Prosaptide exacerbates ischemia-induced behavioral deficits in vivo; an effect that does not involve mitogen-activated protein kinase activation

Neuroscience

Volumn 101, Issue 4, 2000, Pages 811-814

  Lapchak, P A ^a,b,c   Araujo, D M ^b   Shackelford, D A ^a   Zivin, J A ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Extracellular regulated kinase; Mitogen activated protein kinase; Neuroprotection; Prosaposin, ischemia; Prosaptide

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PEPTIDE; PROSAPOSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOBLOTTING; IN VIVO STUDY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPINAL CORD ISCHEMIA;

ANIMALS; ENZYME ACTIVATION; ISCHEMIA; MENTAL DISORDERS; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTORS; RABBITS; SPINAL CORD;

EID: 0034736222     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(00)00466-8     Document Type: Article

References (34)

1. Phosphatidylinositol 3-kinase and Akt protein kinase mediate IGF-I-and prosaptide-induced survival in Schwann cells
2. Induction of MAPK phosphorylation by prosaposin and prosaptide in PC12 cells
3. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells
4. Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule
5. Occurrence of prosaposin as a neuronal surface membrane component
6. Sphingolipid activator protein deficiency in a 16-week-old atypical Gaucher disease patient and his fetal sibling: biochemical signs of combined sphingolipdoses
7. Secretion of sphingolipid hydrolase activator precursor, prosaposin
8. Prosaposin receptor: evidence for a G-protein-associated receptor
9. Isolation, characterization and proteolysis of human prosaposin, the precursor of saposins (sphingolipid activator proteins)
10. Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides
11. Administration of prosaposin ameliorates spatial learning disturbance and reduces cavity formation following stab wounds in rat brain
12. An 18-Mer peptide fragment of prosaposin ameliorates place navigation disability, cortical infarction, and retrograde thalamic degeneration in rats with focal cerebral ischemia
13. Saposins: structure, function, distribution, and molecular genetics
14. Glutamate antagonist therapy reduces neurologic deficits produced by focal central nervous system ischemia
15. A hydrophilic peptide comprising 18 amino acid residues of the prosaposin sequence has neurotrophic activity in vitro and in vivo
16. Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors
17. Molecular aspects of Gaucher disease
18. Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia
19. Saposin A: second cerebrosidase activator protein
20. Identification of prosaposin as a neurotrophic factor
21. Identification of the neurotrophic factor sequence of prosaposin
22. Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by prosaptide TX14(A)
23. Functional organization of saposin C. Definition of the neurotrophic and acid (β-glucosidase activation regions
24. Mannose 6-phosphate-independent membrane association of cathepsin D, glucocerebrosidase, and sphingolipid-activating protein in HepG2 cells
25. Protection by prosaposin against ischemia-induced learning disability and neuronal loss
26. Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion
27. Designing stable blood-brain barrier-permeable prosaptide peptides for treatment of central nervous system neurodegeneration
28. Prosaposin prevents programmed cell death of rat cerebellar granule neurons in culture
29. Prosaptide prevents hyperalgesia and reduces peripheral TNFR1 expression following TNF-a nerve injection
30. Prosaptide D5 reverses hyperalgesia: inhibition of calcium channels through a pertussis toxin-sensitive G-protein mechanism in the rat
31. Activation of nuclear factor-kappaB in the rabbit spinal cord following ischemia and reperfusion
32. Spectrum of neurological deficits in experimental CNS ischemia
33. Quantal bioassay and stroke