Insulin-activated protein kinase Cβ bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells

Molecular and Cellular Biology

Volumn 20, Issue 17, 2000, Pages 6323-6333

  Formisano, P ^a   Oriente, F ^a   Fiory, F ^a   Caruso, M ^a   Miele, C ^a   Maitan, M A ^a   Andreozzi, F ^a   Vigliotta, G ^a   Condorelli, G ^a   Beguinot, F ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; EPIDERMAL GROWTH FACTOR; INSULIN; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; INSULIN SENSITIVITY; MITOGENESIS; MUSCLE CELL; NONHUMAN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BLOTTING, WESTERN; CELL DIVISION; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; GUANOSINE TRIPHOSPHATE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INSULIN; ISOENZYMES; LOVASTATIN; MAP KINASE SIGNALING SYSTEM; MUSCLES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOPROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-RAF; PROTO-ONCOGENE PROTEINS P21(RAS); RAS PROTEINS; RECEPTOR, INSULIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 0033838459     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.17.6323-6333.2000     Document Type: Article

References (55)

1. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain
2. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
3. Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport
4. Evidence for involvement of protein kinase C (PKC)-ζ and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes
5. Protein kinase C isoforms beta 1 and beta 2 inhibit the tyrosine kinase activity of the insulin receptor
6. ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
7. Tyrosine phosphorylation of specific protein kinase C isoenzymes participates in insulin stimulation of glucose transport in primary cultures of rat skeletal muscle
8. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells
9. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
10. Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase
11. Insulin stimulates mitogen-activated protein kinase by a Ras-independent pathway in 3T3-L1 adipocytes
12. In L6 skeletal muscle cells, glucose induces cytosolic translocation of protein kinase C alfa and transactivates the insulin receptor kinase
13. A carboxy-terminal deletion mutant of protein kinase C beta II inhibits insulin-stimulated 2-deoxyglucose uptake in L6 rat skeletal muscle cells
14. Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling
15. Activation of protein kinase C alpha inhibits insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1
16. Insulin-stimulated hydrolysis of phosphatidylcholine by phospholipase C and phospholipase D in cultured rat hepatocytes
17. Mutation in a conserved motif next to the insulin receptor key autophosphorylation sites deregulates kinase activity and impairs insulin action
18. In NIH3T3 fibroblasts, insulin receptor interaction with specific protein kinase isoforms controls receptor intracellular routing
19. Organization and regulation of mitogen-activated protein kinase signaling pathways
20. Protein kinase C isoenzymes: Divergence in signal transduction?
21. Protein kinase C isozymes and substrates
22. (S)-13-[(monomethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21 -dimetheno-1H,13H-dibenzo[E,K]pyrrolo-[3,4-H][1,4,13]oxadiza-cycl ohexadecin-1,3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase Cb (PKCb)
23. Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin
24. Protein kinase C alpha activates RAF-1 by direct phosphorylation
25. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C
26. The extended protein kinase C super-family
27. Requirement of protein kinase Cζ for stimulation of protein synthesis by insulin
28. Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152→Gln insulin receptor
29. The role of insulin receptor autophosphorylation in signal transduction
30. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85
31. Role of IRS-1-GRB-2 complexes in insulin signaling
32. Regulation of protein kinase C
33. The MAP kinase cascade is essential for diverse signal transduction pathways
34. The molecular heterogeneity of protein kinase C and its implications for cellular regulation
35. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
36. Phosphoinositide-specific phospholipase C and mitogenic signaling
37. Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells
38. Rat liver nuclei protein kinase C is the isozyme type II
39. Protein kinase C-ζ and phosphoinositides-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes
40. Inhibitors of ras farnesylation revert the increased resistance to oxidative stress in K-ras transformed NIH 3T3 cells
41. Interactions of protein kinase C with insulin signaling. Influence on GAP and Sos activities
42. 3-induced differentiation
43. The function of GRB2 in linking the insulin receptor to Ras signaling pathways
44. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signalling
45. Activation of the c-Raf protein kinase by protein kinase C phosphorylation
46. Insulin stimulates phospholipase D-dependent phosphatidyl31choline hydrolysis, Rho translocation, de novo phospholipid synthesis, and diacylglycerol/protein kinase C signaling in L6 myotubes
47. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport
48. Effects of knockout of the protein kinase C β gene on glucose transport and glucose homeostasis
49. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
50. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells
51. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
52. Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
53. Requirement for phospholipase C-γ1 enzymatic activity in growth factor-induced mitogenesis
54. The insulin signalling system and the IRS proteins
55. Protein kinase C, but not tyrosine kinases or ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes