9030-9034
    • Stein, G.H.1    Atkins, L.2
  • 104
    • 0025150387 scopus 로고
    • Failure to phosphorylate retinoblastoma gene product in senescent human fibroblasts
    • STEIN, G.H., BEESON, M., and GORDON, L. Failure to phosphorylate retinoblastoma gene product in senescent human fibroblasts. Science 249, 666-669, 1990.
    • (1990) Science , vol.249 , pp. 666-669
    • Stein, G.H.1    Beeson, M.2    Gordon, L.3
  • 106
    • 0001266682 scopus 로고
    • Culture characteristics of human fibroblasts propagated serially
    • SWIM, H.E. and PARKER, R.F. Culture characteristics of human fibroblasts propagated serially. Am. J. Hygiene 66, 235, 1957.
    • (1957) Am. J. Hygiene , vol.66 , pp. 235
    • Swim, H.E.1    Parker, R.F.2
  • 107
    • 0026685043 scopus 로고
    • The regulation of intracellular calcium ion and pH in young and old fibroblast cells (WI-38)
    • TAKAHASHI, Y., YOSHIDA, T., and TAKASHIMA, S. The regulation of intracellular calcium ion and pH in young and old fibroblast cells (WI-38). J. Gerontol. 47, B65-70, 1992.
    • (1992) J. Gerontol. , vol.47
    • Takahashi, Y.1    Yoshida, T.2    Takashima, S.3
  • 108
    • 0028202945 scopus 로고
    • Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression
    • TANG, Z., ZHANG, Z., ZHENG, Y., CORBLEY, M.J., and TONG, T. Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression. Mech. Ageing Dev. 73, 57-67, 1994.
    • (1994) Mech. Ageing Dev. , vol.73 , pp. 57-67
    • Tang, Z.1    Zhang, Z.2    Zheng, Y.3    Corbley, M.J.4    Tong, T.5
  • 109
    • 0018595902 scopus 로고
    • Human lens cells have an in vitro proliferative capacity inversely proportional to the donor age
    • TASSIN, J., MALAISE, E., and COURTOIS, Y. Human lens cells have an in vitro proliferative capacity inversely proportional to the donor age. Exp. Cell Res. 123, 388-392, 1979.
    • (1979) Exp. Cell Res. , vol.123 , pp. 388-392
    • Tassin, J.1    Malaise, E.2    Courtois, Y.3
  • 110
    • 0026779315 scopus 로고
    • A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts
    • THWEATT, R., LUMPKIN, C.K., and GOLDSTEIN, S. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. Biochem. Biophys. Res. Commun. 187, 1-7, 1992a.
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 1-7
    • Thweatt, R.1    Lumpkin, C.K.2    Goldstein, S.3
  • 111
    • 0026708099 scopus 로고
    • Isolation and characterization of gene sequences overexpressed in Werner syndrome fibroblasts during premature replicative senescence
    • THWEATT, R., MURANO, S., FLEISCHMANN, R.D., and GOLDSTEIN, S. Isolation and characterization of gene sequences overexpressed in Werner syndrome fibroblasts during premature replicative senescence. Exp. Gerontol. 27, 433-440, 1992b.
    • (1992) Exp. Gerontol. , vol.27 , pp. 433-440
    • Thweatt, R.1    Murano, S.2    Fleischmann, R.D.3    Goldstein, S.4
  • 112
    • 0018774544 scopus 로고
    • Cytokinetic analysis of impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin
    • TICE, R.R., SCHNEIDER, E.L., KRAM, D., and THORNE, P. Cytokinetic analysis of impaired proliferative response of peripheral lymphocytes from aged humans to phytohemagglutinin. J. Exp. Med. 149, 1029-1041, 1979.
    • (1979) J. Exp. Med. , vol.149 , pp. 1029-1041
    • Tice, R.R.1    Schneider, E.L.2    Kram, D.3    Thorne, P.4
  • 113
    • 0027146392 scopus 로고
    • Selective loss of CDC2 and CDK2 induction by tumor necrosis factor-alpha in senescent human diploid fibroblasts
    • TSUJI, Y., NINOMIYA-TSUJI, J., TORTI, S.V., and TORTI, F.M. Selective loss of CDC2 and CDK2 induction by tumor necrosis factor-alpha in senescent human diploid fibroblasts. Exp. Cell Res. 209, 175-182, 1993.
    • (1993) Exp. Cell Res. , vol.209 , pp. 175-182
    • Tsuji, Y.1    Ninomiya-Tsuji, J.2    Torti, S.V.3    Torti, F.M.4
  • 114
    • 0021927734 scopus 로고
    • A 57,000-mol-wt. protein uniquely present in nonproliferating cells and senescent human fibroblasts
    • WANG, E. A 57,000-mol-wt. protein uniquely present in nonproliferating cells and senescent human fibroblasts. J. Cell Biol. 100, 545-551, 1985a.
