Drug absorption studies of prodrug esters using the Caco-2 model: Evaluation of ester hydrolysis and transepithelial transport

International Journal of Pharmaceutics

Volumn 166, Issue 1, 1998, Pages 45-53

  Augustijns, P ^a   Annaert, P ^a   Heylen, P ^a   Van Den Mooter, G ^a   Kinget, R ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Caco 2; Esterase activity; Esterase prodrugs; Intestinal absorption

Indexed keywords

PREDNISOLONE; PREDNISOLONE ACETATE; PREDNISOLONE DERIVATIVE; PREDNISOLONE HEMISUCCINATE; PRODRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG METABOLISM; DRUG TRANSPORT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; LIPOPHILICITY; PRIORITY JOURNAL;

EID: 0032507740     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00013-1     Document Type: Article

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