(Q) SAR study on the metabolic stability of steroidal androgens

Journal of Molecular Graphics and Modelling

Volumn 19, Issue 6, 2001, Pages

  Bursi, Roberta ^a,b   De Gooyer, Marcel E ^a   Grootenhuis, Arijan ^a   Jacobs, Peter L ^a   Van der Louw, Jaap ^b   Leysen, Dirk ^b  

^a Department of Molecular Design and Informatics ^*  (Netherlands)

^b NV ORGANON   (Netherlands)

Author keywords

Ab initio calculations; Androgens; Cytochrome P450; Decision trees; Male contraception; Metabolic stability; PADAM

Indexed keywords

ACTIVATION ENERGY; METABOLISM; OXIDATION; PHARMACOKINETICS;

ANDROGENS;

MOLECULAR GRAPHICS;

ANDROGEN; CYTOCHROME P450; HYDROGEN; RADICAL; STEROID;

ADULT; ARTICLE; BIOENERGY; CONTRACEPTION; CONTROLLED STUDY; DECISION THEORY; DRUG ANALYSIS; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; FIRST PASS EFFECT; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOLECULAR WEIGHT; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOCHEMISTRY; STEROID METABOLISM;

EID: 0034844616     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1093-3263(01)00089-4     Document Type: Article

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