Primary porcine enterocyte and hepatocyte cultures to study drug oxidation reactions

British Journal of Pharmacology

Volumn 129, Issue 2, 2000, Pages 331-342

  Bader, A ^a,c   Hansen, T ^b   Kirchner, G ^c   Allmeling, C ^a   Haverich, A ^a   Borlak, J T ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

CYP mono oxygenases; Dexamethasone; Enzyme induction; Immunosuppressive FK 506; Isolation and cultivation; Metabolism; Porcine enterocytes; Porcine hepatocytes; Species comparison

Indexed keywords

CYTOCHROME P450 1A; CYTOCHROME P450 3A; DEXAMETHASONE; DRUG METABOLITE; IMMUNOSUPPRESSIVE AGENT; KC 11346; KC 12291; TACROLIMUS; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; INSECT; INTESTINE CELL; LIQUID CHROMATOGRAPHY; LIVER CELL CULTURE; LIVER MICROSOME; MASS SPECTROMETRY; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE;

EID: 0033960105     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703062     Document Type: Article

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