Altered trafficking of membrane proteins in Purkinje cells of SCA1 transgenic mice

American Journal of Pathology

Volumn 159, Issue 3, 2001, Pages 905-913

  Skinner, Pamela J ^a   Vierra Green, Cynthia A ^a   Clark, H Brent ^a   Zoghbi, Huda Y ^c   Orr, Harry T ^a,b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; GLUTAMATE RECEPTOR; MEMBRANE PROTEIN; PROTEASOME; PROTEIN KINASE C; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATROPHY; CELL VACUOLE; CONTROLLED STUDY; DENDRITE; GENE OVEREXPRESSION; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PURKINJE CELL; SPINOCEREBELLAR DEGENERATION; TRANSGENIC MOUSE; WESTERN BLOTTING;

EID: 0034858068     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)61766-X     Document Type: Article

References (34)

1. Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1
2. Glutamine repeats and neurodegeneration
3. SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat
4. Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations
5. Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures
6. Ataxin-1 nuclear localization and aggregation: Role in polyglutamine-induced disease in SCA1 transgenic mice
7. Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1
8. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
9. Spinocerebellar ataxia type 1-modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice
10. The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
11. Selective distribution of multiple protein kinase C isoforms in mouse cerebellar cortex
12. Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells
13. Direct visualization of the translocation of the gamma-subspecies of protein kinase C in living cells using fusion proteins with green fluorescent protein
14. Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals
15. Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice
16. The metabotropic glutamate receptors: Structure and functions
17. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
18. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
19. The ubiquitin system
20. Intracellular targeting of the proteasome
21. ER quality control: The cytoplasmic connection
22. Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins
23. The ubiquitin-proteasome system and endocytosis
24. Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway
25. Stabilization of mutant 46-kDa mannose 6-phosphate receptors by proteasomal inhibitor lactacystin
26. Synergistic activation of protein kinase Calpha, -beta 1, and -gamma isoforms induced by diacylglycerol and phorbol ester: Roles of membrane association and activating conformational changes
27. Calcium is an intracellular mediator of the climbing fiber in induction of cerebellar long-term depression
28. Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites
29. A new class of synaptic response involving calcium release in dendritic spines
30. Ca2+ stores in Purkinje neurons: Endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin
31. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
32. Antibodies inactivating mGluR1 metabotropic glutamate receptor block longterm depression in cultured Purkinje cells
33. Participation of postsynaptic PKC in cerebellar long-term depression in culture
34. Spinocerebellar ataxia type 1