Cellular mechanisms for diminished scarring with aging

Plastic and Reconstructive Surgery

Volumn 105, Issue 5, 2000, Pages 1591-1599

  Marcus, Jeffrey R ^b   Tyrone, John W ^b   Bonomo, Steven ^b   Xia, Yuping ^b   Mustoe, Thomas A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE;

ADOLESCENT; AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; EAR CARTILAGE; EPITHELIZATION; EXCISION; FEMALE; MORPHOMETRICS; NONHUMAN; PRIORITY JOURNAL; RABBIT; SCAR FORMATION; SKIN ULCER; WOUND HEALING;

EID: 0034032779     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006534-200004050-00001     Document Type: Article

References (22)

1. Ferguson, M. W., Whitby, D. J., Shah, M., Armstrong, J., Siebert, J. W., and Longaker, M. T. Scar formation: The spectral nature of fetal and adult wound repair (Review). Plast. Reconstr. Surg. 97: 854, 1996.
2. Longaker, M. T., Whitby, D. J., Ferguson, M. W., et al. Studies in fetal wound healing: III. Early deposition of fibronectin distinguishes fetal from adult wound healing. J. Pediatr. Surg. 24: 799, 1989.
3. Longaker, M. T., Whitby, D. J., Adzick, N. S., et al. Studies in fetal wound healing: VI. Second and early third trimester fetal wounds demonstrate rapid collagen deposition without scar formation. J. Pediatr. Surg. 25: 63, 1990.
4. Ashcroft, G. S., Horan, M. A., and Ferguson, M. W. The effects of ageing on cutaneous wound healing in mammals (Review). J. Anal. 187: 1, 1995.
5. Ashcroft, G. S., Horan, M. A., and Ferguson, M. W. Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model. J. Invest. Dermatol. 108: 430, 1997.
6. Ashcroft, G. S., Horan, M. A., and Ferguson, M. W. The effects of ageing on wound healing: Immunolocalisation of growth factors and their receptors in a murine incisional model. J. Anat. 190: 351, 1997.
7. Bruce, S. A., and Deamond, S. F. Longitudinal study of in vivo wound repair and in vitro cellular senescence of dermal fibroblasts. Exp. Gerontol. 26: 17, 1991.
8. Kondo, H., Yonezawa, Y., and Nomaguchi, T. A. Effects of serum collected from rats of different ages on in vitro cell proliferation. Mech. AgeingDev. 42: 159, 1988.
9. Phillips, P. D., Doggett, D. L., and Cristofalo, V. J. Growth factors and cell aging (Review). Annu. Rev. Gerontol. Geriatr. 10: 43, 1990.
10. Desmouliere, A., Redard, M., Darby, I., and Gabbiani, G. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am. J. Pathol. 146: 56, 1995.
11. Brown, D. L., Kao, W. W., and Greenhalgh, D. G. Apoptosis down-regulates inflammation under the advancing epithelial wound edge: Delayed patterns in diabetes and improvement with topical growth factors. Surgery 121: 372, 1997.
12. Choi, A. M., Olsen, D. R., Cook, K. G., Deamond, S. F., Uitto, J., and Bruce, S. A. Differential extracellular matrix gene expression by fibroblasts during their proliferative life span in vitro and at senescence. J. Cell. Physiol. 151: 147, 1992.
13. Phillips, C. L., Combs, S. B., and Pinnell, S. R. Effects of ascorbic acid on proliferation and collagen synthesis in relation to the donor age of human dermal fibroblasts. J. Invest. Dermatol. 103: 228, 1994.
14. Morris, D. E., Wu, L., Zhao, L. L., et al. Acute and chronic animal models for excessive dermal scarring: Quantitative studies. Plast. Reconstr. Surg. 100: 674, 1997.
15. Darby, I. A., Bisucci, T., Hewitson, T. D., and MacLellan, D. G. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice. Int. J. Biochem. Cell Biol. 29: 191, 1997.
16. Gold, R., Schmied, M., Rothe, G., et al. Detection of DNA fragmentation in apoptosis: Application of in situ nick translation to cell culture systems and tissue sections. J. Histochem. Cytochem. 41: 1023, 1993.
17. Gold, R., Schmied, M., Giegerich, G., et al. Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques (see comments). Lab. Invest. 71: 219, 1994.
18. Joseph, J., and Dyson, M. Tissue replacement in the rabbit's ear. Br. J. Surg. 53: 372, 1966.
19. Appleton, I., Brown, N. J., and Willoughby, D. A. Apoptosis, necrosis, and proliferation: Possible implications in the etiology of keloids. Am. J. Pathol. 149: 1441, 1996.
20. Calderon, M., Lawrence, W. T., and Banes, A. J. Increased proliferation in keloid fibroblasts wounded in vitro. J. Surg. Res. 61: 343, 1996.
21. Nakaoka, H., Miyauchi, S., and Miki, Y. Proliferating activity of dermal fibroblasts in keloids and hypertrophic scars. Acta Derm. Venereol. 75: 102, 1995.
22. Zhou, L. J., Ono, I., and Kaneko, F. Role of transforming growth factor-beta 1 in fibroblasts derived from normal and hypertrophic scarred skin. Arch. Dermatol. Res. 289: 646, 1997.