Induction of chemoresistance in HL-60 cells concomitantly causes a resistance to apoptosis and the synthesis of P-glycoprotein

Leukemia

Volumn 15, Issue 9, 2001, Pages 1377-1387

  Campone, M ^a,b   Vavasseur, F ^a   Le Cabellec, M T ^a   Meflah, K ^a   Vallette, F M ^a   Oliver, L ^a  

^a INSERM   (France)

^b Centre Régional de Lutte Contre le Cancer CRLCC   (France)

Author keywords

Apoptosis; Bcl 2; Bcl XL; Chemoresistance; P glycoprotein; XIAP

Indexed keywords

CELL PROTEIN; CYTARABINE; DOXORUBICIN; GLYCOPROTEIN P; INHIBITOR OF APOPTOSIS PROTEIN; MULTIDRUG RESISTANCE PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG; VERAPAMIL;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CULTURE; CELL STRAIN HL 60; CONTROLLED STUDY; HUMAN; HUMAN CELL; LETHAL DOSE; MULTIDRUG RESISTANCE; PRIORITY JOURNAL;

EID: 0034854749     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402222     Document Type: Article

References (49)

1. Apoptosis and the dilemma of cancer chemotherapy
2. The clinical relevance of multidrug resistance
3. Co-expression of several molecular mechanisms of multidrug resistance and their significance for paclitaxel cytotoxicity in human AML HL-60 cells
4. The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
5. Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia
6. Expression of P-glycoprotein in de novo acute myelogenous leukemia at initial diagnosis: Results of molecular and functional assays, and correlation with treatment outcome
7. In acute myeloid leukemia, coexpression of at least two proteins, including P-glycoprotein, the multidrug resistance-related protein, Bcl-2, mutant p53, and heat-shock protein 27, is predictive of the chemotherapy
8. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
9. P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway
10. La glycoprotéine P: De la résistance croisée aux médicaments au transport des lipides biliares
11. Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death
12. Expression of Bcl-XL can confer a multidrug resistance phenotype
13. Overexpression of Bcl-XL promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model
14. Biochemical and genetic control of apoptosis: Relevance to normal hematopoiesis and hematological malignancies
15. BCL-2 family members and the mitochondria in apoptosis
16. BCL-2 family: Regulators of cell death
17. Apoptosis in cancer
18. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
19. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
20. Caspase structure, proteolytic substrates, and function during apoptotic cell death
21. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
22. Prevention of apoptosis by Bcl-2: Release of cytochrome c from the mitochondria blocked
23. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
24. BCL-X expression in multiple myeloma: Possible indicator of chemoresistance
25. Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-XL
26. An informatics approach identifying markers of chemosensitivity in human cancer cell lines
27. Abrogation of mitochondrial cytochrome c release and caspase-3 activation in acquired multidrug resistance
28. Bcl-XL is heterogeneously expressed by acute myeloblastic leukemia cells and is associated with autonomous growth in vitro and with P-glycoprotein expression
29. IAP family of proteins-suppressors of apoptosis
30. X-linked IAP is a direct inhibitor of cell-death proteases
31. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
32. Human IAP-like protein regulates programmed cell death downstream of Bcl-XL and cytochrome c
33. Multicentric evaluation of the MDR phenotype in leukemia. French network of the drug resistance intergroup, and drug resistance network of assistance publique-hopitaux de Paris
34. Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system
35. Multiple physiological functions for multidrug transporter P-glycoprotein?
36. Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions
37. Novel mechanisms of drug resistance in leukemia
38. P-glycoprotein expression in patients with acute leukemia-clinical relevance
39. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells
40. Identification of immunosuppressant-induced apoptosis in murine B-cell line and its prevention by Bcl-x and not Bcl-2
41. Differential protective effects of Bcl-XL and Bcl-2 on apoptotic liver injury in transgenic mice
42. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmentated hair
43. Massive cell death of immature hematopoietic cells and neurons in Bcl-XL-deficient mice
44. Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse
45. Caspase inhibition extends the commitment to neuronal death beyond cytochrome c release to the point of mitochondrial depolarisation
46. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
47. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
48. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
49. Cell-specific induction of apoptosis by microinjection of cytochrome c