    • (1985) J. Cell Biol. , vol.100 , pp. 545-551
    • Wang, E.1
  • 115
    • 0022406818 scopus 로고
    • Rapid disappearance of statin, a nonproliferating and senescent-cell specific protein, upon reentering the process of cell cycling
    • WANG, E. Rapid disappearance of statin, a nonproliferating and senescent-cell specific protein, upon reentering the process of cell cycling. J. Cell Biol. 101, 1695-1701, 1985b.
    • (1985) J. Cell Biol. , vol.101 , pp. 1695-1701
    • Wang, E.1
  • 116
    • 0024466742 scopus 로고
    • Statin, a nonproliferation-specific protein, is associated with the nuclear envelope and is heterogeneously distributed in cells leaving quiescent state
    • WANG, E. Statin, a nonproliferation-specific protein, is associated with the nuclear envelope and is heterogeneously distributed in cells leaving quiescent state. J. Cell. Physiol. 140, 418-426, 1989.
    • (1989) J. Cell. Physiol. , vol.140 , pp. 418-426
    • Wang, E.1
  • 117
    • 0022929933 scopus 로고
    • Disappearance of statin, a protein marker for nonproliferating and senescent cells, following serum-stimulated cell-cycle entry
    • WANG, E. and LIN, S.L. Disappearance of statin, a protein marker for nonproliferating and senescent cells, following serum-stimulated cell-cycle entry. Exp. Cell Res. 167, 135-143, 1986.
    • (1986) Exp. Cell Res. , vol.167 , pp. 135-143
    • Wang, E.1    Lin, S.L.2
  • 118
    • 0025769345 scopus 로고
    • Granular presence of terminin is the marker to distinguish between the senescent and quiescent states
    • WANG, E. and TOMASZEWSKI, G. Granular presence of terminin is the marker to distinguish between the senescent and quiescent states. J. Cell. Physiol. 147, 514-522, 1991.
    • (1991) J. Cell. Physiol. , vol.147 , pp. 514-522
    • Wang, E.1    Tomaszewski, G.2
  • 119
    • 0342984373 scopus 로고
    • Transcriptional mechanisms regulating the over-expression of plasminogen activator inhibitor-1 in senescent fibroblasts
    • San Francisco, CA
    • WEST, M.D., WRIGHT, W.E., and SHAY, J.W. Transcriptional mechanisms regulating the over-expression of plasminogen activator inhibitor-1 in senescent fibroblasts (Abstract). 44th Ann. Meet. Gerontol. Soc. Am., San Francisco, CA, 1991, p. 314.
    • (1991) 44th Ann. Meet. Gerontol. Soc. Am. , pp. 314
    • West, M.D.1    Wright, W.E.2    Shay, J.W.3
  • 120
    • 0026753051 scopus 로고
    • Cloning and expression of SAG: A novel marker of cellular senescence
    • WISTROM, C. and VILLEPONTEAU, B. Cloning and expression of SAG: A novel marker of cellular senescence. Exp. Cell Res. 199, 355-362, 1992.
    • (1992) Exp. Cell Res. , vol.199 , pp. 355-362
    • Wistrom, C.1    Villeponteau, B.2
  • 121
    • 0026699554 scopus 로고
    • Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts
    • WON, K.-A., XIONG, Y., BEACH, D., and GILMAN, M.Z. Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts. Proc. Natl. Acad. Sci. USA 89, 9910-9914, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9910-9914
    • Won, K.-A.1    Xiong, Y.2    Beach, D.3    Gilman, M.Z.4
  • 122
    • 0024366596 scopus 로고
    • Reversible cellular senescence: Implications for immortalization of normal human diploid cells
    • WRIGHT, W.E., PEREIRA-SMITH, O.M., and SHAY, J.W. Reversible cellular senescence: Implications for immortalization of normal human diploid cells. Mol. Cell. Biol. 9, 3088-3092, 1989.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3088-3092
    • Wright, W.E.1    Pereira-Smith, O.M.2    Shay, J.W.3
  • 123
    • 0028338836 scopus 로고
    • Expression of 72-kDa gelatinase and TIMP-2 in early and late passage human fibroblasts
    • ZENG, G. and MILLIS, A.J. Expression of 72-kDa gelatinase and TIMP-2 in early and late passage human fibroblasts. Exp. Cell Res. 213, 148-155, 1994.
    • (1994) Exp. Cell Res. , vol.213 , pp. 148-155
    • Zeng, G.1    Millis, A.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.