Localization of cytochromes p450 in human tissues: Implications for chemical toxicity

Pathology

Volumn 28, Issue 2, 1996, Pages 148-155

  McKinnon, Ross A ^a   McManus, Michael E ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Carcinogens; Cytochrome P450; In situ hybridization; Metabolism

Indexed keywords

CYTOCHROME P450;

ARTICLE; GASTROINTESTINAL TRACT; HUMAN; NONHUMAN; RABBIT; TOXICITY;

EID: 0030440082     PISSN: 00313025     EISSN: None     Source Type: Journal    
DOI: 10.1080/00313029600169783     Document Type: Article

References (20)

1. Nebert DW. Proposed role of drug-metabolizing enzymes: regulation of steady state ligands that affect growth, homeostasis, differentiation, and neuroendocrine functions. Mol Endocrinol 1991; 5: 1203-14.
2. Nebert DW. Growth signal pathways. Nature 1991; 347: 709-10.
3. Nelson DR, Kamataki T, Waxman DJ et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 1993; 12: 1-51.
4. Gonzalez FJ. The molecular biology of cytochrome P450s. Pharmacol Rev 1989; 40: 243-88.
5. Nebert DW, McKinnon RA. Cytochrome P450: evolution and diversity. Progress in Liver Diseases 1994; 14: 1-31.
6. Johnson EF, Muller-Eberhard U. Resolution of two forms of cytochrome P-450 from liver microsomes of rabbits treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 1977; 252: 2839-45.
7. Goldstein JA, Linko P, Luster MI et al. Purification and characterization of a second form of hepatic cytochrome P-448 from rats treated with a pure polychlorinated biphenyl isomer. J Biol Chem 1982; 257: 2702-7.
8. Guengerich FP, Dannan GA, Wright ST et al. Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or o-naphthoflavone. Biochemistry 1982; 21: 6019-30.
9. McManus ME, Burgess WM, Veronese ME et al. Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res 1990; 50: 3367-76.
10. Johnson EF, Levitt DS, Muller-Eberhard U et al. Catalysis of divergent pathways of 2-acetylaminofluorene metabolism by multiple forms of cytochrome P-450. Cancer Res 1980; 40: 4456-9.
11. McManus ME, Minchin RF, Sanderson N et al. Kinetics of 2-acetylaminofluorene metabolism by six highly purified forms of rabbit liver cytochrome P450. Carcinogenesis 1984; 5: 1717-23.
12. McManus ME, Burgess W, Synderwine EG et al. Specificity of rabbit cytochrome P-450 isozymes involved in the metabolic activation of the food derived mutagen 2-amino-3-methylimidazo[4,5-f]quinolone. Cancer Res 1988; 48: 4513-9.
13. McManus ME, Burgess W, Stupans I et al. Activation of the food-derived mutagen 2-amino-3-methylimidazo[4,5-f]quinolone by human-liver microsomes [published erratum appears in Mutat Res 1988; 206(1): 130]. Mutat Res 1988; 204: 185-93.
14. McManus ME, Felton JS, Knize MG et al. Activation of the food-derived mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450. Carcinogenesis 1989; 10: 357-63.
15. Aoyama T, Gonzalez FJ, Gelboin HV. Human cDNA-expressed cytochrome P450 1A2: mutagen activation and substrate specificity. Mol Carcinog 1989; 2: 192-8.
16. Koop DR, Coon MJ. Ethanol oxidation and toxicity: role of alcohol P-450 oxygenase. Alcohol Clin Exp Res 1986; 10: 445-95.
17. Feierman DE, Cederbaum AI. Increased sensitivity of the microsomal oxidation of ethanol to inhibition by pyrazole and 4-methylpyrazole after chronic ethanol treatment. Biochem Pharmacol 1987; 36: 3277-83.
18. Tredger JM, Smith HM, Read RB et al. Effects of ethanol ingestion on the hepatotoxicity and metabolism of paracetamol in mice. Toxicology 1985; 36: 341-5.
19. Seeff LB, Cuccherini BA, Zimmerman HJ et al. Acetaminophen toxicity in alcoholics. Clin Rev 1986; 104: 399-404.
20. Wrighton SA, Thomas PE, Ryan DE et al. Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj. Arch Biochem Biophys 1987; 258: 292-7.